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Grant Details

Grant Number: 7R01CA207260-04 Interpret this number
Primary Investigator: Schildkraut, Joellen
Organization: Emory University
Project Title: Exploring Factors Related to Racial Disparities in Ovarian Cancer Incidence and Survival: the Ocwaa Consortium
Fiscal Year: 2020


PROJECT SUMMARY / ABSTRACT    Invasive epithelial ovarian cancer accounts for 5% of malignancies and, while it is the eighth most common  cancer in US women, it is the fifth leading cause of cancer deaths. Many of the established and suspected risk  factors for ovarian cancer show racial differences in the prevalence and/or timing of exposures. Racial  differences in incidence and survival are likely due to a combination of factors, including differences in the  prevalence of risk factors, treatment received, prevalence of comorbidities, and socioeconomic characteristics.  The newly-­formed consortium, Ovarian Cancer in Women of African Ancestry (OCWAA), brings together  investigators experienced in studying the epidemiology of ovarian cancer and dedicated to understanding  racial differences in risk and outcomes in ovarian cancer. The OCWAA consortium includes an ongoing  population-­based case-­control study in African American (AA) women, three completed population-­based  case-­control studies that include both AA and white cases and controls and two unique cohort studies with  large numbers of AA participants. To address racial differences in incidence and survival, we will  comprehensively examine reproductive and lifestyle exposures which differ in prevalence and/or timing  between AA and white women, access to care, treatment and socioeconomic factors, and determine whether  they explain racial disparities. We propose to harmonize risk factor, clinical and outcome data from the  participating studies in the OCWAA consortium in order to accomplish the study goals and carry out race-­ specific analyses of incidence and survival. We will use traditional methods to calculate population attributable  risk percent (PAR%) for associated risk factors.  We will use a novel and exploratory approach, a Markov  state-­transition microsimulation model, to estimate the extent to which racial differences in patterns of  exposure to known risk factors explain racial differences in ovarian cancer age-­specific incidence and use this  same method to estimate the extent to which racial differences in patterns of exposure, treatment, and  prognostic factors explain racial differences in ovarian cancer survival. The proposed study will be the largest  of its kind and the first to be adequately powered to evaluate epidemiologic and clinical factors affecting  incidence and survival of ovarian cancer in AA women. The infrastructure generated by this application will  enable OCWAA to create a base on which to support future scientific proposals.     


Genital Powder Use and Risk of Epithelial Ovarian Cancer in the Ovarian Cancer in Women of African Ancestry Consortium.
Authors: Davis C.P. , Bandera E.V. , Bethea T.N. , Camacho F. , Joslin C.E. , Wu A.H. , Beeghly-Fadiel A. , Moorman P.G. , Myers E.R. , Ochs-Balcom H.M. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2021 Sep; 30(9), p. 1660-1668.
EPub date: 2021-06-21.
PMID: 34155063
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First- and second-degree family history of ovarian and breast cancer in relation to risk of invasive ovarian cancer in African American and white women.
Authors: Bethea T.N. , Ochs-Balcom H.M. , Bandera E.V. , Beeghly-Fadiel A. , Camacho F. , Chyn D. , Cloyd E.K. , Harris H.R. , Joslin C.E. , Myers E. , et al. .
Source: International journal of cancer, 2021-06-15; 148(12), p. 2964-2973.
EPub date: 2021-02-17.
PMID: 33521947
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Racial Differences in Population Attributable Risk for Epithelial Ovarian Cancer in the OCWAA Consortium.
Authors: Peres L.C. , Bethea T.N. , Camacho T.F. , Bandera E.V. , Beeghly-Fadiel A. , Chyn D.L. , Harris H.R. , Joslin C.E. , Moorman P.G. , Myers E. , et al. .
Source: Journal of the National Cancer Institute, 2021-06-01; 113(6), p. 710-718.
PMID: 33252629
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Ovarian Cancer in Women of African Ancestry (OCWAA) consortium: a resource of harmonized data from eight epidemiologic studies of African American and white women.
Authors: Schildkraut J.M. , Peres L.C. , Bethea T.N. , Camacho F. , Chyn D. , Cloyd E.K. , Bandera E.V. , Beeghly-Fadiel A. , Lipworth L. , Joslin C.E. , et al. .
Source: Cancer causes & control : CCC, 2019 Sep; 30(9), p. 967-978.
EPub date: 2019-06-24.
PMID: 31236792
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Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage.
Authors: Peres L.C. , Cushing-Haugen K.L. , Köbel M. , Harris H.R. , Berchuck A. , Rossing M.A. , Schildkraut J.M. , Doherty J.A. .
Source: Journal of the National Cancer Institute, 2019-01-01; 111(1), p. 60-68.
PMID: 29718305
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Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.
Authors: Peres L.C. , Risch H. , Terry K.L. , Webb P.M. , Goodman M.T. , Wu A.H. , Alberg A.J. , Bandera E.V. , Barnholtz-Sloan J. , Bondy M.L. , et al. .
Source: International journal of epidemiology, 2018-04-01; 47(2), p. 460-472.
PMID: 29211900
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Recreational physical activity and survival in African-American women with ovarian cancer.
Authors: Abbott S.E. , Camacho F. , Peres L.C. , Alberg A.J. , Bandera E.V. , Bondy M. , Cote M.L. , Funkhouser E. , Moorman P.G. , Peters E.S. , et al. .
Source: Cancer causes & control : CCC, 2018 01; 29(1), p. 77-86.
EPub date: 2017-11-29.
PMID: 29188593
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