||1U24CA232980-01 Interpret this number
||Research Triangle Institute
||Coordinating Center for Research Centers for Improving Management of Symptoms During and Following Cancer Treatment
To advance the Beau Biden Cancer MoonshotSM Initiative to accelerate cancer research and the Blue Ribbon
Panel's recommendation to minimize cancer treatment's debilitating side effects, RTI International proposes to
serve as the Coordinating Center (CC) for the Research Centers (RCs) for Improving Management of
Symptoms Across Cancer Treatments (IMPACT) Consortium. As the CC, RTI will provide leadership, scientific
expertise, and logistical support to unite RCs into a cohesive research group that will provide actionable
evidence based on implementation science principles to improve symptom management across the cancer
treatment continuum (i.e., treatment with curative intent, treatment with noncurative/palliative intent, cancer
survivorship) and address the unique challenges of minority and medically underserved populations.
Specifically, we will (1) enhance research efficiency, productivity, and impact by facilitating collaboration and
providing the logistical, communications, and operational support necessary to run a multicenter research
Consortium; (2) facilitate the development of evidence-based symptom management recommendations by
establishing processes for harmonized data collection, the use of common data elements, and the application
of consistent procedures across studies and research sites; and (3) accelerate adoption of integrated systems
for monitoring and managing patient-reported symptoms by developing and applying analytic approaches to
IMPACT pooled data and collaborating with RCs and other stakeholder to broadly disseminate findings. This
application has specific strengths that will enhance the scientific productivity of the Consortium: (1) Under the
leadership of Dr. Barbara Kroner, the CC will foster collaboration within the IMPACT Consortium by uniting
diverse researchers around shared goals and harmonized studies to advance the research agenda. (2) RTI will
promote effective communication by developing custom web-based tools for communications, document
sharing, and online trainings; establishing and leading SC working groups in topics relevant to IMPACT (e.g.,
Health Disparities; Implementation Science; Data Management, Statistics, and Informatics). (3) RTI will use a
common implementation framework (i.e., Reach, Effectiveness, Adoption, Implementation, and Maintenance
(RE-AIM)) combined with the Consolidated Framework for Implementation Research) to concurrently evaluate
multilevel factors that can influence clinical practice by assessing both effectiveness and implementation
outcomes. (4) RTI will leverage data standards and harmonization across the Consortium to catalyze data
sharing and aggregation. (5) RTI will advocate for a Stakeholder Advisory Group to guide and inform pooled
study design, data collection, analyses, and interpretation of study findings. (6) RTI will combine the
harmonized data with planned pooled analyses which will yield optimal management system models for
implementing integrated systems into routine clinical practice and use implementation science approaches to
accelerate adoption of integrated systems and sustain changes in clinical practice.
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