Skip to main content
Grant Details

Grant Number: 5R01CA236793-02 Interpret this number
Primary Investigator: Whitney, David
Organization: University Of California Berkeley
Project Title: Isolating and Mitigating Sequentially Dependent Perceptual Errors in Clinical Visual Search
Fiscal Year: 2020


Project Summary When looking at an x-ray, radiologists are typically asked to localize a tumor (if present), and to classify it, judging its size, class, position and so on. Importantly, during this task, radiologists examine on a daily basis hundreds and hundreds of x-rays, seeing several images one after the other. A main underlying assumption of this task is that radiologists’ percepts and decisions on a current X-ray are completely independent of prior events. Recent results showed that this is not true: our perception and decisions are strongly biased by our past visual experience. Although serial dependencies were proposed to be a purposeful mechanism to achieve perceptual stability of our otherwise noisy visual input, serial dependencies play a crucial and deleterious role in the everyday task performed by radiologists. For example, an x-ray containing a tumor can be classified as benign depending on the content of the previously seen x-ray. Given the importance and the impact of serial dependencies in clinical tasks, in this proposal, we plan to (1) establish, (2) identify and (3) mitigate the conditions under which serial effects determine our percepts and decisions in tumor search tasks. In Aim 1, we will establish the presence of serial effects in four different clinically relevant domains: tumor detection, tumor classification, tumor position and recognition speed. In Aim 2, we plan to identify the specific boundary conditions under which visual serial dependence impacts tumor search in radiology. In Aim 3, once we will fully understand these boundary conditions in Aim 2, we will propose a series of task and stimulus manipulations to control and mitigate the deleterious effects of visual serial dependence on tumor search. As a result of these manipulations, visual search performance should improve in measurable ways (detection, classification, position, speed). Aim 3 is particularly crucial because it will allow us to propose new guidelines which will greatly improve tumor recognition in x-ray images, making this task even more effective and reliable. Taken together, the proposed studies in Aim 1, 2, and 3 will allow us to establish, identify, and mitigate the deleterious effect of serial dependencies in radiological search tasks, which could have a significant impact on the health and well-being of patients everywhere. ! ! !


Individual differences in classification images of Mooney faces.
Authors: Canas-Bajo T. , Whitney D. .
Source: Journal of vision, 2022-12-01; 22(13), p. 3.
PMID: 36458961
Related Citations

Searching for serial dependencies in the brain.
Authors: Whitney D. , Manassi M. , Murai Y. .
Source: PLoS biology, 2022 Sep; 20(9), p. e3001788.
EPub date: 2022-09-07.
PMID: 36070292
Related Citations

Relative tuning of holistic face processing towards the fovea.
Authors: Canas-Bajo T. , Whitney D. .
Source: Vision research, 2022 Aug; 197, p. 108049.
EPub date: 2022-04-20.
PMID: 35461170
Related Citations

The test-retest reliability and spatial tuning of serial dependence in orientation perception.
Authors: Kondo A. , Murai Y. , Whitney D. .
Source: Journal of vision, 2022-03-02; 22(4), p. 5.
PMID: 35293956
Related Citations

Illusion of visual stability through active perceptual serial dependence.
Authors: Manassi M. , Whitney D. .
Source: Science advances, 2022-01-14; 8(2), p. eabk2480.
EPub date: 2022-01-12.
PMID: 35020432
Related Citations

Global and high-level effects in crowding cannot be predicted by either high-dimensional pooling or target cueing.
Authors: Bornet A. , Choung O.H. , Doerig A. , Whitney D. , Herzog M.H. , Manassi M. .
Source: Journal of vision, 2021-11-01; 21(12), p. 10.
PMID: 34812839
Related Citations

Serial dependence in the perceptual judgments of radiologists.
Authors: Manassi M. , Ghirardo C. , Canas-Bajo T. , Ren Z. , Prinzmetal W. , Whitney D. .
Source: Cognitive research: principles and implications, 2021-10-14; 6(1), p. 65.
EPub date: 2021-10-14.
PMID: 34648124
Related Citations

Serial dependence revealed in history-dependent perceptual templates.
Authors: Murai Y. , Whitney D. .
Source: Current biology : CB, 2021-07-26; 31(14), p. 3185-3191.e3.
EPub date: 2021-06-03.
PMID: 34087105
Related Citations

Holistic ensemble perception.
Authors: Han L. , Yamanashi Leib A. , Chen Z. , Whitney D. .
Source: Attention, perception & psychophysics, 2021 Apr; 83(3), p. 998-1013.
EPub date: 2020-11-25.
PMID: 33241531
Related Citations

Inferential affective tracking reveals the remarkable speed of context-based emotion perception.
Authors: Chen Z. , Whitney D. .
Source: Cognition, 2021 Mar; 208, p. 104549.
EPub date: 2020-12-17.
PMID: 33340812
Related Citations

Idiosyncratic perception: a link between acuity, perceived position and apparent size.
Authors: Wang Z. , Murai Y. , Whitney D. .
Source: Proceedings. Biological sciences, 2020-07-08; 287(1930), p. 20200825.
EPub date: 2020-07-08.
PMID: 32635869
Related Citations

Visual crowding in driving.
Authors: Xia Y. , Manassi M. , Nakayama K. , Zipser K. , Whitney D. .
Source: Journal of vision, 2020-06-03; 20(6), p. 1.
PMID: 32492098
Related Citations

Author Correction: Serial dependence in a simulated clinical visual search task.
Authors: Manassi M. , Kristjánsson Á. , Whitney D. .
Source: Scientific reports, 2020-02-18; 10(1), p. 3221.
EPub date: 2020-02-18.
PMID: 32066813
Related Citations

Serial dependence in a simulated clinical visual search task.
Authors: Manassi M. , Kristjánsson Á. , Whitney D. .
Source: Scientific reports, 2019-12-27; 9(1), p. 19937.
EPub date: 2019-12-27.
PMID: 31882657
Related Citations

Back to Top