Grant Details
Grant Number: |
3R01CA211707-02S1 Interpret this number |
Primary Investigator: |
Gayther, Simon |
Organization: |
Cedars-Sinai Medical Center |
Project Title: |
Functional Effects of Ovarian Cancer Risk Variants |
Fiscal Year: |
2018 |
Abstract
Project Summary/Abstract
The principal goal of this supplement is to streamline and disseminate the large datasets and analyses
resulting from the work of the parent proposal. More specifically, the parent grant was awarded to identify
candidate susceptibility genes associated with ovarian cancer risk loci and establish their role in disease
pathogenesis and to identify the causal variants and regulatory mechanisms underlying ovarian cancer risk
loci. Both of these aims outline an approach requiring extensive bioinformatics expertise, particularly where
they require the curation and integration of petabytes of data, much of it generated from within our own
group. Our group has developed a comprehensive suite of open source bioinformatics tools in parallel with our
prior efforts up to and including the preliminary data presented in the parent grant. What is now required is to
build a gateway to serve as a public resource and disseminate our findings and datasets to the wider research
community and the Ovarian Cancer research community in particular. This gateway will provide a graphical
overview of all the projects associated with the parent grant (as well as other topically related grants) with
clickable links to individual project pages, data repositories, analysis workflows, and user-friendly versions of
the software tools that were used to make key inferences in the study. Researchers (and lay people) who visit
the site will learn how each piece of the research, each manuscript and dataset, fits into the context of the
whole research program. This represents a novel approach and strategy to scientific communication
that will greatly enhance the visibility of the research. It will also set new standards for transparency and
reproducibility above and beyond what is currently required by most journals, but which many in the community
have called for. In addition, the Center for Bioinformatics and Functional genomics has collaborations spanning
a wide range of cancers and other health-related fields (including regenerative medicine and inflammatory
bowel disease). In building these platforms we will be creating a template and precedent for these other
projects, thus magnifying greatly the impact of the original award. We are firm believers in open-source
philosophy and hope to inspire emulation by others that find the work applicable to their own.
Publications
None. See parent grant details.