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Grant Details

Grant Number: 5P20CA210294-02 Interpret this number
Primary Investigator: Ragin, Camille
Organization: Research Inst Of Fox Chase Can Ctr
Project Title: Planning for a Sustainable and Robust Rcre in the Caribbean
Fiscal Year: 2018


PROJECT SUMMARY/ABSTRACT: OVERALL The Caribbean Region is highly diverse, comprising low, upper middle, and high income islands and mainland countries, different language groups, and cultural/ethnic backgrounds. Health data show rapidly increasing non-communicable disease (NCD) burden with a majority of deaths attributed to cardiovascular disease (CVD), cancer, diabetes or chronic respiratory disease. The African-Caribbean Cancer Consortium (AC3), an NCI-EGRP supported consortium, is a global cancer research program of Fox Chase Cancer Center (FCCC), and partnered with The University of the West Indies (UWI), has had a strong partnership since 2007. To date, research in cancer, nutritional epidemiology and genetics has resulted in numerous publications with the majority focused on prostate cancer. UWI, a regional University with its main campus in Jamaica, has a Caribbean-wide network of health research and health care facilities, and contains expertise in the skills required for NCD research including basic science, epidemiology and clinical research. It has a strong tradition of research in obesity, diabetes, CVD, cancer and their risk factors. We will build on the strengths of this partnership and have proposed foundational efforts to establish a Regional Center for Research Excellence in Jamaica with a focus on cancer and cardiometabolic research. Guided by a community health and research/laboratory needs assessment, research enhancement, community engagement activities and a pilot project, plans in Jamaica will include a research program and three shared core facilities. The Methodology/Biostatistics and Biomarker/Biospecimen Cores are already established at UWI and community engagement activities are already ongoing. We will build on the community engagement infrastructure to establish an Outreach Core facility for continued community engagement and research support. The long- term plan is to establish a Regional Center for Cancer and Cardiometabolic Research comprised of Centers of Excellence spread across the Caribbean (the U54 phase). A Caribbean-wide community-health and research/laboratory needs assessment generated in this application will guide the development of a strategic plan by year 2, which will help to prioritize step-wise inclusion of additional partners, and beyond. sustainability of the center and scientific focus during the U54 phase


Trends in prostate cancer incidence among Black men in the Caribbean and the United States.
Authors: Zeigler-Johnson C. , McDonald A.C. , Pinheiro P. , Lynch S. , Taioli E. , Joshi S. , Alpert N. , Baudin J. , Joachim C. , Deloumeaux J. , et al. .
Source: The Prostate, 2023 Sep; 83(12), p. 1207-1216.
EPub date: 2023-05-27.
PMID: 37244749
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Expanding the prostate cancer cell line repertoire with ACRJ-PC28, an AR-negative neuroendocrine cell line derived from an African-Caribbean patient.
Authors: Valentine H. , Aiken W. , Morrison B. , Zhao Z. , Fowle H. , Wasserman J.S. , Thompson E. , Chin W. , Young M. , Clarke S. , et al. .
Source: Cancer research communications, 2022 Nov; 2(11), p. 1355-1371.
EPub date: 2022-11-07.
PMID: 36643868
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Heterogeneity in head and neck cancer incidence among black populations from Africa, the Caribbean and the USA: Analysis of cancer registry data by the AC3.
Authors: Auguste A. , Gathere S. , Pinheiro P.S. , Adebamowo C. , Akintola A. , Alleyne-Mike K. , Anderson S.G. , Ashing K. , Awittor F.K. , Awuah B. , et al. .
Source: Cancer epidemiology, 2021 Dec; 75, p. 102053.
EPub date: 2021-11-04.
PMID: 34743058
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Staff and participant perceptions of optimal recruitment and retention strategies for biomedical cohort studies in the Caribbean.
Authors: Bailey A. , Govia I. , McKenzie J. , Richards S. , Coleman S. , Tulloch-Reid M.K. , Ragin C. , Ashing K. .
Source: Cancer causes & control : CCC, 2021 Aug; 32(8), p. 849-857.
EPub date: 2021-05-07.
PMID: 33961148
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Black Is Diverse: The Untapped Beauty and Benefit of Cancer Genomics and Precision Medicine.
Authors: George S. , Ragin C. , Ashing K.T. .
Source: JCO oncology practice, 2021 May; 17(5), p. 279-283.
PMID: 33974833
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An Evaluation of Regional Cardiovascular Disease and Cancer Research Needs Using Conference Abstracts.
Authors: Williamson G.A. , Rodrigo S. , Blackman E. , Ragin C.C. , Beck J.R. , Tulloch-Reid M.K. .
Source: Annals of global health, 2021; 87(1), p. 76.
EPub date: 2021-08-05.
PMID: 34430226
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A cross-sectional analysis of investigator needs for non-communicable disease research at the University of the West Indies, Mona.
Authors: Williamson G.A. , Rodrigo S. , Guthrie-Dixon N. , Blackman E. , Beck J.R. , Hambleton I. , Bailey A. , Paul T. , Ragin C.C. , Tulloch-Reid M.K. .
Source: Revista panamericana de salud publica = Pan American journal of public health, 2021; 45, p. e35.
EPub date: 2021-04-06.
PMID: 33833787
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Interactive effect of TLR SNPs and exposure to sexually transmitted infections on prostate cancer risk in Jamaican men.
Authors: Dubey B. , Jackson M. , Zeigler-Johnson C. , Devarajan K. , Flores-Obando R.E. , McFarlane-Anderson N. , Tulloch-Reid M. , Aiken W. , Kimbro K. , Reed D. , et al. .
Source: The Prostate, 2020 Nov; 80(15), p. 1365-1372.
EPub date: 2020-09-07.
PMID: 32894795
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Disparities in prostate cancer incidence and mortality rates: Solvable or not?
Authors: Badal S. , Aiken W. , Morrison B. , Valentine H. , Bryan S. , Gachii A. , Ragin C. .
Source: The Prostate, 2020 Jan; 80(1), p. 3-16.
EPub date: 2019-11-08.
PMID: 31702061
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African-Caribbean Cancer Consortium Scientific and Training Conference 2017.
Authors: Ragin C. , Oliver J.S. , Cabral D.N. , Harlemon M. , Louden D. , Morrison-Blidgen B.F. , Alleyne-Mike K. , Ashing K. , Butler R. , Gathere S. , et al. .
Source: Current oncology (Toronto, Ont.), 2019 Dec; 26(6), p. e785-e790.
EPub date: 2019-12-01.
PMID: 31896949
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The need for cell lines from diverse ethnic backgrounds for prostate cancer research.
Authors: Badal S. , Campbell K.S. , Valentine H. , Ragin C. .
Source: Nature reviews. Urology, 2019 Dec; 16(12), p. 691-692.
PMID: 31520083
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Cancer control in the Caribbean island countries and territories: some progress but the journey continues.
Authors: Spence D. , Dyer R. , Andall-Brereton G. , Barton M. , Stanway S. , Argentieri M.A. , Bray F. , Cawich S. , Edwards-Bennett S. , Fosker C. , et al. .
Source: The Lancet. Oncology, 2019 Sep; 20(9), p. e503-e521.
EPub date: 2019-08-05.
PMID: 31395473
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Breast Cancer Research in the Caribbean: Analysis of Reports From 1975 to 2017.
Authors: Ragin C. , Banydeen R. , Zhang C. , Ben A. , Calabrese V. , Villa N.N. , Reville J. , Dasgupta S. , Bandyopadhyay M. , Louden D. , et al. .
Source: Journal of global oncology, 2018 Nov; 4, p. 1-21.
PMID: 30481085
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Inflammation polymorphisms and prostate cancer risk in Jamaican men: Role of obesity/body size.
Authors: Dubey B. , Jackson M.D. , Zeigler-Johnson C. , Devarajan K. , Flores-Obando R.E. , McFarlane-Anderson N. , Tulloch-Reid M.K. , Aiken W. , Kimbro K. , Jones D.Z. , et al. .
Source: Gene, 2017-12-15; 636, p. 96-102.
EPub date: 2017-09-10.
PMID: 28903065
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Cancer in populations of African Ancestry: studies of the African Caribbean Cancer Consortium.
Authors: Ragin C. , Blackman E. , Roberts R. , Butler R. , Gathere S. , Halliday D. , Ashing K. .
Source: Cancer causes & control : CCC, 2017 Nov; 28(11), p. 1173-1176.
PMID: 29086217
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