||5R21CA226726-02 Interpret this number
||University Of Chicago
||Bionic Breast Project: Towards Restoring Breast Sensory Function in Women with Mastectomy
Of more than 3.5 million breast cancer survivors in the U.S. today, an estimated one-third have undergone
mastectomy. Of these 1.2 million survivors, 40% have had or are considering breast reconstruction procedures.
In 2018, an additional 250,000 adult women will receive a breast cancer diagnosis and an estimated 100,000
will undergo mastectomy. Advances in breast reconstruction techniques for women with mastectomy have
contributed to improved patient and partner satisfaction by restoring aesthetic aspects or form of the breast.
However, even the most advanced reconstructive techniques do not preserve breast function. Loss of breast
sensation after mastectomy is a prevalent, well-established and distressing outcome for women that is rarely
addressed in the course of breast cancer care. Failure to restore breast function may explain high rates of sexual
dysfunction (37-77%) in breast cancer survivors, even among women satisfied with the aesthetic outcome. Little
is known about the neural basis of sensory function in the intact breast or about the interactions between sexual
arousal and breast sensation. To fill the gap, we will develop and validate a comprehensive patient-reported
measure of breast sensory function for use in women with and without breast cancer. We will administer this
measure together with the PROMIS Sexual Function and Satisfaction measure to a sample of 500 women with
and without breast cancer to examine the relationship between breast sensory function and sexual function
following treatment for breast cancer. In parallel, we will apply state-of-the-art psychophysical sensory assays to
determine the relative contributions of nerve fibers toward various aspects of breast sensation, as we and others
have successfully done in the glabrous skin of the hand. In addition, we will assess the modulation of breast
sensation as well as the sensory consequences of blocking individual nerves known to innervate the breast.
These experiments on healthy subjects will provide a detailed characterization of breast sensory function, its
neural basis, and its modulation by arousal. The specific aims of this research are to: (1) Develop and validate
a self-report measure of breast sensory function and examine the link between breast sensory function and
sexual function in affected and unaffected women and, (2) Characterize breast sensation, examine its modulation
by arousal, and establish its neural substrates using state-of-the-art psychophysical techniques. Together, these
aims will improve our understanding of breast sensory function and its relationship to sexual function, permit us
to estimate the impact of sensory loss on sexual function and satisfaction, and provide a means to identify women
at greatest risk of sexual dysfunction following mastectomy. This developmental work will lay the foundation for
surgical innovation and/or the development of a bionic breast to preserve or restore breast function following
mastectomy. This proposal addresses NCI’s research priority to alleviate the adverse effects of cancer and its
Racial and Ethnic Disparities in Health-Related Socioeconomic Risks During the Early COVID-19 Pandemic: A National Survey of U.S. Women.
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Change in Health-Related Socioeconomic Risk Factors and Mental Health During the Early Phase of the COVID-19 Pandemic: A National Survey of U.S. Women.
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Journal of women's health (2002), 2021 04; 30(4), p. 502-513.
2020 NAMS Virtual Annual Meeting.
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