||1R03CA238957-01A1 Interpret this number
||University Of Utah
||Identifying the Role of Air Pollution in the Lung and Heart Health Outcomes of Testicular Cancer Survivors
PROJECT SUMMARY ABSTRACT
Fine particulate matter (PM2.5) and ozone (O3) pollution are major risk factors for respiratory and cardiovascular
disease and death. For survivors of testicular cancer, one of the most common and curable cancers occurring
in young men, respiratory and cardiovascular conditions often arise shortly after their treatment ceases. These
health conditions are attributed to the chemotherapies used to cure testicular cancer that also exhibit toxic
effects on heart and lung tissue. Post-treatment exposure to air pollution among testicular cancer survivors
may exacerbate previous damage from chemotherapy, leading to a higher risk for respiratory and
cardiovascular problems. The effects of air pollution exposure on testicular cancer survivors, however, are
unknown. To fill this knowledge gap, we will examine how air pollution is associated with respiratory and
cardiovascular health care encounters among 1,293 testicular cancer survivors diagnosed between 1999 and
2017 who live in Utah, a state with severe air pollution problems. Using the nation’s only statewide population
registry, the Utah Population Database (UPDB), we can link individual identifying information from statewide
administrative data, statewide hospital and ambulatory surgery records, and outpatient medical records from
Utah’s largest health systems to residential data on short-term air pollution exposure for both PM2.5 and O3. We
will: 1) Investigate the association of short-term air pollution exposure with respiratory and cardiovascular
health events among testicular cancer survivors, measured through statewide healthcare encounter data, and
compare the risk between survivors and a cancer-free sample, and 2) Investigate treatments and health
behaviors that may modify the relationship between air pollution exposure and respiratory and cardiovascular
events among testicular cancer survivors. We will also assess how the relationship varies over time. Both aims
will use a case-crossover design to examine the effects of short-term pollution exposure on the risk for
respiratory and cardiovascular-associated outpatient, urgent care, and emergency department visits and
hospitalizations. We will also examine how risk differs among subgroups of survivors based on treatment (e.g.,
surgery alone vs. surgery and chemotherapy), smoking, time since diagnosis, race/ethnicity, and other factors.
Because of the pervasiveness of air pollution in United States and the lack of data on how environmental
pollutants affect vulnerable populations such as cancer survivors, this project represents a unique opportunity
to determine whether air pollution is a risk factor for respiratory and cardiovascular health problems among
testicular cancer survivors. Moreover, our findings will have implications for other populations of cancer
survivors and can help inform cancer survivorship guidelines on reducing air pollution exposure.
If you are accessing this page during weekend or evening hours, the database may currently be offline for maintenance and should operational within a few hours. Otherwise, we have been notified of this error and will be addressing it immediately.
Please contact us
if this error persists.
We apologize for the inconvenience.
- The DCCPS Team.