Grant Number:	5R01CA222147-03 Interpret this number
Primary Investigator:	Vanderweele, Tyler
Organization:	Harvard School Of Public Health
Project Title:	Theory and Methods for Mediation and Interaction
Fiscal Year:	2020

Project Summary The proposed research will develop novel methods to assess mediation and interaction between genetic and environmental exposures and different disease subtypes so as to better tailor treatments and prevention efforts to individuals' characteristics and so as to better understand the mechanisms governing disease. Methods will be developed for settings in which there are multiple disease subtypes and these disease subtypes may have different prognosis for survival and may be more amenable to different types of treatment and preventive efforts. Methodology for assessing the role of interaction in understanding mechanisms will also be developed. This will include elucidating the role of gene-environment interaction in the heritability of disease, understanding mediating pathways from exposure to disease in the presence of interaction, and identifying sufficient cause interaction for diseases or disease subtypes such that an outcome would occur if two (or more) exposures are present, but not if only one or the other were present. The methodology will be applied to understand prognosis, treatment decisions, preventive interventions, and mechanisms for colorectal cancer, and also for the development of skin lesions; the methodology will also be applied to understand the role of gene-environment interaction in the heritability of numerous traits.




Optimal approximate conversions of odds ratios and hazard ratios to risk ratios.
Authors: VanderWeele T.J. .
Source: Biometrics, 2019-12-06; , .
EPub date: 2019-12-06.
PMID: 31808145
Related Citations

Mediational E-values: Approximate Sensitivity Analysis for Unmeasured Mediator-Outcome Confounding.
Authors: Smith L.H. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2019 11; 30(6), p. 835-837.
PMID: 31348008
Related Citations

A general approach to detect gene (G)-environment (E) additive interaction leveraging G-E independence in case-control studies.
Authors: Tchetgen Tchetgen E.J. , Shi X. , Wong B.H.W. , Sofer T. .
Source: Statistics in medicine, 2019-10-30; 38(24), p. 4841-4853.
EPub date: 2019-08-23.
PMID: 31441522
Related Citations

Challenges and suggestions for defining replication "success" when effects may be heterogeneous: Comment on Hedges and Schauer (2019).
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Psychological methods, 2019 10; 24(5), p. 571-575.
PMID: 31580141
Related Citations

Open-source software for mouse-tracking in Qualtrics to measure category competition.
Authors: Mathur M.B. , Reichling D.B. .
Source: Behavior research methods, 2019 10; 51(5), p. 1987-1997.
PMID: 31197629
Related Citations

Simple Sensitivity Analysis for Differential Measurement Error.
Authors: VanderWeele T.J. , Li Y. .
Source: American journal of epidemiology, 2019-10-01; 188(10), p. 1823-1829.
PMID: 31145435
Related Citations

The Interaction Continuum.
Authors: VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2019 09; 30(5), p. 648-658.
PMID: 31205287
Related Citations

Network multipliers and public health.
Authors: VanderWeele T.J. , Christakis N.A. .
Source: International journal of epidemiology, 2019-08-01; 48(4), p. 1032-1037.
PMID: 30793743
Related Citations

Universal Testing, Expanded Treatment, and Incidence of HIV Infection in Botswana.
Authors: Makhema J. , Wirth K.E. , Pretorius Holme M. , Gaolathe T. , Mmalane M. , Kadima E. , Chakalisa U. , Bennett K. , Leidner J. , Manyake K. , et al. .
Source: The New England journal of medicine, 2019-07-18; 381(3), p. 230-242.
PMID: 31314967
Related Citations

Finding Common Ground in Meta-Analysis "Wars" on Violent Video Games.
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Perspectives on psychological science : a journal of the Association for Psychological Science, 2019 07; 14(4), p. 705-708.
EPub date: 2019-06-12.
PMID: 31188714
Related Citations

Positive parenting improves multiple aspects of health and well-being in young adulthood.
Authors: Chen Y. , Haines J. , Charlton B.M. , VanderWeele T.J. .
Source: Nature human behaviour, 2019 07; 3(7), p. 684-691.
EPub date: 2019-05-06.
PMID: 31061491
Related Citations

Bounding Bias Due to Selection.
Authors: Smith L.H. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2019 07; 30(4), p. 509-516.
PMID: 31033690
Related Citations

Counterpoint: Mediation Formulas With Binary Mediators and Outcomes and the "Rare Outcome Assumption".
Authors: VanderWeele T.J. , Valeri L. , Ananth C.V. .
Source: American journal of epidemiology, 2019-07-01; 188(7), p. 1204-1205.
PMID: 30590417
Related Citations

Selecting Optimal Subgroups for Treatment Using Many Covariates.
Authors: VanderWeele T.J. , Luedtke A.R. , van der Laan M.J. , Kessler R.C. .
Source: Epidemiology (Cambridge, Mass.), 2019 05; 30(3), p. 334-341.
PMID: 30789432
Related Citations

Multiplicative Interactions Under Differential Outcome Measurement Error with Perfect Specificity.
Authors: VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2019 05; 30(3), p. e15-e16.
PMID: 30789429
Related Citations

Intersectional decomposition analysis with differential exposure, effects, and construct.
Authors: Jackson J.W. , VanderWeele T.J. .
Source: Social science & medicine (1982), 2019 04; 226, p. 254-259.
EPub date: 2019-01-31.
PMID: 30770131
Related Citations

Sense of Mission and Subsequent Health and Well-Being Among Young Adults: An Outcome-Wide Analysis.
Authors: Chen Y. , Kim E.S. , Koh H.K. , Frazier A.L. , VanderWeele T.J. .
Source: American journal of epidemiology, 2019-04-01; 188(4), p. 664-673.
PMID: 30649174
Related Citations

Principles of confounder selection.
Authors: VanderWeele T.J. .
Source: European journal of epidemiology, 2019 Mar; 34(3), p. 211-219.
EPub date: 2019-03-06.
PMID: 30840181
Related Citations

SOME DESIRABLE PROPERTIES OF THE BONFERRONI CORRECTION: IS THE BONFERRONI CORRECTION REALLY SO BAD?
Authors: VanderWeele T.J. , Mathur M.B. .
Source: American journal of epidemiology, 2019-03-01; 188(3), p. 617-618.
PMID: 30452538
Related Citations

On doubly robust estimation of the hazard difference.
Authors: Dukes O. , Martinussen T. , Tchetgen Tchetgen E.J. , Vansteelandt S. .
Source: Biometrics, 2019 03; 75(1), p. 100-109.
EPub date: 2018-08-22.
PMID: 30133696
Related Citations

Religiously or Spiritually-Motivated Forgiveness and Subsequent Health and Well-Being among Young Adults: An Outcome-Wide Analysis.
Authors: Chen Y. , Harris S.K. , Worthington E.L. , VanderWeele T.J. .
Source: The journal of positive psychology, 2019; 14(5), p. 649-658.
EPub date: 2018-09-13.
PMID: 31360213
Related Citations

Association of Short Interpregnancy Interval With Pregnancy Outcomes According to Maternal Age.
Authors: Schummers L. , Hutcheon J.A. , Hernandez-Diaz S. , Williams P.L. , Hacker M.R. , VanderWeele T.J. , Norman W.V. .
Source: JAMA internal medicine, 2018-12-01; 178(12), p. 1661-1670.
PMID: 30383085
Related Citations

Decomposition Analysis to Identify Intervention Targets for Reducing Disparities.
Authors: Jackson J.W. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2018 11; 29(6), p. 825-835.
PMID: 30063540
Related Citations

Web Site and R Package for Computing E-values.
Authors: Mathur M.B. , Ding P. , Riddell C.A. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2018 09; 29(5), p. e45-e47.
PMID: 29912013
Related Citations

On Well-defined Hypothetical Interventions in the Potential Outcomes Framework.
Authors: VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2018 07; 29(4), p. e24-e25.
PMID: 29561280
Related Citations

R Function for Additive Interaction Measures.
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2018 01; 29(1), p. e5-e6.
PMID: 28901974
Related Citations

Causal mediation analysis in the presence of a mismeasured outcome.
Authors: Jiang Z. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2015 Jan; 26(1), p. e8-9.
PMID: 25437327
Related Citations