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Grant Details

Grant Number: 5R01CA209798-04 Interpret this number
Primary Investigator: Setiawan, Veronica
Organization: University Of Southern California
Project Title: Investigating the Cause of Racial/Ethnic Disparity in Pancreatic Cancer Incidence
Fiscal Year: 2020


Abstract

ABSTRACT Pancreatic cancer (PC) is one of the deadliest cancers with a 5-year survival rate of 7%. Notable racial/ethnic differences in PC incidence have been observed, with U.S. blacks having 30% higher rates compared to whites. The rates of PC in Native Hawaiians and Japanese Americans have been rising in past two decades and have surpassed those of whites, but no study has been conducted to identify the cause(s) of this rising incidence. In the large prospective Multiethnic Cohort Study (MEC; N>200,000) we observed highly significant differences in PC incidence across racial/ethnic populations, with African Americans having 39% higher rates compared to whites. Native Hawaiians are observed to have the highest rates in the cohort that are 74% higher than whites while rates in Japanese Americans are 32% higher and rates in Latinos are similar to whites. We expect that inter-ethnic differences in risk factor prevalence are likely to explain the observed ethnic differences in PC incidence. However, to date, few studies have included African Americans and no studies have included Japanese Americans, Native Hawaiians, or Latinos; thus, the factors underlying PC disparities remain undefined. The goal of this study is to identify factors that explain racial/ethnic disparities in PC incidence, particularly the excess risks observed in African Americans, Japanese Americans, and Native Hawaiians. We hypothesize that in addition to known risk factors, host genetic factors and unknown non-genetic factors contribute to the observed racial/ethnic differences in PC incidence. To test our hypothesis, we will leverage the well-characterized lifestyle and genetic data of the MEC, a long-standing ethnically diverse prospective cohort of >200,000 African American, Latino, Native Hawaiian, Japanese and white participants established in the early 1990's in California and Hawaii. The MEC is uniquely positioned to address racial/ethnic disparities in PC incidence, with >2,100 incident cases of PC diagnosed over >20-years of follow-up and with detailed lifestyle and exposure data collected in a consistent fashion amongst all populations to permit valid ethnic comparisons. Our specific aims are: 1) To quantify racial/ethnic-specific associations of known and potential/suspected risk factors with PC incidence in African Americans, Japanese Americans, Latinos, Native Hawaiians, and whites; 2) To determine whether the risk factors confirmed or discovered in Aim 1 contribute to the observed ethnic differences in PC incidence; 3) To characterize the association of known common genetic variants with PC risk in African Americans, Japanese Americans, Latinos, and Native Hawaiians and build a quantitative risk model to compare the distribution of genetic risks across populations associated with these marker alleles. By leveraging the existing resources/infrastructure, this study will efficiently and cost-effectively examine multiple factors that may contribute to racial/ethnic disparities in PC. Because of the lack of effective treatment and low survivorship, identifying modifiable risk factors is critical in reducing PC burden; this is even more crucial for minority populations who are at greater risk and are likely to have limited access to care.



Publications

Smoking and pancreatic cancer: a sex-specific analysis in the Multiethnic Cohort study.
Authors: Gram I.T. , Park S.Y. , Wilkens L.R. , Le Marchand L. , Setiawan V.W. .
Source: Cancer causes & control : CCC, 2022-10-17; , .
EPub date: 2022-10-17.
PMID: 36253659
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Cancer Mortality Patterns by Birthplace and Generation Status of Mexican Latinos: The Multiethnic Cohort.
Authors: Chen H. , Wu A.H. , Wang S. , Bookstein A. , Le Marchand L. , Wilkens L.R. , Haiman C.A. , Cheng I. , Monroe K.R. , Setiawan V.W. .
Source: Journal of the National Cancer Institute, 2022-07-11; 114(7), p. 959-968.
PMID: 35404450
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Rising Incidence and Racial Disparities of Early-Onset Pancreatic Cancer in the United States, 1995-2018.
Authors: Huang B.Z. , Liu L. , Zhang J. , USC Pancreas Research Team , Pandol S.J. , Grossman S.R. , Setiawan V.W. .
Source: Gastroenterology, 2022 Jul; 163(1), p. 310-312.e1.
EPub date: 2022-03-11.
PMID: 35288111
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Lung Cancer Mortality Racial/Ethnic Disparities in Patient Experiences with Care: a SEER-CAHPS Study.
Authors: Farias A.J. , Chan E. , Navarro S. , David E.A. , Eguchi M. , Cockburn M. .
Source: Journal of racial and ethnic health disparities, 2022-06-29; , .
EPub date: 2022-06-29.
PMID: 35767217
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The association between ambient air pollutants and pancreatic cancer in the Multiethnic Cohort Study.
Authors: Bogumil D. , Wu A.H. , Stram D. , Yang J. , Tseng C.C. , Le Marchand L. , Wu J. , Cheng I. , Setiawan V.W. .
Source: Environmental research, 2021 Nov; 202, p. 111608.
EPub date: 2021-06-30.
PMID: 34214566
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Racial/ethnic disparities in weight or BMI change in adulthood and pancreatic cancer incidence: The multiethnic cohort.
Authors: Farias A.J. , Streicher S.A. , Stram D.O. , Wang S. , Pandol S.J. , Le Marchand L. , Setiawan V.W. .
Source: Cancer medicine, 2021 Jun; 10(12), p. 4097-4106.
EPub date: 2021-05-16.
PMID: 33998145
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Red meat consumption, cooking mutagens, NAT1/2 genotypes and pancreatic cancer risk in two ethnically diverse prospective cohorts.
Authors: Huang B.Z. , Wang S. , Bogumil D. , Wilkens L.R. , Wu L. , Blot W.J. , Zheng W. , Shu X.O. , Pandol S.J. , Le Marchand L. , et al. .
Source: International journal of cancer, 2021-04-12; , .
EPub date: 2021-04-12.
PMID: 33844845
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Replication and Genetic Risk Score Analysis for Pancreatic Cancer in a Diverse Multiethnic Population.
Authors: Bogumil D. , Conti D.V. , Sheng X. , Xia L. , Shu X.O. , Pandol S.J. , Blot W.J. , Zheng W. , Le Marchand L. , Haiman C.A. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020 Dec; 29(12), p. 2686-2692.
EPub date: 2020-09-21.
PMID: 32958499
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New-Onset Diabetes, Longitudinal Trends in Metabolic Markers, and Risk of Pancreatic Cancer in a Heterogeneous Population.
Authors: Huang B.Z. , Pandol S.J. , Jeon C.Y. , Chari S.T. , Sugar C.A. , Chao C.R. , Zhang Z.F. , Wu B.U. , Setiawan V.W. .
Source: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2020 Jul; 18(8), p. 1812-1821.e7.
EPub date: 2019-12-04.
PMID: 31809917
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Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.
Authors: Lin Y. , Nakatochi M. , Hosono Y. , Ito H. , Kamatani Y. , Inoko A. , Sakamoto H. , Kinoshita F. , Kobayashi Y. , Ishii H. , et al. .
Source: Nature communications, 2020-06-24; 11(1), p. 3175.
EPub date: 2020-06-24.
PMID: 32581250
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Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort.
Authors: Huang B.Z. , Stram D.O. , Le Marchand L. , Haiman C.A. , Wilkens L.R. , Pandol S.J. , Zhang Z.F. , Monroe K.R. , Setiawan V.W. .
Source: Cancer medicine, 2019 Jul; 8(7), p. 3592-3603.
EPub date: 2019-05-08.
PMID: 31066497
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Pancreatic Cancer Following Incident Diabetes in African Americans and Latinos: The Multiethnic Cohort.
Authors: Setiawan V.W. , Stram D.O. , Porcel J. , Chari S.T. , Maskarinec G. , Le Marchand L. , Wilkens L.R. , Haiman C.A. , Pandol S.J. , Monroe K.R. .
Source: Journal of the National Cancer Institute, 2019-01-01; 111(1), p. 27-33.
PMID: 29917105
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Atopic allergic conditions and pancreatic cancer risk: Results from the Multiethnic Cohort Study.
Authors: Huang B.Z. , Le Marchand L. , Haiman C.A. , Monroe K.R. , Wilkens L.R. , Zhang Z.F. , Setiawan V.W. .
Source: International journal of cancer, 2018-05-15; 142(10), p. 2019-2027.
EPub date: 2018-01-12.
PMID: 29314003
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