Grant Number:	7R00CA207848-04 Interpret this number
Primary Investigator:	Warren Andersen, Shaneda
Organization:	University Of Wisconsin-Madison
Project Title:	Vitamin D and Colorectal Cancer Risk: an Integrated Molecular and Genetic Epidemiologic Study
Fiscal Year:	2018

PROJECT ABSTRACT The research plan uses Mendelian randomization methods and other genetic and molecular epidemiologic approaches to evaluate the hypothesis that circulating and bioavailable vitamin D levels are associated with decreased colorectal cancer risk and further investigate possible mechanisms for the associations. The Mendelian randomization project will leverage resources from three established epidemiologic consortia, including data from approximately 29,000 cases and 46,000 controls of European, Asian and African descent. Fine-mapping will be conducted to improve the instruments for Mendelian randomization analyses. Race- specific genetic scores for circulating vitamin D and its binding protein will be created and assessed for associations with overall colorectal cancer risk. In addition, data and biological samples obtained from participants of the prospective Southern Community Cohort Study will be used to conduct a molecular epidemiologic study. A subsample of 300 Southern Community Cohort Study participants with available colorectal cancer tumor tissue, will be compared to matched controls to evaluate associations of tumor characteristics with circulating vitamin D levels, bioavailable vitamin D levels, vitamin D binding protein levels, and genetic scores composed of vitamin D loci. Tumor characteristics to be examined represent underlying cellular processes associated with carcinogenesis such as cellular proliferation, differentiation, inflammation and apoptosis. We will measure PIK3CA mutation status, tumor stage, and expression of COX-2, p53, and Ki67. The use of Mendelian randomization and molecular epidemiologic methods should provide a more definitive answer to the questions of the relations between colorectal cancer risk and vitamin D binding protein, genetic loci and circulating and bioavailable vitamin D. The findings from this research project will be used to develop and submit a R01-level project before the completion of the Career Development award. The research topic is of much significance, as the Institute of Medicine’s 2010 Report states, understanding the effect of genetic variation in vitamin D status on health outcomes, including that among racial groups, is an important research need. This study will provide insight into colorectal cancer etiology and potentially identify subgroups of individuals who may benefit the most from vitamin D supplementation.




Metformin's role in lowering colorectal cancer risk among individuals with diabetes from the Southern Community Cohort Study.
Authors: Lawler T. , Walts Z.L. , Giurini L. , Steinwandel M. , Lipworth L. , Murff H.J. , Zheng W. , Warren Andersen S. .
Source: Cancer Epidemiology, 2024 Jun; 90, p. 102566.
EPub date: 2024-03-21 00:00:00.0.
PMID: 38518387
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Race- and Gender-Specific Associations between Neighborhood-Level Socioeconomic Status and Body Mass Index: Evidence from the Southern Community Cohort Study.
Authors: Giurini L. , Lipworth L. , Murff H.J. , Zheng W. , Warren Andersen S. .
Source: International Journal Of Environmental Research And Public Health, 2023-11-30 00:00:00.0; 20(23), .
EPub date: 2023-11-30 00:00:00.0.
PMID: 38063552
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Type 2 Diabetes and Colorectal Cancer Risk.
Authors: Lawler T. , Walts Z.L. , Steinwandel M. , Lipworth L. , Murff H.J. , Zheng W. , Warren Andersen S. .
Source: Jama Network Open, 2023-11-01 00:00:00.0; 6(11), p. e2343333.
EPub date: 2023-11-01 00:00:00.0.
PMID: 37962884
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Associations of Albumin and BMI with Colorectal Cancer Risk in the Southern Community Cohort Study: a Prospective Cohort Study.
Authors: Walts Z. , Parlato L. , Brent R. , Cai Q. , Steinwandel M. , Zheng W. , Warren Andersen S. .
Source: Journal Of Racial And Ethnic Health Disparities, 2023-09-21 00:00:00.0; , .
EPub date: 2023-09-21 00:00:00.0.
PMID: 37733284
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Racial disparities in colorectal cancer clinicopathological and molecular tumor characteristics: a systematic review.
Authors: Lawler T. , Parlato L. , Warren Andersen S. .
Source: Cancer Causes & Control : Ccc, 2023-09-09 00:00:00.0; , .
EPub date: 2023-09-09 00:00:00.0.
PMID: 37688643
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Pre-diagnostic 25-hydroxyvitamin D in association with cancer specific- and all-cause mortality among low income, non-Hispanic Black Americans with colorectal cancer.
Authors: Lawler T.P. , Khankari N.K. , Shu X.O. , Steinwandel M. , Cai Q. , Jurutka P.W. , Zheng W. , Warren Andersen S. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2023-05-31 00:00:00.0; , .
EPub date: 2023-05-31 00:00:00.0.
PMID: 37257199
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Genome-wide association study (GWAS) of circulating vitamin D outcomes among individuals of African ancestry.
Authors: Parlato L.A. , Welch R. , Ong I.M. , Long J. , Cai Q. , Steinwandel M.D. , Blot W.J. , Zheng W. , Warren Andersen S. .
Source: The American Journal Of Clinical Nutrition, 2023 Feb; 117(2), p. 308-316.
EPub date: 2022-12-23 00:00:00.0.
PMID: 36811574
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Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies.
Authors: Lawler T. , Warren Andersen S. .
Source: Nutrients, 2023-01-13 00:00:00.0; 15(2), .
EPub date: 2023-01-13 00:00:00.0.
PMID: 36678292
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Associations between serum vitamin D biomarkers and tumor expression of Ki67, p53, and COX-2 in colorectal cancer cases from the Southern Community Cohort Study.
Authors: Lawler T. , Su T. , Cai Q. , Steinwandel M.D. , Zheng W. , Blot W.J. , Warren Andersen S. .
Source: The Journal Of Steroid Biochemistry And Molecular Biology, 2023 Jan; 225, p. 106201.
EPub date: 2022-10-06 00:00:00.0.
PMID: 36210028
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Associations between Folate and Alcohol Consumption with Colorectal Tumor Ki67 Expression in the Southern Community Cohort Study.
Authors: Lawler T. , Su T. , Cai Q. , Steinwandel M.D. , Zheng W. , Warren Andersen S. .
Source: Nutrition And Cancer, 2023; 75(4), p. 1211-1222.
EPub date: 2023-03-12 00:00:00.0.
PMID: 36908193
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Reduced racial disparity in receipt of optimal locoregional treatment for women with early-stage breast cancer.
Authors: Nadeem H. , Romley J.A. , Warren Andersen S. .
Source: Plos One, 2023; 18(9), p. e0291025.
EPub date: 2023-09-01 00:00:00.0.
PMID: 37656742
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Sociocultural Factors, Access to Healthcare, and Lifestyle: Multifactorial Indicators in Association with Colorectal Cancer Risk.
Authors: Warren Andersen S. , Zheng W. , Steinwandel M. , Murff H.J. , Lipworth L. , Blot W.J. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2022-09-01 00:00:00.0; 15(9), p. 595-603.
PMID: 35609123
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Dispositional optimism and optimistic bias: Associations with cessation motivation, confidence, and attitudes.
Authors: Senft Everson N. , Klein W.M.P. , Lee S.S. , Selove R. , Sanderson M. , Blot W.J. , Tyndale R.F. , King S. , Gilliam K. , Kundu S. , et al. .
Source: Health Psychology : Official Journal Of The Division Of Health Psychology, American Psychological Association, 2022 Sep; 41(9), p. 621-629.
EPub date: 2022-07-28 00:00:00.0.
PMID: 35901400
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Racial Differences in Hepatocellular Carcinoma Incidence and Risk Factors among a Low Socioeconomic Population.
Authors: Muhimpundu S. , Conway R.B.N. , Warren Andersen S. , Lipworth L. , Steinwandel M.D. , Blot W.J. , Shu X.O. , Sudenga S.L. .
Source: Cancers, 2021-07-23 00:00:00.0; 13(15), .
EPub date: 2021-07-23 00:00:00.0.
PMID: 34359611
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Association of Race and Socioeconomic Status With Colorectal Cancer Screening, Colorectal Cancer Risk, and Mortality in Southern US Adults.
Authors: Warren Andersen S. , Blot W.J. , Lipworth L. , Steinwandel M. , Murff H.J. , Zheng W. .
Source: Jama Network Open, 2019-12-02 00:00:00.0; 2(12), p. e1917995.
EPub date: 2019-12-02 00:00:00.0.
PMID: 31860105
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Attitudes toward Precision Treatment of Smoking in the Southern Community Cohort Study.
Authors: Senft N. , Sanderson M. , Selove R. , Blot W.J. , King S. , Gilliam K. , Kundu S. , Steinwandel M. , Sternlieb S.J. , Warren Andersen S. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2019 Aug; 28(8), p. 1345-1352.
EPub date: 2019-06-03 00:00:00.0.
PMID: 31160346
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Does religious involvement affect mortality in low-income Americans? A prospective cohort study.
Authors: Wen W. , Schlundt D. , Andersen S.W. , Blot W.J. , Zheng W. .
Source: Bmj Open, 2019-07-09 00:00:00.0; 9(7), p. e028200.
EPub date: 2019-07-09 00:00:00.0.
PMID: 31289078
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Diabetes, obesity, and subsequent risk of postmenopausal breast cancer among white and black women in the Southern Community Cohort Study.
Authors: Sanderson M. , Lipworth L. , Shrubsole M.J. , Andersen S.W. , Shu X.O. , Zheng W. , Hargreaves M.K. , Blot W.J. .
Source: Cancer Causes & Control : Ccc, 2019 May; 30(5), p. 425-433.
EPub date: 2019-04-02 00:00:00.0.
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Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study.
Authors: Jiang X. , Dimou N.L. , Al-Dabhani K. , Lewis S.J. , Martin R.M. , Haycock P.C. , Gunter M.J. , Key T.J. , Eeles R.A. , Muir K. , et al. .
Source: International Journal Of Epidemiology, 2018-12-28 00:00:00.0; , .
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Identifying Biomarkers for Risk of Premature Menopause Among Childhood Cancer Survivors May Lead to Targeted Interventions and Wellness Strategies.
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Source: Journal Of The National Cancer Institute, 2018-08-01 00:00:00.0; 110(8), p. 801-802.
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Associations Between Neighborhood Environment, Health Behaviors, and Mortality.
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Source: American Journal Of Preventive Medicine, 2018 Jan; 54(1), p. 87-95.
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Total and free circulating vitamin D and vitamin D binding protein in relation to colorectal cancer risk in a prospective study of African Americans.
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Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017-05-08 00:00:00.0; , .
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