Grant Details
Grant Number: |
5R01CA214588-04 Interpret this number |
Primary Investigator: |
Giuliano, Anna |
Organization: |
H. Lee Moffitt Cancer Ctr & Res Inst |
Project Title: |
Investigation of Oral HPV Infection Natural History and Biomarkers of Persistent Infection: the Him Study |
Fiscal Year: |
2020 |
Abstract
ABSTRACT
In 2013, 42,440 adults in the U.S. were diagnosed with oropharyngeal cancer (OPC), the majority at late
stages, with an estimated five-year survival of 50% and a high rate of recurrence. Among those who survive,
surgery and chemoradiotherapy leave patients with long-term pain, disfigurement, and disability that further
add to the burden of the disease. Each year, OPCs are responsible for ~10,000 deaths, 130,000 years of
potential life lost, and ~$3 billion in productivity loss. Earlier OPC diagnoses increase likelihood of single-
modality treatment, lower the risk of mortality, decrease medical expenditures, and improve quality of life.
HPV causes ~70% of OPCs in the US, with the proportion of OPCs due to HPV increasing each year.
Incidence rates of HPV-related OPCs are also ~3-fold higher in males compared to females. While there is
substantial literature regarding the natural history of genital HPV infection and progression to cervical cancer,
little has been published on the natural history of oral HPV infection, thus limiting the development of OPC
prevention interventions. Unlike cervical and anal cancers, no screening tests are available for OPC, nor have
current HPV vaccines been evaluated for efficacy against these cancers. Therefore, in this grant application we
propose to study oral HPV natural history through an established prospective cohort of average risk men,
information urgently needed to inform the development of future prevention strategies, including clinically
relevant screening tools. The HIM Study is the only male prospective study that has the cohort infrastructure
and archived oral specimens to fill this critical research void.
The overall goal of this research is to define the natural history of oral HPV infection to inform future
development of OPC prevention and screening interventions. The central hypothesis is that viral, host, and
behavioral factors are predictive of oral HPV infections that are most likely to persist ≥12 months (surrogate
cancer endpoint), infections most likely to progress to cancer. We will estimate incidence and duration of oral
HPV infections and associated factors. Novel viral (viral methylation, integration, variants), host (methylation),
and behavioral (tobacco use, oral hygiene and health, sexual behavior,) factors will be evaluated in relation to
oral HPV natural history. The proposed research is innovative, as it will be the first to prospectively address
fundamental questions related to oral HPV natural history. Our study builds on an existing large data and
biological specimen repository to efficiently address timely and significant questions identifying markers of
infection that have utility for the design of future HPV-OPC screening/prevention interventions. Our
transdisciplinary team of epidemiologists, biostatisticians, oncologists, and virologists has the experience and
expertise to successfully implement the proposed study.
Publications
Multinational epidemiological analysis of oral human papillomavirus incidence in 3,137 men.
Authors: Dube Mandishora R.S.
, Dickey B.L.
, Fan W.
, Sirak B.
, Isaacs-Soriano K.
, Rathwell J.
, Abrahamsen M.
, Reich R.R.
, Schell M.J.
, Lazcano-Ponce E.
, et al.
.
Source: Nature Microbiology, 2024-10-18 00:00:00.0; , .
EPub date: 2024-10-18 00:00:00.0.
PMID: 39424983
Related Citations
Identification of a Biomarker Panel from Genome-Wide Methylation to Detect Early HPV-Associated Oropharyngeal Cancer.
Authors: Dickey B.L.
, Putney R.M.
, Schell M.J.
, Berglund A.E.
, Amelio A.L.
, Caudell J.J.
, Chung C.H.
, Giuliano A.R.
.
Source: Cancer Prevention Research (philadelphia, Pa.), 2024-04-02 00:00:00.0; 17(4), p. 169-176.
PMID: 38286404
Related Citations
Associations of HPV-16 Gene Methylation With Oral HPV-16 Persistence Among a Multinational Sample of Men.
Authors: Islam J.Y.
, Bettampadi D.
, Reich R.R.
, Nedjai B.
, Giuliano A.R.
.
Source: Sexually Transmitted Diseases, 2023-07-01 00:00:00.0; 50(7), p. 455-457.
EPub date: 2023-03-22 00:00:00.0.
PMID: 36943783
Related Citations
Control of Epstein-Barr virus (EBV) in the oral cavity is associated with persistence of oral HPV 16/18 among men from the HPV Infection in Men (HIM) Study.
Authors: Dickey B.L.
, Giuliano A.R.
, Sirak B.
, Abrahamsen M.
, Lazcano-Ponce E.
, Villa L.L.
, Coghill A.E.
.
Source: The Journal Of Infectious Diseases, 2022-06-09 00:00:00.0; , .
EPub date: 2022-06-09 00:00:00.0.
PMID: 35679351
Related Citations
Methylation of HPV16 and EPB41L3 in oral gargles and the detection of early and late oropharyngeal cancer.
Authors: Dickey B.L.
, Nedjai B.
, Preece M.D.
, Schell M.J.
, Boulware D.
, Whiting J.
, Sirak B.
, Abrahamsen M.
, Isaacs-Soriano K.A.
, Kennedy K.
, et al.
.
Source: Cancer Medicine, 2022-05-26 00:00:00.0; , .
EPub date: 2022-05-26 00:00:00.0.
PMID: 35619332
Related Citations
Sequential acquisition of human papillomavirus infection between genital and oral anatomic sites in males.
Authors: Dickey B.L.
, Fan W.
, Bettampadi D.
, Reich R.R.
, Sirak B.
, Abrahamsen M.
, Baggio M.L.
, Galan L.
, Silva R.C.
, Salmerón J.
, et al.
.
Source: International Journal Of Cancer, 2021-07-05 00:00:00.0; , .
EPub date: 2021-07-05 00:00:00.0.
PMID: 34224588
Related Citations
Oral secretory leukocyte protease inhibitor (SLPI): Associations with oropharyngeal cancer and treatment outcome.
Authors: Dickey B.L.
, Sirak B.
, Martin-Gomez L.
, Reich R.R.
, Abrahamsen M.
, Isaacs-Soriano K.
, Chung C.H.
, Giuliano A.R.
.
Source: Plos One, 2021; 16(7), p. e0254161.
EPub date: 2021-07-02 00:00:00.0.
PMID: 34214131
Related Citations
Factors associated with persistence and clearance of high-risk oral HPV among participants in the HPV Infection in Men (HIM) study.
Authors: Bettampadi D.
, Sirak B.A.
, Abrahamsen M.E.
, Reich R.R.
, Villa L.L.
, Ponce E.L.
, Giuliano A.R.
.
Source: Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America, 2020-11-11 00:00:00.0; , .
EPub date: 2020-11-11 00:00:00.0.
PMID: 33173937
Related Citations
Differences in factors associated with high and low risk oral HPV genotypes in men.
Authors: Bettampadi D.
, Dickey B.
, Abrahamsen M.
, Sirak B.
, Baggio M.L.
, Galan L.
, Silva R.C.
, Villa L.
, Ponce E.L.
, Giuliano A.R.
.
Source: The Journal Of Infectious Diseases, 2020-11-05 00:00:00.0; , .
EPub date: 2020-11-05 00:00:00.0.
PMID: 33151300
Related Citations
Oral HPV prevalence assessment by Linear Array vs. SPF10 PCR-DEIA-LiPA25 system in the HPV Infection in Men (HIM) study.
Authors: Bettampadi D.
, Sirak B.A.
, Fulp W.J.
, Abrahamsen M.
, Villa L.L.
, Lazcano-Ponce E.
, Salmeron J.
, Isaacs-Soriano K.A.
, Baggio M.L.
, Trenado M.Q.
, et al.
.
Source: Papillomavirus Research (amsterdam, Netherlands), 2020 06; 9, p. 100199.
EPub date: 2020-05-25 00:00:00.0.
PMID: 32464335
Related Citations
Untangling the dynamics of persistence and colonization in microbial communities.
Authors: Ranjeva S.L.
, Mihaljevic J.R.
, Joseph M.B.
, Giuliano A.R.
, Dwyer G.
.
Source: The Isme Journal, 2019 Dec; 13(12), p. 2998-3010.
EPub date: 2019-08-23 00:00:00.0.
PMID: 31444482
Related Citations
Oral human papillomavirus prevalence and type distribution by country (Brazil, Mexico and the United States) and age among HPV infection in men study participants.
Authors: Bettampadi D.
, Villa L.L.
, Ponce E.L.
, Salmeron J.
, Sirak B.A.
, Abrahamsen M.
, Rathwell J.A.
, Reich R.R.
, Giuliano A.R.
.
Source: International Journal Of Cancer, 2019-10-03 00:00:00.0; , .
EPub date: 2019-10-03 00:00:00.0.
PMID: 31583681
Related Citations