Grant Number:	5U2CAG054397-04 Interpret this number
Primary Investigator:	Kaye, Jeffrey
Organization:	Oregon Health & Science University
Project Title:	Orcatech Collaborative Aging (in Place) Research Using Technology (CART)
Fiscal Year:	2019

Summary The ORCATECH Collaborative Aging (in Place) Research Using Technology (CART) program develops and validates an infrastructure for rapid and effective conduct of research utilizing technology to facilitate aging in place (AiP). CART is a unique and innovative research organization to enjoin expert leaders from academia and industry with broad-based experience across multiple fields: gerontology, clinical medicine, health care, psychology, user interaction, systems science, engineering, computer science, technology, data science, business development, ethics and public policy. This CART team works closely together to leverage existing considerable infrastructure, with members from ORCATECH at Oregon Health & Science University, Intel, VA (VISN20), Rush University, Oregon State University, University of Pennsylvania and CREATE (Center for Research and Education on Aging and Technology Enhancement) at University of Miami. As a result, our CART will work rapidly, building on an already-existing system demonstrated as adaptable and sustainable for over a decade. In years 1-3 we will apply a systems development life cycle approach with iterative user- centered design and technology and infrastructure creation. To ensure sustained use and ecological validity of the data, the design is as unobtrusive as possible for research participants, as well as technology agnostic. In year 4 the developed system will be assessed in a Demonstration Project with an original AiP hypothesis fundamental to CART research: whether the system created provides evidence for sustained independence. We introduce innovative AiP methods including: a unique Personal Health and Activity Record, combining functionality of a personal health record with ecological momentary assessment capacity; novel use of Bluetooth beacon technology to assess activity of couples and caregivers; assessment of community travel (e.g., driving); and an assessment tool to predict sustainable engagement in future CART research. We rigorously test the AiP hypothesis and these innovations in 360 participants from four diverse senior populations: residents in low income, section 202 housing; veterans in the rural Pacific Northwest; African Americans and other minorities in Chicago (Minority Aging Research Study) and Miami (PRISM study). The secure extensible data system for CART's multidimensional and hierarchical data will accommodate multiple, evolving data ontologies and schema. CART's Data Repository and communications plan will facilitate data and resource sharing of multiple users of different levels of sophistication ensuring the widest impact and dissemination. Several sustainability models will be evaluated to ensure the success of a larger CART phase II effort, resulting in the high-impact research enterprise needed to create evidence for effective assessments and interventions to sustain health and independence for the growing aging population.




Differences in Life Space Activity Patterns Between Older Adults With Mild Cognitive Impairment Living Alone or as a Couple: Cohort Study Using Passive Activity Sensing.
Authors: Muurling M. , Au-Yeung W.M. , Beattie Z. , Wu C.Y. , Dodge H. , Rodrigues N.K. , Gothard S. , Silbert L.C. , Barnes L.L. , Steele J.S. , et al. .
Source: Jmir Aging, 2023-10-11 00:00:00.0; 6, p. e45876.
EPub date: 2023-10-11 00:00:00.0.
PMID: 37819694
Related Citations

Using Continuous Passive Assessment Technology to Describe Health and Behavior Patterns Preceding and Following a Cancer Diagnosis in Older Adults: Proof-of-Concept Case Series Study.
Authors: Wu C.Y. , Tibbitts D. , Beattie Z. , Dodge H. , Shannon J. , Kaye J. , Winters-Stone K. .
Source: Jmir Formative Research, 2023-08-10 00:00:00.0; 7, p. e45693.
EPub date: 2023-08-10 00:00:00.0.
PMID: 37561574
Related Citations

Mood and activity changes during the COVID-19 pandemic in rural and urban Veterans and their cohabitants.
Authors: Lennon J.C. , Hantke N. , Mattek N. , Wu C.Y. , Dodge H. , Wall R. , Beattie Z. , Kaye J. , Silbert L.C. .
Source: Clinical Gerontologist, 2022-10-08 00:00:00.0; , p. 1-8.
EPub date: 2022-10-08 00:00:00.0.
PMID: 36208222
Related Citations

A classification algorithm to predict chronic pain using both regression and machine learning - A stepwise approach.
Authors: Tsai P.F. , Wang C.H. , Zhou Y. , Ren J. , Jones A. , Watts S.O. , Chou C. , Ku W.S. .
Source: Applied Nursing Research : Anr, 2021 12; 62, p. 151504.
EPub date: 2021-09-28 00:00:00.0.
PMID: 34815000
Related Citations

Use of in-home activity monitoring technologies in older adult veterans with mild cognitive impairment: The impact of attitudes and cognition.
Authors: Leese M.I. , Dorociak K.E. , Noland M. , Gaugler J.E. , Mattek N. , Hughes A. .
Source: Gerontechnology : International Journal On The Fundamental Aspects Of Technology To Serve The Ageing Society, 2021 Jun; 20(2), p. 1-12.
PMID: 34305492
Related Citations

The Survey for Memory, Attention, and Reaction Time (SMART): Development and Validation of a Brief Web-Based Measure of Cognition for Older Adults.
Authors: Dorociak K.E. , Mattek N. , Lee J. , Leese M.I. , Bouranis N. , Imtiaz D. , Doane B.M. , Bernstein J.P.K. , Kaye J.A. , Hughes A.M. .
Source: Gerontology, 2021-04-07 00:00:00.0; , p. 1-13.
EPub date: 2021-04-07 00:00:00.0.
PMID: 33827088
Related Citations

Domain Experts on Dementia-Care Technologies: Mitigating Risk in Design and Implementation.
Authors: Berridge C. , Demiris G. , Kaye J. .
Source: Science And Engineering Ethics, 2021-02-18 00:00:00.0; 27(1), p. 14.
EPub date: 2021-02-18 00:00:00.0.
PMID: 33599847
Related Citations

Prolonged Physical Inactivity in Older Adult Couples: A Dyadic Analysis Using Actigraphy.
Authors: Wu C.Y. , Miller L.M. , Wall R.N. , Beattie Z.T. , Silbert L.C. , Kaye J.A. .
Source: Innovation In Aging, 2021; 5(1), p. igaa066.
EPub date: 2020-12-30 00:00:00.0.
PMID: 33718627
Related Citations

Passively-Measured Routine Home Computer Activity and Application Use Can Detect Mild Cognitive Impairment and Correlate with Important Cognitive Functions in Older Adulthood.
Authors: Bernstein J.P.K. , Dorociak K.E. , Mattek N. , Leese M. , Beattie Z.T. , Kaye J.A. , Hughes A. .
Source: Journal Of Alzheimer's Disease : Jad, 2021; 81(3), p. 1053-1064.
PMID: 33843682
Related Citations

Corrigendum to: Prolonged Physical Inactivity in Older Adult Couples: A Dyadic Analysis Using Actigraphy.
Authors: Wu C.Y. , Miller L.M. , Wall R.N. , Beattie Z.T. , Silbert L.C. , Kaye J.A. .
Source: Innovation In Aging, 2021; 5(4), p. igab036.
EPub date: 2021-11-08 00:00:00.0.
PMID: 34761126
Related Citations

Dementia risk reduction: why haven't the pharmacological risk reduction trials worked? An in-depth exploration of seven established risk factors.
Authors: Peters R. , Breitner J. , James S. , Jicha G.A. , Meyer P.F. , Richards M. , Smith A.D. , Yassine H.N. , Abner E. , Hainsworth A.H. , et al. .
Source: Alzheimer's & Dementia (new York, N. Y.), 2021; 7(1), p. e12202.
EPub date: 2021-12-08 00:00:00.0.
PMID: 34934803
Related Citations

Reproducibility and replicability of high-frequency, in-home digital biomarkers in reducing sample sizes for clinical trials.
Authors: Wu C.Y. , Beattie Z. , Mattek N. , Sharma N. , Kaye J. , Dodge H.H. .
Source: Alzheimer's & Dementia (new York, N. Y.), 2021; 7(1), p. e12220.
EPub date: 2021-12-31 00:00:00.0.
PMID: 35005204
Related Citations

The Collaborative Aging Research Using Technology Initiative: An Open, Sharable, Technology-Agnostic Platform for the Research Community.
Authors: Beattie Z. , Miller L.M. , Almirola C. , Au-Yeung W.M. , Bernard H. , Cosgrove K.E. , Dodge H.H. , Gamboa C.J. , Golonka O. , Gothard S. , et al. .
Source: Digital Biomarkers, 2020 Winter; 4(Suppl 1), p. 100-118.
EPub date: 2020-11-26 00:00:00.0.
PMID: 33442584
Related Citations

Step Count Standardization: Validation of Step Counts from the Withings Activite using PiezoRxD and wGT3X-BT.
Authors: Au-Yeung W.M. , Kaye J.A. , Beattie Z. .
Source: Annual International Conference Of The Ieee Engineering In Medicine And Biology Society. Ieee Engineering In Medicine And Biology Society. Annual International Conference, 2020 07; 2020, p. 4608-4611.
PMID: 33019020
Related Citations

An Ecologically Valid, Longitudinal, and Unbiased Assessment of Treatment Efficacy in Alzheimer Disease (the EVALUATE-AD Trial): Proof-of-Concept Study.
Authors: Thomas N.W.D. , Beattie Z. , Marcoe J. , Wright K. , Sharma N. , Mattek N. , Dodge H. , Wild K. , Kaye J. .
Source: Jmir Research Protocols, 2020-05-27 00:00:00.0; 9(5), p. e17603.
EPub date: 2020-05-27 00:00:00.0.
PMID: 32459184
Related Citations

The Five W's of Falls: Weekly Online Health Survey of Community-Dwelling Older Adults: Analysis of 4 Years Prospective Follow-up.
Authors: Piau A. , Mattek N. , Duncan C. , Sharma N. , Riley T. , Kaye J. .
Source: The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences, 2020-04-17 00:00:00.0; 75(5), p. 946-951.
PMID: 31054258
Related Citations

When Will My Patient Fall? Sensor-Based In-Home Walking Speed Identifies Future Falls in Older Adults.
Authors: Piau A. , Mattek N. , Crissey R. , Beattie Z. , Dodge H. , Kaye J. .
Source: The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences, 2020-04-17 00:00:00.0; 75(5), p. 968-973.
PMID: 31095283
Related Citations

Brain health INnovation Diplomacy: a model binding diverse disciplines to manage the promise and perils of technological innovation.
Authors: Ternes K. , Iyengar V. , Lavretsky H. , Dawson W.D. , Booi L. , Ibanez A. , Vahia I. , Reynolds C. , DeKosky S. , Cummings J. , et al. .
Source: International Psychogeriatrics, 2020-02-13 00:00:00.0; , p. 1-25.
EPub date: 2020-02-13 00:00:00.0.
PMID: 32019621
Related Citations

Improving the Assessment of Mild Cognitive Impairment in Advanced Age With a Novel Multi-Feature Automated Speech and Language Analysis of Verbal Fluency.
Authors: Chen L. , Asgari M. , Gale R. , Wild K. , Dodge H. , Kaye J. .
Source: Frontiers In Psychology, 2020; 11, p. 535.
EPub date: 2020-04-09 00:00:00.0.
PMID: 32328008
Related Citations

Automatic Assessment of Cognitive Tests for Differentiating Mild Cognitive Impairment: A Proof of Concept Study of the Digit Span Task.
Authors: Asgari M. , Gale R. , Wild K. , Dodge H. , Kaye J. .
Source: Current Alzheimer Research, 2020; 17(7), p. 658-666.
PMID: 33032509
Related Citations

Choosing the right time granularity for analysis of digital biomarker trajectories.
Authors: Wakim N.I. , Braun T.M. , Kaye J.A. , Dodge H.H. , for ORCATECH .
Source: Alzheimer's & Dementia (new York, N. Y.), 2020; 6(1), p. e12094.
EPub date: 2020-12-18 00:00:00.0.
PMID: 33354618
Related Citations

Current State of Digital Biomarker Technologies for Real-Life, Home-Based Monitoring of Cognitive Function for Mild Cognitive Impairment to Mild Alzheimer Disease and Implications for Clinical Care: Systematic Review.
Authors: Piau A. , Wild K. , Mattek N. , Kaye J. .
Source: Journal Of Medical Internet Research, 2019-08-30 00:00:00.0; 21(8), p. e12785.
EPub date: 2019-08-30 00:00:00.0.
PMID: 31471958
Related Citations

A randomized clinical trial to evaluate home-based assessment of people over 75 years old.
Authors: Sano M. , Zhu C.W. , Kaye J. , Mundt J.C. , Hayes T.L. , Ferris S. , Thomas R.G. , Sun C.K. , Jiang Y. , Donohue M.C. , et al. .
Source: Alzheimer's & Dementia : The Journal Of The Alzheimer's Association, 2019 05; 15(5), p. 615-624.
EPub date: 2019-03-11 00:00:00.0.
PMID: 30872114
Related Citations

Pathologies Underlying Longitudinal Cognitive Decline in the Oldest Old.
Authors: Nguyen M.T. , Mattek N. , Woltjer R. , Howieson D. , Silbert L. , Hofer S. , Kaye J. , Dodge H. , Erten-Lyons D. .
Source: Alzheimer Disease And Associated Disorders, 2018 Oct-Dec; 32(4), p. 265-269.
PMID: 30052535
Related Citations

Use of nonintrusive sensor-based information and communication technology for real-world evidence for clinical trials in dementia.
Authors: Teipel S. , König A. , Hoey J. , Kaye J. , Krüger F. , Robillard J.M. , Kirste T. , Babiloni C. .
Source: Alzheimer's & Dementia : The Journal Of The Alzheimer's Association, 2018 Sep; 14(9), p. 1216-1231.
EPub date: 2018-06-21 00:00:00.0.
PMID: 29936147
Related Citations

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data.
Authors: Kaye J. , Reynolds C. , Bowman M. , Sharma N. , Riley T. , Golonka O. , Lee J. , Quinn C. , Beattie Z. , Austin J. , et al. .
Source: Journal Of Visualized Experiments : Jove, 2018-07-27 00:00:00.0; (137), .
EPub date: 2018-07-27 00:00:00.0.
PMID: 30102277
Related Citations

Baseline NAWM structural integrity and CBF predict periventricular WMH expansion over time.
Authors: Promjunyakul N.O. , Dodge H.H. , Lahna D. , Boespflug E.L. , Kaye J.A. , Rooney W.D. , Silbert L.C. .
Source: Neurology, 2018-06-12 00:00:00.0; 90(24), p. e2119-e2126.
EPub date: 2018-05-16 00:00:00.0.
PMID: 29769375
Related Citations

Weekly observations of online survey metadata obtained through home computer use allow for detection of changes in everyday cognition before transition to mild cognitive impairment.
Authors: Seelye A. , Mattek N. , Sharma N. , Riley T. , Austin J. , Wild K. , Dodge H.H. , Lore E. , Kaye J. .
Source: Alzheimer's & Dementia : The Journal Of The Alzheimer's Association, 2017-10-26 00:00:00.0; , .
EPub date: 2017-10-26 00:00:00.0.
PMID: 29107052
Related Citations

Passive Assessment of Routine Driving with Unobtrusive Sensors: A New Approach for Identifying and Monitoring Functional Level in Normal Aging and Mild Cognitive Impairment.
Authors: Seelye A. , Mattek N. , Sharma N. , Witter P. , Brenner A. , Wild K. , Dodge H. , Kaye J. .
Source: Journal Of Alzheimer's Disease : Jad, 2017; 59(4), p. 1427-1437.
PMID: 28731434
Related Citations

Making Pervasive Computing Technology Pervasive for Health & Wellness in Aging.
Authors: Kaye J. .
Source: The Public Policy And Aging Report, 2017; 27(2), p. 53-61.
EPub date: 2017-06-09 00:00:00.0.
PMID: 31148911
Related Citations