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Grant Details

Grant Number: 5R01CA184681-05 Interpret this number
Primary Investigator: Mermelstein, Robin
Organization: University Of Illinois At Chicago
Project Title: Context and Subjective Experience Surrounding Dual Cigarette and E Cigarette Use
Fiscal Year: 2019


 DESCRIPTION (Provided by Applicant): Tobacco use behavior is complex and changing, with electronic cigarettes (e-cigarettes) increasing in use. In the face of these changes, we need to know more about the behavioral phenomenon of e-cigarette use and its association with other factors, such as continued combustible tobacco use (conventional cigarettes), nicotine dependence, or changes in patterns of tobacco product use, including reductions or cessation of conventional cigarettes and uptake of e-cigarettes. Understanding e-cigarettes, "as they are actually used," will help guide the FDA in their regulatory decisions. This project will use Ecological Momentary Assessments (EMA) to gather real-time reports of dual product (both conventional and e-cigarette) users' daily experiences and tobacco use to examine how the immediate context of tobacco use, along with the individual's subjective reactions to those experiences, varies by product and individual characteristics, and influences future patterns of conventional and e-cigarette use. We address several FDA research priorities: 1) the diversity of tobacco use behavior and associated attitudes, perceptions, and subjective experiences; 2) how subjective experiences associated with the use of diverse tobacco products are associated with tobacco dependence and changes in dependence; and 3) how awareness of e-cigarette messages is associated with expectancies and experiences surrounding e-cigarette use. We will recruit 450 adult cigarette smokers who also use or who are at "high risk" for using e-cigarettes and conduct two longitudinal waves of EMA. Our aims include: 1) examining the micro-contexts of tobacco use and how they vary by product and individual differences (e.g., demographics, tobacco history, dependence) in order to understand better the functional value of e-cigarettes; 2) examining real-time withdrawal, cravings, and satisfaction with tobacco products and how these affect transitions in tobacco use; and 3) examining how proximal tobacco cues relate to tobacco use experiences, contexts, and patterns of use. Our in-depth examination of the real-time reactions to the use of e-cigarettes directly addresses FDA questions of interest.


Introducing a Real-Time Method for Identifying the Predictors of Noncompliance with Event-Based Reporting of Tobacco Use in Ecological Momentary Assessment.
Authors: Kendall A.D. , Robinson C.S.H. , Diviak K.R. , Hedeker D. , Mermelstein R.J. .
Source: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2023-04-22; 57(5), p. 399-408.
PMID: 36541688
Related Citations

Association between affect and cannabis use varies by social context.
Authors: Denson R.K. , Hedeker D. , Mermelstein R.J. .
Source: Drug and alcohol dependence, 2023-02-01; 243, p. 109750.
EPub date: 2022-12-20.
PMID: 36634576
Related Citations

A shared-parameter location-scale mixed model to link the responsivity in self-initiated event reports and the event-contingent Ecological Momentary Assessments.
Authors: Ma Q. , Mermelstein R.J. , Hedeker D. .
Source: Statistics in medicine, 2022-05-10; 41(10), p. 1780-1796.
EPub date: 2022-02-09.
PMID: 35139579
Related Citations

Preferred flavors and tobacco use patterns in adult dual users of cigarettes and ENDS.
Authors: Rest E.C. , Brikmanis K.N. , Mermelstein R.J. .
Source: Addictive behaviors, 2022 Feb; 125, p. 107168.
EPub date: 2021-10-30.
PMID: 34772504
Related Citations

Negative Affect and Cigarette Cessation in Dual Users of Cigarettes and Electronic Nicotine Delivery Systems.
Authors: Brooks J.M. , Mermelstein R.J. .
Source: Substance use & misuse, 2022; 57(8), p. 1294-1302.
EPub date: 2022-05-25.
PMID: 35611915
Related Citations

Response To: Can We Measure Nicotine Dependence in Dual Users of Cigarettes and ENDS?
Authors: Mermelstein R.J. , Hedeker D. , Rest E.C. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2021-05-04; 23(5), p. 874-875.
PMID: 33331899
Related Citations

Nicotine Dependence in Dual Users of Cigarettes and E-Cigarettes: Common and Distinct Elements.
Authors: Rest E.C. , Mermelstein R.J. , Hedeker D. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2021-03-19; 23(4), p. 662-668.
PMID: 33097952
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