||5P20CA210294-02 Interpret this number
||Research Inst Of Fox Chase Can Ctr
||Planning for a Sustainable and Robust Rcre in the Caribbean
PROJECT SUMMARY/ABSTRACT: OVERALL
The Caribbean Region is highly diverse, comprising low, upper middle, and high income islands and mainland countries,
different language groups, and cultural/ethnic backgrounds. Health data show rapidly increasing non-communicable
disease (NCD) burden with a majority of deaths attributed to cardiovascular disease (CVD), cancer, diabetes or chronic
respiratory disease. The African-Caribbean Cancer Consortium (AC3), an NCI-EGRP supported consortium, is a global
cancer research program of Fox Chase Cancer Center (FCCC), and partnered with The University of the West Indies
(UWI), has had a strong partnership since 2007. To date, research in cancer, nutritional epidemiology and genetics has
resulted in numerous publications with the majority focused on prostate cancer. UWI, a regional University with its main
campus in Jamaica, has a Caribbean-wide network of health research and health care facilities, and contains expertise in
the skills required for NCD research including basic science, epidemiology and clinical research. It has a strong tradition
of research in obesity, diabetes, CVD, cancer and their risk factors. We will build on the strengths of this partnership and
have proposed foundational efforts to establish a Regional Center for Research Excellence in Jamaica with a focus on
cancer and cardiometabolic research. Guided by a community health and research/laboratory needs assessment, research
enhancement, community engagement activities and a pilot project, plans in Jamaica will include a research program and
three shared core facilities. The Methodology/Biostatistics and Biomarker/Biospecimen Cores are already established at
UWI and community engagement activities are already ongoing. We will build on the community engagement
infrastructure to establish an Outreach Core facility for continued community engagement and research support. The long-
term plan is to establish a Regional Center for Cancer and Cardiometabolic Research comprised of Centers of Excellence
spread across the Caribbean (the U54 phase). A Caribbean-wide community-health and research/laboratory needs
assessment generated in this application will guide the development of a
strategic plan by year 2, which
will help to
prioritize step-wise inclusion of additional partners,
sustainability of the center and scientific focus
during the U54 phase
Breast Cancer Research in the Caribbean: Analysis of Reports From 1975 to 2017.
, Banydeen R.
, Zhang C.
, Ben A.
, Calabrese V.
, Villa N.N.
, Reville J.
, Dasgupta S.
, Bandyopadhyay M.
, Louden D.
, et al.
Journal of global oncology, 2018 11; 4, p. 1-21.
Cancer in populations of African Ancestry: studies of the African Caribbean Cancer Consortium.
, Blackman E.
, Roberts R.
, Butler R.
, Gathere S.
, Halliday D.
, Ashing K.
Cancer causes & control : CCC, 2017 11; 28(11), p. 1173-1176.
Inflammation polymorphisms and prostate cancer risk in Jamaican men: Role of obesity/body size.
, Jackson M.D.
, Zeigler-Johnson C.
, Devarajan K.
, Flores-Obando R.E.
, McFarlane-Anderson N.
, Tulloch-Reid M.K.
, Aiken W.
, Kimbro K.
, Jones D.Z.
, et al.
Gene, 2017-12-15; 636, p. 96-102.