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Grant Details

Grant Number: 5R00CA207736-04 Interpret this number
Primary Investigator: Tabung, Fred
Organization: Ohio State University
Project Title: Pro-Inflammatory and Hyper-Insulinemic Dietary Patterns and Colorectal Cancer Risk: Role of the Metabolome
Fiscal Year: 2019
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Abstract

PROJECT SUMMARY / ABSTRACT The candidate's long-term career goal is to become an independent investigator with interdisciplinary skills and expertise in dietary patterns, epidemiology, biomarkers and metabolomics, with a focus on cancer prevention and control. Several dietary patterns have been associated with colorectal cancer (CRC) risk but underlying mechanisms are not fully understood. Also, evidence is lacking on the consistency of dietary guidelines for overall health and CRC prevention given that it is not feasible to have an optimal diet for every disease. Furthermore, other biomarkers of diet, such as metabolomic profiling, have not been assessed with respect to CRC risk. Metabolomics is uniquely suited to assess metabolic responses to dietary stimuli, given that it is situated downstream to all the other ?omics?. Building on his prior work in hypothesis-driven dietary patterns and CRC prevention, the candidate seeks to fill these knowledge gaps by proposing to: 1) use a standardized methodology to compare the best diet for overall health with the best diet for CRC prevention, and further determine if any associations of dietary patterns with CRC prevention are mediated by mechanisms involving inflammation and insulin; 2) determine the inflammatory metabolome that intersects pathways due to inflammatory diets and circulating inflammatory markers, and evaluate the association of this unique metabolome with CRC risk; 3) determine the insulinemic metabolome that intersects pathways due to insulinemic diets and circulating insulin markers, and evaluate the association of the unique metabolome with CRC risk. To achieve these goals, the candidate and his mentors have designed a career development plan for research and educational training to: 1) help him develop expertise in dietary patterns research methods; 2) acquire skills in mediation analyses and 3) integrate and synthesize data from multiple sources including epidemiological, nutritional, and biological data. To achieve the proposed research aims, the candidate will utilize two large prospective cohort studies, the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS), in which dietary and nondietary data have been collected every 2 to 4 years among 173,230 women and men over the last ?30 years, with ?3,400 CRC cases and ?43,800 all-cause deaths. Within these cohorts, a substantial number of participants donated blood samples that have been used to measure concentrations of several circulating inflammatory and insulin markers, and metabolites. This integrated interrogation of dietary patterns, biomarkers and metabolomics data will identify novel biomarkers for CRC early detection and prevention, and will improve the design of guidelines for healthful lifestyles that are optimized for CRC prevention. The interdisciplinary mentoring team will provide the requisite expertise to ensure the successful implementation of this K99/R00 proposal and the candidate's smooth transition to an independent investigator.  

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Publications

Association of type and intensity of physical activity with plasma biomarkers of inflammation and insulin response.
Authors: Lee D.H. , de Rezende L.F.M. , Eluf-Neto J. , Wu K. , Tabung F.K. , Giovannucci E.L. .
Source: International journal of cancer, 2019-07-15; 145(2), p. 360-369.
EPub date: 2019-01-24.
PMID: 30614528
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Identifying Metabolomic Profiles of Insulinemic Dietary Patterns.
Authors: Tabung F.K. , Balasubramanian R. , Liang L. , Clinton S.K. , Cespedes Feliciano E.M. , Manson J.E. , Van Horn L. , Wactawski-Wende J. , Clish C.B. , Giovannucci E.L. , et al. .
Source: Metabolites, 2019-06-24; 9(6), .
EPub date: 2019-06-24.
PMID: 31238601
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Mediation of associations between adiposity and colorectal cancer risk by inflammatory and metabolic biomarkers.
Authors: Petimar J. , Tabung F.K. , Valeri L. , Rosner B. , Chan A.T. , Smith-Warner S.A. , Giovannucci E.L. .
Source: International journal of cancer, 2019-06-15; 144(12), p. 2945-2953.
EPub date: 2019-01-14.
PMID: 30521066
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Inflammatory dietary pattern and incident psoriasis, psoriatic arthritis, and atopic dermatitis in women: A cohort study.
Authors: Bridgman A.C. , Qureshi A.A. , Li T. , Tabung F.K. , Cho E. , Drucker A.M. .
Source: Journal of the American Academy of Dermatology, 2019 Jun; 80(6), p. 1682-1690.
EPub date: 2019-02-21.
PMID: 30797850
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Long-Term Change in both Dietary Insulinemic and Inflammatory Potential Is Associated with Weight Gain in Adult Women and Men.
Authors: Tabung F.K. , Satija A. , Fung T.T. , Clinton S.K. , Giovannucci E.L. .
Source: The Journal of nutrition, 2019-05-01; 149(5), p. 804-815.
PMID: 31004153
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Post-cancer diagnosis dietary inflammatory potential is associated with survival among women diagnosed with colorectal cancer in the Women's Health Initiative.
Authors: Zheng J. , Tabung F.K. , Zhang J. , Murphy E.A. , Shivappa N. , Ockene J.K. , Caan B. , Kroenke C.H. , Hébert J.R. , Steck S.E. .
Source: European journal of nutrition, 2019-04-06; , .
EPub date: 2019-04-06.
PMID: 30955051
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Coffee consumption and plasma biomarkers of metabolic and inflammatory pathways in US health professionals.
Authors: Hang D. , Kværner A.S. , Ma W. , Hu Y. , Tabung F.K. , Nan H. , Hu Z. , Shen H. , Mucci L.A. , Chan A.T. , et al. .
Source: The American journal of clinical nutrition, 2019-03-01; 109(3), p. 635-647.
PMID: 30834441
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Postprandial Duration Influences the Association of Insulin-Related Dietary Indexes and Plasma C-peptide Concentrations in Adult Men and Women.
Authors: Tabung F.K. , Nimptsch K. , Giovannucci E.L. .
Source: The Journal of nutrition, 2019-02-01; 149(2), p. 286-294.
PMID: 30590589
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Inflammatory dietary pattern and risk of developing rheumatoid arthritis in women.
Authors: Sparks J.A. , Barbhaiya M. , Tedeschi S.K. , Leatherwood C.L. , Tabung F.K. , Speyer C.B. , Malspeis S. , Costenbader K.H. , Karlson E.W. , Lu B. .
Source: Clinical rheumatology, 2019 Jan; 38(1), p. 243-250.
EPub date: 2018-08-14.
PMID: 30109509
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Diet-quality scores and the risk of symptomatic gallstone disease: a prospective cohort study of male US health professionals.
Authors: Wirth J. , Song M. , Fung T.T. , Joshi A.D. , Tabung F.K. , Chan A.T. , Weikert C. , Leitzmann M. , Willett W.C. , Giovannucci E. , et al. .
Source: International journal of epidemiology, 2018-12-01; 47(6), p. 1938-1946.
PMID: 30312404
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Recommendation-based dietary indexes and risk of colorectal cancer in the Nurses' Health Study and Health Professionals Follow-up Study.
Authors: Petimar J. , Smith-Warner S.A. , Fung T.T. , Rosner B. , Chan A.T. , Hu F.B. , Giovannucci E.L. , Tabung F.K. .
Source: The American journal of clinical nutrition, 2018-11-01; 108(5), p. 1092-1103.
PMID: 30289433
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Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum.
Authors: Liu L. , Tabung F.K. , Zhang X. , Nowak J.A. , Qian Z.R. , Hamada T. , Nevo D. , Bullman S. , Mima K. , Kosumi K. , et al. .
Source: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2018 Oct; 16(10), p. 1622-1631.e3.
EPub date: 2018-04-24.
PMID: 29702299
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Association of dietary insulinemic potential and colorectal cancer risk in men and women.
Authors: Tabung F.K. , Wang W. , Fung T.T. , Smith-Warner S.A. , Keum N. , Wu K. , Fuchs C.S. , Hu F.B. , Giovannucci E.L. .
Source: The American journal of clinical nutrition, 2018-08-01; 108(2), p. 363-370.
PMID: 29901698
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An Empirical Dietary Inflammatory Pattern Score Is Associated with Circulating Inflammatory Biomarkers in a Multi-Ethnic Population of Postmenopausal Women in the United States.
Authors: Tabung F.K. , Giovannucci E.L. , Giulianini F. , Liang L. , Chandler P.D. , Balasubramanian R. , Manson J.E. , Cespedes Feliciano E.M. , Hayden K.M. , Van Horn L. , et al. .
Source: The Journal of nutrition, 2018-05-01; 148(5), p. 771-780.
PMID: 29897561
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Association of Dietary Inflammatory Potential With Colorectal Cancer Risk in Men and Women.
Authors: Tabung F.K. , Liu L. , Wang W. , Fung T.T. , Wu K. , Smith-Warner S.A. , Cao Y. , Hu F.B. , Ogino S. , Fuchs C.S. , et al. .
Source: JAMA oncology, 2018-03-01; 4(3), p. 366-373.
PMID: 29346484
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Dietary Patterns and Colorectal Cancer Risk: A Review of 17 Years of Evidence (2000-2016).
Authors: Tabung F.K. , Brown L.S. , Fung T.T. .
Source: Current colorectal cancer reports, 2017 Dec; 13(6), p. 440-454.
EPub date: 2017-10-17.
PMID: 29399003
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Influence of Dietary Patterns on Plasma Soluble CD14, a Surrogate Marker of Gut Barrier Dysfunction.
Authors: Tabung F.K. , Birmann B.M. , Epstein M.M. , Martínez-Maza O. , Breen E.C. , Wu K. , Giovannucci E.L. .
Source: Current developments in nutrition, 2017-11-01; 1(11), .
EPub date: 2017-10-17.
PMID: 29595830
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Inaccurate data in meta-analysis 'Dietary patterns and colorectal cancer risk: a meta-analysis'.
Authors: Tabung F.K. .
Source: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2019 01; 28(1), p. 58-59.
PMID: 29424754
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Association between Post-Cancer Diagnosis Dietary Inflammatory Potential and Mortality among Invasive Breast Cancer Survivors in the Women's Health Initiative.
Authors: Zheng J. , Tabung F.K. , Zhang J. , Liese A.D. , Shivappa N. , Ockene J.K. , Caan B. , Kroenke C.H. , Hébert J.R. , Steck S.E. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2018 04; 27(4), p. 454-463.
EPub date: 2018-01-22.
PMID: 29358225
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Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor.
Authors: Liu L. , Nishihara R. , Qian Z.R. , Tabung F.K. , Nevo D. , Zhang X. , Song M. , Cao Y. , Mima K. , Masugi Y. , et al. .
Source: Gastroenterology, 2017 12; 153(6), p. 1517-1530.e14.
EPub date: 2017-09-01.
PMID: 28865736
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The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women's Health Initiative Memory Study.
Authors: Hayden K.M. , Beavers D.P. , Steck S.E. , Hebert J.R. , Tabung F.K. , Shivappa N. , Casanova R. , Manson J.E. , Padula C.B. , Salmoirago-Blotcher E. , et al. .
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017 Nov; 13(11), p. 1187-1196.
EPub date: 2017-05-19.
PMID: 28531379
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The inflammatory potential of diet and ovarian cancer risk: results from two prospective cohort studies.
Authors: Tabung F.K. , Huang T. , Giovannucci E.L. , Smith-Warner S.A. , Tworoger S.S. , Poole E.M. .
Source: British journal of cancer, 2017-09-05; 117(6), p. 907-911.
EPub date: 2017-08-03.
PMID: 28772285
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An Empirical Dietary Inflammatory Pattern Score Enhances Prediction of Circulating Inflammatory Biomarkers in Adults.
Authors: Tabung F.K. , Smith-Warner S.A. , Chavarro J.E. , Fung T.T. , Hu F.B. , Willett W.C. , Giovannucci E.L. .
Source: The Journal of nutrition, 2017 08; 147(8), p. 1567-1577.
EPub date: 2017-06-28.
PMID: 28659407
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Biomarker-calibrated nutrient intake and healthy diet index associations with mortality risks among older and frail women from the Women's Health Initiative.
Authors: Zaslavsky O. , Zelber-Sagi S. , Hebert J.R. , Steck S.E. , Shivappa N. , Tabung F.K. , Wirth M.D. , Bu Y. , Shikany J.M. , Orchard T. , et al. .
Source: The American journal of clinical nutrition, 2017 06; 105(6), p. 1399-1407.
EPub date: 2017-04-19.
PMID: 28424183
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Dietary glycemic and insulin scores and colorectal cancer survival by tumor molecular biomarkers.
Authors: Keum N. , Yuan C. , Nishihara R. , Zoltick E. , Hamada T. , Martinez Fernandez A. , Zhang X. , Hanyuda A. , Liu L. , Kosumi K. , et al. .
Source: International journal of cancer, 2017-06-15; 140(12), p. 2648-2656.
EPub date: 2017-03-28.
PMID: 28268248
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Associations between adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and biomarkers of inflammation, hormonal, and insulin response.
Authors: Tabung F.K. , Fung T.T. , Chavarro J.E. , Smith-Warner S.A. , Willett W.C. , Giovannucci E.L. .
Source: International journal of cancer, 2017-02-15; 140(4), p. 764-776.
EPub date: 2016-11-14.
PMID: 27798951
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