Grant Details
Grant Number: |
7R01CA207260-04 Interpret this number |
Primary Investigator: |
Schildkraut, Joellen |
Organization: |
Emory University |
Project Title: |
Exploring Factors Related to Racial Disparities in Ovarian Cancer Incidence and Survival: the Ocwaa Consortium |
Fiscal Year: |
2020 |
Abstract
PROJECT SUMMARY / ABSTRACT
Invasive epithelial ovarian cancer accounts for 5% of malignancies and, while it is the eighth most common
cancer in US women, it is the fifth leading cause of cancer deaths. Many of the established and suspected risk
factors for ovarian cancer show racial differences in the prevalence and/or timing of exposures. Racial
differences in incidence and survival are likely due to a combination of factors, including differences in the
prevalence of risk factors, treatment received, prevalence of comorbidities, and socioeconomic characteristics.
The newly-formed consortium, Ovarian Cancer in Women of African Ancestry (OCWAA), brings together
investigators experienced in studying the epidemiology of ovarian cancer and dedicated to understanding
racial differences in risk and outcomes in ovarian cancer. The OCWAA consortium includes an ongoing
population-based case-control study in African American (AA) women, three completed population-based
case-control studies that include both AA and white cases and controls and two unique cohort studies with
large numbers of AA participants. To address racial differences in incidence and survival, we will
comprehensively examine reproductive and lifestyle exposures which differ in prevalence and/or timing
between AA and white women, access to care, treatment and socioeconomic factors, and determine whether
they explain racial disparities. We propose to harmonize risk factor, clinical and outcome data from the
participating studies in the OCWAA consortium in order to accomplish the study goals and carry out race-
specific analyses of incidence and survival. We will use traditional methods to calculate population attributable
risk percent (PAR%) for associated risk factors. We will use a novel and exploratory approach, a Markov
state-transition microsimulation model, to estimate the extent to which racial differences in patterns of
exposure to known risk factors explain racial differences in ovarian cancer age-specific incidence and use this
same method to estimate the extent to which racial differences in patterns of exposure, treatment, and
prognostic factors explain racial differences in ovarian cancer survival. The proposed study will be the largest
of its kind and the first to be adequately powered to evaluate epidemiologic and clinical factors affecting
incidence and survival of ovarian cancer in AA women. The infrastructure generated by this application will
enable OCWAA to create a base on which to support future scientific proposals.
Publications
Menopausal hormone therapy use and risk of ovarian cancer by race: the ovarian cancer in women of African ancestry consortium.
Authors: Petrick J.L.
, Joslin C.E.
, Johnson C.E.
, Camacho T.F.
, Peres L.C.
, Bandera E.V.
, Barnard M.E.
, Beeghly A.
, Bethea T.N.
, Dempsey L.F.
, et al.
.
Source: British Journal Of Cancer, 2023-10-21 00:00:00.0; , .
EPub date: 2023-10-21 00:00:00.0.
PMID: 37865688
Related Citations
Racial Differences in the Association of Endometriosis and Uterine Leiomyomas With the Risk of Ovarian Cancer.
Authors: Harris H.R.
, Peres L.C.
, Johnson C.E.
, Guertin K.A.
, Beeghly A.
, Bandera E.V.
, Bethea T.N.
, Joslin C.E.
, Wu A.H.
, Moorman P.G.
, et al.
.
Source: Obstetrics And Gynecology, 2023-05-04 00:00:00.0; , .
EPub date: 2023-05-04 00:00:00.0.
PMID: 37159277
Related Citations
Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium.
Authors: Ochs-Balcom H.M.
, Johnson C.
, Guertin K.A.
, Qin B.
, Beeghly-Fadiel A.
, Camacho F.
, Bethea T.N.
, Dempsey L.F.
, Rosenow W.
, Joslin C.E.
, et al.
.
Source: British Journal Of Cancer, 2022-09-22 00:00:00.0; , .
EPub date: 2022-09-22 00:00:00.0.
PMID: 36138071
Related Citations
Race Differences in the Associations between Menstrual Cycle Characteristics and Epithelial Ovarian Cancer.
Authors: Nash R.
, Johnson C.E.
, Harris H.R.
, Peres L.C.
, Joslin C.E.
, Bethea T.N.
, Bandera E.V.
, Ochs-Balcom H.M.
, Myers E.R.
, Guertin K.A.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2022-08-02 00:00:00.0; 31(8), p. 1610-1620.
PMID: 35654411
Related Citations
Racial disparities in epithelial ovarian cancer survival: An examination of contributing factors in the Ovarian Cancer in Women of African Ancestry consortium.
Authors: Harris H.R.
, Guertin K.A.
, Camacho T.F.
, Johnson C.E.
, Wu A.H.
, Moorman P.G.
, Myers E.
, Bethea T.N.
, Bandera E.V.
, Joslin C.E.
, et al.
.
Source: International Journal Of Cancer, 2022-05-28 00:00:00.0; , .
EPub date: 2022-05-28 00:00:00.0.
PMID: 35633315
Related Citations
Genital powder use and risk of epithelial ovarian cancer in the Ovarian Cancer in Women of African Ancestry Consortium.
Authors: Davis C.P.
, Bandera E.V.
, Bethea T.N.
, Camacho F.
, Joslin C.E.
, Wu A.H.
, Beeghly-Fadiel A.
, Moorman P.G.
, Myers E.R.
, Ochs-Balcom H.M.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2021-06-21 00:00:00.0; , .
EPub date: 2021-06-21 00:00:00.0.
PMID: 34155063
Related Citations
Racial Differences in Population Attributable Risk for Epithelial Ovarian Cancer in the OCWAA Consortium.
Authors: Peres L.C.
, Bethea T.N.
, Camacho T.F.
, Bandera E.V.
, Beeghly-Fadiel A.
, Chyn D.L.
, Harris H.R.
, Joslin C.E.
, Moorman P.G.
, Myers E.
, et al.
.
Source: Journal Of The National Cancer Institute, 2021-06-01 00:00:00.0; 113(6), p. 710-718.
PMID: 33252629
Related Citations
First- and second-degree family history of ovarian and breast cancer in relation to risk of invasive ovarian cancer in African American and white women.
Authors: Bethea T.N.
, Ochs-Balcom H.M.
, Bandera E.V.
, Beeghly-Fadiel A.
, Camacho F.
, Chyn D.
, Cloyd E.K.
, Harris H.R.
, Joslin C.E.
, Myers E.
, et al.
.
Source: International Journal Of Cancer, 2021-01-31 00:00:00.0; , .
EPub date: 2021-01-31 00:00:00.0.
PMID: 33521947
Related Citations
Ovarian Cancer in Women of African Ancestry (OCWAA) consortium: a resource of harmonized data from eight epidemiologic studies of African American and white women.
Authors: Schildkraut J.M.
, Peres L.C.
, Bethea T.N.
, Camacho F.
, Chyn D.
, Cloyd E.K.
, Bandera E.V.
, Beeghly-Fadiel A.
, Lipworth L.
, Joslin C.E.
, et al.
.
Source: Cancer Causes & Control : Ccc, 2019-06-24 00:00:00.0; , .
EPub date: 2019-06-24 00:00:00.0.
PMID: 31236792
Related Citations
Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage.
Authors: Peres L.C.
, Cushing-Haugen K.L.
, Köbel M.
, Harris H.R.
, Berchuck A.
, Rossing M.A.
, Schildkraut J.M.
, Doherty J.A.
.
Source: Journal Of The National Cancer Institute, 2019-01-01 00:00:00.0; 111(1), p. 60-68.
PMID: 29718305
Related Citations
Recreational physical activity and survival in African-American women with ovarian cancer.
Authors: Abbott S.E.
, Camacho F.
, Peres L.C.
, Alberg A.J.
, Bandera E.V.
, Bondy M.
, Cote M.L.
, Funkhouser E.
, Moorman P.G.
, Peters E.S.
, et al.
.
Source: Cancer Causes & Control : Ccc, 2018 Jan; 29(1), p. 77-86.
EPub date: 2017-11-29 00:00:00.0.
PMID: 29188593
Related Citations
Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.
Authors: Peres L.C.
, Risch H.
, Terry K.L.
, Webb P.M.
, Goodman M.T.
, Wu A.H.
, Alberg A.J.
, Bandera E.V.
, Barnholtz-Sloan J.
, Bondy M.L.
, et al.
.
Source: International Journal Of Epidemiology, 2017-12-02 00:00:00.0; , .
EPub date: 2017-12-02 00:00:00.0.
PMID: 29211900
Related Citations
Alcohol Intake and Breast Cancer Risk in African American Women from the AMBER Consortium.
Authors: Williams L.A.
, Olshan A.F.
, Hong C.C.
, Bandera E.V.
, Rosenberg L.
, Cheng T.D.
, Lunetta K.L.
, McCann S.E.
, Poole C.
, Kolonel L.N.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017 May; 26(5), p. 787-794.
EPub date: 2017-04-18 00:00:00.0.
PMID: 28420652
Related Citations