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Grant Details

Grant Number: 5U54MD010706-05 Interpret this number
Primary Investigator: Hughes-Halbert, Chanita
Organization: Medical University Of South Carolina
Project Title: Medical University of South Carolina Transdisciplinary Collaborative Center in Precision Medicine and Minority Men's Health
Fiscal Year: 2020


 DESCRIPTION (provided by applicant): The overarching goal of the Medical University of South Carolina (MUSC) Transdisciplinary Collaborative Center (TCC) in Precision Medicine for Minority Men's Health is to determine the most effective ways to integrate, interpret, and apply biological, social, psychological, and clinical determinants of disease risks and outcomes into more precise medical strategies to prevent, diagnose, and treat chronic health conditions and diseases. To accomplish this goal, the MUSC TCC will: (1) utilize a multi-regional consortium network representing academic medical centers, community-based health organizations, public health agencies, and community stakeholders who will continually shape research priorities and strategies by embracing the principles of community-based participatory research; (2) conduct novel transdisciplinary research examining the synergistic effects of the multi-level, individual-specific characteristics that impact disease risks and outcomes; and (3) determine and disseminate best practices for delivering precision medicine-based care in an effort to reverse health care disparities among minority men in different clinical and community settings. Center partners will include NIMHD-funded centers at the University of Pennsylvania, Hampton University, and the University of Texas Health Sciences Center, San Antonio as well as forefront thought-leaders in minority health from the Hope Institute, the National Black Leadership Initiative on Cancer, Southeast Health Equity Council, and regional HRSA-funded Area Health Education Centers. Key elements of the MUSC TCC organizational structure include a well-defined academic home at MUSC with synergistic health disparity- focused missions and support from an NCI-designated Cancer Center and an NCATS-funded Clinical and Translational Science Award; three initial precision medicine research projects linked by a novel theoretical framework; a Data Integration Core led by nationally-recognized bioinformatic and medical informatic experts charged with creating integrated data sets that include clinical health outcomes data, biospecimen data, and data on social, psychological, and behavioral determinants; an Implementation Core that will deploy the latest approaches in dissemination research through the use of regional Evidence Academies; and a governance structure comprised of three highly qualified multi-PIs with expertise in health disparities, precision medicine, and translational medicine who set the tone for the transdisciplinary underpinnings of this TCC. The MUSC TCC and its partners across Health and Human Services Regions III, IV, and VI are poised to significantly impact the health outcomes of minority men throughout their regional communities utilizing innovative precision medicine-based insights and interventions.


Social and clinical determinants of physical activity in prostate cancer survivors.
Authors: Halbert C.H. , Jefferson M.S. , Drake R. , Lilly M. , Savage S.J. , Nahhas G.J. , Price S.T. , Loftley A.E. , Bauer A. .
Source: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021 Jan; 29(1), p. 459-465.
EPub date: 2020-05-11.
PMID: 32394247
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Financial toxicity and strain among men receiving prostate cancer care in an equal access healthcare system.
Authors: Bauer A.G. , Jefferson M. , Nahhas G.J. , Savage S. , Drake R. , Lilly M. , Ambrose L. , Caulder S. , Mahvi D. , Hughes Halbert C. .
Source: Cancer medicine, 2020-10-17; , .
EPub date: 2020-10-17.
PMID: 33070458
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Zonal regulation of collagen-type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry.
Authors: Angel P.M. , Spruill L. , Jefferson M. , Bethard J.R. , Ball L.E. , Hughes-Halbert C. , Drake R.R. .
Source: The Prostate, 2020 09; 80(13), p. 1071-1086.
EPub date: 2020-07-20.
PMID: 32687633
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New Enzymatic Approach to Distinguish Fucosylation Isomers of N-Linked Glycans in Tissues Using MALDI Imaging Mass Spectrometry.
Authors: West C.A. , Liang H. , Drake R.R. , Mehta A.S. .
Source: Journal of proteome research, 2020-08-07; 19(8), p. 2989-2996.
EPub date: 2020-06-08.
PMID: 32441096
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Utilization of health information technology among cancer genetic counselors.
Authors: Ritchie J.B. , Allen C.G. , Morrison H. , Nichols M. , Lauzon S.D. , Schiffman J.D. , Hughes Halbert C. , Welch B.M. .
Source: Molecular genetics & genomic medicine, 2020 08; 8(8), p. e1315.
EPub date: 2020-05-28.
PMID: 32468681
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A thematic analysis of health information technology use among cancer genetic counselors.
Authors: Allen C.G. , Ritchie J.B. , Morrison H. , Lauzon S.D. , Nichols M. , Schiffman J.D. , Hughes Halbert C. , Welch B.M. .
Source: Journal of genetic counseling, 2020-07-08; , .
EPub date: 2020-07-08.
PMID: 32643297
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Automating a Process Convolution Approach to Account for Spatial Information in Imaging Mass Spectrometry Data.
Authors: Miller C. , Lawson A. , Chung D. , Gebregziabher M. , Yeh E. , Drake R. , Hill E. .
Source: Spatial statistics, 2020 Apr; 36, .
EPub date: 2020-02-19.
PMID: 32318329
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An Introduction to Systems Analytics and Integration of Big Omics Data.
Authors: Hardiman G. .
Source: Genes, 2020-02-26; 11(3), .
EPub date: 2020-02-26.
PMID: 32111000
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How else can we approach prostate cancer biomarker discovery?
Authors: Drake R.R. , Angel P.M. , Wu J. , Pachynski R.K. , Ippolito J.E. .
Source: Expert review of molecular diagnostics, 2020 02; 20(2), p. 123-125.
EPub date: 2019-09-10.
PMID: 31498690
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How can biomarkers assist the prognosis of urologic malignancies?
Authors: Falzarano S.M. , Feely M.M. .
Source: Expert review of molecular diagnostics, 2020 02; 20(2), p. 131-133.
EPub date: 2019-09-09.
PMID: 31495243
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Co-morbidities in a Retrospective Cohort of Prostate Cancer Patients.
Authors: Jefferson M. , Drake R.R. , Lilly M. , Savage S.J. , Tucker Price S. , Hughes Halbert C. .
Source: Ethnicity & disease, 2020; 30(Suppl 1), p. 185-192.
EPub date: 2020-04-02.
PMID: 32269460
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Resiliency and Allostatic Load among Veterans at Risk for Adverse Prostate Cancer Outcomes.
Authors: Hughes Halbert C. , Jefferson M. , Ambrose L. , Caulder S. , Savage S.J. .
Source: Ethnicity & disease, 2020; 30(Suppl 1), p. 177-184.
EPub date: 2020-04-02.
PMID: 32269459
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Reporting of race in genome and exome sequencing studies of cancer: a scoping review of the literature.
Authors: Nugent A. , Conatser K.R. , Turner L.L. , Nugent J.T. , Sarino E.M.B. , Ricks-Santi L.J. .
Source: Genetics in medicine : official journal of the American College of Medical Genetics, 2019 12; 21(12), p. 2676-2680.
EPub date: 2019-06-04.
PMID: 31160752
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Automatically identifying social isolation from clinical narratives for patients with prostate Cancer.
Authors: Zhu V.J. , Lenert L.A. , Bunnell B.E. , Obeid J.S. , Jefferson M. , Halbert C.H. .
Source: BMC medical informatics and decision making, 2019-03-14; 19(1), p. 43.
EPub date: 2019-03-14.
PMID: 30871518
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Racial disparities, cancer and response to oxidative stress.
Authors: Zhang J. , Ye Z.W. , Townsend D.M. , Hughes-Halbert C. , Tew K.D. .
Source: Advances in cancer research, 2019; 144, p. 343-383.
EPub date: 2019-04-23.
PMID: 31349903
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Artificial Intelligence and Integrated Genotype⁻Phenotype Identification.
Authors: Frey L.J. .
Source: Genes, 2018-12-28; 10(1), .
EPub date: 2018-12-28.
PMID: 30597900
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Genetic counseling among minority populations in the era of precision medicine.
Authors: Halbert C.H. , Harrison B.W. .
Source: American journal of medical genetics. Part C, Seminars in medical genetics, 2018 03; 178(1), p. 68-74.
EPub date: 2018-03-25.
PMID: 29575517
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Discordance in perceived risk and epidemiological outcomes of prostate cancer among African American men.
Authors: Rice L.J. , Jefferson M. , Briggs V. , Delmoor E. , Johnson J.C. , Gattoni-Celli S. , Savage S.J. , Lilly M. , Prasad S.M. , Kittles R. , et al. .
Source: Preventive medicine reports, 2017 Sep; 7, p. 1-6.
EPub date: 2017-04-26.
PMID: 28507891
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Beliefs about Genetically Targeted Care in African Americans.
Authors: Halbert C.H. , McDonald J.A. , Magwood G. , Jefferson M. .
Source: Journal of the National Medical Association, 2017 Summer; 109(2), p. 98-106.
EPub date: 2017-03-13.
PMID: 28599763
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