Skip to main content
Grant Details

Grant Number: 5R01CA186251-05 Interpret this number
Primary Investigator: Kiecolt-Glaser, Janice
Organization: Ohio State University
Project Title: Aerobic Capacity, Depression, & Inflammatory Responsivity in Cancer Survivors
Fiscal Year: 2019
Back to top


Abstract

? DESCRIPTION (provided by applicant): Cancer survivors' cardiorespiratory fitness often declines substantially during and following cancer treatment, and this pattern is alarming because inflammation is higher in sedentary than in active individuals. Indeed, when cardiorespiratory fitness is assessed objectively by maximal exercise testing, poorer physical fitness (VO2peak) is associated with higher inflammation. Chronic elevations in inflammation increase the risk for age- related diseases; the ability to limit initial inflammatory responses isan important homeostatic process. An immune challenge provides a useful paradigm for studying individual differences in inflammatory responses to infection or tissue injury. Accordingly, this project will use a typhoid vaccine as a peripheral immune stimulus to assess the magnitude and kinetics of a transient inflammatory response in breast cancer survivors. Inflammation-associated behavioral changes that have particular importance for breast cancer survivors will also be assessed--depressive symptoms, fatigue, pain, and cognitive problems. Our study addresses a novel question: does poorer cardiorespiratory fitness heighten the magnitude and duration of inflammatory responses to immune challenges, as well as magnifying maladaptive behavioral responses? Furthermore, biological and behavioral vulnerabilities intensify adverse responses to immune challenges. For example, both aging and depression enhance and prolong inflammatory responses to vaccines, and thus the ability of cardiorespiratory fitness to moderate age- and depression-related proinflammatory responses will also be assessed. This double-blind, randomized, crossover trial will evaluate inflammatory and behavioral responses to typhoid and placebo inoculations as a function of cardiorespiratory fitness, age, and depression in breast cancer survivors. The aims of the project are (1) to evaluate the relationships between cardiorespiratory fitness and inflammatory and behavioral responses (negative mood, fatigue, pain, and cognitive problems) to typhoid vaccine; (2) to determine the effects of age and depressive symptoms on inflammatory and behavioral responses to typhoid vaccine and placebo; and (3) to assess the ability of cardiorespiratory fitness to moderate age- and depression-related responses to typhoid vaccine. These questions are important because inflammation, a robust and reliable predictor of all-cause mortality in older adults, is one of the key candidate mechanisms for age-related decrements in physical function and disability. Individuals frequently encounter immune challenges in daily life, and the ability to minimize inflammatory responsiveness influences the total burden that infectious challenges or tissue injury place on an individual. Larger, more frequent, or more persistent inflammatory changes have negative consequences for health. If better cardiorespiratory fitness dampens or limits inflammatory responsiveness, then this study could demonstrate a new and novel mechanism through which regular exercise produces its substantial health benefits.

Back to top


Publications

Marriage and Gut (Microbiome) Feelings: Tracing Novel Dyadic Pathways to Accelerated Aging.
Authors: Kiecolt-Glaser J.K. , Wilson S.J. , Madison A. .
Source: Psychosomatic medicine, 2018-10-10; , .
EPub date: 2018-10-10.
PMID: 30308579
Related Citations

Caregiver Vulnerability and Brain Structural Markers: Compounding Risk.
Authors: Kiecolt-Glaser J.K. , Wilson S.J. .
Source: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2017 06; 25(6), p. 592-594.
EPub date: 2017-02-28.
PMID: 28320582
Related Citations

Lovesick: How Couples' Relationships Influence Health.
Authors: Kiecolt-Glaser J.K. , Wilson S.J. .
Source: Annual review of clinical psychology, 2017-05-08; 13, p. 421-443.
EPub date: 2017-03-16.
PMID: 28301763
Related Citations

Psychiatric Disorders, Morbidity, and Mortality: Tracing Mechanistic Pathways to Accelerated Aging.
Authors: Kiecolt-Glaser J.K. , Wilson S.J. .
Source: Psychosomatic medicine, 2016 09; 78(7), p. 772-5.
PMID: 27428860
Related Citations

Erythrocyte linoleic acid, but not oleic acid, is associated with improvements in body composition in men and women.
Authors: Belury M.A. , Cole R.M. , Bailey B.E. , Ke J.Y. , Andridge R.R. , Kiecolt-Glaser J.K. .
Source: Molecular nutrition & food research, 2016 05; 60(5), p. 1206-12.
EPub date: 2016-03-22.
PMID: 26923704
Related Citations

Inflammation: depression fans the flames and feasts on the heat.
Authors: Kiecolt-Glaser J.K. , Derry H.M. , Fagundes C.P. .
Source: The American journal of psychiatry, 2015-11-01; 172(11), p. 1075-91.
EPub date: 2015-09-11.
PMID: 26357876
Related Citations

Sex Differences in Depression: Does Inflammation Play a Role?
Authors: Derry H.M. , Padin A.C. , Kuo J.L. , Hughes S. , Kiecolt-Glaser J.K. .
Source: Current psychiatry reports, 2015 Oct; 17(10), p. 78.
PMID: 26272539
Related Citations




Back to Top