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Grant Details

Grant Number: 5R01CA222147-03 Interpret this number
Primary Investigator: Vanderweele, Tyler
Organization: Harvard School Of Public Health
Project Title: Theory and Methods for Mediation and Interaction
Fiscal Year: 2020
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Abstract

Project Summary The proposed research will develop novel methods to assess mediation and interaction between genetic and environmental exposures and different disease subtypes so as to better tailor treatments and prevention efforts to individuals' characteristics and so as to better understand the mechanisms governing disease. Methods will be developed for settings in which there are multiple disease subtypes and these disease subtypes may have different prognosis for survival and may be more amenable to different types of treatment and preventive efforts. Methodology for assessing the role of interaction in understanding mechanisms will also be developed. This will include elucidating the role of gene-environment interaction in the heritability of disease, understanding mediating pathways from exposure to disease in the presence of interaction, and identifying sufficient cause interaction for diseases or disease subtypes such that an outcome would occur if two (or more) exposures are present, but not if only one or the other were present. The methodology will be applied to understand prognosis, treatment decisions, preventive interventions, and mechanisms for colorectal cancer, and also for the development of skin lesions; the methodology will also be applied to understand the role of gene-environment interaction in the heritability of numerous traits.

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Publications

Optimal approximate conversions of odds ratios and hazard ratios to risk ratios.
Authors: VanderWeele T.J. .
Source: Biometrics, 2019-12-06; , .
EPub date: 2019-12-06.
PMID: 31808145
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Mediational E-values: Approximate Sensitivity Analysis for Unmeasured Mediator-Outcome Confounding.
Authors: Smith L.H. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2019 11; 30(6), p. 835-837.
PMID: 31348008
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A general approach to detect gene (G)-environment (E) additive interaction leveraging G-E independence in case-control studies.
Authors: Tchetgen Tchetgen E.J. , Shi X. , Wong B.H.W. , Sofer T. .
Source: Statistics in medicine, 2019-10-30; 38(24), p. 4841-4853.
EPub date: 2019-08-23.
PMID: 31441522
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Challenges and suggestions for defining replication "success" when effects may be heterogeneous: Comment on Hedges and Schauer (2019).
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Psychological methods, 2019 10; 24(5), p. 571-575.
PMID: 31580141
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Open-source software for mouse-tracking in Qualtrics to measure category competition.
Authors: Mathur M.B. , Reichling D.B. .
Source: Behavior research methods, 2019 10; 51(5), p. 1987-1997.
PMID: 31197629
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Simple Sensitivity Analysis for Differential Measurement Error.
Authors: VanderWeele T.J. , Li Y. .
Source: American journal of epidemiology, 2019-10-01; 188(10), p. 1823-1829.
PMID: 31145435
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The Interaction Continuum.
Authors: VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2019 09; 30(5), p. 648-658.
PMID: 31205287
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Network multipliers and public health.
Authors: VanderWeele T.J. , Christakis N.A. .
Source: International journal of epidemiology, 2019-08-01; 48(4), p. 1032-1037.
PMID: 30793743
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Universal Testing, Expanded Treatment, and Incidence of HIV Infection in Botswana.
Authors: Makhema J. , Wirth K.E. , Pretorius Holme M. , Gaolathe T. , Mmalane M. , Kadima E. , Chakalisa U. , Bennett K. , Leidner J. , Manyake K. , et al. .
Source: The New England journal of medicine, 2019-07-18; 381(3), p. 230-242.
PMID: 31314967
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Finding Common Ground in Meta-Analysis "Wars" on Violent Video Games.
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Perspectives on psychological science : a journal of the Association for Psychological Science, 2019 07; 14(4), p. 705-708.
EPub date: 2019-06-12.
PMID: 31188714
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Positive parenting improves multiple aspects of health and well-being in young adulthood.
Authors: Chen Y. , Haines J. , Charlton B.M. , VanderWeele T.J. .
Source: Nature human behaviour, 2019 07; 3(7), p. 684-691.
EPub date: 2019-05-06.
PMID: 31061491
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Bounding Bias Due to Selection.
Authors: Smith L.H. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2019 07; 30(4), p. 509-516.
PMID: 31033690
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Counterpoint: Mediation Formulas With Binary Mediators and Outcomes and the "Rare Outcome Assumption".
Authors: VanderWeele T.J. , Valeri L. , Ananth C.V. .
Source: American journal of epidemiology, 2019-07-01; 188(7), p. 1204-1205.
PMID: 30590417
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Selecting Optimal Subgroups for Treatment Using Many Covariates.
Authors: VanderWeele T.J. , Luedtke A.R. , van der Laan M.J. , Kessler R.C. .
Source: Epidemiology (Cambridge, Mass.), 2019 05; 30(3), p. 334-341.
PMID: 30789432
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Multiplicative Interactions Under Differential Outcome Measurement Error with Perfect Specificity.
Authors: VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2019 05; 30(3), p. e15-e16.
PMID: 30789429
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Intersectional decomposition analysis with differential exposure, effects, and construct.
Authors: Jackson J.W. , VanderWeele T.J. .
Source: Social science & medicine (1982), 2019 04; 226, p. 254-259.
EPub date: 2019-01-31.
PMID: 30770131
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Sense of Mission and Subsequent Health and Well-Being Among Young Adults: An Outcome-Wide Analysis.
Authors: Chen Y. , Kim E.S. , Koh H.K. , Frazier A.L. , VanderWeele T.J. .
Source: American journal of epidemiology, 2019-04-01; 188(4), p. 664-673.
PMID: 30649174
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Principles of confounder selection.
Authors: VanderWeele T.J. .
Source: European journal of epidemiology, 2019 Mar; 34(3), p. 211-219.
EPub date: 2019-03-06.
PMID: 30840181
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SOME DESIRABLE PROPERTIES OF THE BONFERRONI CORRECTION: IS THE BONFERRONI CORRECTION REALLY SO BAD?
Authors: VanderWeele T.J. , Mathur M.B. .
Source: American journal of epidemiology, 2019-03-01; 188(3), p. 617-618.
PMID: 30452538
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On doubly robust estimation of the hazard difference.
Authors: Dukes O. , Martinussen T. , Tchetgen Tchetgen E.J. , Vansteelandt S. .
Source: Biometrics, 2019 03; 75(1), p. 100-109.
EPub date: 2018-08-22.
PMID: 30133696
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Religiously or Spiritually-Motivated Forgiveness and Subsequent Health and Well-Being among Young Adults: An Outcome-Wide Analysis.
Authors: Chen Y. , Harris S.K. , Worthington E.L. , VanderWeele T.J. .
Source: The journal of positive psychology, 2019; 14(5), p. 649-658.
EPub date: 2018-09-13.
PMID: 31360213
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Association of Short Interpregnancy Interval With Pregnancy Outcomes According to Maternal Age.
Authors: Schummers L. , Hutcheon J.A. , Hernandez-Diaz S. , Williams P.L. , Hacker M.R. , VanderWeele T.J. , Norman W.V. .
Source: JAMA internal medicine, 2018-12-01; 178(12), p. 1661-1670.
PMID: 30383085
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Decomposition Analysis to Identify Intervention Targets for Reducing Disparities.
Authors: Jackson J.W. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2018 11; 29(6), p. 825-835.
PMID: 30063540
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Web Site and R Package for Computing E-values.
Authors: Mathur M.B. , Ding P. , Riddell C.A. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2018 09; 29(5), p. e45-e47.
PMID: 29912013
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On Well-defined Hypothetical Interventions in the Potential Outcomes Framework.
Authors: VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2018 07; 29(4), p. e24-e25.
PMID: 29561280
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R Function for Additive Interaction Measures.
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2018 01; 29(1), p. e5-e6.
PMID: 28901974
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Causal mediation analysis in the presence of a mismeasured outcome.
Authors: Jiang Z. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2015 Jan; 26(1), p. e8-9.
PMID: 25437327
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