Skip to main content
Grant Details

Grant Number: 5R01CA212517-03 Interpret this number
Primary Investigator: Mccabe, Sean
Organization: University Of Michigan At Ann Arbor
Project Title: Health, Stress, and Tobacco Use Disparities Among Sexual Minority Populations
Fiscal Year: 2019
Back to top


PROJECT SUMMARY/ABSTRACT In response to PA-15-261: The Health of Sexual and Gender Minority Populations, this project “Health, Stress, and Tobacco Use Disparities among Sexual Minority Populations” proposes to use an existing nationally representative dataset to assess the relationships among sexual orientation, discrimination, stress, tobacco/nicotine use behaviors, and DSM-5 tobacco use disorder in the U.S. Tobacco use remains the leading preventable cause of death; cigarette smoking is responsible for more than 480,000 deaths per year in the U.S. Past research has generally found sexual minorities are at heightened risk for cigarette smoking and other tobacco/nicotine use. However, many of these studies are plagued by methodological limitations including small, non-representative samples, lack of heterosexual comparison groups and/or limited sexual orientation measures. To date, no nationally representative studies have examined the DSM-5 tobacco use disorder disparities among sexual minorities and few data exists on severity, comorbidity, disability, help seeking, and recovery associated with DSM-5 tobacco use disorder among sexual minorities. Thus, we propose to build on our prior work and conduct secondary analyses of the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC-III), a nationally representative survey of 36,309 U.S. adults 18 years and older in the U.S. The NESARC-III study represents the only nationally representative study that has sufficient measures and sample size to test for potential age, gender, racial/ethnic, and socioeconomic status differences and to meet the objectives of our study, which aims to: (1) examine the prevalence of (a) cigarette smoking, e-cigarette use, and other tobacco/nicotine use, (b) DSM-5 tobacco use disorder severity (includes tobacco and/or nicotine products), and (c) comorbidity of DSM-5 tobacco use disorder and mental health disorders based on major dimensions of sexual orientation (attraction, behavior, and identity); (2) assess the disability (e.g., general health, physical functioning, and social functioning), help seeking (e.g., counseling, nicotine replacement therapy, and medication), and recovery (e.g., early and sustained remission) associated with tobacco/nicotine use and DSM-5 tobacco use disorder based on sexual orientation; and (3) determine the relationships among stressful events, sexual orientation discrimination (individual-level and institutional-level), tobacco/nicotine use and DSM-5 tobacco use disorder based on the Comprehensive Developmental and Minority Stress Model. This project will take advantage of the unique opportunities afforded by the 2012-2013 NESARC-III: the availability of an ethnically / racially diverse sample with large numbers of sexual minorities; the inclusion of multiple measures of sexual orientation based on attraction, behavior and identity; and the wealth of data on cigarette smoking, other tobacco/nicotine use, DSM-5 tobacco use disorder, and DSM-5 mental health disorders. Measures of stressful life events and sexual orientation discrimination will enable assessment of two of the major factors presumed to account for health disparities among sexual minorities.

Back to top


Functional and structural social support, substance use and sexual orientation from a nationally representative sample of US adults.
Authors: Kahle E.M. , Veliz P. , McCabe S.E. , Boyd C.J. .
Source: Addiction (Abingdon, England), 2020 03; 115(3), p. 546-558.
EPub date: 2019-12-26.
PMID: 31599027
Related Citations

Severity of DSM-5 cannabis use disorders in a nationally representative sample of sexual minorities.
Authors: Boyd C.J. , Veliz P.T. , McCabe S.E. .
Source: Substance abuse, 2020; 41(2), p. 191-195.
EPub date: 2019-10-22.
PMID: 31638867
Related Citations

Association of early onset of cannabis, cigarette, other drug use and schizophrenia or psychosis.
Authors: Ryan J.E. , Veliz P. , McCabe S.E. , Stoddard S.A. , Boyd C.J. .
Source: Schizophrenia research, 2020 01; 215, p. 482-484.
EPub date: 2019-10-15.
PMID: 31623965
Related Citations

Associations between sexual orientation discrimination and substance use disorders: differences by age in US adults.
Authors: Evans-Polce R.J. , Veliz P.T. , Boyd C.J. , Hughes T.L. , McCabe S.E. .
Source: Social psychiatry and psychiatric epidemiology, 2020 Jan; 55(1), p. 101-110.
EPub date: 2019-03-22.
PMID: 30903234
Related Citations

Prescription Opioid Misuse in US Older Adults: Associated Comorbidities and Reduced Quality of Life in the National Epidemiologic Survey of Alcohol and Related Conditions-III.
Authors: Schepis T.S. , McCabe S.E. .
Source: The Journal of clinical psychiatry, 2019-11-19; 80(6), .
EPub date: 2019-11-19.
PMID: 31747489
Related Citations

Initiation Sequence of E-Cigarette and Cigarette Smoking among US Adolescents: A National Study.
Authors: McCabe S.E. , Veliz P. , McCabe V.V. , Boyd C.J. .
Source: The American journal on addictions, 2019 07; 28(4), p. 285-294.
EPub date: 2019-04-16.
PMID: 30993786
Related Citations

LDCT lung cancer screening eligibility and use of CT scans for lung cancer among sexual minorities.
Authors: Veliz P. , Matthews A.K. , Arslanian-Engoren C. , Evans-Polce R.J. , Lee J.G.L. , Boyd C.J. , Hughes T. , McCabe V.V. , McCabe S.E. .
Source: Cancer epidemiology, 2019 06; 60, p. 51-54.
EPub date: 2019-03-23.
PMID: 30909153
Related Citations

DSM-5 substance use disorders among college-age young adults in the United States: Prevalence, remission and treatment.
Authors: Arterberry B.J. , Boyd C.J. , West B.T. , Schepis T.S. , McCabe S.E. .
Source: Journal of American college health : J of ACH, 2019-04-04; , p. 1-8.
EPub date: 2019-04-04.
PMID: 30946626
Related Citations

Sexual Orientation Discrimination and Tobacco Use Disparities in the United States.
Authors: McCabe S.E. , Hughes T.L. , Matthews A.K. , Lee J.G.L. , West B.T. , Boyd C.J. , Arslanian-Engoren C. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2019-03-30; 21(4), p. 523-531.
PMID: 29300994
Related Citations

Severity of Alcohol, Tobacco, and Drug Use Disorders Among Sexual Minority Individuals and Their "Not Sure" Counterparts.
Authors: Boyd C.J. , Veliz P.T. , Stephenson R. , Hughes T.L. , McCabe S.E. .
Source: LGBT health, 2019 Jan; 6(1), p. 15-22.
EPub date: 2019-01-14.
PMID: 30638419
Related Citations

Prescription opioid and benzodiazepine misuse is associated with suicidal ideation in older adults.
Authors: Schepis T.S. , Simoni-Wastila L. , McCabe S.E. .
Source: International journal of geriatric psychiatry, 2019 01; 34(1), p. 122-129.
EPub date: 2018-10-16.
PMID: 30328160
Related Citations

Persistence/recurrence of and remission from DSM-5 substance use disorders in the United States: Substance-specific and substance-aggregated correlates.
Authors: McCabe S.E. , West B.T. , Strobbe S. , Boyd C.J. .
Source: Journal of substance abuse treatment, 2018 10; 93, p. 38-48.
EPub date: 2018-07-25.
PMID: 30126540
Related Citations

Differences in smoking prevalence and eligibility for low-dose computed tomography (LDCT) lung cancer screening among older U.S. adults: role of sexual orientation.
Authors: Matthews A.K. , McCabe S.E. , Lee J.G.L. , Veliz P. .
Source: Cancer causes & control : CCC, 2018 08; 29(8), p. 769-774.
EPub date: 2018-06-15.
PMID: 29948516
Related Citations

Associations Between Early Onset of E-cigarette Use and Cigarette Smoking and Other Substance Use Among US Adolescents: A National Study.
Authors: McCabe S.E. , West B.T. , McCabe V.V. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2018-07-09; 20(8), p. 923-930.
PMID: 29986103
Related Citations

Tobacco Use and Sexual Orientation in a National Cross-sectional Study: Age, Race/Ethnicity, and Sexual Identity-Attraction Differences.
Authors: McCabe S.E. , Matthews A.K. , Lee J.G.L. , Veliz P. , Hughes T.L. , Boyd C.J. .
Source: American journal of preventive medicine, 2018 06; 54(6), p. 736-745.
EPub date: 2018-04-12.
PMID: 29656916
Related Citations

Smoking behaviors and intentions among current e-cigarette users, cigarette smokers, and dual users: A national survey of U.S. high school seniors.
Authors: McCabe S.E. , Veliz P. , McCabe V.V. , Boyd C.J. .
Source: Preventive medicine, 2017 Jun; 99, p. 228-235.
EPub date: 2017-03-01.
PMID: 28257785
Related Citations

Back to Top