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Grant Details

Grant Number: 5P20CA217231-02 Interpret this number
Primary Investigator: Irazola, Vilma
Organization: Instituto De Efectividad Clinica Y Sanit
Project Title: Building Sustainable and Innovative Research in Cancer and Cardiovascular Disease: Planning the Design and Development of the South American Center of Research Excellence to Counter Ncds (SACREN)
Fiscal Year: 2018
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Abstract

SUMMARY OF THE OVERALL COMPONENT  Although non‐communicable diseases (NCD) represent over 80% of the disease burden in  South America, most health resources in the region are still dedicated to infectious disease and  maternal and child health. As the region completes its epidemiological, demographic and  nutritional transition, there is an urgent need to improve strategies to reduce the increasing  burden of NCD. This application describes the design and development of the South American  Center of Research Excellence in Chronic Non‐communicable diseases (SACREN) to establish  research activities related to cancer and cardiovascular diseases (CVD) prevention and control.  The Center will be hosted by two former National Heart, Lung Blood Institute (NIH/NHLBI)  Centers of Excellence (COE): The South American Center of Excellence for Chronic diseases  (CESCAS) at the Institute for Clinical Effectiveness and Health Policy (IECS) in Buenos Aires,  Argentina which covers the Southern Cone of Latin America (Argentina, Chile and Uruguay)  and the CRONICAS Center of Excellence in Chronic Diseases at the Universidad Peruana  Cayetano Heredia (UPCH), in Peru , both thriving research and providing a rich environment for  research capacity building in the region. In fact, both teams, which are currently supported by  NIH and other international and national funders, have a remarkable track record of successful  research in terms of publications and grants. More importantly, taken this to the next level to  establish SACREN, both CESCAS and CRONICAS will partner with the Division of Population  Sciences at Dana‐Farber Cancer Institute, (DFCI) and Harvard Medical School (HMS), where  both will contribute their world‐class expertise and leadership in building capacity for cancer  research that spans the spectrum from prevention to treatment. SACREN will taking advantage  of the capacity building experience of the three partners and establish shared resources and  facilities to allow enhancing innovative population, translational (T4), clinical, implementation  and policy research to counter cancer and CVD. For this planning grant, SACREN will develop  two research programs in cancer and CVD epidemiology, building on the integration of the  population‐based cohorts in Argentina, Chile, Peru and Uruguay. In addition, it will undertake a  pilot collaborative project on geo‐mapping of GBC and GC in South America, based on GIS  technology. SACREN will develop its initial activities in Argentina, Chile, Peru and Uruguay, and  will later expand to Bolivia and Paraguay. In this regard, our proposal has been endorsed by  the current Ministers of Health of Argentina and Peru and the authorities of the national  cancer institutes and/or the Ministries of Health of all countries involved   

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Publications

Physical activity and sedentary behavior patterns and sociodemographic correlates in 116,982 adults from six South American countries: the South American physical activity and sedentary behavior network (SAPASEN).
Authors: Werneck A.O. , Baldew S.S. , Miranda J.J. , Díaz Arnesto O. , Stubbs B. , Silva D.R. , on the behalf of the South American Physical Activity and Sedentary Behavior Network (SAPASEN) collaborators .
Source: The international journal of behavioral nutrition and physical activity, 2019-08-20; 16(1), p. 68.
EPub date: 2019-08-20.
PMID: 31429772
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Joint association of urinary sodium and potassium excretion with cardiovascular events and mortality: prospective cohort study.
Authors: O'Donnell M. , Mente A. , Rangarajan S. , McQueen M.J. , O'Leary N. , Yin L. , Liu X. , Swaminathan S. , Khatib R. , Rosengren A. , et al. .
Source: BMJ (Clinical research ed.), 2019-03-13; 364, p. l772.
EPub date: 2019-03-13.
PMID: 30867146
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Within-country migration and obesity dynamics: analysis of 94,783 women from the Peruvian demographic and health surveys.
Authors: Najera H. , Nandy S. , Carrillo-Larco R.M. , Miranda J.J. .
Source: BMC public health, 2019-03-04; 19(1), p. 263.
EPub date: 2019-03-04.
PMID: 30832623
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A secondary analysis examining the concordance of self-perception of weight and actual measurement of body fat percentage: The CRONICAS Cohort Study.
Authors: Bui A.L. , Moscoso M.G. , Bernabe-Ortiz A. , Checkley W. , Gilman R.H. , Smeeth L. , Miranda J.J. .
Source: BMC obesity, 2019; 6, p. 9.
EPub date: 2019-04-01.
PMID: 30984403
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Global patterns of mortality in international migrants: a systematic review and meta-analysis.
Authors: Aldridge R.W. , Nellums L.B. , Bartlett S. , Barr A.L. , Patel P. , Burns R. , Hargreaves S. , Miranda J.J. , Tollman S. , Friedland J.S. , et al. .
Source: Lancet (London, England), 2018-12-15; 392(10164), p. 2553-2566.
EPub date: 2018-12-05.
PMID: 30528484
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Low prevalence of ideal cardiovascular health in Peru.
Authors: Benziger C.P. , Zavala-Loayza J.A. , Bernabe-Ortiz A. , Gilman R.H. , Checkley W. , Smeeth L. , Malaga G. , Miranda J.J. , CRONICAS Cohort Study group .
Source: Heart (British Cardiac Society), 2018 08; 104(15), p. 1251-1256.
EPub date: 2018-01-11.
PMID: 29326111
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