Grant Number:	5P20CA217231-02 Interpret this number
Primary Investigator:	Irazola, Vilma
Organization:	Instituto De Efectividad Clinica Y Sanit
Project Title:	Building Sustainable and Innovative Research in Cancer and Cardiovascular Disease: Planning the Design and Development of the South American Center of Research Excellence to Counter Ncds (SACREN)
Fiscal Year:	2018

SUMMARY OF THE OVERALL COMPONENT  Although non‐communicable diseases (NCD) represent over 80% of the disease burden in  South America, most health resources in the region are still dedicated to infectious disease and  maternal and child health. As the region completes its epidemiological, demographic and  nutritional transition, there is an urgent need to improve strategies to reduce the increasing  burden of NCD. This application describes the design and development of the South American  Center of Research Excellence in Chronic Non‐communicable diseases (SACREN) to establish  research activities related to cancer and cardiovascular diseases (CVD) prevention and control.  The Center will be hosted by two former National Heart, Lung Blood Institute (NIH/NHLBI)  Centers of Excellence (COE): The South American Center of Excellence for Chronic diseases  (CESCAS) at the Institute for Clinical Effectiveness and Health Policy (IECS) in Buenos Aires,  Argentina which covers the Southern Cone of Latin America (Argentina, Chile and Uruguay)  and the CRONICAS Center of Excellence in Chronic Diseases at the Universidad Peruana  Cayetano Heredia (UPCH), in Peru , both thriving research and providing a rich environment for  research capacity building in the region. In fact, both teams, which are currently supported by  NIH and other international and national funders, have a remarkable track record of successful  research in terms of publications and grants. More importantly, taken this to the next level to  establish SACREN, both CESCAS and CRONICAS will partner with the Division of Population  Sciences at Dana‐Farber Cancer Institute, (DFCI) and Harvard Medical School (HMS), where  both will contribute their world‐class expertise and leadership in building capacity for cancer  research that spans the spectrum from prevention to treatment. SACREN will taking advantage  of the capacity building experience of the three partners and establish shared resources and  facilities to allow enhancing innovative population, translational (T4), clinical, implementation  and policy research to counter cancer and CVD. For this planning grant, SACREN will develop  two research programs in cancer and CVD epidemiology, building on the integration of the  population‐based cohorts in Argentina, Chile, Peru and Uruguay. In addition, it will undertake a  pilot collaborative project on geo‐mapping of GBC and GC in South America, based on GIS  technology. SACREN will develop its initial activities in Argentina, Chile, Peru and Uruguay, and  will later expand to Bolivia and Paraguay. In this regard, our proposal has been endorsed by  the current Ministers of Health of Argentina and Peru and the authorities of the national  cancer institutes and/or the Ministries of Health of all countries involved   




Multimorbidity patterns, sociodemographic characteristics, and mortality: Data science insights from low-resource settings.
Authors: Bazo-Alvarez J.C. , Del Castillo D. , Piza L. , Bernabé-Ortiz A. , Carrillo-Larco R.M. , Smeeth L. , Gilman R.H. , Checkley W. , Miranda J.J. .
Source: American Journal Of Epidemiology, 2026-03-17 00:00:00.0; 195(4), p. 901-911.
PMID: 39703173
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The exposome of healthy and accelerated aging across 40 countries.
Authors: Hernandez H. , Santamaria-Garcia H. , Moguilner S. , Farina F.R. , Legaz A. , Prado P. , Cuadros J. , Gonzalez L. , Gonzalez-Gomez R. , Migeot J. , et al. .
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WHO's Salt Substitution Guidelines for Population-Wide Impact: Act on Strong Evidence, Monitor for the Long Term.
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Source: Global Heart, 2025; 20(1), p. 32.
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PMID: 40161861
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Epidemiology of cardiometabolic health in Latin America and strategies to address disparities.
Authors: Brant L.C.C. , Miranda J.J. , Carrillo-Larco R.M. , Flood D. , Irazola V. , Ribeiro A.L.P. .
Source: Nature Reviews. Cardiology, 2024 Dec; 21(12), p. 849-864.
EPub date: 2024-07-25 00:00:00.0.
PMID: 39054376
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Allostasis, health, and development in Latin America.
Authors: Migeot J. , Panesso C. , Duran-Aniotz C. , Ávila-Rincón C. , Ochoa C. , Huepe D. , Santamaría-García H. , Miranda J.J. , Escobar M.J. , Pina-Escudero S. , et al. .
Source: Neuroscience And Biobehavioral Reviews, 2024 Jul; 162, p. 105697.
EPub date: 2024-05-04 00:00:00.0.
PMID: 38710422
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Effect of preterm birth on growth and blood pressure in adulthood in the Pelotas 1993 cohort.
Authors: Lapidaire W. , Proaño A. , Blumenberg C. , Loret de Mola C. , Delgado C.A. , Del Castillo D. , Wehrmeister F.C. , Gonçalves H. , Gilman R.H. , Oberhelman R.A. , et al. .
Source: International Journal Of Epidemiology, 2023-12-25 00:00:00.0; 52(6), p. 1870-1877.
PMID: 37354551
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Are we settling for less in nutritional policy?
Authors: Prasad N. , Miranda J.J. .
Source: The Lancet. Diabetes & Endocrinology, 2023 Nov; 11(11), p. 791-793.
PMID: 37884322
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The impacts of social determinants of health and cardiometabolic factors on cognitive and functional aging in Colombian underserved populations.
Authors: Santamaria-Garcia H. , Moguilner S. , Rodriguez-Villagra O.A. , Botero-Rodriguez F. , Pina-Escudero S.D. , O'Donovan G. , Albala C. , Matallana D. , Schulte M. , Slachevsky A. , et al. .
Source: Geroscience, 2023 Aug; 45(4), p. 2405-2423.
EPub date: 2023-02-28 00:00:00.0.
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Peru initiates the IMPACT project.
Authors: Lúcar M.G. , Vera Tudela J.C. , Anza-Ramirez C. , Miranda J.J. , Butler C.R. , IMPACT Dementia Study Group .
Source: The Lancet. Neurology, 2023 Aug; 22(8), p. 653.
PMID: 37479367
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Challenges of design, implementation, acceptability, and potential for, biomedical technologies in the Peruvian Amazon.
Authors: Bressan T. , Valdivia-Gago A. , Silvera-Ccallo R.M. , Llanos-Cuentas A. , Condor D.F. , Padilla-Huamantinco P.G. , Vilcarromero S. , Miranda J.J. , Zavaleta-Cortijo C. .
Source: International Journal For Equity In Health, 2022-12-19 00:00:00.0; 21(1), p. 183.
EPub date: 2022-12-19 00:00:00.0.
PMID: 36536404
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Multimorbidity.
Authors: Skou S.T. , Mair F.S. , Fortin M. , Guthrie B. , Nunes B.P. , Miranda J.J. , Boyd C.M. , Pati S. , Mtenga S. , Smith S.M. .
Source: Nature Reviews. Disease Primers, 2022-07-14 00:00:00.0; 8(1), p. 48.
EPub date: 2022-07-14 00:00:00.0.
PMID: 35835758
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Nutrition-related health taxes: setting expectations.
Authors: Miranda J.J. , Thow A.M. , Cárdenas M.K. , Corvalán C. , Barrientos-Gutiérrez T. , Kaufman J.S. .
Source: The Lancet. Diabetes & Endocrinology, 2022 02; 10(2), p. 93-94.
EPub date: 2021-12-20 00:00:00.0.
PMID: 34942086
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Multimorbidity matters in low and middle-income countries.
Authors: Basto-Abreu A. , Barrientos-Gutierrez T. , Wade A.N. , Oliveira de Melo D. , Semeão de Souza A.S. , Nunes B.P. , Perianayagam A. , Tian M. , Yan L.L. , Ghosh A. , et al. .
Source: Journal Of Multimorbidity And Comorbidity, 2022 Jan-Dec; 12, p. 26335565221106074.
EPub date: 2022-06-16 00:00:00.0.
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Does food biodiversity protect against malnutrition and favour the resilience to climate change-related events in Amazon Indigenous communities? A protocol for a mixed methods study.
Authors: Zavaleta-Cortijo C. , Cade J. , Ford J. , Greenwood D.C. , Carcamo C. , Silvera-Ccallo R. , Fernandez-Neyra C. , Lancha-Rucoba G. , Pizango-Tangoa M. , Pizango-Inuma R. , et al. .
Source: Wellcome Open Research, 2022; 7, p. 246.
EPub date: 2023-06-26 00:00:00.0.
PMID: 38463717
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Process evaluation of complex interventions in chronic and neglected tropical diseases in low- and middle-income countries-a scoping review protocol.
Authors: Lazo-Porras M. , Liu H. , Miranda J.J. , Moore G. , Burri M. , Chappuis F. , Perel P. , Beran D. .
Source: Systematic Reviews, 2021-09-07 00:00:00.0; 10(1), p. 244.
EPub date: 2021-09-07 00:00:00.0.
PMID: 34488877
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Diabetes care quality according to facility setting: A cross-sectional analysis in six Peruvian regions.
Authors: Calderon-Ticona J.R. , Taype-Rondan A. , Villamonte G. , Labán-Seminario L.M. , Helguero-Santín L.M. , Miranda J.J. , Lazo-Porras M. .
Source: Primary Care Diabetes, 2021 06; 15(3), p. 488-494.
EPub date: 2020-12-24 00:00:00.0.
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[Association between exclusive breastfeeding and obesity in children: a cross-sectional study of three Latin American countries].
Authors: Paca-Palao A. , Huayanay-Espinoza C.A. , Parra D.C. , Velasquez-Melendez G. , Miranda J.J. .
Source: Gaceta Sanitaria, 2021 Mar-Apr; 35(2), p. 168-176.
EPub date: 2019-11-29 00:00:00.0.
PMID: 31787405
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Design of financial incentive interventions to improve lifestyle behaviors and health outcomes: A systematic review.
Authors: Miranda J.J. , Pesantes M.A. , Lazo-Porras M. , Portocarrero J. , Diez-Canseco F. , Carrillo-Larco R.M. , Bernabe-Ortiz A. , Trujillo A.J. , Aldridge R.W. .
Source: Wellcome Open Research, 2021; 6, p. 163.
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Macroeconomic, demographic and human developmental correlates of physical activity and sitting time among South American adults.
Authors: Werneck A.O. , Sadarangani K.P. , Ramírez-Vélez R. , Baldew S.S. , Gomes T.N. , Ferrari G. , Szwarcwald C.L. , Miranda J.J. , Silva D.R. , South American Physical Activity and Sedentary Behavior Network (SAPASEN) collaborators .
Source: The International Journal Of Behavioral Nutrition And Physical Activity, 2020-12-14 00:00:00.0; 17(1), p. 163.
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Comorbid depression in medical diseases.
Authors: Gold S.M. , Köhler-Forsberg O. , Moss-Morris R. , Mehnert A. , Miranda J.J. , Bullinger M. , Steptoe A. , Whooley M.A. , Otte C. .
Source: Nature Reviews. Disease Primers, 2020-08-20 00:00:00.0; 6(1), p. 69.
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Climate change and COVID-19: reinforcing Indigenous food systems.
Authors: Zavaleta-Cortijo C. , Ford J.D. , Arotoma-Rojas I. , Lwasa S. , Lancha-Rucoba G. , García P.J. , Miranda J.J. , Namanya D.B. , New M. , Wright C.J. , et al. .
Source: The Lancet. Planetary Health, 2020-08-07 00:00:00.0; , .
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Multimorbidity: Not Just for the West.
Authors: Banerjee A. , Hurst J. , Fottrell E. , Miranda J.J. .
Source: Global Heart, 2020-07-02 00:00:00.0; 15(1), p. 45.
EPub date: 2020-07-02 00:00:00.0.
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The Effect of a Priest-Led Intervention on the Choice and Preference of Soda Beverages: A Cluster-Randomized Controlled Trial in Catholic Parishes.
Authors: Miranda J.J. , Taype-Rondan A. , Bazalar-Palacios J. , Bernabe-Ortiz A. , Ariely D. .
Source: Annals Of Behavioral Medicine : A Publication Of The Society Of Behavioral Medicine, 2020-05-25 00:00:00.0; 54(6), p. 436-446.
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Revealing the air pollution burden associated with internal Migration in Peru.
Authors: Carrasco-Escobar G. , Schwarz L. , Miranda J.J. , Benmarhnia T. .
Source: Scientific Reports, 2020-04-28 00:00:00.0; 10(1), p. 7147.
EPub date: 2020-04-28 00:00:00.0.
PMID: 32346063
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Intermediate hyperglycaemia and 10-year mortality in resource-constrained settings: the PERU MIGRANT Study.
Authors: Lazo-Porras M. , Ruiz-Alejos A. , Miranda J.J. , Carrillo-Larco R.M. , Gilman R.H. , Smeeth L. , Bernabé-Ortiz A. .
Source: Diabetic Medicine : A Journal Of The British Diabetic Association, 2020-03-17 00:00:00.0; , .
EPub date: 2020-03-17 00:00:00.0.
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Trends in cardiometabolic risk factors in the Americas between 1980 and 2014: a pooled analysis of population-based surveys.
Authors: NCD Risk Factor Collaboration (NCD-RisC)—Americas Working Group .
Source: The Lancet. Global Health, 2020 Jan; 8(1), p. e123-e133.
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Foot thermometry with mHeath-based supplementation to prevent diabetic foot ulcers: A randomized controlled trial.
Authors: Lazo-Porras M. , Bernabe-Ortiz A. , Taype-Rondan A. , Gilman R.H. , Malaga G. , Manrique H. , Neyra L. , Calderon J. , Pinto M. , Armstrong D.G. , et al. .
Source: Wellcome Open Research, 2020; 5, p. 23.
EPub date: 2020-08-28 00:00:00.0.
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Travel Time to Health Facilities as a Marker of Geographical Accessibility Across Heterogeneous Land Coverage in Peru.
Authors: Carrasco-Escobar G. , Manrique E. , Tello-Lizarraga K. , Miranda J.J. .
Source: Frontiers In Public Health, 2020; 8, p. 498.
EPub date: 2020-09-16 00:00:00.0.
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The shift of obesity burden by socioeconomic status between 1998 and 2017 in Latin America and the Caribbean: a cross-sectional series study.
Authors: Jiwani S.S. , Carrillo-Larco R.M. , Hernández-Vásquez A. , Barrientos-Gutiérrez T. , Basto-Abreu A. , Gutierrez L. , Irazola V. , Nieto-Martínez R. , Nunes B.P. , Parra D.C. , et al. .
Source: The Lancet. Global Health, 2019 12; 7(12), p. e1644-e1654.
PMID: 31708145
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Regression from prediabetes to normal glucose levels is more frequent than progression towards diabetes: The CRONICAS Cohort Study.
Authors: Lazo-Porras M. , Bernabe-Ortiz A. , Ruiz-Alejos A. , Smeeth L. , Gilman R.H. , Checkley W. , Málaga G. , Miranda J.J. .
Source: Diabetes Research And Clinical Practice, 2019-08-26 00:00:00.0; , p. 107829.
EPub date: 2019-08-26 00:00:00.0.
PMID: 31465811
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Physical activity and sedentary behavior patterns and sociodemographic correlates in 116,982 adults from six South American countries: the South American physical activity and sedentary behavior network (SAPASEN).
Authors: Werneck A.O. , Baldew S.S. , Miranda J.J. , Díaz Arnesto O. , Stubbs B. , Silva D.R. , on the behalf of the South American Physical Activity and Sedentary Behavior Network (SAPASEN) collaborators .
Source: The International Journal Of Behavioral Nutrition And Physical Activity, 2019-08-20 00:00:00.0; 16(1), p. 68.
EPub date: 2019-08-20 00:00:00.0.
PMID: 31429772
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What is a COPD-Like Spirometry Test Result in Resource Constrained Settings?
Authors: Gianella G.E. , Miranda J.J. , Hurst J.R. .
Source: Copd, 2019 08; 16(3-4), p. 213-214.
EPub date: 2019-08-19 00:00:00.0.
PMID: 31423849
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Joint association of urinary sodium and potassium excretion with cardiovascular events and mortality: prospective cohort study.
Authors: O'Donnell M. , Mente A. , Rangarajan S. , McQueen M.J. , O'Leary N. , Yin L. , Liu X. , Swaminathan S. , Khatib R. , Rosengren A. , et al. .
Source: Bmj (clinical Research Ed.), 2019-03-13 00:00:00.0; 364, p. l772.
EPub date: 2019-03-13 00:00:00.0.
PMID: 30867146
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Within-country migration and obesity dynamics: analysis of 94,783 women from the Peruvian demographic and health surveys.
Authors: Najera H. , Nandy S. , Carrillo-Larco R.M. , Miranda J.J. .
Source: Bmc Public Health, 2019-03-04 00:00:00.0; 19(1), p. 263.
EPub date: 2019-03-04 00:00:00.0.
PMID: 30832623
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Million Migrants study of healthcare and mortality outcomes in non-EU migrants and refugees to England: Analysis protocol for a linked population-based cohort study of 1.5 million migrants.
Authors: Burns R. , Pathak N. , Campos-Matos I. , Zenner D. , Vittal Katikireddi S. , Muzyamba M.C. , Miranda J.J. , Gilbert R. , Rutter H. , Jones L. , et al. .
Source: Wellcome Open Research, 2019; 4, p. 4.
EPub date: 2019-01-17 00:00:00.0.
PMID: 30801036
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A secondary analysis examining the concordance of self-perception of weight and actual measurement of body fat percentage: The CRONICAS Cohort Study.
Authors: Bui A.L. , Moscoso M.G. , Bernabe-Ortiz A. , Checkley W. , Gilman R.H. , Smeeth L. , Miranda J.J. .
Source: Bmc Obesity, 2019; 6, p. 9.
EPub date: 2019-04-01 00:00:00.0.
PMID: 30984403
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Multimorbidity at sea level and high-altitude urban and rural settings: The CRONICAS Cohort Study.
Authors: Miranda J.J. , Bernabe-Ortiz A. , Gilman R.H. , Smeeth L. , Malaga G. , Wise R.A. , Checkley W. , CRONICAS Cohort Study Group .
Source: Journal Of Comorbidity, 2019 Jan-Dec; 9, p. 2235042X19875297.
EPub date: 2019-11-06 00:00:00.0.
PMID: 34249770
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Global patterns of mortality in international migrants: a systematic review and meta-analysis.
Authors: Aldridge R.W. , Nellums L.B. , Bartlett S. , Barr A.L. , Patel P. , Burns R. , Hargreaves S. , Miranda J.J. , Tollman S. , Friedland J.S. , et al. .
Source: Lancet (london, England), 2018-12-15 00:00:00.0; 392(10164), p. 2553-2566.
EPub date: 2018-12-05 00:00:00.0.
PMID: 30528484
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Low prevalence of ideal cardiovascular health in Peru.
Authors: Benziger C.P. , Zavala-Loayza J.A. , Bernabe-Ortiz A. , Gilman R.H. , Checkley W. , Smeeth L. , Malaga G. , Miranda J.J. , CRONICAS Cohort Study group .
Source: Heart (british Cardiac Society), 2018 Aug; 104(15), p. 1251-1256.
EPub date: 2018-01-11 00:00:00.0.
PMID: 29326111
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Integration of a Technology-Based Mental Health Screening Program Into Routine Practices of Primary Health Care Services in Peru (The Allillanchu Project): Development and Implementation.
Authors: Diez-Canseco F. , Toyama M. , Ipince A. , Perez-Leon S. , Cavero V. , Araya R. , Miranda J.J. .
Source: Journal Of Medical Internet Research, 2018-03-15 00:00:00.0; 20(3), p. e100.
EPub date: 2018-03-15 00:00:00.0.
PMID: 29588272
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Provision of mental health care within primary care in Peru: A qualitative study exploring the perspectives of psychologists, primary health care providers, and patients.
Authors: Cavero V. , Diez-Canseco F. , Toyama M. , Flórez Salcedo G. , Ipince A. , Araya R. , Miranda J.J. .
Source: Wellcome Open Research, 2018; 3, p. 9.
EPub date: 2018-02-12 00:00:00.0.
PMID: 29623297
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Design and content validation of a set of SMS to promote seeking of specialized mental health care within the Allillanchu Project.
Authors: Toyama M. , Diez-Canseco F. , Busse P. , Del Mastro I. , Miranda J.J. .
Source: Global Health, Epidemiology And Genomics, 2018; 3, p. e2.
EPub date: 2018-01-31 00:00:00.0.
PMID: 29868227
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The effect of individual and mixed rewards on diabetes management: A feasibility randomized controlled trial.
Authors: Miranda J.J. , Lazo-Porras M. , Bernabe-Ortiz A. , Pesantes M.A. , Diez-Canseco F. , Cornejo S.D.P. , Trujillo A.J. .
Source: Wellcome Open Research, 2018; 3, p. 139.
EPub date: 2019-02-05 00:00:00.0.
PMID: 30662958
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A descriptive study of potential participant preferences for the design of an incentivised weight loss programme for people with type 2 diabetes mellitus attending a public hospital in Lima, Peru.
Authors: Akehurst H. , Pesantes M.A. , Cornejo S.D.P. , Manrique K. , Lazo-Porras M. , Portocarrero J. , Diez-Canseco F. , Bernabe-Ortiz A. , Trujillo A.J. , Miranda J.J. .
Source: Wellcome Open Research, 2018; 3, p. 53.
EPub date: 2018-09-27 00:00:00.0.
PMID: 30740534
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