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Grant Details

Grant Number: 5U01CA206110-03 Interpret this number
Primary Investigator: Ulrich, Cornelia
Organization: University Of Utah
Project Title: Transdisciplinary Team Science in Colorectal Cancer Prognosis: the Colocare Study
Fiscal Year: 2018
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Abstract

? DESCRIPTION (provided by applicant): Colorectal cancer will affect one in 20 individuals over the course of their lifetime. The ColoCare Study is a prospective cohort of men and women newly diagnosed with a first primary invasive colorectal cancer (stage I-IV) with repeat data and biospecimen collection beginning prior to surgery. The ColoCare Study was initiated at the Fred Hutchinson Cancer Research Center with subsequent consortium sites at the Moffitt Cancer Center, the German Cancer Research Center, and Huntsman Cancer Institute with institutional pilot/start-up funding to support patient recruitment. The goal of this study is to uniformly collet comprehensive sets of data and biospecimens from over 4000 multiethnic colorectal cancer patients at multiple time points (prior to surgery and 3, 6, 12, 24, 36, 48 and 60 months post-surgery), including detailed treatment and risk factor data, fresh and fixed tumor and normal tissue, visceral adipose tissue, blood, stool, urine, saliva, and quantitative accelerometry data t assess physical activity. Each ColoCare Study site leverages existing infrastructure, including access to electronic medical records and NCI comprehensive/designated cancer center cores, while utilizing well-established protocols for recruitment, data collection, and biospecimen ascertainment that are consistently applied across all sites. Patients are followed up both actively and passively by study staff (in-person and through medical record reviews), as well as via linkages to cancer registry and vital status records. Currently, using pilot/institutional fund at four existing sites, we have recruited >1100 patients (n=1010 baseline bloods). With this infrastructure grant, we propose 1) to extend the ColoCare consortium to two new study centers that will enrich our numbers of underrepresented minority participants (University of Southern California, LA, and Washington University School of Medicine, St. Louis) and 2) to continue and expand study procedures at all US sites, including energy balance assessments and molecular characterization of tumors. The support for expanded enrollment and continued follow-up of the ColoCare cohort will result in an estimated 4167 highly characterized enrollees. The repeat sampling of data and a diverse set of accompanying biospecimens at critical time points enables unprecedented epidemiologic and biomarker research that can inform clinical decision making and support evidence-based guidelines regarding lifestyle changes that impact outcomes. Additionally, we will establish an external advisory board and a community/participant advisory board to further guide infrastructure development and prioritize research use of this cohort. We will continue to participate in national and international consorti by contributing data and biospecimens. Support for this unique cohort of colorectal cancer patients will create a valuable resource for the broader research community. In-depth, repeated phenotyping within a single cohort will enable one-of-a-kind studies focused on the effects of health behaviors on prognosis, as well as the discovery of new biomarkers of clinically important outcomes.

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Publications

Body fatness, adipose tissue compartments and biomarkers of inflammation and angiogenesis in colorectal cancer: the ColoCare Study.
Authors: Himbert C. , Ose J. , Nattenmüller J. , Warby C.A. , Holowatyj A.N. , Böhm J. , Lin T. , Haffa M. , Gigic B. , Hardikar S. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2018-10-17 00:00:00.0; , .
EPub date: 2018-10-17 00:00:00.0.
PMID: 30333223
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Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer.
Authors: Neumeyer S. , Banbury B.L. , Arndt V. , Berndt S.I. , Bezieau S. , Bien S.A. , Buchanan D.D. , Butterbach K. , Caan B.J. , Campbell P.T. , et al. .
Source: British Journal Of Cancer, 2018 Jun; 118(12), p. 1639-1647.
EPub date: 2018-05-24 00:00:00.0.
PMID: 29795306
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Administration of adjuvant chemotherapy for stage II-III colon cancer patients: An European population-based study.
Authors: Babaei M. , Balavarca Y. , Jansen L. , Lemmens V. , van Erning F.N. , van Eycken L. , Vaes E. , Sjövall A. , Glimelius B. , Ulrich C.M. , et al. .
Source: International Journal Of Cancer, 2018-04-01 00:00:00.0; 142(7), p. 1480-1489.
EPub date: 2017-12-04 00:00:00.0.
PMID: 29159866
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Neoadjuvant Therapy in Rectal Cancer Patients With Clinical Stage II to III Across European Countries: Variations and Outcomes.
Authors: Babaei M. , Jansen L. , Balavarca Y. , Sjövall A. , Bos A. , van de Velde T. , Moreau M. , Liberale G. , Gonçalves A.F. , Bento M.J. , et al. .
Source: Clinical Colorectal Cancer, 2018 Mar; 17(1), p. e129-e142.
EPub date: 2017-09-28 00:00:00.0.
PMID: 29074354
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Associations of branched-chain amino acids with parameters of energy balance and survival in colorectal cancer patients: Results from the ColoCare Study.
Authors: Delphan M. , Lin T. , Liesenfeld D.B. , Nattenmüller J. , Böhm J.T. , Gigic B. , Habermann N. , Zielske L. , Schrotz-King P. , Schneider M. , et al. .
Source: Metabolomics : Official Journal Of The Metabolomic Society, 2018 Mar; 2018(14), .
EPub date: 2018-01-31 00:00:00.0.
PMID: 29706852
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Associations Between Dietary Patterns and Longitudinal Quality of Life Changes in Colorectal Cancer Patients: The ColoCare Study.
Authors: Gigic B. , Boeing H. , Toth R. , Böhm J. , Habermann N. , Scherer D. , Schrotz-King P. , Abbenhardt-Martin C. , Skender S. , Brenner H. , et al. .
Source: Nutrition And Cancer, 2018 Jan; 70(1), p. 51-60.
EPub date: 2017-12-15 00:00:00.0.
PMID: 29244538
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Dynamic plasma microRNAs are biomarkers for prognosis and early detection of recurrence in colorectal cancer.
Authors: Yuan Z. , Baker K. , Redman M.W. , Wang L. , Adams S.V. , Yu M. , Dickinson B. , Makar K. , Ulrich N. , Böhm J. , et al. .
Source: British Journal Of Cancer, 2017-10-10 00:00:00.0; 117(8), p. 1202-1210.
EPub date: 2017-08-15 00:00:00.0.
PMID: 28809863
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Signals from the Adipose Microenvironment and the Obesity-Cancer Link-A Systematic Review.
Authors: Himbert C. , Delphan M. , Scherer D. , Bowers L.W. , Hursting S. , Ulrich C.M. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2017 Sep; 10(9), p. 494-506.
PMID: 28864539
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Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study.
Authors: Barrow T.M. , Klett H. , Toth R. , Böhm J. , Gigic B. , Habermann N. , Scherer D. , Schrotz-King P. , Skender S. , Abbenhardt-Martin C. , et al. .
Source: The Journal Of Pathology, 2017-08-09 00:00:00.0; , .
EPub date: 2017-08-09 00:00:00.0.
PMID: 28791728
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Quantitative Assessment of Visceral Obesity and Postoperative Colon Cancer Outcomes.
Authors: Ozoya O.O. , Siegel E.M. , Srikumar T. , Bloomer A.M. , DeRenzis A. , Shibata D. .
Source: Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract, 2017 Mar; 21(3), p. 534-542.
EPub date: 2017-01-18 00:00:00.0.
PMID: 28101721
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Plasma 25-Hydroxyvitamin D3 Levels in Colorectal Cancer Patients and Associations with Physical Activity.
Authors: Skender S. , Böhm J. , Schrotz-King P. , Chang-Claude J. , Siegel E.M. , Steindorf K. , Owen R.W. , Ose J. , Hoffmeister M. , Brenner H. , et al. .
Source: Nutrition And Cancer, 2017 Feb-Mar; 69(2), p. 229-237.
EPub date: 2017-01-17 00:00:00.0.
PMID: 28094599
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A systematic review of the interrelation between diet- and surgery-induced weight loss and vitamin D status.
Authors: Himbert C. , Ose J. , Delphan M. , Ulrich C.M. .
Source: Nutrition Research (new York, N.y.), 2017 Feb; 38, p. 13-26.
EPub date: 2016-12-08 00:00:00.0.
PMID: 28381350
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CT-based compartmental quantification of adipose tissue versus body metrics in colorectal cancer patients.
Authors: Nattenmueller J. , Hoegenauer H. , Boehm J. , Scherer D. , Paskow M. , Gigic B. , Schrotz-King P. , Grenacher L. , Ulrich C. , Kauczor H.U. .
Source: European Radiology, 2016 Nov; 26(11), p. 4131-4140.
EPub date: 2016-02-06 00:00:00.0.
PMID: 26852215
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Discovery Of Novel Plasma Proteins As Biomarkers For The Development Of Incisional Hernias After Midline Incision In Patients With Colorectal Cancer: The Colocare Study
Authors: Böhm J. , Pianka F. , Stüttgen N. , Rho J. , Gigic B. , Zhang Y. , Habermann N. , Schrotz-King P. , Abbenhardt-Martin C. , Zielske L. , et al. .
Source: Surgery, 2016-10-13 00:00:00.0; , .
PMID: 27745870
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Genome-wide Interaction Analyses Between Genetic Variants And Alcohol Consumption And Smoking For Risk Of Colorectal Cancer
Authors: Gong J. , Hutter C.M. , Newcomb P.A. , Ulrich C.M. , Bien S.A. , Campbell P.T. , Baron J.A. , Berndt S.I. , Bezieau S. , Brenner H. , et al. .
Source: Plos Genetics, 2016 Oct; 12(10), p. e1006296.
PMID: 27723779
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Accelerometry and physical activity questionnaires - a systematic review.
Authors: Skender S. , Ose J. , Chang-Claude J. , Paskow M. , Brühmann B. , Siegel E.M. , Steindorf K. , Ulrich C.M. .
Source: Bmc Public Health, 2016-06-16 00:00:00.0; 16, p. 515.
EPub date: 2016-06-16 00:00:00.0.
PMID: 27306667
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Cyp24a1 Variant Modifies The Association Between Use Of Oestrogen Plus Progestogen Therapy And Colorectal Cancer Risk
Authors: Garcia-Albeniz X. , Rudolph A. , Hutter C. , White E. , Lin Y. , Rosse S.A. , Figueiredo J.C. , Harrison T.A. , Jiao S. , Brenner H. , et al. .
Source: British Journal Of Cancer, 2016-01-19 00:00:00.0; 114(2), p. 221-9.
PMID: 26766742
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Metabolomics and transcriptomics identify pathway differences between visceral and subcutaneous adipose tissue in colorectal cancer patients: the ColoCare study.
Authors: Liesenfeld D.B. , Grapov D. , Fahrmann J.F. , Salou M. , Scherer D. , Toth R. , Habermann N. , Böhm J. , Schrotz-King P. , Gigic B. , et al. .
Source: The American Journal Of Clinical Nutrition, 2015 Aug; 102(2), p. 433-43.
EPub date: 2015-07-08 00:00:00.0.
PMID: 26156741
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Changes in urinary metabolic profiles of colorectal cancer patients enrolled in a prospective cohort study (ColoCare).
Authors: Liesenfeld D.B. , Habermann N. , Toth R. , Owen R.W. , Frei E. , Staffa J. , Schrotz-King P. , Klika K.D. , Ulrich C.M. .
Source: Metabolomics : Open Access, 2015 Aug; 11(4), p. 998-1012.
EPub date: 2014-12-20 00:00:00.0.
PMID: 29250455
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Repeat physical activity measurement by accelerometry among colorectal cancer patients--feasibility and minimal number of days of monitoring.
Authors: Skender S. , Schrotz-King P. , Böhm J. , Abbenhardt C. , Gigic B. , Chang-Claude J. , Siegel E.M. , Steindorf K. , Ulrich C.M. .
Source: Bmc Research Notes, 2015-06-06 00:00:00.0; 8, p. 222.
EPub date: 2015-06-06 00:00:00.0.
PMID: 26048683
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MethyLight droplet digital PCR for detection and absolute quantification of infrequently methylated alleles.
Authors: Yu M. , Carter K.T. , Makar K.W. , Vickers K. , Ulrich C.M. , Schoen R.E. , Brenner D. , Markowitz S.D. , Grady W.M. .
Source: Epigenetics, 2015; 10(9), p. 803-9.
PMID: 26186366
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Suitability of circulating miRNAs as potential prognostic markers in colorectal cancer.
Authors: Ristau J. , Staffa J. , Schrotz-King P. , Gigic B. , Makar K.W. , Hoffmeister M. , Brenner H. , Ulrich A. , Schneider M. , Ulrich C.M. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2014 Dec; 23(12), p. 2632-7.
PMID: 25472670
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Potential of fecal microbiota for early-stage detection of colorectal cancer.
Authors: Zeller G. , Tap J. , Voigt A.Y. , Sunagawa S. , Kultima J.R. , Costea P.I. , Amiot A. , Böhm J. , Brunetti F. , Habermann N. , et al. .
Source: Molecular Systems Biology, 2014-11-28 00:00:00.0; 10, p. 766.
EPub date: 2014-11-28 00:00:00.0.
PMID: 25432777
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Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer.
Authors: Luo Y. , Wong C.J. , Kaz A.M. , Dzieciatkowski S. , Carter K.T. , Morris S.M. , Wang J. , Willis J.E. , Makar K.W. , Ulrich C.M. , et al. .
Source: Gastroenterology, 2014 Aug; 147(2), p. 418-29.e8.
PMID: 24793120
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Tumor-infiltrating lymphocytes in colorectal tumors display a diversity of T cell receptor sequences that differ from the T cells in adjacent mucosal tissue.
Authors: Sherwood A.M. , Emerson R.O. , Scherer D. , Habermann N. , Buck K. , Staffa J. , Desmarais C. , Halama N. , Jaeger D. , Schirmacher P. , et al. .
Source: Cancer Immunology, Immunotherapy : Cii, 2013 Sep; 62(9), p. 1453-61.
EPub date: 2013-06-16 00:00:00.0.
PMID: 23771160
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Quantitative measures of visceral adiposity and body mass index in predicting rectal cancer outcomes after neoadjuvant chemoradiation.
Authors: Clark W. , Siegel E.M. , Chen Y.A. , Zhao X. , Parsons C.M. , Hernandez J.M. , Weber J. , Thareja S. , Choi J. , Shibata D. .
Source: Journal Of The American College Of Surgeons, 2013 Jun; 216(6), p. 1070-81.
EPub date: 2013-03-21 00:00:00.0.
PMID: 23523147
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Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients: a pilot study.
Authors: Ulrich C.M. , Toriola A.T. , Siegel E.M. , Brenner H. , Chang-Claude J. , Abbenhardt C. , Kotzmann J. , Song X. , Owen R.W. , Hoffmeister M. , et al. .
Source: Journal Of Nutritional Science, 2013; 2, p. e9.
EPub date: 2013-04-09 00:00:00.0.
PMID: 25191595
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High Accumulation of Metformin in Colonic Tissue of Subjects With Diabetes or the Metabolic Syndrome.
Authors: Paleari L. , Burhenne J. , Weiss J. , Foersch S. , Roth W. , Parodi A. , Gnant M. , Bachleitner-Hofmann T. , Scherer D. , Ulrich C.M. , et al. .
Source: Gastroenterology, 2018 04; 154(5), p. 1543-1545.
EPub date: 2018-03-08 00:00:00.0.
PMID: 29526732
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