Grant Details
Grant Number: |
3R01CA196337-04S1 Interpret this number |
Primary Investigator: |
Newcomb, Polly |
Organization: |
Fred Hutchinson Cancer Research Center |
Project Title: |
Serrated Colorectal Cancer: an Emerging Disease Subtype (Admin Supplement) |
Fiscal Year: |
2018 |
Abstract
ABSTRACT
A recently-defined subtype of colorectal cancer (CRC), “serrated CRC”, is thought to arise from a distinct
developmental pathway involving the progression of serrated polyps through accumulation of aberrant
methylation and specific somatic mutations in BRAF or KRAS. Despite growing evidence that serrated CRC is
a particularly aggressive subtype, little is known as to what factors may predispose individuals to serrated
CRC, and the clinical implications of this disease subtype have not been well-characterized. Therefore, our
parent award goals are to compare serrated CRC to non-serrated CRC with respect to 1) germline genotype,
2) personal and histopathological features, and 3) prognosis. This research will provide important information
on common genetic variants that predispose individuals to serrated CRC, and on the clinical presentation and
outcomes of this high-risk CRC subtype. In this application, we seek to enhance the value of our ongoing
parent project by contributing data to the NCI-supported Cancer Epidemiology Data Repository (CEDR), a
centralized, controlled-access database, where Investigators can deposit individual-level de-identified
observational cancer datasets. Modeled after successful NIH-supported data repositories, CEDR will enable
broad collaboration, exploration of new hypotheses, development of innovative statistical methodologies, and
replication of published findings. We will provide data from the parent project to CEDR across several different
categories: histopathological, epidemiologic, clinical, outcomes, and tumor molecular data. This data may be
accessed and further analyzed in conjunction with genomic data collected in our study, which will be available
in dbGaP. This supplement will increase utilization of the resource by making well-annotated data available to
a wider range of scientists, accelerate scientific discovery and increase opportunities for collaboration to
provide new clues to cancer etiology, determine risk factors, and improve cancer survivorship.
Publications
None. See parent grant details.