Grant Number:	5R01CA234205-02 Interpret this number
Primary Investigator:	Perez, Adriana
Organization:	University Of Texas Hlth Sci Ctr Houston
Project Title:	Age of Initiation of Tobacco Products Among Usa Youth and Young Adults
Fiscal Year:	2020

PROJECT SUMMARY The Surgeon General's 2012 report provided data that the initiation of cigarette smoking begins before adulthood. Considering the new and emerging tobacco products available, estimating the age and onset of initiation, changing patterns of tobacco use and correlates of tobacco use among U.S. youth and young adults is paramount to informing contemporary tobacco regulatory science. We will directly inform the Food and Drug Administration (FDA) authority on tobacco regulation about all tobacco products to protect the public’s health. This project directly address the FDA's research priority areas that focus on understanding the knowledge, attitudes, and behaviors that contribute to tobacco product (TP) initiation, age of TP initiation, and factors associated with age of initiation. Our study involves a prospective secondary analysis of the first three waves of the Population Assessment of Tobacco and Health (PATH) study among U.S. youth (12-17 years old) and young adults (18-24 years old) who reported never use at baseline. Six TPs will be considered: cigarettes, e- cigarettes, cigars (i.e. traditional cigars, cigarillo, filtered cigars), hookah; smokeless tobacco, and any of these TPs. Seven outcomes are considered for each TP: age to first report ever or past 30-day use, age to become susceptible to use, age to be an established user (i.e. ever use fairly regularly), age to first report dual/poly TP use, age to first use flavored TP, and age of ever combustible use. There is a gap in the knowledge related to the age of first reporting of each one of the seven outcomes prospectively and with contemporary data. This project has three aims. Aim 1: Among youth ages 12-17 years old who are never users of TPs at wave 1, to estimate prospectively their age of initiation of TPs and to identify the risk factors associated with the age of initiation of cigarettes and each one of the NCTPs: e-cigarettes, cigars, hookah, and smokeless tobacco. Aim 2: same as aim 1 but among young adults ages 18-24 years old who are never users of TPs at wave 1. Aim 3: Among youth and young adults ages 12-24 who are never users of TPs at wave 1, to identify the trajectories and transitions in the onset of TPs across time, from wave 1 to waves 2 and 3, and to identify the risk factors associated with these trajectories and transitions. We plan to explore socio-demographic, interpersonal, intrapersonal, social, and environmental factors potentially associated with the age of initiation of the different TPs. Consistent with research priorities FDA has set forth, this project focuses on our understanding of the knowledge and behaviors to best predict age of initiation. Few studies can test hypotheses with longitudinal data that span youth and young adults. This project strengthens the evidence for tobacco regulatory science by expanding the evidence regarding emerging tobacco products, using a national longitudinal study, and taking advantage of contemporary data that reflects the evolving tobacco product landscape. This project addresses RFA-OD-18-002.




Racial and Ethnic Disparities in the Medical Management of Poststroke Complications Among Patients With Acute Stroke.
Authors: Simmonds K.P. , Atem F.D. , Welch B.G. , Ifejika N.L. .
Source: Journal Of The American Heart Association, 2024-03-05 00:00:00.0; 13(5), p. e030537.
EPub date: 2024-02-23 00:00:00.0.
PMID: 38390802
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Application of inverse weighting analysis to assess the association of youth perceptions with the age of initiation of tobacco products.
Authors: Atem F.D. , Bluestein M.A. , Chen B. , Harrell M.B. , Messiah S.E. , Kuk A.E. , Pérez A. .
Source: Frontiers In Public Health, 2024; 12, p. 1203631.
EPub date: 2024-02-21 00:00:00.0.
PMID: 38450147
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Longitudinal Transition Patterns of Tobacco Use Among Youth and Young Adults Never Tobacco Product Users: Findings From the Population Assessment of Tobacco and Health Study, 2014-2019.
Authors: Bluestein M.A. , Kuk A.E. , Harrell M.B. , Chen B. , Hébert E.T. , Pérez A. .
Source: Tobacco Use Insights, 2023; 16, p. 1179173X231161314.
EPub date: 2023-03-09 00:00:00.0.
PMID: 36923154
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Precise Estimation for the Age of Initiation of Tobacco Use Among U.S. Youth: Finding from the Population Assessment of Tobacco and Health (PATH) Study, 2013-2017.
Authors: Atem F.D. , Bluestein M.A. , Harrell M.B. , Chen B. , Messiah S.E. , Kuk A.E. , Sterling K.L. , Spells C.E. , Pérez A. .
Source: Biostatistics And Biometrics Open Access Journal, 2022 Oct; 11(1), .
EPub date: 2022-10-21 00:00:00.0.
PMID: 36777448
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Internalizing and externalizing problems on the age of e-cigarette initiation in youth: Findings from the Population Assessment of Tobacco and Health (PATH), 2013-2017.
Authors: Pérez A. , Bluestein M.A. , Kuk A.E. , Chen B. , Harrell M.B. .
Source: Preventive Medicine, 2022 Aug; 161, p. 107111.
EPub date: 2022-06-16 00:00:00.0.
PMID: 35716810
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The Effect of Perceptions of Hookah Harmfulness and Addictiveness on the Age of Initiation of Hookah Use among Population Assessment of Tobacco and Health (PATH) Youth.
Authors: Kuk A.E. , Bluestein M.A. , Chen B. , Harrell M. , Spells C.E. , Atem F. , Pérez A. .
Source: International Journal Of Environmental Research And Public Health, 2022-04-21 00:00:00.0; 19(9), .
EPub date: 2022-04-21 00:00:00.0.
PMID: 35564430
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Age of initiation of smokeless tobacco use among young adults: Findings from the population assessment of tobacco and health (PATH) study, 2013-2017.
Authors: Pérez A. , Kuk A.E. , Bluestein M.A. , Chen B. , Harrell M.B. .
Source: Tobacco Prevention & Cessation, 2022; 8, p. 11.
EPub date: 2022-03-10 00:00:00.0.
PMID: 35342846
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Age of initiation of cigarillo use among young adults: Findings from the Population Assessment of Tobacco and Health (PATH) study, 2013-2017.
Authors: Chen B. , Sterling K.L. , Bluestein M.A. , Penedo E. , Kuk A.E. , Harrell M.B. , Perry C.L. , Pérez A. .
Source: Plos One, 2022; 17(3), p. e0264168.
EPub date: 2022-03-31 00:00:00.0.
PMID: 35358201
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The Longitudinal Impact of Seeing and Posting Tobacco-related Social Media on Tobacco Use Behaviors Among Youth (Aged 12-17): Findings From the 2014-2016 Population Assessment of Tobacco and Health (PATH) Study.
Authors: Pérez A. , Spells C.E. , Bluestein M.A. , Harrell M.B. , Hébert E.T. .
Source: Tobacco Use Insights, 2022; 15, p. 1179173X221087554.
EPub date: 2022-03-14 00:00:00.0.
PMID: 35634272
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Associations Between Perceptions of e-Cigarette Harmfulness and Addictiveness and the Age of E-Cigarette Initiation Among the Population Assessment of Tobacco and Health (PATH) Youth.
Authors: Bluestein M.A. , Harrell M.B. , Hébert E.T. , Chen B. , Kuk A.E. , Spells C.E. , Pérez A. .
Source: Tobacco Use Insights, 2022; 15, p. 1179173X221133645.
EPub date: 2022-10-19 00:00:00.0.
PMID: 36276166
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The association of perceptions of harmfulness and addictiveness on the age of initiation of cigar product use among youth: Findings from the Population Assessment of Tobacco and Health (PATH) study, 2013-2017.
Authors: Chen B. , Spells C.E. , Bluestein M.A. , Kuk A.E. , Harrell M.B. , Pérez A. .
Source: Frontiers In Public Health, 2022; 10, p. 882434.
EPub date: 2022-10-05 00:00:00.0.
PMID: 36276402
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Age of Initiation of Dual Tobacco Use and Binge Drinking among Youth (12-17 Years Old): Findings from the Population Assessment of Tobacco and Health (PATH) Study.
Authors: Pérez A. , Kuk A.E. , Bluestein M.A. , Sia H.M.S. , Chen B. .
Source: International Journal Of Environmental Research And Public Health, 2021-12-09 00:00:00.0; 18(24), .
EPub date: 2021-12-09 00:00:00.0.
PMID: 34948595
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Prospective estimation of the age of initiation of hookah use among youth: Findings from the Population Assessment of Tobacco and Health (PATH) study waves 1-4 (2013-2017).
Authors: Pérez A. , Kuk A.E. , Bluestein M.A. , Harrell M.B. , Perry C.L. , Chen B. .
Source: Addictive Behaviors, 2021 Jun; 117, p. 106838.
EPub date: 2021-01-21 00:00:00.0.
PMID: 33545623
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Age at Initiation of Cigarette Use in a Nationally Representative Sample of US Youth, 2013-2017.
Authors: Pérez A. , N'hpang R.S. , Callahan E. , Bluestein M. , Kuk A.E. , Chen B. , Perry C.L. , Harrell M.B. .
Source: Jama Network Open, 2021-02-01 00:00:00.0; 4(2), p. e210218.
EPub date: 2021-02-01 00:00:00.0.
PMID: 33635326
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Prospective estimation of the age of initiation of cigarettes among young adults (18-24 years old): Findings from the Population Assessment of Tobacco and Health (PATH) waves 1-4 (2013-2017).
Authors: Pérez A. , Kuk A.E. , Bluestein M.A. , Penedo E. , N'hpang R.S. , Chen B. , Perry C.L. , Sterling K.L. , Harrell M.B. .
Source: Plos One, 2021; 16(5), p. e0251246.
EPub date: 2021-05-05 00:00:00.0.
PMID: 33951097
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Age of initiation of hookah use among young adults: Findings from the Population Assessment of Tobacco and Health (PATH) study, 2013-2017.
Authors: Pérez A. , Kuk A.E. , Bluestein M.A. , Chen B. , Sterling K.L. , Harrell M.B. .
Source: Plos One, 2021; 16(10), p. e0258422.
EPub date: 2021-10-12 00:00:00.0.
PMID: 34637482
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Age of e-cigarette initiation in USA young adults: Findings from the Population Assessment of Tobacco and Health (PATH) study (2013-2017).
Authors: Pérez A. , Bluestein M.A. , Kuk A.E. , Chen B. .
Source: Plos One, 2021; 16(12), p. e0261243.
EPub date: 2021-12-13 00:00:00.0.
PMID: 34898629
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Age of Onset of Susceptibility to Different Tobacco Products Among Non-Susceptible US Young Adults: Findings from the Population Assessment of Tobacco and Health Study Waves 2-4 (2014-2017).
Authors: Pérez A. , Bluestein M.A. , Kuk A.E. , Chen B. , Sterling K.L. , Harrell M.B. .
Source: Tobacco Use Insights, 2021; 14, p. 1179173X211065643.
EPub date: 2021-12-13 00:00:00.0.
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The Recalled Age of Initiation of Multiple Tobacco Products among 26-34 Year Olds: Findings from the Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014).
Authors: Pérez A. , Penedo E. , Bluestein M.A. , Chen B. , Perry C.L. , Harrell M.B. .
Source: International Journal Of Environmental Research And Public Health, 2020-12-03 00:00:00.0; 17(23), .
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Age of initiation of cigarillos, filtered cigars and/or traditional cigars among youth: Findings from the Population Assessment of Tobacco and Health (PATH) study, 2013-2017.
Authors: Chen B. , Sterling K.L. , Bluestein M.A. , Kuk A.E. , Harrell M.B. , Perry C.L. , Pérez A. .
Source: Plos One, 2020; 15(12), p. e0243372.
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PROSPECTIVELY ESTIMATING THE AGE OF INITIATION OF E-CIGARETTES AMONG U.S. YOUTH: FINDINGS FROM THE POPULATION ASSESSMENT OF TOBACCO AND HEALTH (PATH) STUDY, 2013-2017.
Authors: Pérez A. , Bluestein M. , Chen B. , Perry C.L. , Harrell M.B. .
Source: Journal Of Biometrics & Biostatistics, 2020; 11(4), .
EPub date: 2020-05-19 00:00:00.0.
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