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Grant Details

Grant Number: 5R00CA207848-06 Interpret this number
Primary Investigator: Warren Andersen, Shaneda
Organization: University Of Wisconsin-Madison
Project Title: Vitamin D and Colorectal Cancer Risk: an Integrated Molecular and Genetic Epidemiologic Study
Fiscal Year: 2020


PROJECT ABSTRACT This K99/R00 Career Development Award will provide the applicant, Dr. Warren Andersen, with the research experience and training to propel her into a career as an independent investigator in the field of genetic and molecular epidemiology with a focus on the interplay between race, modifiable risk factors, and the genetic determinants of cancer risk and outcomes. The research plan uses Mendelian randomization methods to evaluate the hypothesis that circulating and bioavailable vitamin D levels are associated with decreased colorectal cancer risk. Mendelian randomization (MR) methods can be used to evaluate the associations between long-term exposures and diseases by using genetic variants as instrumental variables in place of exposures. Dr. Warren Andersen will also assess whether vitamin D binding protein modifies the association between vitamin D and colorectal cancer risk. The project will leverage resources from three established epidemiologic consortia (the ColoRectal Transdisciplinary Study (CORECT) consortium, a colorectal cancer genome-wide association study consortium among African Americans, and the Asia Colorectal Cancer Consortium) and the Southern Community Cohort Study to evaluate associations in large samples including individuals of European, Asian and African descent. Dr. Warren Andersen will create race-specific genetic scores to represent circulating vitamin D and vitamin D binding protein. Fine-mapping will be conducted to identify potentially causal variants to be included in the vitamin D genetic scores. These genetic scores will then be assessed for associations with overall colorectal cancer risk, and colorectal cancer risk stratified by specific characteristics of the tumor such as COX-2 expression, PIK3CA mutation status, and stage. During the Career Development Award Dr. Warren Andersen will gain additional skills in genetic analysis and increase her knowledge in colorectal cancer biology and health disparities. The findings from this research project will be used to develop and submit two R01 level projects before the completion of the Career Development Award. The additional experience gained from this Career Development Award will prepare Dr. Warren Andersen to be a leader in the field of genetic and molecular epidemiology of cancer, with expertise in colorectal cancer etiology, genetic and cancer epidemiology, and the root causes of racial differences in disease risk. This research topic is of much significance, as the Institute of Medicine's 2010 Report stated, investigation into the causal relationships between vitamin D and total and site-specific cancers is an important research need. The use of MR and molecular epidemiologic methods should provide a more definitive answer to the questions of the relationships of colorectal cancer risk with circulating vitamin D, bioavailable vitamin D and vitamin D binding protein. This study will provide insight into colorectal cancer etiology and potentially identify subgroups of individuals who may benefit the most from vitamin D supplementation.


Associations of Albumin and BMI with Colorectal Cancer Risk in the Southern Community Cohort Study: a Prospective Cohort Study.
Authors: Walts Z. , Parlato L. , Brent R. , Cai Q. , Steinwandel M. , Zheng W. , Warren Andersen S. .
Source: Journal of racial and ethnic health disparities, 2023-09-21; , .
EPub date: 2023-09-21.
PMID: 37733284
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Racial disparities in colorectal cancer clinicopathological and molecular tumor characteristics: a systematic review.
Authors: Lawler T. , Parlato L. , Warren Andersen S. .
Source: Cancer causes & control : CCC, 2023-09-09; , .
EPub date: 2023-09-09.
PMID: 37688643
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Prediagnostic 25-Hydroxyvitamin D in Association with Cancer-specific and All-cause Mortality among Low-income, Non-Hispanic Black Americans with Colorectal Cancer.
Authors: Lawler T.P. , Khankari N.K. , Shu X.O. , Steinwandel M. , Cai Q. , Jurutka P.W. , Zheng W. , Warren Andersen S. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2023-08-01; 32(8), p. 1061-1068.
PMID: 37257199
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Genome-wide association study (GWAS) of circulating vitamin D outcomes among individuals of African ancestry.
Authors: Parlato L.A. , Welch R. , Ong I.M. , Long J. , Cai Q. , Steinwandel M.D. , Blot W.J. , Zheng W. , Warren Andersen S. .
Source: The American journal of clinical nutrition, 2023 Feb; 117(2), p. 308-316.
EPub date: 2022-12-23.
PMID: 36811574
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Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies.
Authors: Lawler T. , Warren Andersen S. .
Source: Nutrients, 2023-01-13; 15(2), .
EPub date: 2023-01-13.
PMID: 36678292
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Reduced racial disparity in receipt of optimal locoregional treatment for women with early-stage breast cancer.
Authors: Nadeem H. , Romley J.A. , Warren Andersen S. .
Source: PloS one, 2023; 18(9), p. e0291025.
EPub date: 2023-09-01.
PMID: 37656742
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Associations between Folate and Alcohol Consumption with Colorectal Tumor Ki67 Expression in the Southern Community Cohort Study.
Authors: Lawler T. , Su T. , Cai Q. , Steinwandel M.D. , Zheng W. , Warren Andersen S. .
Source: Nutrition and cancer, 2023; 75(4), p. 1211-1222.
EPub date: 2023-03-12.
PMID: 36908193
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Associations between serum vitamin D biomarkers and tumor expression of Ki67, p53, and COX-2 in colorectal cancer cases from the Southern Community Cohort Study.
Authors: Lawler T. , Su T. , Cai Q. , Steinwandel M.D. , Zheng W. , Blot W.J. , Warren Andersen S. .
Source: The Journal of steroid biochemistry and molecular biology, 2023 Jan; 225, p. 106201.
EPub date: 2022-10-06.
PMID: 36210028
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Sociocultural Factors, Access to Healthcare, and Lifestyle: Multifactorial Indicators in Association with Colorectal Cancer Risk.
Authors: Warren Andersen S. , Zheng W. , Steinwandel M. , Murff H.J. , Lipworth L. , Blot W.J. .
Source: Cancer prevention research (Philadelphia, Pa.), 2022-09-01; 15(9), p. 595-603.
PMID: 35609123
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Racial Differences in Hepatocellular Carcinoma Incidence and Risk Factors among a Low Socioeconomic Population.
Authors: Muhimpundu S. , Conway R.B.N. , Warren Andersen S. , Lipworth L. , Steinwandel M.D. , Blot W.J. , Shu X.O. , Sudenga S.L. .
Source: Cancers, 2021-07-23; 13(15), .
EPub date: 2021-07-23.
PMID: 34359611
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Association of Race and Socioeconomic Status With Colorectal Cancer Screening, Colorectal Cancer Risk, and Mortality in Southern US Adults.
Authors: Warren Andersen S. , Blot W.J. , Lipworth L. , Steinwandel M. , Murff H.J. , Zheng W. .
Source: JAMA network open, 2019-12-02; 2(12), p. e1917995.
EPub date: 2019-12-02.
PMID: 31860105
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Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study.
Authors: Jiang X. , Dimou N.L. , Al-Dabhani K. , Lewis S.J. , Martin R.M. , Haycock P.C. , Gunter M.J. , Key T.J. , Eeles R.A. , Muir K. , et al. .
Source: International journal of epidemiology, 2019-10-01; 48(5), p. 1416-1424.
PMID: 30597039
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Attitudes toward Precision Treatment of Smoking in the Southern Community Cohort Study.
Authors: Senft N. , Sanderson M. , Selove R. , Blot W.J. , King S. , Gilliam K. , Kundu S. , Steinwandel M. , Sternlieb S.J. , Warren Andersen S. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019 Aug; 28(8), p. 1345-1352.
EPub date: 2019-06-03.
PMID: 31160346
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Does religious involvement affect mortality in low-income Americans? A prospective cohort study.
Authors: Wen W. , Schlundt D. , Andersen S.W. , Blot W.J. , Zheng W. .
Source: BMJ open, 2019-07-09; 9(7), p. e028200.
EPub date: 2019-07-09.
PMID: 31289078
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Diabetes, obesity, and subsequent risk of postmenopausal breast cancer among white and black women in the Southern Community Cohort Study.
Authors: Sanderson M. , Lipworth L. , Shrubsole M.J. , Andersen S.W. , Shu X.O. , Zheng W. , Hargreaves M.K. , Blot W.J. .
Source: Cancer causes & control : CCC, 2019 May; 30(5), p. 425-433.
EPub date: 2019-04-02.
PMID: 30941541
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Identifying Biomarkers for Risk of Premature Menopause Among Childhood Cancer Survivors May Lead to Targeted Interventions and Wellness Strategies.
Authors: Warren Andersen S. .
Source: Journal of the National Cancer Institute, 2018-08-01; 110(8), p. 801-802.
PMID: 29432587
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Associations Between Neighborhood Environment, Health Behaviors, and Mortality.
Authors: Warren Andersen S. , Blot W.J. , Shu X.O. , Sonderman J.S. , Steinwandel M. , Hargreaves M.K. , Zheng W. .
Source: American journal of preventive medicine, 2018 Jan; 54(1), p. 87-95.
PMID: 29254556
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Total and Free Circulating Vitamin D and Vitamin D-Binding Protein in Relation to Colorectal Cancer Risk in a Prospective Study of African Americans.
Authors: Andersen S.W. , Shu X.O. , Cai Q. , Khankari N.K. , Steinwandel M.D. , Jurutka P.W. , Blot W.J. , Zheng W. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017 Aug; 26(8), p. 1242-1247.
EPub date: 2017-05-08.
PMID: 28483970
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