||5R01CA190329-05 Interpret this number
||University Of Utah
||Socioeconomic Status, Stress, and Smoking Cessation
The prevalence of electronic nicotine delivery systems (ENDS) is rising dramatically among both adults and
youth and ENDS use is fast becoming a major public health issue. However, because of their recent
emergence, researchers know little about ENDS, their use, their effects on human physiology and health, their
risks and benefits, or their impact on tobacco control efforts. A common barrier to studying ENDS is the lack of
data on objective, real world use of ENDS. Thus, the proposed project aims to adapt existing innovative mobile
assessment tools that can be used to target critical ENDS research gaps by providing mobile sensing
technology that can objectively collect precise data regarding ENDS use in real time in real world. Specifically,
the proposed revision project will expand the scope of Project On Track (1R01CA190329-01A1, PI: Wetter) by
extending the application of puffMarker, an existing tool that automatically detects smoking, for the assessment
of ENDS use. The current project has three aims: 1) adapt and validate puffMarker to identify discrete
episodes of ENDS use, 2) adapt and validate puffMarker to distinguish between cigarette smoking and ENDS
use among dual users of ENDS and cigarettes, and 3) utilize the Project On Track protocol to collect real time,
real world data investigating potential determinants of ENDS use among both exclusive ENDS users as well as
dual users of cigarettes and ENDS. Altogether, 120 participants (30 for Aim 1, 30 for Aim 2, and 60 for Aim 3)
will be enrolled. Participants recruited for Aims 1 and 2 will attend laboratory (three 2-hour sessions) and field
(3 days) studies. In the laboratory sessions, participants will wear the AutoSense wireless sensors and be
asked to use ENDS (Aim 1) or use ENDS and smoke a cigarette (Aim 2). Participants' ENDS and cigarette
puffs will be recorded by an independent observer. In the field studies, participants will wear the AutoSense
wireless sensors and be asked to use ENDS (Aim 1) or use ENDS and smoke cigarettes (Aim 2). Participants
will be asked to record each instance of ENDS use or cigarette smoking on a SP. The goals of the laboratory
studies are to collect data to train puffMarker to identify ENDS use and to distinguish between cigarette
smoking and ENDS use. The goal of the field studies is to validate puffMarker in real-life, natural environments.
Aim 3 will utilize the Project On Track protocol to collect the first real time, real world data on ENDS and dual
use. Participants will be assessed for 6 days using AutoSense, EMA, and GPS to examine potential
determinants of ENDS use. A validated puffMarker that detects ENDS use and distinguishes between ENDS
use and smoking can enhance many areas of research inquiry on ENDS. Knowledge learned from Aim 3 will
be essential for the development of comprehensive conceptual models with respect to ENDS use and smoking
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