Endometrial cancer survivors are a growing population with high prevalence of inactivity and obesity. Despite
the benefits of strength training and the risk of functional limitations for obese individuals, interventions for this
population have focused mainly on weight loss and aerobic physical activity. A small number of studies have
tested resistance training, but only as part of a larger multi-modal approach; thus the specific benefits of
resistance training have not been identified. Due to low long-term success rates of weight loss interventions,
focusing on building strength and confidence through resistance training may be a promising approach to
engaging endometrial cancer survivors in the process of health lifestyle change. The proposed pilot trial will
determine the feasibility and safety of our home-based strength training intervention, which consists of an in-
person instructional session followed by video coaching. All equipment is provided and all exercises can be
done within the home. This home-based approach is important for preserving our reach to rural cancer
survivors. Main outcomes will include adherence to the exercise sessions and the video calls, as well as
participant feedback about the intervention. We will also measure anthropometrics, body composition,
functional fitness, biomarkers, quality of life, and self-efficacy. However, the core purpose of a pilot study is to
establish feasibility rather than to test hypotheses, therefore our specific aims focus specifically on the
feasibility of both the intervention and the measures and will provide the data needed to refine our protocols to
support a fully-powered trial.
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