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Grant Details

Grant Number: 5R03CA228909-02 Interpret this number
Primary Investigator: Dai, Hongying
Organization: University Of Nebraska Medical Center
Project Title: Effects of the FDA Compliance Inspections of Tobacco Retailers on Youth E-Cigarette and Cigar Use: a National Study
Fiscal Year: 2019


PROJECT SUMMARY The use of emerging tobacco products is gaining popularity among youth. Among U.S. high school students, current use of e-cigarettes has outpaced the use of traditional cigarettes. E-cigarettes contain varying levels of nicotine and a number of potentially toxic substances and youth use of e-cigarettes might serve as a gateway for future cigarette use. Cigars currently rank third among the tobacco products most commonly used by youth and also pose serious threats to health; cigar smoke is possibly more toxic than cigarette smoke. The recently finalized “Deeming Rule” from the Food and Drug Administration (FDA) expanded the agency's regulatory authority over tobacco to include e-cigarettes, cigars, and other newly deemed tobacco products. The first round of new requirements on “retailer environment” for “covered tobacco products,” including mandatory age and photo ID checks to prevent illegal sale of these products to minors, was implemented on August 8, 2016. Early studies that were primarily based on community data have shown mixed results regarding the effectiveness of youth access laws to reduce youth cigarette smoking. Recent studies using national probability samples have shown that retail compliance of underage sales laws and restricting tobacco sales to minors are important tobacco prevention strategies. Over the decades, the prevalence of youth cigarette smoking and youth commercial access to cigarettes has been significantly reduced. Despite this progress, the tobacco industry has been promoting alternative tobacco products, such as e-cigarettes, cigars, to entice a new generation of users. The overarching goal of this study is to conduct a quasi-experimental design to assess the impacts of the FDA retail compliance inspections on youth cigar and e-cigarette use behaviors (e.g., ever, current, and frequency of use). This study is innovative in its focus on developing propensity models to predict the violation rate for underage retail sales of e-cigarettes and cigars at the zip code level, and on linking the compliance inspection data with multiple years of national youth survey data in order to assess the potential impacts of regulatory actions. This research will address two of the FDA Center for Tobacco Products (CTP) scientific interest areas: #4 (behavior) and #7 (impact analysis). Results from this study are expected to inform appropriate retail compliance inspection strategies and further expand our knowledge of the potential impacts of regulatory actions on youth e-cigarette and cigar use behaviors.


Using place-based characteristics to inform FDA tobacco sales inspections: results from a multilevel propensity score model.
Authors: Dai H. , Henriksen L. , Xu Z. , Rathnayake N. .
Source: Tobacco control, 2022 Dec; 31(e2), p. e148-e155.
EPub date: 2021-10-25.
PMID: 34697089
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Online popularity of JUUL and Puff Bars in the USA: 2019-2020.
Authors: Dai H. , Hao J. .
Source: Tobacco control, 2022 Jan; 31(1), p. 7-10.
EPub date: 2020-10-13.
PMID: 33051277
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Prevalence of Flavored e-Cigarette Use Among Subpopulations of Adults in the United States.
Authors: Leventhal A.M. , Dai H. .
Source: Journal of the National Cancer Institute, 2021-04-06; 113(4), p. 418-424.
PMID: 32785659
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Youth Observation of E-Cigarette Use in or Around School, 2019.
Authors: Dai H. .
Source: American journal of preventive medicine, 2021 Feb; 60(2), p. 241-249.
PMID: 33353794
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A Longitudinal Study of Exposure to Tobacco-Related Toxicants and Subsequent Respiratory Symptoms Among U.S. Adults with Varying E-cigarette Use Status.
Authors: Dai H. , Khan A.S. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2020-12-15; 22(Suppl 1), p. S61-S69.
PMID: 33320254
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Retail violations of sales to minors on e-cigarettes and cigars.
Authors: Dai H. , Hao J. , Catley D. .
Source: Public health, 2020 Oct; 187, p. 36-40.
EPub date: 2020-09-02.
PMID: 32889230
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Heated tobacco product use and associated factors among U.S. youth, 2019.
Authors: Dai H. .
Source: Drug and alcohol dependence, 2020-09-01; 214, p. 108150.
EPub date: 2020-07-02.
PMID: 32645682
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Exposure to Secondhand Aerosol From Electronic Cigarettes Among US Youth From 2015 to 2018.
Authors: Dai H. .
Source: JAMA pediatrics, 2020-03-01; 174(3), p. 298-300.
PMID: 31985771
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Self-reported Marijuana Use in Electronic Cigarettes Among US Youth, 2017 to 2018.
Authors: Dai H. .
Source: JAMA, 2020-02-04; 323(5), p. 473-474.
PMID: 31848567
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Use of E-Cigarettes for Nicotine, Marijuana, and Just Flavoring Among U.S. Youth.
Authors: Dai H. , Siahpush M. .
Source: American journal of preventive medicine, 2020 Feb; 58(2), p. 244-249.
EPub date: 2019-12-16.
PMID: 31859171
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Prevalence of e-Cigarette Use Among Adults in the United States, 2014-2018.
Authors: Dai H. , Leventhal A.M. .
Source: JAMA, 2019-11-12; 322(18), p. 1824-1827.
PMID: 31524940
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Trends in Single, Dual, and Poly Use of Alcohol, Cigarettes, and Marijuana Among US High-School Students: 1991-2017.
Authors: Dai H. .
Source: American journal of public health, 2019 Aug; 109(8), p. 1138-1140.
EPub date: 2019-06-20.
PMID: 31219719
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Association of electronic cigarette vaping and subsequent smoking relapse among former smokers.
Authors: Dai H. , Leventhal A.M. .
Source: Drug and alcohol dependence, 2019-06-01; 199, p. 10-17.
EPub date: 2019-03-15.
PMID: 30978519
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Changes in Flavored Tobacco Product Use Among Current Youth Tobacco Users in the United States, 2014-2017.
Authors: Dai H. .
Source: JAMA pediatrics, 2019-03-01; 173(3), p. 282-284.
PMID: 30615022
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Flavored Tobacco Use Among U.S. Adults by Age Group: 2013-2014.
Authors: Dai H. , Hao J. .
Source: Substance use & misuse, 2019; 54(2), p. 315-323.
EPub date: 2018-10-31.
PMID: 30380969
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