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Grant Details

Grant Number: 5U24DA041147-05 Interpret this number
Primary Investigator: Jernigan, Terry
Organization: University Of California, San Diego
Project Title: Abcd-Usa Consortium: Coordinating Center
Fiscal Year: 2019
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Abstract

DESCRIPTION (provided by applicant): The ABCD-USA Consortium proposes a study designed to permit our investigators and the scientific community to answer important questions about the effects of substance use (SU) on behavioral and brain development of adolescents. We have assembled a team of investigators with unparalleled research experience with youth, and specific expertise in adolescent SU, child and adolescent development, developmental psychopathology, longitudinal multi-site imaging, developmental neuroimaging and cognitive neuroscience, genetics and imaging genetics, bioassays, epidemiology, survey research, bioinformatics, and mobile assessment technologies. We propose a nationwide study of 10,000 9-10 year olds conducted at 21 sites organized into 11 hubs (29% of the US population lives within 50 miles of our geographically spread sites), that, uniquely, can provide a nationally representative sample and a large twin sample that together can help distinguish environmental, sociocultural, and genetic factors relevant to SU and brain development. We ensure cohesion and standardization with a recruitment strategy designed by a professional survey company (experience with Monitoring the Future); standardized environmental, neurocognitive and mental health assessments, MRI assessments with scanners using harmonized Human Connectome Project procedures, and computerized data collection with real-time quality control. Developmentally tailored assessments will have stable sensitivity and construct validity across childhood and adolescence, minimize participant burden, capture even subtle changes in SU, mental health, neurocognition, development, and environment, and employ novel bioassays and passive data collection from mobile devices. The retention plan builds on the experience of our investigators to ensure success. This application describes the ABCD-USA Coordinating Center (CC) which will: provide overall administrative and logistical support and scientific integration fr the consortium; establish and implement procedures for core protocols, participant recruitment and retention, and data quality control; provide initial and ongoing training of personnel for standardization; monitor cohort attributes, recruiting and retention practices, data quality, and consortium-wide consistency in real time, and monitor progress toward benchmarks and timelines. CC will ensure adherence to ethical standards and cultural sensitivity of research, and establish and implement policies for dispute resolution, internal and external data sharing, and publication. CC organizes and provides logistical support for meetings and teleconferences of the consortium, steering committee, scientific advisory board and workgroups as well as for educational, scientific, outreach, and dissemination events. By design, CC processes are flexible for problem resolution and incorporation of emerging scientific opportunities. We provide transparent study updates to the public via the web, and a well-managed and fully annotated repository of data for timely sharing. Importantly, we provide training and mentoring to developing scientists in the drug abuse area.

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Publications

Stress exposures, neurodevelopment and health measures in the ABCD study.
Authors: Hoffman E.A. , Clark D.B. , Orendain N. , Hudziak J. , Squeglia L.M. , Dowling G.J. .
Source: Neurobiology of stress, 2019 Feb; 10, p. 100157.
EPub date: 2019-03-19.
PMID: 30949565
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Involvement in Sports, Hippocampal Volume, and Depressive Symptoms in Children.
Authors: Gorham L.S. , Jernigan T. , Hudziak J. , Barch D.M. .
Source: Biological psychiatry. Cognitive neuroscience and neuroimaging, 2019 05; 4(5), p. 484-492.
EPub date: 2019-02-04.
PMID: 30905689
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Resting-State Functional Connectivity and Psychotic-like Experiences in Childhood: Results From the Adolescent Brain Cognitive Development Study.
Authors: Karcher N.R. , O'Brien K.J. , Kandala S. , Barch D.M. .
Source: Biological psychiatry, 2019-07-01; 86(1), p. 7-15.
EPub date: 2019-01-26.
PMID: 30850130
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Sexual minority children: Mood disorders and suicidality disparities.
Authors: Blashill A.J. , Calzo J.P. .
Source: Journal of affective disorders, 2019-03-01; 246, p. 96-98.
EPub date: 2018-12-17.
PMID: 30578952
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Screen media activity and brain structure in youth: Evidence for diverse structural correlation networks from the ABCD study.
Authors: Paulus M.P. , Squeglia L.M. , Bagot K. , Jacobus J. , Kuplicki R. , Breslin F.J. , Bodurka J. , Morris A.S. , Thompson W.K. , Bartsch H. , et al. .
Source: NeuroImage, 2019-01-15; 185, p. 140-153.
EPub date: 2018-10-16.
PMID: 30339913
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Associations between 24 hour movement behaviours and global cognition in US children: a cross-sectional observational study.
Authors: Walsh J.J. , Barnes J.D. , Cameron J.D. , Goldfield G.S. , Chaput J.P. , Gunnell K.E. , Ledoux A.A. , Zemek R.L. , Tremblay M.S. .
Source: The Lancet. Child & adolescent health, 2018 11; 2(11), p. 783-791.
EPub date: 2018-09-27.
PMID: 30268792
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Assessment of the Prodromal Questionnaire-Brief Child Version for Measurement of Self-reported Psychoticlike Experiences in Childhood.
Authors: Karcher N.R. , Barch D.M. , Avenevoli S. , Savill M. , Huber R.S. , Simon T.J. , Leckliter I.N. , Sher K.J. , Loewy R.L. .
Source: JAMA psychiatry, 2018-08-01; 75(8), p. 853-861.
PMID: 29874361
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A description of the ABCD organizational structure and communication framework.
Authors: Auchter A.M. , Hernandez Mejia M. , Heyser C.J. , Shilling P.D. , Jernigan T.L. , Brown S.A. , Tapert S.F. , Dowling G.J. .
Source: Developmental cognitive neuroscience, 2018 08; 32, p. 8-15.
EPub date: 2018-04-16.
PMID: 29706313
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Assessment of culture and environment in the Adolescent Brain and Cognitive Development Study: Rationale, description of measures, and early data.
Authors: Zucker R.A. , Gonzalez R. , Feldstein Ewing S.W. , Paulus M.P. , Arroyo J. , Fuligni A. , Morris A.S. , Sanchez M. , Wills T. .
Source: Developmental cognitive neuroscience, 2018 08; 32, p. 107-120.
EPub date: 2018-03-17.
PMID: 29627333
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The Adolescent Brain Cognitive Development (ABCD) study: Imaging acquisition across 21 sites.
Authors: Casey B.J. , Cannonier T. , Conley M.I. , Cohen A.O. , Barch D.M. , Heitzeg M.M. , Soules M.E. , Teslovich T. , Dellarco D.V. , Garavan H. , et al. .
Source: Developmental cognitive neuroscience, 2018 08; 32, p. 43-54.
EPub date: 2018-03-14.
PMID: 29567376
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Adolescent brain cognitive development (ABCD) study: Overview of substance use assessment methods.
Authors: Lisdahl K.M. , Sher K.J. , Conway K.P. , Gonzalez R. , Feldstein Ewing S.W. , Nixon S.J. , Tapert S. , Bartsch H. , Goldstein R.Z. , Heitzeg M. .
Source: Developmental cognitive neuroscience, 2018 08; 32, p. 80-96.
EPub date: 2018-02-21.
PMID: 29559216
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Demographic, physical and mental health assessments in the adolescent brain and cognitive development study: Rationale and description.
Authors: Barch D.M. , Albaugh M.D. , Avenevoli S. , Chang L. , Clark D.B. , Glantz M.D. , Hudziak J.J. , Jernigan T.L. , Tapert S.F. , Yurgelun-Todd D. , et al. .
Source: Developmental cognitive neuroscience, 2018 08; 32, p. 55-66.
EPub date: 2017-11-03.
PMID: 29113758
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Biomedical ethics and clinical oversight in multisite observational neuroimaging studies with children and adolescents: The ABCD experience.
Authors: Clark D.B. , Fisher C.B. , Bookheimer S. , Brown S.A. , Evans J.H. , Hopfer C. , Hudziak J. , Montoya I. , Murray M. , Pfefferbaum A. , et al. .
Source: Developmental cognitive neuroscience, 2018 Aug; 32, p. 143-154.
EPub date: 2017-06-28.
PMID: 28716389
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Ethanol's effects on auditory thresholds and reaction times during the acquisition of chronic ethanol self-administration in baboons.
Authors: Hienz R.D. , Brady J.V. , Bowers D.A. , Ator N.A. .
Source: Drug and alcohol dependence, 1989 Dec; 24(3), p. 213-25.
PMID: 2605997
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