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Grant Details

Grant Number: 5R01CA118553-10 Interpret this number
Primary Investigator: Fuchs, Charles
Organization: Yale University
Project Title: Dietary and Lifestyle Determinants of Colon Cancer Recurrence and Survival
Fiscal Year: 2019
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Abstract

DESCRIPTION (provided by applicant): Epidemiologic and scientific research indicates that diet and other lifestyle factors have a significant influence on the risk of developing colon cancer. However, the influence of diet and lifestyle factors on the outcome of patients with established colon cancer is virtually unknown. Randomized clinical trials demonstrate a significant survival advantage for individuals with stage III colon cancer who receive adjuvant fluorouracil- based chemotherapy. Nonetheless, 40-45% of stage III patients receiving current adjuvant chemotherapy will develop metastases. Patients often seek to understand what, if any, diet and lifestyle will reduce their chances of cancer recurrence beyond standard surgery and post-operative adjuvant therapy. Moreover, how diet and lifestyle influence prognosis may depend, in part, on molecular characteristics of the tumor. During the previous funding period, we found that relative states of hyperinsulinemia and insulin resistance, including a history of type 2 diabetes, obesity, sedentary lifestyle, high intake of a Western pattern diet, high dietary glycemic load, and elevated plasma C-peptide conferred an increased risk of colon cancer recurrence. Additionally, recognizing the intersection of nutrient excess and derangements in cellular and molecular mediators of inflammation, we concurrently found that regular aspirin or selective COX-2 inhibitor use was associated with reduced cancer recurrence and mortality. In this competitive renewal application, (Aim 1) we propose to identify novel dietary and lifestyle risk factors for CRC recurrence and mortality, and, moreover, identify potential mechanisms of action through detailed, hypothesis-based molecular analysis of patient tumors. Additionally, recognizing that energy excess and insulin resistance may alternatively drive cancer recurrence through promotion of inflammation-related pathways, (Aim 2) we will further assess the role of anti- inflammatory medications to abrogate the increased risk of cancer recurrence associated with energy excess. Finally, (Aim 3) we will combine the available data to develop a novel comprehensive dietary risk prediction model for cancer recurrence and mortality, incorporating dietary/lifestyle factors with established clinical- pathologic covariates, and validate the model n 3 independent CRC patient cohorts to provide a more robust risk assessment tool for newly diagnosed CRC patients that can meaningfully inform clinical care and potentially incorporate lifestyle modification into CRC treatment recommendations. Many hypotheses would be interesting on their own, but the most unique strength of this proposal is our ability to assess simultaneously diet, medication, lifestyle factors, and molecular alterations in tumor tissue. Ultimately, we believe the proposed work will advance our understanding of CRC biology, identify interventions that can improve patient survival, and, with the extensive clinical, pathologic, and biomarker data available for analysis, inform clinicians how to maximally utilize these interventions to improve clinical care.

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Publications

Non-alcoholic fatty liver disease and colorectal cancer survival.
Authors: Wu K. , Zhai M.Z. , Weltzien E.K. , Cespedes Feliciano E.M. , Meyerhardt J.A. , Giovannucci E. , Caan B.J. .
Source: Cancer Causes & Control : Ccc, 2018-11-15 00:00:00.0; , .
EPub date: 2018-11-15 00:00:00.0.
PMID: 30443695
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Association of Obesity With Risk of Early-Onset Colorectal Cancer Among Women.
Authors: Liu P.H. , Wu K. , Ng K. , Zauber A.G. , Nguyen L.H. , Song M. , He X. , Fuchs C.S. , Ogino S. , Willett W.C. , et al. .
Source: Jama Oncology, 2018-10-11 00:00:00.0; , .
EPub date: 2018-10-11 00:00:00.0.
PMID: 30326010
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Continuity of transcriptomes among colorectal cancer subtypes based on meta-analysis.
Authors: Ma S. , Ogino S. , Parsana P. , Nishihara R. , Qian Z. , Shen J. , Mima K. , Masugi Y. , Cao Y. , Nowak J.A. , et al. .
Source: Genome Biology, 2018-09-25 00:00:00.0; 19(1), p. 142.
EPub date: 2018-09-25 00:00:00.0.
PMID: 30253799
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Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status.
Authors: Hamada T. , Zhang X. , Mima K. , Bullman S. , Sukawa Y. , Nowak J.A. , Kosumi K. , Masugi Y. , Twombly T.S. , Cao Y. , et al. .
Source: Cancer Immunology Research, 2018-09-18 00:00:00.0; , .
EPub date: 2018-09-18 00:00:00.0.
PMID: 30228205
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Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour.
Authors: Hamada T. , Liu L. , Nowak J.A. , Mima K. , Cao Y. , Ng K. , Twombly T.S. , Song M. , Jung S. , Dou R. , et al. .
Source: European Journal Of Cancer (oxford, England : 1990), 2018-09-12 00:00:00.0; 103, p. 98-107.
EPub date: 2018-09-12 00:00:00.0.
PMID: 30219720
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Associations of pre-existing co-morbidities with skeletal muscle mass and radiodensity in patients with non-metastatic colorectal cancer.
Authors: Xiao J. , Caan B.J. , Weltzien E. , Cespedes Feliciano E.M. , Kroenke C.H. , Meyerhardt J.A. , Baracos V.E. , Kwan M.L. , Castillo A.L. , Prado C.M. .
Source: Journal Of Cachexia, Sarcopenia And Muscle, 2018 Aug; 9(4), p. 654-663.
EPub date: 2018-04-19 00:00:00.0.
PMID: 29675984
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Association of dietary insulinemic potential and colorectal cancer risk in men and women.
Authors: Tabung F.K. , Wang W. , Fung T.T. , Smith-Warner S.A. , Keum N. , Wu K. , Fuchs C.S. , Hu F.B. , Giovannucci E.L. .
Source: The American Journal Of Clinical Nutrition, 2018-08-01 00:00:00.0; 108(2), p. 363-370.
PMID: 29901698
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Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma.
Authors: Ng K. , Hendifar A. , Starodub A. , Chaves J. , Yang Y. , Koh B. , Barbie D. , Hahn W.C. , Fuchs C.S. .
Source: Investigational New Drugs, 2018-07-30 00:00:00.0; , .
EPub date: 2018-07-30 00:00:00.0.
PMID: 30105668
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Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival: CALGB 89803 (Alliance).
Authors: Van Blarigan E.L. , Ou F.S. , Niedzwiecki D. , Zhang S. , Fuchs C.S. , Saltz L. , Mayer R.J. , Venook A. , Ogino S. , Song M. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2018-07-23 00:00:00.0; , .
EPub date: 2018-07-23 00:00:00.0.
PMID: 30038051
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The deterioration of muscle mass and radiodensity is prognostic of poor survival in stage I-III colorectal cancer: a population-based cohort study (C-SCANS).
Authors: Brown J.C. , Caan B.J. , Meyerhardt J.A. , Weltzien E. , Xiao J. , Cespedes Feliciano E.M. , Kroenke C.H. , Castillo A. , Kwan M.L. , Prado C.M. .
Source: Journal Of Cachexia, Sarcopenia And Muscle, 2018-05-15 00:00:00.0; , .
EPub date: 2018-05-15 00:00:00.0.
PMID: 29766660
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Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum.
Authors: Liu L. , Tabung F.K. , Zhang X. , Nowak J.A. , Qian Z.R. , Hamada T. , Nevo D. , Bullman S. , Mima K. , Kosumi K. , et al. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2018-04-24 00:00:00.0; , .
EPub date: 2018-04-24 00:00:00.0.
PMID: 29702299
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Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance).
Authors: Fadelu T. , Zhang S. , Niedzwiecki D. , Ye X. , Saltz L.B. , Mayer R.J. , Mowat R.B. , Whittom R. , Hantel A. , Benson A.B. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2018-04-10 00:00:00.0; 36(11), p. 1112-1120.
EPub date: 2018-02-28 00:00:00.0.
PMID: 29489429
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Marine ?-3 Polyunsaturated Fatty Acid and Fish Intake after Colon Cancer Diagnosis and Survival: CALGB 89803 (Alliance).
Authors: Van Blarigan E.L. , Fuchs C.S. , Niedzwiecki D. , Ye X. , Zhang S. , Song M. , Saltz L.B. , Mayer R.J. , Mowat R.B. , Whittom R. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2018 Apr; 27(4), p. 438-445.
EPub date: 2018-01-22 00:00:00.0.
PMID: 29358223
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Garlic intake and gastric cancer risk: results from two large prospective US cohort studies.
Authors: Kim H. , Keum N. , Giovannucci E.L. , Fuchs C.S. , Bao Y. .
Source: International Journal Of Cancer, 2018-03-23 00:00:00.0; , .
EPub date: 2018-03-23 00:00:00.0.
PMID: 29569711
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Genetic mechanisms of immune evasion in colorectal cancer.
Authors: Grasso C.S. , Giannakis M. , Wells D.K. , Hamada T. , Mu X.J. , Quist M. , Nowak J.A. , Nishihara R. , Qian Z.R. , Inamura K. , et al. .
Source: Cancer Discovery, 2018-03-06 00:00:00.0; , .
EPub date: 2018-03-06 00:00:00.0.
PMID: 29510987
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Psychological symptoms and subsequent healthy lifestyle after a colorectal cancer diagnosis.
Authors: Trudel-Fitzgerald C. , Tworoger S.S. , Poole E.M. , Zhang X. , Giovannucci E.L. , Meyerhardt J.A. , Kubzansky L.D. .
Source: Health Psychology : Official Journal Of The Division Of Health Psychology, American Psychological Association, 2018 Mar; 37(3), p. 207-217.
EPub date: 2017-11-20 00:00:00.0.
PMID: 29154605
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Association of Dietary Inflammatory Potential With Colorectal Cancer Risk in Men and Women.
Authors: Tabung F.K. , Liu L. , Wang W. , Fung T.T. , Wu K. , Smith-Warner S.A. , Cao Y. , Hu F.B. , Ogino S. , Fuchs C.S. , et al. .
Source: Jama Oncology, 2018-03-01 00:00:00.0; 4(3), p. 366-373.
PMID: 29346484
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Inherited DNA-Repair Defects in Colorectal Cancer.
Authors: AlDubayan S.H. , Giannakis M. , Moore N.D. , Han G.C. , Reardon B. , Hamada T. , Mu X.J. , Nishihara R. , Qian Z. , Liu L. , et al. .
Source: American Journal Of Human Genetics, 2018-03-01 00:00:00.0; 102(3), p. 401-414.
EPub date: 2018-02-22 00:00:00.0.
PMID: 29478780
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Grain Intake and Clinical Outcome in Stage III Colon Cancer: Results From CALGB 89803 (Alliance).
Authors: Brown J.C. , Zhang S. , Niedzwiecki D. , Saltz L.B. , Mayer R.J. , Mowat R.B. , Whittom R. , Hantel A. , Benson A. , Atienza D. , et al. .
Source: Jnci Cancer Spectrum, 2018 Feb; 2(2), p. pky017.
EPub date: 2018-05-30 00:00:00.0.
PMID: 29877501
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(PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas.
Authors: Hamada T. , Soong T.R. , Masugi Y. , Kosumi K. , Nowak J.A. , da Silva A. , Mu X.J. , Twombly T.S. , Koh H. , Yang J. , et al. .
Source: Oncoimmunology, 2018; 7(7), p. e1442999.
EPub date: 2018-03-19 00:00:00.0.
PMID: 29900052
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Tumor expression of calcium sensing receptor and colorectal cancer survival: Results from the nurses' health study and health professionals follow-up study.
Authors: Momen-Heravi F. , Masugi Y. , Qian Z.R. , Nishihara R. , Liu L. , Smith-Warner S.A. , Keum N. , Zhang L. , Tchrakian N. , Nowak J.A. , et al. .
Source: International Journal Of Cancer, 2017-12-15 00:00:00.0; 141(12), p. 2471-2479.
EPub date: 2017-09-20 00:00:00.0.
PMID: 28856682
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Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer.
Authors: Bullman S. , Pedamallu C.S. , Sicinska E. , Clancy T.E. , Zhang X. , Cai D. , Neuberg D. , Huang K. , Guevara F. , Nelson T. , et al. .
Source: Science (new York, N.y.), 2017-12-15 00:00:00.0; 358(6369), p. 1443-1448.
EPub date: 2017-11-23 00:00:00.0.
PMID: 29170280
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Association of Systemic Inflammation and Sarcopenia With Survival in Nonmetastatic Colorectal Cancer: Results From the C SCANS Study.
Authors: Feliciano E.M.C. , Kroenke C.H. , Meyerhardt J.A. , Prado C.M. , Bradshaw P.T. , Kwan M.L. , Xiao J. , Alexeeff S. , Corley D. , Weltzien E. , et al. .
Source: Jama Oncology, 2017-12-01 00:00:00.0; 3(12), p. e172319.
PMID: 28796857
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Social integration and survival after diagnosis of colorectal cancer.
Authors: Sarma E.A. , Kawachi I. , Poole E.M. , Tworoger S.S. , Giovannucci E.L. , Fuchs C.S. , Bao Y. .
Source: Cancer, 2017-11-21 00:00:00.0; , .
EPub date: 2017-11-21 00:00:00.0.
PMID: 29160897
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Association Between Coffee Intake After Diagnosis of Colorectal Cancer and Reduced mortality.
Authors: Hu Y. , Ding M. , Yuan C. , Wu K. , Smith-Warner S.A. , Hu F.B. , Chan A.T. , Meyerhardt J.A. , Ogino S. , Fuchs C.S. , et al. .
Source: Gastroenterology, 2017-11-17 00:00:00.0; , .
EPub date: 2017-11-17 00:00:00.0.
PMID: 29158191
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Adjuvant Chemoradiotherapy With Epirubicin, Cisplatin, and Fluorouracil Compared With Adjuvant Chemoradiotherapy With Fluorouracil and Leucovorin After Curative Resection of Gastric Cancer: Results From CALGB 80101 (Alliance).
Authors: Fuchs C.S. , Niedzwiecki D. , Mamon H.J. , Tepper J.E. , Ye X. , Swanson R.S. , Enzinger P.C. , Haller D.G. , Dragovich T. , Alberts S.R. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2017-11-10 00:00:00.0; 35(32), p. 3671-3677.
EPub date: 2017-10-04 00:00:00.0.
PMID: 28976791
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Fiber Intake and Survival After Colorectal Cancer Diagnosis.
Authors: Song M. , Wu K. , Meyerhardt J.A. , Ogino S. , Wang M. , Fuchs C.S. , Giovannucci E.L. , Chan A.T. .
Source: Jama Oncology, 2017-11-02 00:00:00.0; , .
EPub date: 2017-11-02 00:00:00.0.
PMID: 29098294
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Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells.
Authors: Gu M. , Nishihara R. , Chen Y. , Li W. , Shi Y. , Masugi Y. , Hamada T. , Kosumi K. , Liu L. , da Silva A. , et al. .
Source: Oncotarget, 2017-10-20 00:00:00.0; 8(50), p. 87379-87389.
EPub date: 2017-09-18 00:00:00.0.
PMID: 29152088
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Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer.
Authors: Masugi Y. , Nishihara R. , Hamada T. , Song M. , da Silva A. , Kosumi K. , Gu M. , Shi Y. , Li W. , Liu L. , et al. .
Source: Cancer Immunology Research, 2017-10-16 00:00:00.0; , .
EPub date: 2017-10-16 00:00:00.0.
PMID: 29038297
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Influence of dietary insulin scores on survival in colorectal cancer patients.
Authors: Yuan C. , Bao Y. , Sato K. , Nimptsch K. , Song M. , Brand-Miller J.C. , Morales-Oyarvide V. , Zoltick E.S. , Keum N. , Wolpin B.M. , et al. .
Source: British Journal Of Cancer, 2017-09-26 00:00:00.0; 117(7), p. 1079-1087.
EPub date: 2017-08-17 00:00:00.0.
PMID: 28817837
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Muscle mass at the time of diagnosis of nonmetastatic colon cancer and early discontinuation of chemotherapy, delays, and dose reductions on adjuvant FOLFOX: The C-SCANS study.
Authors: Cespedes Feliciano E.M. , Lee V.S. , Prado C.M. , Meyerhardt J.A. , Alexeeff S. , Kroenke C.H. , Xiao J. , Castillo A.L. , Caan B.J. .
Source: Cancer, 2017-09-07 00:00:00.0; , .
EPub date: 2017-09-07 00:00:00.0.
PMID: 28881381
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Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor.
Authors: Liu L. , Nishihara R. , Qian Z.R. , Tabung F.K. , Nevo D. , Zhang X. , Song M. , Cao Y. , Mima K. , Masugi Y. , et al. .
Source: Gastroenterology, 2017-08-30 00:00:00.0; , .
EPub date: 2017-08-30 00:00:00.0.
PMID: 28865736
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Calcium intake and risk of colorectal cancer according to expression status of calcium-sensing receptor (CASR).
Authors: Yang W. , Liu L. , Masugi Y. , Qian Z.R. , Nishihara R. , Keum N. , Wu K. , Smith-Warner S. , Ma Y. , Nowak J.A. , et al. .
Source: Gut, 2017-07-04 00:00:00.0; , .
EPub date: 2017-07-04 00:00:00.0.
PMID: 28676564
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Biomarker correlation network in colorectal carcinoma by tumor anatomic location.
Authors: Nishihara R. , Glass K. , Mima K. , Hamada T. , Nowak J.A. , Qian Z.R. , Kraft P. , Giovannucci E.L. , Fuchs C.S. , Chan A.T. , et al. .
Source: Bmc Bioinformatics, 2017-06-17 00:00:00.0; 18(1), p. 304.
EPub date: 2017-06-17 00:00:00.0.
PMID: 28623901
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Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status.
Authors: Hamada T. , Cao Y. , Qian Z.R. , Masugi Y. , Nowak J.A. , Yang J. , Song M. , Mima K. , Kosumi K. , Liu L. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2017-06-01 00:00:00.0; 35(16), p. 1836-1844.
EPub date: 2017-04-13 00:00:00.0.
PMID: 28406723
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Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status.
Authors: Hanyuda A. , Cao Y. , Hamada T. , Nowak J.A. , Qian Z.R. , Masugi Y. , da Silva A. , Liu L. , Kosumi K. , Soong T.R. , et al. .
Source: European Journal Of Epidemiology, 2017-05-16 00:00:00.0; , .
EPub date: 2017-05-16 00:00:00.0.
PMID: 28510098
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Habitual coffee consumption and genetic predisposition to obesity: gene-diet interaction analyses in three US prospective studies.
Authors: Wang T. , Huang T. , Kang J.H. , Zheng Y. , Jensen M.K. , Wiggs J.L. , Pasquale L.R. , Fuchs C.S. , Campos H. , Rimm E.B. , et al. .
Source: Bmc Medicine, 2017-05-09 00:00:00.0; 15(1), p. 97.
EPub date: 2017-05-09 00:00:00.0.
PMID: 28486942
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Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies.
Authors: Nimptsch K. , Song M. , Aleksandrova K. , Katsoulis M. , Freisling H. , Jenab M. , Gunter M.J. , Tsilidis K.K. , Weiderpass E. , Bueno-De-Mesquita H.B. , et al. .
Source: European Journal Of Epidemiology, 2017 May; 32(5), p. 419-430.
EPub date: 2017-05-26 00:00:00.0.
PMID: 28550647
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Long-term use of antibiotics and risk of colorectal adenoma.
Authors: Cao Y. , Wu K. , Mehta R. , Drew D.A. , Song M. , Lochhead P. , Nguyen L.H. , Izard J. , Fuchs C.S. , Garrett W.S. , et al. .
Source: Gut, 2017-04-04 00:00:00.0; , .
EPub date: 2017-04-04 00:00:00.0.
PMID: 28377387
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Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer.
Authors: Yurgelun M.B. , Kulke M.H. , Fuchs C.S. , Allen B.A. , Uno H. , Hornick J.L. , Ukaegbu C.I. , Brais L.K. , McNamara P.G. , Mayer R.J. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2017-04-01 00:00:00.0; 35(10), p. 1086-1095.
EPub date: 2017-01-30 00:00:00.0.
PMID: 28135145
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Dietary Glycemic And Insulin Scores And Colorectal Cancer Survival By Tumor Molecular Biomarkers
Authors: Keum N. , Yuan C. , Nishihara R. , Zoltick E. , Hamada T. , Fernandez A.M. , Zhang X. , Hanyuda A. , Liu L. , Kosumi K. , et al. .
Source: International Journal Of Cancer, 2017-03-07 00:00:00.0; , .
PMID: 28268248
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Dietary Patterns And Risk Of Colorectal Cancer: Analysis By Tumor Location And Molecular Subtypes
Authors: Mehta R.S. , Song M. , Nishihara R. , Drew D.A. , Wu K. , Qian Z.R. , Fung T.T. , Hamada T. , Masugi Y. , da Silva A. , et al. .
Source: Gastroenterology, 2017-02-26 00:00:00.0; , .
PMID: 28249812
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A Comprehensive Model Of Colorectal Cancer By Risk Factor Status And Subsite Using Data From The Nurses' Health Study
Authors: Wei E.K. , Colditz G.A. , Giovannucci E.L. , Wu K. , Glynn R.J. , Fuchs C.S. , Stampfer M. , Willett W. , Ogino S. , Rosner B. .
Source: American Journal Of Epidemiology, 2017-02-01 00:00:00.0; 185(3), p. 224-237.
PMID: 28073766
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Association Of Dietary Patterns With Risk Of Colorectal Cancer Subtypes Classified By Fusobacterium Nucleatum In Tumor Tissue
Authors: Mehta R.S. , Nishihara R. , Cao Y. , Song M. , Mima K. , Qian Z.R. , Nowak J.A. , Kosumi K. , Hamada T. , Masugi Y. , et al. .
Source: Jama Oncology, 2017-01-26 00:00:00.0; , .
PMID: 28125762
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A Prospective Study Of Smoking And Risk Of Synchronous Colorectal Cancers
Authors: Drew D.A. , Nishihara R. , Lochhead P. , Kuchiba A. , Qian Z.R. , Mima K. , Nosho K. , Wu K. , Wang M. , Giovannucci E. , et al. .
Source: The American Journal Of Gastroenterology, 2017-01-24 00:00:00.0; , .
PMID: 28117362
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Rotating Night Shift Work, Sleep, And Colorectal Adenoma In Women
Authors: Devore E.E. , Massa J. , Papantoniou K. , Schernhammer E.S. , Wu K. , Zhang X. , Willett W.C. , Fuchs C.S. , Chan A.T. , Ogino S. , et al. .
Source: International Journal Of Colorectal Disease, 2017-01-17 00:00:00.0; , .
PMID: 28097381
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Tumor SQSTM1 (p62) expression and T cells in colorectal cancer.
Authors: Kosumi K. , Masugi Y. , Yang J. , Qian Z.R. , Kim S.A. , Li W. , Shi Y. , da Silva A. , Hamada T. , Liu L. , et al. .
Source: Oncoimmunology, 2017; 6(3), p. e1284720.
EPub date: 2017-01-31 00:00:00.0.
PMID: 28405513
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Obesity And Energy Balance In Gi Cancer
Authors: Brown J.C. , Meyerhardt J.A. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2016-12-10 00:00:00.0; 34(35), p. 4217-4224.
PMID: 27903148
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Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis.
Authors: Mima K. , Nishihara R. , Qian Z.R. , Cao Y. , Sukawa Y. , Nowak J.A. , Yang J. , Dou R. , Masugi Y. , Song M. , et al. .
Source: Gut, 2016 Dec; 65(12), p. 1973-1980.
PMID: 26311717
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Fusobacterium Nucleatum In Colorectal Carcinoma Tissue According To Tumor Location
Authors: Mima K. , Cao Y. , Chan A.T. , Qian Z.R. , Nowak J.A. , Masugi Y. , Shi Y. , Song M. , da Silva A. , Gu M. , et al. .
Source: Clinical And Translational Gastroenterology, 2016-11-03 00:00:00.0; 7(11), p. e200.
PMID: 27811909
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