Grant Number:	5U01HG006485-08 Interpret this number
Primary Investigator:	Plon, Sharon
Organization:	Baylor College Of Medicine
Project Title:	Evaluating Utility and Improving Implementation of Genomic Sequencing for Pediatric Cancer Patients in the Diverse Population and Healthcare Settings of Texas: the Kidscanseq Study
Fiscal Year:	2020

Through this Clinical Sequencing Evidence-Generating Research (CSER2) with Enhanced Diversity project we will complete a trial (The Texas KidsCanSeq Study) comparing the results of targeted cancer panel sequencing versus genome-scale testing in pediatric cancer patients across diverse clinical settings. We will compare the targeted cancer panel to germline whole exome sequencing (WES) of unselected childhood cancer patients (n=1100) and WES, transcriptome sequencing and copy number array of FFPE tumor samples for the subset of patients with high-risk tumors (n=360). We will build on our success completing the CSER program BASIC3 exome sequencing trial (which included 60% Hispanic and African-American patients from a single large academic center) in this large multi-institutional study of an even more diverse patient population from five heterogeneous healthcare settings across Texas. The trial will be led by an experienced multi-PI team of Drs. Plon (medical geneticist), Parsons (pediatric oncologist) and McGuire (ethicist and health policy expert). We will assess clinical utility of these tests by measuring the frequency of diagnostic and/or actionable germline and tumor findings and the effect on treatment decisions (Aim 1). We will compare uptake by first degree relatives for familial genetic testing and recommended cancer surveillance by race, ethnicity and clinical settings (Aim 2). We will describe perceived utility (clinical, psychological, and pragmatic) by surveying and interviewing parents and participating pediatric oncologists (n=40) (Aim 3). Working with our pediatric cancer stakeholders, including advocates, BASIC3 study parents, and national organizations, we will create and evaluate the use of culturally sensitive educational materials, including videos in English and Spanish, improved integrated genomic test reports and counseling materials, and will compare in-person versus telemedicine exome results disclosure (Aim 4). Finally, we will provide data to guide future application of clinical genomics through three innovative pilot projects focused on health economics, decision support for cancer surveillance and whole genome sequencing (Aim 5). Baylor College of Medicine, Texas Children’s Hospital, and our partner institutions across the state are ideally suited to conduct this study and play leadership roles in CSER2 consortium activities based on our longstanding pediatric oncology and cancer genetics expertise, extensive experience in CLIA-certified clinical germline and cancer genomic diagnostic testing, and a track record of scholarship in ethical and social implications of genomics and health disparities research.




Genomic sequencing in diverse and underserved pediatric populations: parent perspectives on understanding, uncertainty, psychosocial impact, and personal utility of results.
Authors: Biesecker B.B. , Ackerman S.L. , Brothers K.B. , East K.M. , Katherine M Foreman A. , Hindorff L.A. , Horowitz C.R. , Jarvik G.P. , Knight S.J. , Leo M.C. , et al. .
Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2025-01-19 00:00:00.0; , p. 101363.
EPub date: 2025-01-19 00:00:00.0.
PMID: 39846247
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Measuring perceived utility of genomic sequencing: Development and validation of the GENEtic Utility (GENE-U) scale for adult screening.
Authors: Smith H.S. , Rubanovich C.K. , Robinson J.O. , Levchenko A.N. , Classen S.A. , Malek J. , Buchanan A.H. , Biesecker B. , Brothers K.B. , Wilfond B.S. , et al. .
Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2024 Nov; 26(11), p. 101240.
EPub date: 2024-08-10 00:00:00.0.
PMID: 39140259
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Comparing the Diagnostic Yield of Germline Exome Versus Panel Sequencing in the Diverse Population of the Texas KidsCanSeq Pediatric Cancer Study.
Authors: Desrosiers-Battu L.R. , Wang T. , Reuther J. , Miles G. , Dai H. , Jo E. , Russell H. , Raesz-Martinez R. , Recinos A. , Gutierrez S. , et al. .
Source: Jco Precision Oncology, 2024 Sep; 8, p. e2400187.
PMID: 39259914
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Genomic sequencing research in pediatric cancer care: Decision making, attitudes, and perceived utility among adolescents and young adults and their parents.
Authors: Gutierrez A.M. , Robinson J.O. , Smith H.S. , Desrosiers-Battu L.R. , Scollon S.R. , Canfield I. , Hsu R.L. , Schneider N.M. , Parsons D.W. , Plon S.E. , et al. .
Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2024-05-17 00:00:00.0; , p. 101168.
EPub date: 2024-05-17 00:00:00.0.
PMID: 38767058
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Measuring perceived utility of genomic sequencing: Development and validation of the GENEtic Utility (GENE-U) scale for pediatric diagnostic testing.
Authors: Smith H.S. , Rubanovich C.K. , Robinson J.O. , Levchenko A.N. , Classen S.A. , Malek J. , Biesecker B. , Brothers K.B. , Wilfond B.S. , Rini C. , et al. .
Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2024-04-24 00:00:00.0; , p. 101146.
EPub date: 2024-04-24 00:00:00.0.
PMID: 38676451
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Measuring health-related quality of life in children with suspected genetic conditions: validation of the PedsQL proxy-report versions.
Authors: Smith H.S. , Leo M. , Goddard K. , Muessig K. , Angelo F. , Knight S. , Outram S. , Kelly N.R. , Rini C. .
Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2024-03-12 00:00:00.0; , .
EPub date: 2024-03-12 00:00:00.0.
PMID: 38472717
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Families' experiences accessing care after genomic sequencing in the pediatric cancer context: "It's just been a big juggle".
Authors: Vuocolo B. , Gutierrez A.M. , Robinson J.O. , Recinos A.M. , Desrosiers L.R. , Majumder M.A. , Bernini J.C. , Gill J. , Griffin T. , Tomlinson G.E. , et al. .
Source: Journal Of Genetic Counseling, 2024-01-15 00:00:00.0; , .
EPub date: 2024-01-15 00:00:00.0.
PMID: 38225886
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The motivation and process for developing a consortium-wide time and motion study to estimate resource implications of innovations in the use of genome sequencing to inform patient care.
Authors: Hoban H.G. , Yip T.A. , Chau J.C. , Bensen J.T. , Desrosiers L.R. , Finnila C.R. , Hindorff L.A. , Kelly N.R. , Lynch F.L. , Rolf B.A. , et al. .
Source: Clinical And Translational Science, 2024 Jan; 17(1), p. e13635.
EPub date: 2023-12-08 00:00:00.0.
PMID: 38064200
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Combined Bioinformatic and Splicing Analysis of Likely Benign Intronic and Synonymous Variants Reveals Evidence for Pathogenicity.
Authors: Hirschi O.R. , Felker S.A. , Rednam S.P. , Vallance K.L. , Parsons D.W. , Roy A. , Cooper G.M. , Plon S.E. .
Source: Medrxiv : The Preprint Server For Health Sciences, 2023-11-01 00:00:00.0; , .
EPub date: 2023-11-01 00:00:00.0.
PMID: 37961416
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Views of Adolescents and Young Adults with Cancer and Their Oncologists Toward Patients' Participation in Genomic Research.
Authors: Gutierrez A.M. , Robinson J.O. , Raesz-Martinez R. , Canfield I. , Majumder M.A. , Scollon S. , Desrosiers L.R. , Hsu R.L. , Allen-Rhoades W. , Parsons D.W. , et al. .
Source: Journal Of Adolescent And Young Adult Oncology, 2023 Oct; 12(5), p. 773-781.
EPub date: 2023-01-02 00:00:00.0.
PMID: 36595372
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Views of Adolescents and Young Adults with Cancer and Their Oncologists Toward Patients' Participation in Genomic Research.
Authors: Gutierrez A.M. , Robinson J.O. , Raesz-Martinez R. , Canfield I. , Majumder M.A. , Scollon S. , Desrosiers L.R. , Hsu R.L. , Allen-Rhoades W. , Parsons D.W. , et al. .
Source: Journal Of Adolescent And Young Adult Oncology, 2023 Oct; 12(5), p. 773-781.
EPub date: 2023-01-02 00:00:00.0.
PMID: 36595372
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Germline pathogenic SMARCA4 variants in neuroblastoma.
Authors: Witkowski L. , Nichols K.E. , Jongmans M. , van Engelen N. , de Krijger R.R. , Herrera-Mullar J. , Tytgat L. , Bahrami A. , Mar Fan H. , Davidson A.L. , et al. .
Source: Journal Of Medical Genetics, 2023 Oct; 60(10), p. 987-992.
EPub date: 2023-02-22 00:00:00.0.
PMID: 36813544
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Parent-Reported Clinical Utility of Pediatric Genomic Sequencing.
Authors: Smith H.S. , Ferket B.S. , Gelb B.D. , Hindorff L. , Ferar K.D. , Norton M.E. , Sahin-Hodoglugil N. , Slavotinek A. , Lich K.H. , Berg J.S. , et al. .
Source: Pediatrics, 2023-08-01 00:00:00.0; 152(2), .
PMID: 37470118
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Circulating tumor DNA sequencing of pediatric solid and brain tumor patients: An institutional feasibility study.
Authors: Mangum R. , Reuther J. , Sen Baksi K. , Gandhi I. , Zabriskie R.C. , Recinos A. , Raesz-Martinez R. , Lin F.Y. , Potter S.L. , Sher A.C. , et al. .
Source: Pediatric Hematology And Oncology, 2023-06-27 00:00:00.0; , p. 1-20.
EPub date: 2023-06-27 00:00:00.0.
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Authors: Russell H. , Smith H.S. , Bensen J.T. , Murali P. , Ferket B.S. , Finnila C. , Hindorff L.A. , Sahin-Hodoglugil N. .
Source: Contemporary Clinical Trials, 2022-12-22 00:00:00.0; 125, p. 107063.
EPub date: 2022-12-22 00:00:00.0.
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Source: Genome Medicine, 2022-11-21 00:00:00.0; 14(1), p. 131.
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Source: American Journal Of Medical Genetics. Part A, 2022-11-07 00:00:00.0; , .
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Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2022 10; 24(10), p. 2014-2027.
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Source: The Journal Of Molecular Diagnostics : Jmd, 2022 Jul; 24(7), p. 760-774.
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Source: Pediatric Blood & Cancer, 2022-06-17 00:00:00.0; , p. e29859.
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Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2022-02-25 00:00:00.0; , .
EPub date: 2022-02-25 00:00:00.0.
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Source: Cancer Genetics, 2022-01-05 00:00:00.0; 262-263, p. 53-56.
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Authors: Plon S.E. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2022-01-01 00:00:00.0; 40(1), p. 5-7.
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Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2022 Jan; 24(1), p. 238-244.
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Authors: Smith H.S. , Brothers K.B. , Knight S.J. , Ackerman S.L. , Rini C. , Veenstra D.L. , McGuire A.L. , Wilfond B.S. , Malek J. .
Source: American Journal Of Human Genetics, 2021-11-04 00:00:00.0; 108(11), p. 2027-2036.
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Source: The Patient, 2021-10-18 00:00:00.0; , .
EPub date: 2021-10-18 00:00:00.0.
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Authors: Amendola L.M. , Golden-Grant K. , Scollon S. .
Source: Annual Review Of Genomics And Human Genetics, 2021-08-31 00:00:00.0; 22, p. 339-355.
EPub date: 2021-03-15 00:00:00.0.
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Authors: Lindberg N.M. , Gutierrez A.M. , Mittendorf K.F. , Ramos M.A. , Anguiano B. , Angelo F. , Joseph G. .
Source: Personalized Medicine, 2021-08-27 00:00:00.0; , .
EPub date: 2021-08-27 00:00:00.0.
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Source: Journal Of Personalized Medicine, 2021-06-18 00:00:00.0; 11(6), .
EPub date: 2021-06-18 00:00:00.0.
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Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2021-06-10 00:00:00.0; , .
EPub date: 2021-06-10 00:00:00.0.
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Source: The Journal Of Pathology, 2021-06-04 00:00:00.0; , .
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Authors: Suckiel S.A. , O'Daniel J.M. , Donohue K.E. , Gallagher K.M. , Gilmore M.J. , Hendon L.G. , Joseph G. , Lianoglou B.R. , Mathews J.M. , Norton M.E. , et al. .
Source: Journal Of Personalized Medicine, 2021-03-13 00:00:00.0; 11(3), .
EPub date: 2021-03-13 00:00:00.0.
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Authors: O'Doherty K.C. , Shabani M. , Dove E.S. , Bentzen H.B. , Borry P. , Burgess M.M. , Chalmers D. , De Vries J. , Eckstein L. , Fullerton S.M. , et al. .
Source: Nature Genetics, 2021 Jan; 53(1), p. 2-8.
PMID: 33414545
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Authors: Gutierrez A.M. , Robinson J.O. , Outram S.M. , Smith H.S. , Kraft S.A. , Donohue K.E. , Biesecker B.B. , Brothers K.B. , Chen F. , Hailu B. , et al. .
Source: Journal Of Clinical And Translational Science, 2021; 5(1), p. e193.
EPub date: 2021-09-14 00:00:00.0.
PMID: 34888063
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Examining access to care in clinical genomic research and medicine: Experiences from the CSER Consortium.
Authors: Gutierrez A.M. , Robinson J.O. , Outram S.M. , Smith H.S. , Kraft S.A. , Donohue K.E. , Biesecker B.B. , Brothers K.B. , Chen F. , Hailu B. , et al. .
Source: Journal Of Clinical And Translational Science, 2021; 5(1), p. e193.
EPub date: 2021-09-14 00:00:00.0.
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Authors: Biesecker B.B. , Lillie S.E. , Amendola L.M. , Donohue K.E. , East K.M. , Foreman A.K.M. , Gilmore M.J. , Greve V. , Liangolou B. , O'Daniel J.M. , et al. .
Source: Journal Of Genetic Counseling, 2020-12-05 00:00:00.0; , .
EPub date: 2020-12-05 00:00:00.0.
PMID: 33278053
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Authors: Amendola L.M. , Muenzen K. , Biesecker L.G. , Bowling K.M. , Cooper G.M. , Dorschner M.O. , Driscoll C. , Foreman A.K.M. , Golden-Grant K. , Greally J.M. , et al. .
Source: American Journal Of Human Genetics, 2020-11-05 00:00:00.0; 107(5), p. 932-941.
EPub date: 2020-10-26 00:00:00.0.
PMID: 33108757
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Authors: Lemke A.A. , Amendola L.M. , Kuchta K. , Dunnenberger H.M. , Thompson J. , Johnson C. , Ilbawi N. , Oshman L. , Hulick P.J. .
Source: Journal Of Personalized Medicine, 2020-10-13 00:00:00.0; 10(4), .
EPub date: 2020-10-13 00:00:00.0.
PMID: 33066060
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Clinical Genetics Lacks Standard Definitions and Protocols for the Collection and Use of Diversity Measures.
Authors: Popejoy A.B. , Crooks K.R. , Fullerton S.M. , Hindorff L.A. , Hooker G.W. , Koenig B.A. , Pino N. , Ramos E.M. , Ritter D.I. , Wand H. , et al. .
Source: American Journal Of Human Genetics, 2020-07-02 00:00:00.0; 107(1), p. 72-82.
EPub date: 2020-06-06 00:00:00.0.
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Lessons learned about harmonizing survey measures for the CSER consortium.
Authors: Goddard K.A.B. , Angelo F.A.N. , Ackerman S.L. , Berg J.S. , Biesecker B.B. , Danila M.I. , East K.M. , Hindorff L.A. , Horowitz C.R. , Hunter J.E. , et al. .
Source: Journal Of Clinical And Translational Science, 2020-04-24 00:00:00.0; 4(6), p. 537-546.
EPub date: 2020-04-24 00:00:00.0.
PMID: 33948230
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Authors: Rubanovich C.K. , Smith H.S. , Bloss C.S. .
Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2020 03; 22(3), p. 665-666.
PMID: 31740737
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A brief history of human disease genetics.
Authors: Claussnitzer M. , Cho J.H. , Collins R. , Cox N.J. , Dermitzakis E.T. , Hurles M.E. , Kathiresan S. , Kenny E.E. , Lindgren C.M. , MacArthur D.G. , et al. .
Source: Nature, 2020 01; 577(7789), p. 179-189.
EPub date: 2020-01-08 00:00:00.0.
PMID: 31915397
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Authors: Childerhose J.E. , Finnila C.R. , Yu J.H. , Koenig B.A. , McEwen J. , Berg S.L. , Wilfond B.S. , Appelbaum P.S. , Brothers K.B. .
Source: Ethics & Human Research, 2019 Sep; 41(5), p. 2-15.
PMID: 31541538
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Genetic Predisposition to Childhood Cancer in the Genomic Era.
Authors: Plon S.E. , Lupo P.J. .
Source: Annual Review Of Genomics And Human Genetics, 2019-08-31 00:00:00.0; 20, p. 241-263.
EPub date: 2019-05-13 00:00:00.0.
PMID: 31082280
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Characterization of pediatric hepatocellular carcinoma reveals genomic heterogeneity and diverse signaling pathway activation.
Authors: Haines K. , Sarabia S.F. , Alvarez K.R. , Tomlinson G. , Vasudevan S.A. , Heczey A.A. , Roy A. , Finegold M.J. , Parsons D.W. , Plon S.E. , et al. .
Source: Pediatric Blood & Cancer, 2019 Jul; 66(7), p. e27745.
EPub date: 2019-04-11 00:00:00.0.
PMID: 30977242
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Consent for clinical genome sequencing: considerations from the Clinical Sequencing Exploratory Research Consortium.
Authors: Yu J.H. , Appelbaum P.S. , Brothers K.B. , Joffe S. , Kauffman T.L. , Koenig B.A. , Prince A.E. , Scollon S. , Wolf S.M. , Bernhardt B.A. , et al. .
Source: Personalized Medicine, 2019 Jul; 16(4), p. 325-333.
EPub date: 2019-07-17 00:00:00.0.
PMID: 31313633
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Responsibility, culpability, and parental views on genomic testing for seriously ill children.
Authors: Malek J. , Pereira S. , Robinson J.O. , Gutierrez A.M. , Slashinski M.J. , Parsons D.W. , Plon S.E. , McGuire A.L. .
Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2019-06-12 00:00:00.0; , .
EPub date: 2019-06-12 00:00:00.0.
PMID: 31186522
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The Genomic Medicine Integrative Research Framework: A Conceptual Framework for Conducting Genomic Medicine Research.
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Source: American Journal Of Human Genetics, 2019-06-06 00:00:00.0; 104(6), p. 1088-1096.
EPub date: 2019-05-16 00:00:00.0.
PMID: 31104772
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Secondary findings from clinical genomic sequencing: prevalence, patient perspectives, family history assessment, and health-care costs from a multisite study.
Authors: Hart M.R. , Biesecker B.B. , Blout C.L. , Christensen K.D. , Amendola L.M. , Bergstrom K.L. , Biswas S. , Bowling K.M. , Brothers K.B. , Conlin L.K. , et al. .
Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2019 May; 21(5), p. 1100-1110.
EPub date: 2018-10-05 00:00:00.0.
PMID: 30287922
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Agents of empathy: How medical interpreters bridge sociocultural gaps in genomic sequencing disclosures with Spanish-speaking families.
Authors: Gutierrez A.M. , Statham E.E. , Robinson J.O. , Slashinski M.J. , Scollon S. , Bergstrom K.L. , Street R.L. , Parsons D.W. , Plon S.E. , McGuire A.L. .
Source: Patient Education And Counseling, 2019 05; 102(5), p. 895-901.
EPub date: 2018-12-10 00:00:00.0.
PMID: 30581014
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