Grant Number:	5R01CA239097-02 Interpret this number
Primary Investigator:	Harrell, Melissa
Organization:	University Of Texas Hlth Sci Ctr Houston
Project Title:	Ends Use Trajectories From Adolescence Through Young Adulthood: a Longitudinal Study of Risk Factors and Profiles
Fiscal Year:	2020

ABSTRACT The primary objective of this study is to identify, describe, and differentiate stable and persistent patterns in trajectories of ENDS use, from 11 to 22 years of age. Seventy percent of adolescent never users will be susceptible to ENDS and other tobacco use by the age of 17 – and, by age 22, in young adulthood, the same proportion will have ever used ENDS or tobacco. Understanding what accelerates this rapid progression in tobacco use behaviors and related outcomes from them (e.g., nicotine dependence) will help inform the development of effective interventions. Considerable controversy exists regarding the role that electronic nicotine delivery systems (ENDS) play in the uptake, progression, and/or cessation of combustible tobacco product use, and appropriate ways to measure and model this. To date, almost all studies of ENDS use behaviors are either cross-sectional or limited to short-term (e.g., 1 year) follow-up, which is inadequate for identifying sustained patterns in ENDS use trajectories across the life course, given that transitions in tobacco use behaviors (i.e., initiation to sustained use or quitting) and between tobacco products (e.g., ENDS and cigarettes) are frequent and erratic. Longer-term studies of patterns in ENDS use trajectories are critical, but they will require additional data collection efforts; especially, regionally. Using a cohort-sequential design, we propose to follow and connect 3 existing, population-based cohorts of adolescents (11-15 years old at Wave 1, 2014-15) through young adulthood (18-22 years old at Wave 14, 2021), to represent developmental changes in ENDS use behaviors across these critical stages in the life course. At Wave 1, during the 2014-15 academic year, the sample included 3,907 (N=461,069) students in the 6th, 8th, and 10th grades in 79 middle schools and high schools (N=1969) in the 4 largest metropolitan areas of Texas: Houston, Dallas/Ft. Worth, San Antonio, and Austin. At Wave 8 (June, 2018), retention remained high, at 85%; the oldest cohort is now 1 year post high school. We propose to follow these cohorts for an additional 6 waves of data collection, every 6 months, to track them all through high school (1, 3, and 5 years post-graduation), into young adulthood. Our web-based surveys include robust measures of ENDS use and other tobacco use behaviors; nicotine dependence; and a broad spectrum of potential risk factors, including intrapersonal, interpersonal, and environmental influences. Growth mixture models shall be applied to these data to empirically identify stable developmental patterns in ENDS use behaviors, from 11 to 22 years of age; we anticipate there will be substantial heterogeneity in them. We will be able to identify young adult outcomes of persistent patterns in ENDS use that begin in adolescence; and risk factors in adolescence that predict ENDS use trajectories that persist into young adulthood. The use of combustible tobacco products in adolescence and young adulthood will be considered, accordingly. Almost all (>95% of) existing cohorts and studies of ENDS use focus on either adolescents or young adults. Very few, like ours, are able to track adolescents into young adulthood to investigate developmental trajectories of risk.




Re: Impact of the "e-cigarette era" on cigarette smoking among youth: A population-level study.
Authors: Harrell M.B. , Mantey D.S. , Chen B. , Kelder S.H. , Barrington-Trimis J. .
Source: Preventive medicine, 2023 Apr; 169, p. 107447.
EPub date: 2023-03-02.
PMID: 36870807
Related Citations

Patterns in Mental Health Symptomatology and Cigarette, E-cigarette, and Marijuana Use Among Texas Youth and Young Adults Amid the Coronavirus Disease 2019 Pandemic.
Authors: Clendennen S.L. , Chen B. , Sumbe A. , Harrell M.B. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2023-01-05; 25(2), p. 266-273.
PMID: 36018816
Related Citations

Symptoms of Depression and Anxiety and Subsequent Use of Nicotine and THC in Electronic Cigarettes.
Authors: Clendennen S.L. , Smith J. , Sumbe A. , Chen B. , Wilkinson A.V. , Harrell M.B. .
Source: Substance use & misuse, 2023; 58(5), p. 591-600.
EPub date: 2023-02-22.
PMID: 36912516
Related Citations

Impact of the e-cigarette era on cigarette smoking among youth in the United States: A population-level study.
Authors: Harrell M.B. , Mantey D.S. , Chen B. , Kelder S.H. , Barrington-Trimis J. .
Source: Preventive medicine, 2022 Nov; 164, p. 107265.
EPub date: 2022-09-22.
PMID: 36152819
Related Citations

Perceived stress and E-cigarette use during emerging adulthood: A longitudinal examination of initiation, progression, and continuation.
Authors: Mantey D.S. , Clendennen S.I. , Sumbe A. , Wilkinson A.V. , Harrell M.B. .
Source: Preventive medicine, 2022 Jul; 160, p. 107080.
EPub date: 2022-05-11.
PMID: 35568160
Related Citations

Risk of respiratory, gastrointestinal, and constitutional health symptoms: A cross-sectional study of Texas adolescent and young adult nicotine and marijuana vapers.
Authors: Case K.R. , Clendennen S.L. , Tsevat J. , Harrell M.B. .
Source: Preventive medicine, 2022 Jun; 159, p. 107057.
EPub date: 2022-04-20.
PMID: 35452713
Related Citations

Changes in marijuana and nicotine vaping perceptions and use behaviors among young adults since the COVID-19 pandemic: A qualitative study.
Authors: Case K.R. , Clendennen S.L. , Shah J. , Tsevat J. , Harrell M.B. .
Source: Addictive behaviors reports, 2022 Jun; 15, p. 100408.
EPub date: 2022-01-19.
PMID: 35075434
Related Citations

Perceived Parental Knowledge Reduces Risk for Initiation of Nicotine and Cannabis Vaping: A Longitudinal Study of Adolescents.
Authors: Mantey D.S. , Clendennen S.L. , Springer A.E. , Harrell M.B. .
Source: American journal of health promotion : AJHP, 2022 May; 36(4), p. 623-632.
EPub date: 2022-01-14.
PMID: 35030966
Related Citations

Timing of ENDS Uptake by Sexual Orientation among Adolescents and Young Adults in Urban Texas.
Authors: Tami-Maury I. , Chen B. , Sumbe A. , Harrell M.B. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2022-02-14; 24(3), p. 388-394.
PMID: 34865138
Related Citations

Electronic nicotine delivery systems use predicts transitions in cigarette smoking among young adults.
Authors: Loukas A. , Marti C.N. , Harrell M.B. .
Source: Drug and alcohol dependence, 2022-02-01; 231, p. 109251.
EPub date: 2021-12-31.
PMID: 34999270
Related Citations

Cannabis Vaping Among Youth and Young Adults: a Scoping Review.
Authors: Harrell M.B. , Clendennen S.L. , Sumbe A. , Case K.R. , Mantey D.S. , Swan S. .
Source: Current addiction reports, 2022; 9(3), p. 217-234.
EPub date: 2022-05-07.
PMID: 35573056
Related Citations

Association of tobacco and marijuana use with symptoms of depression and anxiety among adolescents and young adults in Texas.
Authors: Sumbe A. , Wilkinson A.V. , Clendennen S.L. , Bataineh B.S. , Sterling K.L. , Chen B. , Harrell M.B. .
Source: Tobacco prevention & cessation, 2022; 8, p. 03.
EPub date: 2022-01-27.
PMID: 35128214
Related Citations

A Simulation of the potential impact of restricting tobacco retail outlets around middle and high schools on tobacco advertisements.
Authors: Obinwa U. , Pasch K.E. , Jetelina K.K. , Ranjit N. , Perez A. , Perry C. , Harrell M. .
Source: Tobacco control, 2022 Jan; 31(1), p. 81-87.
EPub date: 2020-12-11.
PMID: 33310775
Related Citations

Comparing Risk Factors for Past 30-day E-cigarette and Combustible Tobacco Use: A Longitudinal Analysis of the Texas Adolescent Tobacco and Marketing Surveillance Study (2014-2017).
Authors: Obinwa U. , Clendennen S.L. , Rangwalam S. , Sumbe A. , Case K.R. , Harrell M.B. .
Source: Texas public health journal, 2021 Winter; 73(1), p. 25-32.
PMID: 35759323
Related Citations

Understanding college students' experiences using e-cigarettes and marijuana through qualitative interviews.
Authors: Clendennen S.L. , Rangwala S. , Sumbe A. , Case K.R. , Wilkinson A.V. , Loukas A. , Harrell M.B. .
Source: Journal of American college health : J of ACH, 2021-12-06; , p. 1-11.
EPub date: 2021-12-06.
PMID: 34871132
Related Citations

Subjective experiences at e-cigarette initiation: Implications for e-cigarette and dual/poly tobacco use among youth.
Authors: Mantey D.S. , Case K.R. , Chen B. , Kelder S. , Loukas A. , Harrell M.B. .
Source: Addictive behaviors, 2021 Nov; 122, p. 107028.
EPub date: 2021-06-23.
PMID: 34186298
Related Citations

Positive Affect and Multiple-tobacco Product Use among Youth: A 3-year Longitudinal Study.
Authors: Mantey D.S. , Clendennen S.L. , Sumbe A. , Wilkinson A.V. , Harrell M.B. .
Source: American journal of health behavior, 2021-09-30; 45(5), p. 849-855.
PMID: 34702432
Related Citations

Longitudinal trajectories of E-cigarette use among adolescents: A 5-year, multiple cohort study of vaping with and without marijuana.
Authors: Harrell M.B. , Chen B. , Clendennen S.L. , Sumbe A. , Case K.R. , Wilkinson A.V. , Loukas A. , Perry C.L. .
Source: Preventive medicine, 2021 Sep; 150, p. 106670.
EPub date: 2021-06-01.
PMID: 34087321
Related Citations

Language Gap in Reach of "The Real Cost": Examination of a Federal Mass Media Campaign From 2017 to 2019.
Authors: Mantey D.S. , Clendennen S.L. , Ruiz F.A. , Perry C.L. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2021-08-18; 23(9), p. 1602-1606.
PMID: 33782698
Related Citations

Multi-directional pathways of tobacco and marijuana use, including comorbid use, among a population-based cohort of adolescents in Texas: A six-wave cross-lagged model.
Authors: Rogers S.M. , Harrell M.B. , Chen B. , Springer A. , Loukas A. , Perry C.L. .
Source: Addictive behaviors, 2021 Apr; 115, p. 106771.
EPub date: 2020-12-08.
PMID: 33387975
Related Citations

ENDS Device Type and Initiation of Combustible Tobacco Products Among Adolescents.
Authors: Sumbe A. , Clendennen S.L. , Opara S.C. , Jackson C.D. , Chen B. , Wilkinson A.V. , Harrell M.B. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2021-02-16; 23(3), p. 479-486.
PMID: 32598453
Related Citations

Stress, Dependence, and COVID-19-related Changes in Past 30-day Marijuana, Electronic Cigarette, and Cigarette Use among Youth and Young Adults.
Authors: Clendennen S.L. , Case K.R. , Sumbe A. , Mantey D.S. , Mason E.J. , Harrell M.B. .
Source: Tobacco use insights, 2021; 14, p. 1179173X211067439.
EPub date: 2021-12-20.
PMID: 34987299
Related Citations

Emotional symptoms and sensation seeking: Implications for tobacco interventions for youth and young adults.
Authors: Bataineh B.S. , Wilkinson A.V. , Case K.R. , Clendennen S.L. , Sumbe A. , Chen B. , Harrell M.B. .
Source: Tobacco prevention & cessation, 2021; 7, p. 37.
EPub date: 2021-05-21.
PMID: 34046534
Related Citations

Predictors of JUUL, other electronic nicotine delivery systems, and combustible tobacco initiation among Texas youth.
Authors: Case K.R. , Obinwa U.C. , Clendennen S.L. , Perry C.L. , Harrell M.B. .
Source: Preventive medicine, 2020 Sep; 138, p. 106097.
EPub date: 2020-04-23.
PMID: 32335030
Related Citations