Grant Number:	5R01CA164751-07 Interpret this number
Primary Investigator:	Jones, Lee
Organization:	Sloan-Kettering Inst Can Research
Project Title:	Aerobic Training During or After Adjuvant Therapy: a Randomized Trial
Fiscal Year:	2019

DESCRIPTION (provided by applicant): Exercise training is a safe and efficacious intervention for breast cancer patients following the completion of primary therapy (i.e., chemotherapy and radiation). In contrast, the role of exercise during primary BC therapy is less well accepted. Indeed, a perception exists that the conduct of scientifically rigorous exercise trials may not be possible during therapy due to poor adherence and attrition rates, elevated risk of adverse events, and significant patient selection bias. Nevertheless, a growing number of studies indicate that exercise is an effective therapy to mitigate certain cancer-related toxicities (e.g., deconditioning, fatigue) with adherence and attrition rates well within conventionally accepted levels, and with minimal AEs. Although the acceptance of exercise during therapy has made significant strides over the past decade, the prevailing dogma is still that exercise should be avoided during primary therapy. We propose a four-arm RCT to compare the effects and safety of supervised aerobic training performed during, after, or during and after (i.e., continuous AT) standard primary therapy, relative to attention-control, in 160 (n=40/group) early-stage BC patients. This grant has the following objectives: Primary aims: (1) To compare the difference in cardiorespiratory fitness between aerobic training and control during therapy versus aerobic training and control after therapy, (2) To compare the difference in oxygen transport organs that govern the aerobic training - fitness relationship, and (3) to compare the difference in patient-reported outcomes, adverse events, adherence, and attrition rates between study groups. A secondary aim is to compare the effect of continuous aerobic training, relative to all other groups, on primary aims 1 - 3.




Effects of exercise therapy on chemotherapy delivery and response in primary breast cancer: A secondary analysis of a randomized trial.
Authors: Iyengar N.M. , Scott J.M. , Lee J. , Lavery J.A. , Foug K.L. , Lee C.P. , Michalski M.G. , Chun S.S. , Harrison J. , Moskowitz C.S. , et al. .
Source: Cancer, 2024-09-22 00:00:00.0; , .
EPub date: 2024-09-22 00:00:00.0.
PMID: 39306704
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Mechanisms of Exercise Intolerance Across the Breast Cancer Continuum: A Pooled Analysis of Individual Patient Data.
Authors: Scott J.M. , Lee J. , Michalski M.G. , Batch K. , Simpson A.L. , Peoples J. , Lee C.P. , Harrison J.N. , Yu A.F. , Sasso J.P. , et al. .
Source: Medicine And Science In Sports And Exercise, 2024-04-01 00:00:00.0; 56(4), p. 590-599.
EPub date: 2023-11-27 00:00:00.0.
PMID: 38485730
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Timing of exercise therapy when initiating adjuvant chemotherapy for breast cancer: a randomized trial.
Authors: Scott J.M. , Lee J. , Herndon J.E. , Michalski M.G. , Lee C.P. , O'Brien K.A. , Sasso J.P. , Yu A.F. , Rowed K.A. , Bromberg J.F. , et al. .
Source: European Heart Journal, 2023-02-21 00:00:00.0; , .
EPub date: 2023-02-21 00:00:00.0.
PMID: 36806405
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Precision Oncology Framework for Investigation of Exercise As Treatment for Cancer.
Authors: Jones L.W. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2015-12-10 00:00:00.0; 33(35), p. 4134-7.
EPub date: 2015-12-10 00:00:00.0.
PMID: 26460301
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Physical Activity and Prostate Tumor Vessel Morphology: Data from the Health Professionals Follow-up Study.
Authors: Van Blarigan E.L. , Gerstenberger J.P. , Kenfield S.A. , Giovannucci E.L. , Stampfer M.J. , Jones L.W. , Clinton S.K. , Chan J.M. , Mucci L.A. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2015 Oct; 8(10), p. 962-7.
PMID: 26276753
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Safety and efficacy of aerobic training in patients with cancer who have heart failure: an analysis of the HF-ACTION randomized trial.
Authors: Jones L.W. , Douglas P.S. , Khouri M.G. , Mackey J.R. , Wojdyla D. , Kraus W.E. , Whellan D.J. , O'Connor C.M. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2014-08-10 00:00:00.0; 32(23), p. 2496-502.
EPub date: 2014-08-10 00:00:00.0.
PMID: 25002717
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Safety and efficacy of aerobic training in operable breast cancer patients receiving neoadjuvant chemotherapy: a phase II randomized trial.
Authors: Hornsby W.E. , Douglas P.S. , West M.J. , Kenjale A.A. , Lane A.R. , Schwitzer E.R. , Ray K.A. , Herndon J.E. , Coan A. , Gutierrez A. , et al. .
Source: Acta Oncologica (stockholm, Sweden), 2014 Jan; 53(1), p. 65-74.
PMID: 23957716
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Immunological and hormonal effects of exercise: implications for cancer cachexia.
Authors: Maddocks M. , Jones L.W. , Wilcock A. .
Source: Current Opinion In Supportive And Palliative Care, 2013 Dec; 7(4), p. 376-82.
PMID: 24157716
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Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice.
Authors: Dolinsky V.W. , Rogan K.J. , Sung M.M. , Zordoky B.N. , Haykowsky M.J. , Young M.E. , Jones L.W. , Dyck J.R. .
Source: American Journal Of Physiology. Endocrinology And Metabolism, 2013-07-15 00:00:00.0; 305(2), p. E243-53.
EPub date: 2013-07-15 00:00:00.0.
PMID: 23695218
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The influence of adjuvant therapy on cardiorespiratory fitness in early-stage breast cancer seven years after diagnosis: the Cooper Center Longitudinal Study.
Authors: Lakoski S.G. , Barlow C.E. , Koelwyn G.J. , Hornsby W.E. , Hernandez J. , Defina L.F. , Radford N.B. , Thomas S.M. , Herndon J.E. , Peppercorn J. , et al. .
Source: Breast Cancer Research And Treatment, 2013 Apr; 138(3), p. 909-16.
PMID: 23504137
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Exercise-oncology research: past, present, and future.
Authors: Jones L.W. , Alfano C.M. .
Source: Acta Oncologica (stockholm, Sweden), 2013 Feb; 52(2), p. 195-215.
PMID: 23244677
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The potential role of aerobic exercise to modulate cardiotoxicity of molecularly targeted cancer therapeutics.
Authors: Scott J.M. , Lakoski S. , Mackey J.R. , Douglas P.S. , Haykowsky M.J. , Jones L.W. .
Source: The Oncologist, 2013; 18(2), p. 221-31.
PMID: 23335619
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Running on empty: cardiovascular reserve capacity and late effects of therapy in cancer survivorship.
Authors: Koelwyn G.J. , Khouri M. , Mackey J.R. , Douglas P.S. , Jones L.W. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2012-12-20 00:00:00.0; 30(36), p. 4458-61.
EPub date: 2012-12-20 00:00:00.0.
PMID: 23045598
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