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Grant Details

Grant Number: 5U01CA193632-05 Interpret this number
Primary Investigator: Barrett, Lisa
Organization: Northeastern University
Project Title: Fundamental Subcortical Mechanisms of Affective Processing
Fiscal Year: 2020


Abstract

 DESCRIPTION (provided by applicant): Between 50-66% of deaths caused by cancer could be prevented through behavioral modification. Accumulating evidence points towards a family of basic, affective psychological processes related to emotion, stress, and pain that influence behavioral choices, facilitating healthful choices or promoting unhealthful choices, and that have the capacity to influence key aspects of successful survivorship. While the links between affect and cancer-related decision making are becoming well-known, the research remains largely descriptive. A mechanistic understanding of these links is hampered by a major barrier: the neural circuitry underlying affective processing is still largely underspecified. A further barrierto progress is that subdomains of affective science including stress, emotion, and pain, have largely been studied independently of one another even though they overlap tremendously as psychological constructs. The historical divides that pose a critical barrier to using affective processes to improve cancer-related decision-making are exacerbated by a tendency for researchers to focus either on peripheral and central biomarkers of affect, but not to study them simultaneously. Our goal is to unify subdomains of affective processes into a common neural framework centered on subcortical brainstem regions that are known to be critically involved in affective processes, with a particular emphasis on the periaqueductal gray (PAG) which non-human animal research shows is a critical hub controlling autonomic output, analgesic responses, and other physiological responses during emotion, pain, and stress. Affective research in humans relies primarily on non-invasive neuroimaging techniques, but the spatial resolution of these techniques in prior work has been too small to examine the brainstem and particularly the PAG and its connectivity with any degree of specificity. We have developed an ultra-high field magnetic resonance imaging procedure at 7 Tesla that overcomes this problem. In Specific Aim 1, we will map the structural and functional connectivity of the brainstem, with a focus on the PAG, within subcortical and cortical networks using anatomical, diffusion weighted, and resting state (task-independent) functional connectivity within a 7T imaging environment. In Specific Aim 2, we will examine the functional organization of these brainstem networks across tasks that evoke stress, pain, and emotional experience to assess the construct validity of these three affective processes from a unified neuroscience perspective, and we further examine how these brainstem networks participate in executive function using a working memory task. Finally, in the Exploratory Aim, we will examine the extent to which peripheral physiological measurements (e.g., heart rate variability, skin conductance, respiratory rate) mediate the relation between brainstem network structure / activity and behavioral responses in each affective domain. Our main deliverable at the end of this R01 is a working neural theory of affective processes that can be used by cancer researchers to study the influence of affect on cancer-related decision making.



Publications

Seven Tesla Evidence for Columnar and Rostral-Caudal Organization of the Human Periaqueductal Gray Response in the Absence of Threat: A Working Memory Study.
Authors: Fischbach A.K. , Satpute A.B. , Quigley K. , Kragel P.A. , Chen D. , Bianciardi M. , Wald L. , Wager T.D. , Choi J.K. , Zhang J. , et al. .
Source: The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience, 2024-06-26 00:00:00.0; 44(26), .
EPub date: 2024-06-26 00:00:00.0.
PMID: 38664013
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Publication guidelines for human heart rate and heart rate variability studies in psychophysiology-Part 1: Physiological underpinnings and foundations of measurement.
Authors: Quigley K.S. , Gianaros P.J. , Norman G.J. , Jennings J.R. , Berntson G.G. , de Geus E.J.C. .
Source: Psychophysiology, 2024-06-14 00:00:00.0; , p. e14604.
EPub date: 2024-06-14 00:00:00.0.
PMID: 38873876
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Adaptive thresholding increases sensitivity to detect changes in the rate of skin conductance responses to psychologically arousing stimuli in both laboratory and ambulatory settings.
Authors: Kleckner I.R. , Wormwood J.B. , Jones R.M. , Culakova E. , Barrett L.F. , Lord C. , Quigley K.S. , Goodwin M.S. .
Source: International Journal Of Psychophysiology : Official Journal Of The International Organization Of Psychophysiology, 2023-12-15 00:00:00.0; 196, p. 112280.
EPub date: 2023-12-15 00:00:00.0.
PMID: 38104772
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A functional account of stimulation-based aerobic glycolysis and its role in interpreting BOLD signal intensity increases in neuroimaging experiments.
Authors: Theriault J.E. , Shaffer C. , Dienel G.A. , Sander C.Y. , Hooker J.M. , Dickerson B.C. , Barrett L.F. , Quigley K.S. .
Source: Neuroscience And Biobehavioral Reviews, 2023 Oct; 153, p. 105373.
EPub date: 2023-08-25 00:00:00.0.
PMID: 37634556
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Signal processing in the vagus nerve: Hypotheses based on new genetic and anatomical evidence.
Authors: Shaffer C. , Barrett L.F. , Quigley K.S. .
Source: Biological Psychology, 2023 Sep; 182, p. 108626.
EPub date: 2023-07-06 00:00:00.0.
PMID: 37419401
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Cortical and subcortical mapping of the allostatic-interoceptive system in the human brain: replication and extension with 7 Tesla fMRI.
Authors: Zhang J. , Chen D. , Srirangarajan T. , Theriault J. , Kragel P.A. , Hartley L. , Lee K.M. , McVeigh K. , Wager T.D. , Wald L.L. , et al. .
Source: Biorxiv : The Preprint Server For Biology, 2023-07-24 00:00:00.0; , .
EPub date: 2023-07-24 00:00:00.0.
PMID: 37546889
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What We Can Learn About Emotion by Talking With the Hadza.
Authors: Hoemann K. , Gendron M. , Crittenden A.N. , Mangola S.M. , Endeko E.S. , Dussault È. , Barrett L.F. , Mesquita B. .
Source: Perspectives On Psychological Science : A Journal Of The Association For Psychological Science, 2023-07-10 00:00:00.0; , p. 17456916231178555.
EPub date: 2023-07-10 00:00:00.0.
PMID: 37428509
Related Citations

Context reconsidered: Complex signal ensembles, relational meaning, and population thinking in psychological science.
Authors: Barrett L.F. .
Source: The American Psychologist, 2022 Nov; 77(8), p. 894-920.
PMID: 36409120
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Allostasis, Action, and Affect in Depression: Insights from the Theory of Constructed Emotion.
Authors: Shaffer C. , Westlin C. , Quigley K.S. , Whitfield-Gabrieli S. , Barrett L.F. .
Source: Annual Review Of Clinical Psychology, 2022-05-09 00:00:00.0; 18, p. 553-580.
PMID: 35534123
Related Citations

Sinful Pleasures and Pious Woes? Using fMRI to Examine Evaluative and Hedonic Emotion Knowledge.
Authors: Lee K.M. , Lee S. , Satpute A.B. .
Source: Social Cognitive And Affective Neuroscience, 2022-03-26 00:00:00.0; , .
EPub date: 2022-03-26 00:00:00.0.
PMID: 35348768
Related Citations

Interoception as modeling, allostasis as control.
Authors: Sennesh E. , Theriault J. , Brooks D. , van de Meent J.W. , Barrett L.F. , Quigley K.S. .
Source: Biological Psychology, 2022 01; 167, p. 108242.
EPub date: 2021-12-20 00:00:00.0.
PMID: 34942287
Related Citations

Allostasis as a core feature of hierarchical gradients in the human brain.
Authors: Katsumi Y. , Theriault J.E. , Quigley K.S. , Barrett L.F. .
Source: Network Neuroscience (cambridge, Mass.), 2022; 6(4), p. 1010-1031.
EPub date: 2022-10-01 00:00:00.0.
PMID: 38800458
Related Citations

Expertise in emotion: A scoping review and unifying framework for individual differences in the mental representation of emotional experience.
Authors: Hoemann K. , Nielson C. , Yuen A. , Gurera J.W. , Quigley K.S. , Barrett L.F. .
Source: Psychological Bulletin, 2021 11; 147(11), p. 1159-1183.
PMID: 35238584
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Probabilistic Atlas of the Mesencephalic Reticular Formation, Isthmic Reticular Formation, Microcellular Tegmental Nucleus, Ventral Tegmental Area Nucleus Complex, and Caudal-Rostral Linear Raphe Nucleus Complex in Living Humans from 7 Tesla Magnetic Resonance Imaging.
Authors: Singh K. , García-Gomar M.G. , Bianciardi M. .
Source: Brain Connectivity, 2021 10; 11(8), p. 613-623.
EPub date: 2021-06-17 00:00:00.0.
PMID: 33926237
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Professional actors demonstrate variability, not stereotypical expressions, when portraying emotional states in photographs.
Authors: Le Mau T. , Hoemann K. , Lyons S.H. , Fugate J.M.B. , Brown E.N. , Gendron M. , Barrett L.F. .
Source: Nature Communications, 2021-08-19 00:00:00.0; 12(1), p. 5037.
EPub date: 2021-08-19 00:00:00.0.
PMID: 34413313
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A human colliculus-pulvinar-amygdala pathway encodes negative emotion.
Authors: Kragel P.A. , Čeko M. , Theriault J. , Chen D. , Satpute A.B. , Wald L.W. , Lindquist M.A. , Feldman Barrett L. , Wager T.D. .
Source: Neuron, 2021-08-04 00:00:00.0; 109(15), p. 2404-2412.e5.
EPub date: 2021-06-23 00:00:00.0.
PMID: 34166604
Related Citations

Situating and extending the sense of should: Reply to comments on "The sense of should: A biologically-based framework for modeling social pressure".
Authors: Theriault J.E. , Young L. , Barrett L.F. .
Source: Physics Of Life Reviews, 2021 Jul; 37, p. 10-16.
EPub date: 2021-03-05 00:00:00.0.
PMID: 33714026
Related Citations

The sense of should: A biologically-based framework for modeling social pressure.
Authors: Theriault J.E. , Young L. , Barrett L.F. .
Source: Physics Of Life Reviews, 2021 03; 36, p. 100-136.
EPub date: 2020-01-23 00:00:00.0.
PMID: 32008953
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Functions of Interoception: From Energy Regulation to Experience of the Self.
Authors: Quigley K.S. , Kanoski S. , Grill W.M. , Barrett L.F. , Tsakiris M. .
Source: Trends In Neurosciences, 2021 Jan; 44(1), p. 29-38.
PMID: 33378654
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The N400 indexes acquisition of novel emotion concepts via conceptual combination.
Authors: Hoemann K. , Hartley L. , Watanabe A. , Solana Leon E. , Katsumi Y. , Barrett L.F. , Quigley K.S. .
Source: Psychophysiology, 2020-11-25 00:00:00.0; , p. e13727.
EPub date: 2020-11-25 00:00:00.0.
PMID: 33241553
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Framework for selecting and benchmarking mobile devices in psychophysiological research.
Authors: Kleckner I.R. , Feldman M.J. , Goodwin M.S. , Quigley K.S. .
Source: Behavior Research Methods, 2020-08-03 00:00:00.0; , .
EPub date: 2020-08-03 00:00:00.0.
PMID: 32748241
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Context-aware experience sampling reveals the scale of variation in affective experience.
Authors: Hoemann K. , Khan Z. , Feldman M.J. , Nielson C. , Devlin M. , Dy J. , Barrett L.F. , Wormwood J.B. , Quigley K.S. .
Source: Scientific Reports, 2020-07-27 00:00:00.0; 10(1), p. 12459.
EPub date: 2020-07-27 00:00:00.0.
PMID: 32719368
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Topography Impacts Topology: Anatomically Central Areas Exhibit a "High-Level Connector" Profile in the Human Cortex.
Authors: Zhang J. , Scholtens L.H. , Wei Y. , van den Heuvel M.P. , Chanes L. , Barrett L.F. .
Source: Cerebral Cortex (new York, N.y. : 1991), 2020-03-14 00:00:00.0; 30(3), p. 1357-1365.
PMID: 31504277
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The influence of fear on risk taking: a meta-analysis.
Authors: Wake S. , Wormwood J. , Satpute A.B. .
Source: Cognition & Emotion, 2020-03-02 00:00:00.0; , p. 1-17.
EPub date: 2020-03-02 00:00:00.0.
PMID: 32116122
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Ultra High Field fMRI of Human Superior Colliculi Activity during Affective Visual Processing.
Authors: Wang Y.C. , Bianciardi M. , Chanes L. , Satpute A.B. .
Source: Scientific Reports, 2020-01-28 00:00:00.0; 10(1), p. 1331.
EPub date: 2020-01-28 00:00:00.0.
PMID: 31992744
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Social interoception and social allostasis through touch: Legacy of the Somatovisceral Afference Model of Emotion.
Authors: Burleson M.H. , Quigley K.S. .
Source: Social Neuroscience, 2019-12-18 00:00:00.0; , p. 1-11.
EPub date: 2019-12-18 00:00:00.0.
PMID: 31810428
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Biological Characteristics of Connection-Wise Resting-State Functional Connectivity Strength.
Authors: Pijnenburg R. , Scholtens L.H. , Mantini D. , Vanduffel W. , Barrett L.F. , van den Heuvel M.P. .
Source: Cerebral Cortex (new York, N.y. : 1991), 2019-12-17 00:00:00.0; 29(11), p. 4646-4653.
PMID: 30668705
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Developing an Understanding of Emotion Categories: Lessons from Objects.
Authors: Hoemann K. , Wu R. , LoBue V. , Oakes L.M. , Xu F. , Barrett L.F. .
Source: Trends In Cognitive Sciences, 2019-11-28 00:00:00.0; , .
EPub date: 2019-11-28 00:00:00.0.
PMID: 31787499
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Intrinsic Functional Connectivity is Organized as Three Interdependent Gradients.
Authors: Zhang J. , Abiose O. , Katsumi Y. , Touroutoglou A. , Dickerson B.C. , Barrett L.F. .
Source: Scientific Reports, 2019-11-04 00:00:00.0; 9(1), p. 15976.
EPub date: 2019-11-04 00:00:00.0.
PMID: 31685830
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The Default Mode Network's Role in Discrete Emotion.
Authors: Satpute A.B. , Lindquist K.A. .
Source: Trends In Cognitive Sciences, 2019 Oct; 23(10), p. 851-864.
EPub date: 2019-08-16 00:00:00.0.
PMID: 31427147
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Emotion words, emotion concepts, and emotional development in children: A constructionist hypothesis.
Authors: Hoemann K. , Xu F. , Barrett L.F. .
Source: Developmental Psychology, 2019 Sep; 55(9), p. 1830-1849.
PMID: 31464489
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Physiological indices of challenge and threat: A data-driven investigation of autonomic nervous system reactivity during an active coping stressor task.
Authors: Wormwood J.B. , Khan Z. , Siegel E. , Lynn S.K. , Dy J. , Barrett L.F. , Quigley K.S. .
Source: Psychophysiology, 2019-08-13 00:00:00.0; , p. e13454.
EPub date: 2019-08-13 00:00:00.0.
PMID: 31407813
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Functional Involvement of Human Periaqueductal Gray and Other Midbrain Nuclei in Cognitive Control.
Authors: Kragel P.A. , Bianciardi M. , Hartley L. , Matthewson G. , Choi J.K. , Quigley K.S. , Wald L.L. , Wager T.D. , Feldman Barrett L. , Satpute A.B. .
Source: The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience, 2019-07-31 00:00:00.0; 39(31), p. 6180-6189.
EPub date: 2019-06-03 00:00:00.0.
PMID: 31160537
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Emotional Expressions Reconsidered: Challenges to Inferring Emotion From Human Facial Movements.
Authors: Barrett L.F. , Adolphs R. , Marsella S. , Martinez A.M. , Pollak S.D. .
Source: Psychological Science In The Public Interest : A Journal Of The American Psychological Society, 2019 Jul; 20(1), p. 1-68.
PMID: 31313636
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Emotion schemas are embedded in the human visual system.
Authors: Kragel P.A. , Reddan M.C. , LaBar K.S. , Wager T.D. .
Source: Science Advances, 2019 07; 5(7), p. eaaw4358.
EPub date: 2019-07-24 00:00:00.0.
PMID: 31355334
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The power of predictions: An emerging paradigm for psychological research.
Authors: Hutchinson J.B. , Barrett L.F. .
Source: Current Directions In Psychological Science, 2019 Jun; 28(3), p. 280-291.
EPub date: 2019-04-16 00:00:00.0.
PMID: 31749520
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Primary Interoceptive Cortex Activity during Simulated Experiences of the Body.
Authors: Wilson-Mendenhall C.D. , Henriques A. , Barsalou L.W. , Barrett L.F. .
Source: Journal Of Cognitive Neuroscience, 2019 Feb; 31(2), p. 221-235.
EPub date: 2018-10-02 00:00:00.0.
PMID: 30277431
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Words are a context for mental inference.
Authors: Betz N. , Hoemann K. , Barrett L.F. .
Source: Emotion (washington, D.c.), 2019-01-10 00:00:00.0; , .
EPub date: 2019-01-10 00:00:00.0.
PMID: 30628815
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Vegetarians' and omnivores' affective and physiological responses to images of food.
Authors: Anderson E.C. , Wormwood J. , Barrett L.F. , Quigley K.S. .
Source: Food Quality And Preference, 2019 Jan; 71, p. 96-105.
EPub date: 2018-06-26 00:00:00.0.
PMID: 31217670
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In vivo Probabilistic Structural Atlas of the Inferior and Superior Colliculi, Medial and Lateral Geniculate Nuclei and Superior Olivary Complex in Humans Based on 7 Tesla MRI.
Authors: García-Gomar M.G. , Strong C. , Toschi N. , Singh K. , Rosen B.R. , Wald L.L. , Bianciardi M. .
Source: Frontiers In Neuroscience, 2019; 13, p. 764.
EPub date: 2019-08-07 00:00:00.0.
PMID: 31440122
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Applying the Theory of Constructed Emotion to Police Decision Making.
Authors: Fridman J. , Barrett L.F. , Wormwood J.B. , Quigley K.S. .
Source: Frontiers In Psychology, 2019; 10, p. 1946.
EPub date: 2019-09-11 00:00:00.0.
PMID: 31572250
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Motivation in the Service of Allostasis: The Role of anterior Mid Cingulate Cortex.
Authors: Touroutoglou A. , Andreano J.M. , Adebayo M. , Lyons S. , Barrett L.F. .
Source: Advances In Motivation Science, 2019; 6, p. 1-25.
EPub date: 2018-09-25 00:00:00.0.
PMID: 31788441
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Cross-Species Evidence of Interplay Between Neural Connectivity at the Micro- and Macroscale of Connectome Organization in Human, Mouse, and Rat Brain.
Authors: Scholtens L.H. , Feldman Barrett L. , van den Heuvel M.P. .
Source: Brain Connectivity, 2018 12; 8(10), p. 595-603.
PMID: 30479137
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Concepts, Goals and the Control of Survival-Related Behaviors.
Authors: Barrett L.F. , Finlay B.L. .
Source: Current Opinion In Behavioral Sciences, 2018 Dec; 24, p. 172-179.
EPub date: 2018-10-29 00:00:00.0.
PMID: 31157289
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Context facilitates performance on a classic cross-cultural emotion perception task.
Authors: Hoemann K. , Crittenden A.N. , Msafiri S. , Liu Q. , Li C. , Roberson D. , Ruark G.A. , Gendron M. , Feldman Barrett L. .
Source: Emotion (washington, D.c.), 2018-11-26 00:00:00.0; , .
EPub date: 2018-11-26 00:00:00.0.
PMID: 30475026
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Conscious awareness is necessary for affective faces to influence social judgments.
Authors: Kleckner I.R. , Anderson E.C. , Betz N.J. , Wormwood J.B. , Eskew R.T. , Barrett L.F. .
Source: Journal Of Experimental Social Psychology, 2018 Nov; 79, p. 181-187.
EPub date: 2018-08-04 00:00:00.0.
PMID: 31097841
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Concepts dissolve artificial boundaries in the study of emotion and cognition, uniting body, brain, and mind.
Authors: Hoemann K. , Feldman Barrett L. .
Source: Cognition & Emotion, 2018-10-18 00:00:00.0; , p. 1-10.
EPub date: 2018-10-18 00:00:00.0.
PMID: 30336722
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Hormonal Cycles, Brain Network Connectivity, and Windows of Vulnerability to Affective Disorder.
Authors: Andreano J.M. , Touroutoglou A. , Dickerson B. , Barrett L.F. .
Source: Trends In Neurosciences, 2018 10; 41(10), p. 660-676.
EPub date: 2018-09-25 00:00:00.0.
PMID: 30274602
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Seeing Fear: It's All in the Eyes?
Authors: Barrett L.F. .
Source: Trends In Neurosciences, 2018 09; 41(9), p. 559-563.
PMID: 30143181
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Representation, Pattern Information, and Brain Signatures: From Neurons to Neuroimaging.
Authors: Kragel P.A. , Koban L. , Barrett L.F. , Wager T.D. .
Source: Neuron, 2018-07-25 00:00:00.0; 99(2), p. 257-273.
PMID: 30048614
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