Grant Details
Grant Number: |
5P01CA206980-04 Interpret this number |
Primary Investigator: |
Berwick, Marianne |
Organization: |
University Of New Mexico Health Scis Ctr |
Project Title: |
Integration of Clinical and Molecular Biomarkers for Melanoma Survival |
Fiscal Year: |
2020 |
Abstract
Program Project Abstract/Summary
We have brought together 12 institutions in order to promote a better understanding of the biology of
melanoma and how that affects an individual’s survival. Our hypothesis is that primary melanomas will have
molecular and clinical features that will allow the stratification of melanoma tumors at AJCC TNM Stages
IIA/IIB/IIC/IIIA/IIIB, where there is little effective adjuvant therapy, into those with a good prognosis and those
with poor prognosis. The current mortality rate for individuals diagnosed at these stages ranges between 18-
47% for Stages IIA/IIB/IIC and 32-78% for Stage IIIA/IIIB patients. The ability to improve clinical care and
patient outcomes for these patients might be achieved by focusing on the identification and prioritization of
biomarkers – both molecular and clinical – that might triage high risk patients for new adjuvant therapies.
In this study, we will identify somatic tumor mutations, CNVs, an immune profile, methylation profiles, and
microRNA/mRNA signatures in primary melanoma that are associated with prognosis, with the ultimate intent
of translating this information into the clinic to personalize care. Currently, there is a dearth of studies in the
melanoma field looking at epidemiologic/genomic factors and melanoma survival. In order to identify, confirm
and develop such biomarkers, we have brought together 9 cohorts of melanoma patients at AJCC TNM stages
IIA/IIB/IIC/IIIA/IIIB, comprising 1000 individuals, 500 of whom have died from their disease as of 2012 and 500
whom have lived at least 5 years. Patients will be frequency matched for stage. As we integrate data from
multiple platforms, we will randomly divide the dataset into a training set (660 tumors, half aggressive and half
non-aggressive) and a validation set (340 tumors, half aggressive and half non-aggressive). Significant
findings in the training set will be replicated in the validation set. These patients have all been treated using
standard-of-care surgery. All patients in this study will have adequate tumor tissue, germline DNA and clinical,
pathologic and demographic information recorded.
Our objective is to identify prognostic biomarkers associated with survival. The goal is to identify patients for
whom more aggressive therapy prior to developing metastases would be relevant, that is would make a
difference to their survival. Our central hypothesis is that melanoma prognosis is largely determined early in
tumor development and that DNA and RNA markers, combined with clinicopathologic and protein
characteristics in primary melanoma will add information to outcome prediction beyond the pathologic features
used in AJCC tumor staging. We are taking an integrative approach to take advantage of and organize the
large amount of information generated from each project. Such information will be available to clinicians and
other investigators as soon as possible.
Publications
Region of Interest Detection in Melanocytic Skin Tumor Whole Slide Images-Nevus and Melanoma.
Authors: Cui Y.
, Li Y.
, Miedema J.R.
, Edmiston S.N.
, Farag S.W.
, Marron J.S.
, Thomas N.E.
.
Source: Cancers, 2024-07-23 00:00:00.0; 16(15), .
EPub date: 2024-07-23 00:00:00.0.
PMID: 39123344
Related Citations
Region of Interest Detection in Melanocytic Skin Tumor Whole Slide Images - Nevus & Melanoma.
Authors: Cui Y.
, Li Y.
, Miedema J.R.
, Edmiston S.N.
, Farag S.
, Marron J.S.
, Thomas N.E.
.
Source: Arxiv, 2024-05-16 00:00:00.0; , .
EPub date: 2024-05-16 00:00:00.0.
PMID: 38800658
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Adaptation of a mutual exclusivity framework to identify driver mutations within oncogenic pathways.
Authors: Wang X.
, Kostrzewa C.
, Reiner A.
, Shen R.
, Begg C.
.
Source: American Journal Of Human Genetics, 2024-01-10 00:00:00.0; , .
EPub date: 2024-01-10 00:00:00.0.
PMID: 38232729
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Genetic Variants Associated With Hidradenitis Suppurativa.
Authors: Sun Q.
, Broadaway K.A.
, Edmiston S.N.
, Fajgenbaum K.
, Miller-Fleming T.
, Westerkam L.L.
, Melendez-Gonzalez M.
, Bui H.
, Blum F.R.
, Levitt B.
, et al.
.
Source: Jama Dermatology, 2023-09-01 00:00:00.0; 159(9), p. 930-938.
PMID: 37494057
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Association of functional, inherited vitamin D-binding protein variants with melanoma-specific death.
Authors: Gibbs D.C.
, Thomas N.E.
, Kanetsky P.A.
, Luo L.
, Busam K.J.
, Cust A.E.
, Anton-Culver H.
, Gallagher R.P.
, Zanetti R.
, Rosso S.
, et al.
.
Source: Jnci Cancer Spectrum, 2023-08-31 00:00:00.0; 7(5), .
PMID: 37494457
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Sex-Specific Associations of MDM2 and MDM4 Variants with Risk of Multiple Primary Melanomas and Melanoma Survival in Non-Hispanic Whites.
Authors: Ward S.V.
, Autuori I.
, Luo L.
, LaPilla E.
, Yoo S.
, Sharma A.
, Busam K.J.
, Olilla D.W.
, Dwyer T.
, Anton-Culver H.
, et al.
.
Source: Cancers, 2023-05-11 00:00:00.0; 15(10), .
EPub date: 2023-05-11 00:00:00.0.
PMID: 37345045
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An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma.
Authors: Davalos V.
, Lovell C.D.
, Von Itter R.
, Dolgalev I.
, Agrawal P.
, Baptiste G.
, Kahler D.J.
, Sokolova E.
, Moran S.
, Piqué L.
, et al.
.
Source: Nature Communications, 2023-04-04 00:00:00.0; 14(1), p. 1867.
EPub date: 2023-04-04 00:00:00.0.
PMID: 37015919
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Pathway Alterations in Stage II/III Primary Melanoma.
Authors: Kostrzewa C.E.
, Luo L.
, Arora A.
, Seshan V.E.
, Ernstoff M.S.
, Edmiston S.N.
, Conway K.
, Gorlov I.
, Busam K.
, Orlow I.
, et al.
.
Source: Jco Precision Oncology, 2023 Mar; 7, p. e2200439.
PMID: 36926987
Related Citations
Methylation of nonessential genes in cutaneous melanoma - Rule Out hypothesis.
Authors: Gorlov I.P.
, Conway K.
, Edmiston S.N.
, Parrish E.A.
, Hao H.
, Amos C.I.
, Tsavachidis S.
, Gorlova O.Y.
, Begg C.
, Hernando E.
, et al.
.
Source: Melanoma Research, 2023-02-20 00:00:00.0; , .
EPub date: 2023-02-20 00:00:00.0.
PMID: 36805567
Related Citations
Social and structural determinants of COVID-19 vaccine uptake among racial and ethnic groups.
Authors: Peña J.M.
, Schwartz M.R.
, Hernandez-Vallant A.
, Sanchez G.R.
.
Source: Journal Of Behavioral Medicine, 2023-01-18 00:00:00.0; , .
EPub date: 2023-01-18 00:00:00.0.
PMID: 36652085
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InterMEL: An international biorepository and clinical database to uncover predictors of survival in early-stage melanoma.
Authors: Orlow I.
, Sadeghi K.D.
, Edmiston S.N.
, Kenney J.M.
, Lezcano C.
, Wilmott J.S.
, Cust A.E.
, Scolyer R.A.
, Mann G.J.
, Lee T.K.
, et al.
.
Source: Plos One, 2023; 18(4), p. e0269324.
EPub date: 2023-04-03 00:00:00.0.
PMID: 37011054
Related Citations
Epigenetic Mechanisms Underlying Melanoma Resistance to Immune and Targeted Therapies.
Authors: Rubanov A.
, Berico P.
, Hernando E.
.
Source: Cancers, 2022-11-28 00:00:00.0; 14(23), .
EPub date: 2022-11-28 00:00:00.0.
PMID: 36497341
Related Citations
Landscape of mutations in early stage primary cutaneous melanoma: An InterMEL study.
Authors: Luo L.
, Shen R.
, Arora A.
, Orlow I.
, Busam K.J.
, Lezcano C.
, Lee T.K.
, Hernando E.
, Gorlov I.
, Amos C.
, et al.
.
Source: Pigment Cell & Melanoma Research, 2022-07-25 00:00:00.0; , .
EPub date: 2022-07-25 00:00:00.0.
PMID: 35876628
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Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis.
Authors: Kleffman K.
, Levinson G.
, Rose I.V.L.
, Blumenberg L.M.
, Shadaloey S.A.A.
, Dhabaria A.
, Wong E.
, Galán-Echevarría F.
, Karz A.
, Argibay D.
, et al.
.
Source: Cancer Discovery, 2022-05-02 00:00:00.0; 12(5), p. 1314-1335.
PMID: 35262173
Related Citations
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis.
Authors: Shadaloey A.A.S.
, Karz A.
, Moubarak R.S.
, Agrawal P.
, Levinson G.
, Kleffman K.
, Aristizabal O.
, Osman I.
, Wadghiri Y.Z.
, Hernando E.
.
Source: Journal Of Visualized Experiments : Jove, 2022-03-08 00:00:00.0; (181), .
EPub date: 2022-03-08 00:00:00.0.
PMID: 35343960
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The histone demethylase PHF8 regulates TGFβ signaling and promotes melanoma metastasis.
Authors: Moubarak R.S.
, de Pablos-Aragoneses A.
, Ortiz-Barahona V.
, Gong Y.
, Gowen M.
, Dolgalev I.
, Shadaloey S.A.A.
, Argibay D.
, Karz A.
, Von Itter R.
, et al.
.
Source: Science Advances, 2022-02-18 00:00:00.0; 8(7), p. eabi7127.
EPub date: 2022-02-18 00:00:00.0.
PMID: 35179962
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SNP characteristics and validation success in genome wide association studies.
Authors: Gorlova O.Y.
, Xiao X.
, Tsavachidis S.
, Amos C.I.
, Gorlov I.P.
.
Source: Human Genetics, 2022-01-04 00:00:00.0; , .
EPub date: 2022-01-04 00:00:00.0.
PMID: 34981173
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In Vivo miRNA Decoy Screen Reveals miR-124a as a Suppressor of Melanoma Metastasis.
Authors: Moubarak R.S.
, Koetz-Ploch L.
, Mullokandov G.
, Gaziel A.
, de Pablos-Aragoneses A.
, Argibay D.
, Kleffman K.
, Sokolova E.
, Berwick M.
, Thomas N.E.
, et al.
.
Source: Frontiers In Oncology, 2022; 12, p. 852952.
EPub date: 2022-04-04 00:00:00.0.
PMID: 35480113
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Identification of lung cancer drivers by comparison of the observed and the expected numbers of missense and nonsense mutations in individual human genes.
Authors: Gorlova O.Y.
, Kimmel M.
, Tsavachidis S.
, Amos C.I.
, Gorlov I.P.
.
Source: Oncotarget, 2022; 13, p. 756-767.
EPub date: 2022-05-25 00:00:00.0.
PMID: 35634240
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Minimally invasive microbiopsy for genetic profiling of melanocytic lesions: A case series.
Authors: Jain M.
, Autuori I.
, Everett N.
, Harris U.
, Yamada M.
, Prow T.
, Busam K.
, Marchetti M.A.
, Halpern A.C.
, Orlow I.
.
Source: Journal Of The American Academy Of Dermatology, 2021-12-16 00:00:00.0; , .
EPub date: 2021-12-16 00:00:00.0.
PMID: 34922919
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Characterization of the CpG island hypermethylated phenotype (CIMP) subclass in primary melanomas.
Authors: Conway K.
, Tsai Y.S.
, Edmiston S.N.
, Parker J.S.
, Parrish E.A.
, Hao H.
, Kuan P.F.
, Scott G.A.
, Frank J.S.
, Googe P.
, et al.
.
Source: The Journal Of Investigative Dermatology, 2021-11-26 00:00:00.0; , .
EPub date: 2021-11-26 00:00:00.0.
PMID: 34843679
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Association of Melanoma-Risk Variants with Primary Melanoma Tumor Prognostic Characteristics and Melanoma-Specific Survival in the GEM Study.
Authors: Davari D.R.
, Orlow I.
, Kanetsky P.A.
, Luo L.
, Busam K.J.
, Sharma A.
, Kricker A.
, Cust A.E.
, Anton-Culver H.
, Gruber S.B.
, et al.
.
Source: Current Oncology (toronto, Ont.), 2021-11-16 00:00:00.0; 28(6), p. 4756-4771.
EPub date: 2021-11-16 00:00:00.0.
PMID: 34898573
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Disease-Associated Risk Variants in ANRIL are Associated with Tumor-Infiltrating Lymphocytes Presence in Primary Melanomas in the Population-Based GEM Study.
Authors: Davari D.R.
, Orlow I.
, Kanetsky P.A.
, Luo L.
, Edmiston S.N.
, Conway K.
, Parrish E.A.
, Hao H.
, Busam K.J.
, Sharma A.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2021-10-04 00:00:00.0; , .
EPub date: 2021-10-04 00:00:00.0.
PMID: 34607836
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Comparison of community pathologists with expert dermatopathologists evaluating Breslow thickness and histopathologic subtype in a large international population-based study of melanoma.
Authors: Yardman-Frank J.M.
, Bronner B.
, Rosso S.
, From L.
, Busam K.
, Groben P.
, Tucker P.
, Cust A.
, Armstrong B.
, Kricker A.
, et al.
.
Source: Jaad International, 2021 Sep; 4, p. 25-27.
EPub date: 2021-06-01 00:00:00.0.
PMID: 34409386
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Mining mutation contexts across the cancer genome to map tumor site of origin.
Authors: Chakraborty S.
, Martin A.
, Guan Z.
, Begg C.B.
, Shen R.
.
Source: Nature Communications, 2021-05-24 00:00:00.0; 12(1), p. 3051.
EPub date: 2021-05-24 00:00:00.0.
PMID: 34031376
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The State of Melanoma: Emergent Challenges and Opportunities.
Authors: Atkins M.B.
, Curiel-Lewandrowski C.
, Fisher D.E.
, Swetter S.M.
, Tsao H.
, Aguirre-Ghiso J.A.
, Soengas M.S.
, Weeraratna A.T.
, Flaherty K.T.
, Herlyn M.
, et al.
.
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2021-05-15 00:00:00.0; 27(10), p. 2678-2697.
EPub date: 2021-01-07 00:00:00.0.
PMID: 33414132
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Melanoma models for the next generation of therapies.
Authors: Patton E.E.
, Mueller K.L.
, Adams D.J.
, Anandasabapathy N.
, Aplin A.E.
, Bertolotto C.
, Bosenberg M.
, Ceol C.J.
, Burd C.E.
, Chi P.
, et al.
.
Source: Cancer Cell, 2021-05-10 00:00:00.0; 39(5), p. 610-631.
EPub date: 2021-02-04 00:00:00.0.
PMID: 33545064
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Not every age is created equal: risk factors for melanoma differ by age.
Authors: Osmani S.
, Chao Z.
, Barnhill R.
, Berwick M.
.
Source: International Journal Of Dermatology, 2021-05-02 00:00:00.0; , .
EPub date: 2021-05-02 00:00:00.0.
PMID: 33934340
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Targeting the IL-2 inducible kinase in melanoma; a phase 2 study of ibrutinib in systemic treatment-refractory distant metastatic cutaneous melanoma: preclinical rationale, biology, and clinical activity (NCI9922).
Authors: Moschos S.J.
, Eroglu Z.
, Khushalani N.I.
, Kendra K.L.
, Ansstas G.
, In G.K.
, Wang P.
, Liu G.
, Collichio F.A.
, Googe P.B.
, et al.
.
Source: Melanoma Research, 2021-04-01 00:00:00.0; 31(2), p. 162-172.
PMID: 33661190
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Bayesian network-driven clustering analysis with feature selection for high-dimensional multi-modal molecular data.
Authors: Zhao Y.
, Chang C.
, Hannum M.
, Lee J.
, Shen R.
.
Source: Scientific Reports, 2021-03-04 00:00:00.0; 11(1), p. 5146.
EPub date: 2021-03-04 00:00:00.0.
PMID: 33664338
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Differences in Melanoma Between Canada and New South Wales, Australia: A Population-Based Genes, Environment, and Melanoma (GEM) Study.
Authors: Yardman-Frank J.M.
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, Armstrong B.K.
, Marrett L.D.
, Luo L.
, Cust A.E.
, Busam K.J.
, Orlow I.
, Gallagher R.P.
, et al.
.
Source: Jid Innovations, 2021 Mar; 1(1), .
EPub date: 2021-01-25 00:00:00.0.
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Network models of primary melanoma microenvironments identify key melanoma regulators underlying prognosis.
Authors: Song W.M.
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, Von Itter R.
, Fontanals-Cirera B.
, Wang M.
, Zhou X.
, Mahal L.K.
, Hernando E.
, Zhang B.
.
Source: Nature Communications, 2021-02-22 00:00:00.0; 12(1), p. 1214.
EPub date: 2021-02-22 00:00:00.0.
PMID: 33619278
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Exome-Wide Pan-Cancer Analysis of Germline Variants in 8,719 Individuals Finds Little Evidence of Rare Variant Associations.
Authors: Guan Z.
, Shen R.
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.
Source: Human Heredity, 2021; 86(1-4), p. 34-44.
EPub date: 2021-10-29 00:00:00.0.
PMID: 34718237
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Pan-cancer identification of clinically relevant genomic subtypes using outcome-weighted integrative clustering.
Authors: Arora A.
, Olshen A.B.
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, Shen R.
.
Source: Genome Medicine, 2020-12-03 00:00:00.0; 12(1), p. 110.
EPub date: 2020-12-03 00:00:00.0.
PMID: 33272320
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Tumor somatic mutations also existing as germline polymorphisms may help to identify functional SNPs from genome-wide association studies.
Authors: Gorlov I.P.
, Xia X.
, Tsavachidis S.
, Gorlova O.Y.
, Amos C.I.
.
Source: Carcinogenesis, 2020-10-15 00:00:00.0; 41(10), p. 1353-1362.
PMID: 32681635
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Non-Cell-Autonomous Activity of the Hemidesmosomal Protein BP180/Collagen XVII in Granulopoiesis in Humanized NC16A Mice.
Authors: Lin L.
, Hwang B.J.
, Li N.
, Googe P.
, Diaz L.A.
, Miao E.
, Vilen B.
, Thomas N.E.
, Ting J.
, Liu Z.
.
Source: Journal Of Immunology (baltimore, Md. : 1950), 2020-09-30 00:00:00.0; , .
EPub date: 2020-09-30 00:00:00.0.
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Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
Authors: Ngo B.
, Kim E.
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, Liang R.J.
, Luengo A.
, Davidson S.M.
, Ali A.
, Ferraro G.B.
, et al.
.
Source: Cancer Discovery, 2020 Sep; 10(9), p. 1352-1373.
EPub date: 2020-06-22 00:00:00.0.
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Association of Known Melanoma Risk Factors with Primary Melanoma of the Scalp and Neck.
Authors: Wood R.P.
, Heyworth J.S.
, McCarthy N.S.
, Mauguen A.
, Berwick M.
, Thomas N.E.
, Millward M.J.
, Anton-Culver H.
, Cust A.E.
, Dwyer T.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2020-08-20 00:00:00.0; , .
EPub date: 2020-08-20 00:00:00.0.
PMID: 32856602
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Human genes differ by their UV sensitivity estimated through analysis of UV-induced silent mutations in melanoma.
Authors: Gorlov I.P.
, Amos C.I.
, Tsavachidis S.
, Begg C.
, Hernando E.
, Cheng C.
, Shen R.
, Orlow I.
, Luo L.
, Ernstoff M.S.
, et al.
.
Source: Human Mutation, 2020-07-09 00:00:00.0; , .
EPub date: 2020-07-09 00:00:00.0.
PMID: 32643855
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Impact of concomitant medication use and immune-related adverse events on response to immune checkpoint inhibitors.
Authors: Gandhi S.
, Pandey M.
, Ammannagari N.
, Wang C.
, Bucsek M.J.
, Hamad L.
, Repasky E.
, Ernstoff M.S.
.
Source: Immunotherapy, 2020 02; 12(2), p. 141-149.
EPub date: 2020-02-17 00:00:00.0.
PMID: 32064978
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Association of IRF4 single-nucleotide polymorphism rs12203592 with melanoma-specific survival.
Authors: Ward S.V.
, Gibbs D.C.
, Orlow I.
, Thomas N.E.
, Kanetsky P.A.
, Luo L.
, Cust A.E.
, Anton-Culver H.
, Gruber S.B.
, Gallagher R.P.
, et al.
.
Source: The British Journal Of Dermatology, 2020-01-20 00:00:00.0; , .
EPub date: 2020-01-20 00:00:00.0.
PMID: 31958143
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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis.
Authors: Hanniford D.
, Ulloa-Morales A.
, Karz A.
, Berzoti-Coelho M.G.
, Moubarak R.S.
, Sánchez-Sendra B.
, Kloetgen A.
, Davalos V.
, Imig J.
, Wu P.
, et al.
.
Source: Cancer Cell, 2020-01-13 00:00:00.0; 37(1), p. 55-70.e15.
PMID: 31935372
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SNP eQTL status and eQTL density in the adjacent region of the SNP are associated with its statistical significance in GWA studies.
Authors: Gorlov I.
, Xiao X.
, Mayes M.
, Gorlova O.
, Amos C.
.
Source: Bmc Genetics, 2019-11-12 00:00:00.0; 20(1), p. 85.
EPub date: 2019-11-12 00:00:00.0.
PMID: 31718536
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Functional analysis of RPS27 mutations and expression in melanoma.
Authors: Floristán A.
, Morales L.
, Hanniford D.
, Martinez C.
, Castellano-Sanz E.
, Dolgalev I.
, Ulloa-Morales A.
, Vega-Saenz de Miera E.
, Moran U.
, Darvishian F.
, et al.
.
Source: Pigment Cell & Melanoma Research, 2019-10-30 00:00:00.0; , .
EPub date: 2019-10-30 00:00:00.0.
PMID: 31663663
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Inherited Melanoma Risk Variants Associated with Histopathologically Amelanotic Melanoma.
Authors: Gibbs D.C.
, Orlow I.
, Vernali S.
, Powell H.B.
, Kanetsky P.A.
, Luo L.
, Busam K.J.
, Sharma A.
, Kricker A.
, Armstrong B.K.
, et al.
.
Source: The Journal Of Investigative Dermatology, 2019-09-27 00:00:00.0; , .
EPub date: 2019-09-27 00:00:00.0.
PMID: 31568773
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A risk prediction model for development of subsequent primary melanoma in a population-based cohort.
Authors: Cust A.E.
, Badcock C.
, Smith J.
, Thomas N.E.
, Haydu L.E.
, Armstrong B.K.
, Law M.H.
, Thompson J.F.
, Kanetsky P.A.
, Begg C.B.
, et al.
.
Source: The British Journal Of Dermatology, 2019-09-14 00:00:00.0; , .
EPub date: 2019-09-14 00:00:00.0.
PMID: 31520533
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MC1R Variation in a New Mexico Population.
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, Dailey Y.T.
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, Zielaskowski K.
, Robers E.
, Sussman A.
, Hunley K.
, Hughes C.R.
, Schwartz M.R.
, Kaphingst K.A.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2019-09-05 00:00:00.0; , .
EPub date: 2019-09-05 00:00:00.0.
PMID: 31488411
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.
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