Grant Number:	5U54MD010706-05 Interpret this number
Primary Investigator:	Hughes-Halbert, Chanita
Organization:	Medical University Of South Carolina
Project Title:	Medical University of South Carolina Transdisciplinary Collaborative Center in Precision Medicine and Minority Men's Health
Fiscal Year:	2020

 DESCRIPTION (provided by applicant): The overarching goal of the Medical University of South Carolina (MUSC) Transdisciplinary Collaborative Center (TCC) in Precision Medicine for Minority Men's Health is to determine the most effective ways to integrate, interpret, and apply biological, social, psychological, and clinical determinants of disease risks and outcomes into more precise medical strategies to prevent, diagnose, and treat chronic health conditions and diseases. To accomplish this goal, the MUSC TCC will: (1) utilize a multi-regional consortium network representing academic medical centers, community-based health organizations, public health agencies, and community stakeholders who will continually shape research priorities and strategies by embracing the principles of community-based participatory research; (2) conduct novel transdisciplinary research examining the synergistic effects of the multi-level, individual-specific characteristics that impact disease risks and outcomes; and (3) determine and disseminate best practices for delivering precision medicine-based care in an effort to reverse health care disparities among minority men in different clinical and community settings. Center partners will include NIMHD-funded centers at the University of Pennsylvania, Hampton University, and the University of Texas Health Sciences Center, San Antonio as well as forefront thought-leaders in minority health from the Hope Institute, the National Black Leadership Initiative on Cancer, Southeast Health Equity Council, and regional HRSA-funded Area Health Education Centers. Key elements of the MUSC TCC organizational structure include a well-defined academic home at MUSC with synergistic health disparity- focused missions and support from an NCI-designated Cancer Center and an NCATS-funded Clinical and Translational Science Award; three initial precision medicine research projects linked by a novel theoretical framework; a Data Integration Core led by nationally-recognized bioinformatic and medical informatic experts charged with creating integrated data sets that include clinical health outcomes data, biospecimen data, and data on social, psychological, and behavioral determinants; an Implementation Core that will deploy the latest approaches in dissemination research through the use of regional Evidence Academies; and a governance structure comprised of three highly qualified multi-PIs with expertise in health disparities, precision medicine, and translational medicine who set the tone for the transdisciplinary underpinnings of this TCC. The MUSC TCC and its partners across Health and Human Services Regions III, IV, and VI are poised to significantly impact the health outcomes of minority men throughout their regional communities utilizing innovative precision medicine-based insights and interventions.




Association of Perceived Neighborhood Disorder with Substance Use Behaviors and Retail Access Among Southern California Adolescents.
Authors: Harlow A.F. , Hughes Halbert C. , Ranker L.R. , Cho J. , Thompson L.K. , Cockburn M. , Eckel S.P. , Barrington-Trimis J.L. .
Source: Substance Use & Misuse, 2024-11-04 00:00:00.0; , p. 1-8.
EPub date: 2024-11-04 00:00:00.0.
PMID: 39497034
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Social and clinical drivers of stress responses in African American breast cancer survivors.
Authors: Sanogo F. , Jefferson M. , Beard T.A. , Salhia B. , Babatunde O.A. , Cho J. , Hughes Halbert C. .
Source: Scientific Reports, 2024-08-26 00:00:00.0; 14(1), p. 19729.
EPub date: 2024-08-26 00:00:00.0.
PMID: 39183189
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Using nursing science to advance policy and practice in the context of social and structural determinants of health.
Authors: Rice B.M. .
Source: Nursing Outlook, 2023 Nov-Dec; 71(6), p. 102060.
EPub date: 2023-10-16 00:00:00.0.
PMID: 37852871
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Social Drivers of Cancer Risk and Outcomes Among African American Men.
Authors: Halbert C.H. .
Source: Cancer Journal (sudbury, Mass.), 2023 Nov-Dec 01; 29(6), p. 293-296.
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Transcriptome Profiling Reveals Enhanced Mitochondrial Activity as a Cold Adaptive Strategy to Hypothermia in Zebrafish Muscle.
Authors: Cahill T. , Chan S. , Overton I.M. , Hardiman G. .
Source: Cells, 2023-05-11 00:00:00.0; 12(10), .
EPub date: 2023-05-11 00:00:00.0.
PMID: 37408201
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Genetic and epigenetic studies of opioid abuse disorder - the potential for future diagnostics.
Authors: Abdulmalek S. , Hardiman G. .
Source: Expert Review Of Molecular Diagnostics, 2023 May; 23(5), p. 361-373.
EPub date: 2023-04-20 00:00:00.0.
PMID: 37078260
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African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A.
Authors: Siddappa M. , Hussain S. , Wani S.A. , White J. , Tang H. , Gray J.S. , Jafari H. , Wu H.C. , Long M.D. , Elhussin I. , et al. .
Source: Cancer Research Communications, 2023 Apr; 3(4), p. 621-639.
EPub date: 2023-04-18 00:00:00.0.
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Investigating the effects of chronic low-dose radiation exposure in the liver of a hypothermic zebrafish model.
Authors: Cahill T. , da Silveira W.A. , Renaud L. , Wang H. , Williamson T. , Chung D. , Chan S. , Overton I. , Hardiman G. .
Source: Scientific Reports, 2023-01-17 00:00:00.0; 13(1), p. 918.
EPub date: 2023-01-17 00:00:00.0.
PMID: 36650199
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Social Determinants of Health and Cancer Care: Where Do We Go From Here?
Authors: Hughes Halbert C. .
Source: Journal Of The National Cancer Institute, 2022-12-08 00:00:00.0; 114(12), p. 1564-1566.
PMID: 36073955
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Racial Distribution of Neighborhood-Level Social Deprivation in a Retrospective Cohort of Prostate Cancer Survivors.
Authors: Babatunde O.A. , Pearce J.L. , Jefferson M.S. , Frey L.J. , Angel P.M. , Drake R.R. , Allen C.G. , Lilly M.B. , Savage S.J. , Hughes Halbert C. .
Source: Diseases (basel, Switzerland), 2022-10-03 00:00:00.0; 10(4), .
EPub date: 2022-10-03 00:00:00.0.
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Equity in Genomic Medicine.
Authors: Halbert C.H. .
Source: Annual Review Of Genomics And Human Genetics, 2022-08-31 00:00:00.0; 23, p. 613-625.
EPub date: 2022-04-01 00:00:00.0.
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Elevated serum CEA is associated with liver metastasis and distinctive circulating tumor DNA alterations in patients with castration-resistant prostate cancer.
Authors: Bray A.W. , Duan R. , Malalur P. , Drusbosky L.M. , Gourdin T.S. , Hill E.G. , Lilly M.B. .
Source: The Prostate, 2022-06-29 00:00:00.0; , .
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A Convergent Mixed Methods Study of Cardiovascular Disease Risk Factors among Young Black Men in the United States.
Authors: Brawner B.M. , Talley L.M. , Baker J.L. , Bowleg L. , Dominique T.B. , Robinson D.Y. , Riegel B. , Black Men’s Health Initiative of the Penn Center for AIDS Research .
Source: Ethnicity & Disease, 2022 Summer; 32(3), p. 169-184.
EPub date: 2022-07-21 00:00:00.0.
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Fusion Genes in Prostate Cancer: A Comparison in Men of African and European Descent.
Authors: Morgan R. , Keeley D. , Hazard E.S. , Allott E.H. , Wolf B. , Savage S.J. , Hughes Halbert C. , Gattoni-Celli S. , Hardiman G. .
Source: Biology, 2022-04-20 00:00:00.0; 11(5), .
EPub date: 2022-04-20 00:00:00.0.
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miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells.
Authors: da Silveira W.A. , Renaud L. , Hazard E.S. , Hardiman G. .
Source: Genes, 2022-01-24 00:00:00.0; 13(2), .
EPub date: 2022-01-24 00:00:00.0.
PMID: 35205253
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miRNA-Mediated Priming of Macrophage M1 Differentiation Differs in Gram-Positive and Gram-Negative Settings.
Authors: Riechert G. , Maucher D. , Schmidt B. , Schumann J. .
Source: Genes, 2022-01-24 00:00:00.0; 13(2), .
EPub date: 2022-01-24 00:00:00.0.
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Integrated Genomic and Bioinformatics Approaches to Identify Molecular Links between Endocrine Disruptors and Adverse Outcomes.
Authors: Verga J.U. , Huff M. , Owens D. , Wolf B.J. , Hardiman G. .
Source: International Journal Of Environmental Research And Public Health, 2022-01-05 00:00:00.0; 19(1), .
EPub date: 2022-01-05 00:00:00.0.
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Long non-coding RNAs and their potential impact on diagnosis, prognosis, and therapy in prostate cancer: racial, ethnic, and geographical considerations.
Authors: Morgan R. , da Silveira W.A. , Kelly R.C. , Overton I. , Allott E.H. , Hardiman G. .
Source: Expert Review Of Molecular Diagnostics, 2021 Dec; 21(12), p. 1257-1271.
EPub date: 2021-11-25 00:00:00.0.
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Basic behavioral science research priorities in minority health and health disparities.
Authors: Halbert C.H. , Allen C.G. .
Source: Translational Behavioral Medicine, 2021-11-30 00:00:00.0; 11(11), p. 2033-2042.
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Contemporary Approaches to the Discovery and Development of Broad-Spectrum Natural Product Prototypes for the Control of Coronaviruses.
Authors: Hanna G.S. , Choo Y.M. , Harbit R. , Paeth H. , Wilde S. , Mackle J. , Verga J.U. , Wolf B.J. , Thomas O.P. , Croot P. , et al. .
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A Systems Approach to Interrogate Gene Expression Patterns in African American Men Presenting with Clinically Localized Prostate Cancer.
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RNA expression differences in prostate tumors and tumor-adjacent stroma between Black and White Americans.
Authors: Rahmatpanah F. , Robles G. , Lilly M. , Keane T. , Kumar V. , Mercola D. , Randhawa P. , McClelland M. .
Source: Oncotarget, 2021-07-20 00:00:00.0; 12(15), p. 1457-1469.
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Mass Spectrometry Imaging of Fibroblasts: Promise and Challenge.
Authors: Angel P.M. , Rujchanarong D. , Pippin S. , Spruill L. , Drake R. .
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Racial Differences in Patient Portal Activation and Research Enrollment Among Patients With Prostate Cancer.
Authors: Halbert C.H. , Jefferson M. , Allen C.G. , Babatunde O.A. , Drake R. , Angel P. , Savage S.J. , Frey L. , Lilly M. , Obi T. , et al. .
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Induced Torpor as a Countermeasure for Low Dose Radiation Exposure in a Zebrafish Model.
Authors: Cahill T. , da Silveira W.A. , Renaud L. , Williamson T. , Wang H. , Chung D. , Overton I. , Chan S.S.L. , Hardiman G. .
Source: Cells, 2021-04-14 00:00:00.0; 10(4), .
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Academic careers and the COVID-19 pandemic: Reversing the tide.
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Differential DNA Methylation Landscape in Skin Fibroblasts from African Americans with Systemic Sclerosis.
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Optimization of Multiple Glycosidase and Chemical Stabilization Strategies for N-Glycan Isomer Detection by Mass Spectrometry Imaging in Formalin-Fixed, Paraffin-Embedded Tissues.
Authors: West C.A. , Lu X. , Grimsley G. , Norris-Caneda K. , Mehta A.S. , Angel P.M. , Drake R.R. .
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From Race-Based to Precision Oncology: Leveraging Behavioral Economics and the Electronic Health Record to Advance Health Equity in Cancer Care.
Authors: Lau-Min K.S. , Guerra C.E. , Nathanson K.L. , Bekelman J.E. .
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Direct N-Glycosylation Profiling of Urine and Prostatic Fluid Glycoproteins and Extracellular Vesicles.
Authors: Blaschke C.R.K. , Hartig J.P. , Grimsley G. , Liu L. , Semmes O.J. , Wu J.D. , Ippolito J.E. , Hughes-Halbert C. , Nyalwidhe J.O. , Drake R.R. .
Source: Frontiers In Chemistry, 2021; 9, p. 734280.
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Rapid N-Glycan Profiling of Serum and Plasma by a Novel Slide-Based Imaging Mass Spectrometry Workflow.
Authors: Blaschke C.R.K. , Black A.P. , Mehta A.S. , Angel P.M. , Drake R.R. .
Source: Journal Of The American Society For Mass Spectrometry, 2020-12-02 00:00:00.0; 31(12), p. 2511-2520.
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Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact.
Authors: da Silveira W.A. , Fazelinia H. , Rosenthal S.B. , Laiakis E.C. , Kim M.S. , Meydan C. , Kidane Y. , Rathi K.S. , Smith S.M. , Stear B. , et al. .
Source: Cell, 2020-11-25 00:00:00.0; 183(5), p. 1185-1201.e20.
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Lessons Learned from the Medical University of South Carolina Transdisciplinary Collaborative Center (TCC) in Precision Medicine and Minority Men's Health.
Authors: Halbert C.H. , Allen C.G. , Jefferson M. , Magwood G.S. , Melvin C. , Babatunde O.A. , Baquet C. , Delmoor E. , Johnson J. , Mathews D. , et al. .
Source: American Journal Of Men's Health, 2020 Nov-Dec; 14(6), p. 1557988320979236.
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Financial toxicity and strain among men receiving prostate cancer care in an equal access healthcare system.
Authors: Bauer A.G. , Jefferson M. , Nahhas G.J. , Savage S. , Drake R. , Lilly M. , Ambrose L. , Caulder S. , Mahvi D. , Hughes Halbert C. .
Source: Cancer Medicine, 2020-10-17 00:00:00.0; , .
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New Enzymatic Approach to Distinguish Fucosylation Isomers of N-Linked Glycans in Tissues Using MALDI Imaging Mass Spectrometry.
Authors: West C.A. , Liang H. , Drake R.R. , Mehta A.S. .
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Zonal regulation of collagen-type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry.
Authors: Angel P.M. , Spruill L. , Jefferson M. , Bethard J.R. , Ball L.E. , Hughes-Halbert C. , Drake R.R. .
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A thematic analysis of health information technology use among cancer genetic counselors.
Authors: Allen C.G. , Ritchie J.B. , Morrison H. , Lauzon S.D. , Nichols M. , Schiffman J.D. , Hughes Halbert C. , Welch B.M. .
Source: Journal Of Genetic Counseling, 2020-07-08 00:00:00.0; , .
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Utilization of health information technology among cancer genetic counselors.
Authors: Ritchie J.B. , Allen C.G. , Morrison H. , Nichols M. , Lauzon S.D. , Schiffman J.D. , Hughes Halbert C. , Welch B.M. .
Source: Molecular Genetics & Genomic Medicine, 2020-05-28 00:00:00.0; , p. e1315.
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Social and clinical determinants of physical activity in prostate cancer survivors.
Authors: Halbert C.H. , Jefferson M.S. , Drake R. , Lilly M. , Savage S.J. , Nahhas G.J. , Price S.T. , Loftley A.E. , Bauer A. .
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2020-05-11 00:00:00.0; , .
EPub date: 2020-05-11 00:00:00.0.
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Automating a Process Convolution Approach to Account for Spatial Information in Imaging Mass Spectrometry Data.
Authors: Miller C. , Lawson A. , Chung D. , Gebregziabher M. , Yeh E. , Drake R. , Hill E. .
Source: Spatial Statistics, 2020 Apr; 36, .
EPub date: 2020-02-19 00:00:00.0.
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An Introduction to Systems Analytics and Integration of Big Omics Data.
Authors: Hardiman G. .
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How can biomarkers assist the prognosis of urologic malignancies?
Authors: Falzarano S.M. , Feely M.M. .
Source: Expert Review Of Molecular Diagnostics, 2020 02; 20(2), p. 131-133.
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How else can we approach prostate cancer biomarker discovery?
Authors: Drake R.R. , Angel P.M. , Wu J. , Pachynski R.K. , Ippolito J.E. .
Source: Expert Review Of Molecular Diagnostics, 2020 02; 20(2), p. 123-125.
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Artificial Intelligence Pipeline to Bridge the Gap between Bench Researchers and Clinical Researchers in Precision Medicine.
Authors: Frey L.J. , Talbert D.A. .
Source: Med One, 2020-01-10 00:00:00.0; 5, .
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Resiliency and Allostatic Load among Veterans at Risk for Adverse Prostate Cancer Outcomes.
Authors: Hughes Halbert C. , Jefferson M. , Ambrose L. , Caulder S. , Savage S.J. .
Source: Ethnicity & Disease, 2020; 30(Suppl 1), p. 177-184.
EPub date: 2020-04-02 00:00:00.0.
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Co-morbidities in a Retrospective Cohort of Prostate Cancer Patients.
Authors: Jefferson M. , Drake R.R. , Lilly M. , Savage S.J. , Tucker Price S. , Hughes Halbert C. .
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Automatically Identifying Financial Stress Information from Clinical Notes for Patients with Prostate Cancer.
Authors: Zhu V. , Lenert L. , Bunnell B. , Obeid J. , Jefferson M. , Halbert C.H. .
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Reporting of race in genome and exome sequencing studies of cancer: a scoping review of the literature.
Authors: Nugent A. , Conatser K.R. , Turner L.L. , Nugent J.T. , Sarino E.M.B. , Ricks-Santi L.J. .
Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2019-06-04 00:00:00.0; , .
EPub date: 2019-06-04 00:00:00.0.
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Automatically identifying social isolation from clinical narratives for patients with prostate Cancer.
Authors: Zhu V.J. , Lenert L.A. , Bunnell B.E. , Obeid J.S. , Jefferson M. , Halbert C.H. .
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