||1R01CA246540-01 Interpret this number
||University Of Iowa
||Living Well: a Web-Based Intervention to Improve Quality of Life in Rural and Urban Ovarian Cancer Survivors
Over the last two decades, we and others have documented the chronic and often debilitating experience
of ovarian cancer survivorship which may include poor health related quality of life (HRQOL), elevated
anxiety and depression, poor sleep, fatigue, multiple symptoms/side effects, existential concerns, and a
generally poor prognosis. Because of compromises to many aspects of HRQOL combined with low rates
of survival for the majority of these patients, development of innovative approaches for improving HRQOL
and potentially improving clinical outcomes is of paramount importance. This need is particularly true in
rural settings where women may have less access to clinic-based support systems. Despite the multiple
challenges experienced by ovarian cancer survivors, research targeting the potential efficacy of
psychosocial interventions in enhancing HRQOL has been extremely limited. Over the last several years
this research team has developed and piloted a web-based group conferencing intervention entitled
Living Well (Web-Enhanced Lessons for Living) targeting key concerns of ovarian cancer survivors and
developed with input from survivors. The overarching goal of the present submission is to examine the
efficacy of the Living Well intervention vs. a Health Promotion active control intervention in a randomized
controlled trial in 256 ovarian cancer survivors who have completed primary treatment and are less than
5-years post-diagnosis. We hypothesize that the Living Well Intervention will be efficacious in improving
HRQOL, decreasing perceived stress (primary outcomes) and in decreasing depressive mood, anxiety,
and fatigue (secondary outcomes). This application is highly innovative because it combines elements of
evidence-based psychosocial interventions in a novel way to target the needs of ovarian cancer survivors,
using a state-of-the-art web and video conferencing platform that allows wide dissemination, including to
rural survivors. This work is highly translational as it is a direct application of findings from mechanistic
stress-related research to testing an intervention to reduce stress in ovarian cancer survivors. The
significance of the application is that this intervention has the potential to overcome prior barriers to the
implementation of such psychosocial interventions and improve HRQOL, thus providing public health
benefits to an understudied and compromised cancer population with a high likelihood of recurrence.
Epithelial-mesenchymal transition polarization in ovarian carcinomas from patients with high social isolation.
, Penedo F.
, Goodheart M.J.
, Dahmoush L.
, Arevalo J.M.G.
, Thaker P.H.
, Slavich G.M.
, Sood A.K.
, Cole S.W.
Cancer, 2020-07-21; , .