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Grant Details

Grant Number: 5UM1CA182913-05 Interpret this number
Primary Investigator: Buring, Julie
Organization: Brigham And Women'S Hospital
Project Title: The Women's Health Study: Infrastructure Support for Continued Cohort Follow-Up
Fiscal Year: 2018
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Abstract

DESCRIPTION (provided by applicant): The WHS began in 1992 as a randomized controlled trial testing aspirin, beta-carotene, and vitamin E for preventing cancer and cardiovascular disease (CVD) in 39,876 healthy women, aged >45, The trial ended in 2004, and women have been followed observationally since that time. At study entry and annually, women report via questionnaires on a wide range of exposures and endpoints, including cancer and CVD. We confirm these self-reported endpoints with medical records, and cause of death in decedents is ascertained using medical records and death certificates. At baseline, 28,345 women also provided a blood sample, from which plasma, buffy coat, and red blood cells were obtained and stored at -170 ?C. GWAS data on common variation are available for all women with blood, measurement of rare variants in exomes have just been completed for >23,000 women; and all samples have been assayed for several biomarkers. Objectively assessed 7-day physical activity by accelerometer is being collected on ~18,000 women. The WHS cohort is unique in having GWAS and objectively-assessed physical activity in such a large cohort. Follow-up is excellent; after almost 20 years, morbidity follow-up is 94 percent; and mortality follow-up is virtually 100 percent. At the end of current funding, 6,086 confirmed cancers (2,440 breast, 583 colorectal, 537 lung, 1,517 cancer deaths) will have occurred. During the proposed funding period, cancer and CVD endpoints will increase by 30 percent and 51 percent. The WHS has actively provided data to internal and external researchers, with 444 papers published, 89 ancillary studies funded, and participation in 19 NCI Cohort Consortium collaborative projects. In the proposed funding period, we intend to: (1) continue to update exposure and endpoint information, and maintain the repository of biospecimens, to further facilitate data sharing and collaboration, and (2) use the WHS infrastructure to address specific aims related to physical activity; evaluate the translational potential of gene-based risk and explore gene-by-environment interactions; and examine long-term chemo-protection of low-dose aspirin on cancer. None of the ancillary studies provides funding for ascertainment and validation of cancer (and CVD) endpoints. Continued infrastructure support and follow-up is crucial for maximizing the cost-effective use of this valuable large-scale cohort of women with a rich bank of already collected phenotypic and genetic data. RELEVANCE: This application seeks support over the next 5 years for the infrastructure of the Women's Health Study, a large-scale cancer epidemiology cohort of 39,876 women followed since 1992, Data are available on a wide range of characteristics, chronic disease development, blood biomarkers, genetic information, and objectively measured physical activity. Continued follow-up is crucial for building on the enormous amount of data already collected in order to answer critical questions related to cancer.

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Publications

Age At Natural Menopause Genetic Risk Score In Relation To Age At Natural Menopause And Primary Open-angle Glaucoma In A Us-based Sample
Authors: Pasquale L.R. , Aschard H. , Kang J.H. , Bailey J.N. , Lindström S. , Chasman D.I. , Christen W.G. , Allingham R.R. , Ashley-Koch A. , Lee R.K. , et al. .
Source: Menopause (new York, N.y.), 2017 Feb; 24(2), p. 150-156.
PMID: 27760082
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Strength Training and the Risk of Type 2 Diabetes and Cardiovascular Disease.
Authors: Shiroma E.J. , Cook N.R. , Manson J.E. , Moorthy M.V. , Buring J.E. , Rimm E.B. , Lee I.M. .
Source: Medicine And Science In Sports And Exercise, 2017 Jan; 49(1), p. 40-46.
PMID: 27580152
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Hemoglobin A1c levels and risk of sudden cardiac death: A nested case-control study.
Authors: Patel R.B. , Moorthy M.V. , Chiuve S.E. , Pradhan A.D. , Cook N.R. , Albert C.M. .
Source: Heart Rhythm, 2017 Jan; 14(1), p. 72-78.
EPub date: 2016-08-31 00:00:00.0.
PMID: 27591826
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Fish Consumption, Omega-3 Fatty Acids, And Risk Of Cardiovascular Disease
Authors: Rhee J.J. , Kim E. , Buring J.E. , Kurth T. .
Source: American Journal Of Preventive Medicine, 2017 Jan; 52(1), p. 10-19.
PMID: 27646568
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Pancreatic Cancer Risk Associated with Prediagnostic Plasma Levels of Leptin and Leptin Receptor Genetic Polymorphisms.
Authors: Babic A. , Bao Y. , Qian Z.R. , Yuan C. , Giovannucci E.L. , Aschard H. , Kraft P. , Amundadottir L.T. , Stolzenberg-Solomon R. , Morales-Oyarvide V. , et al. .
Source: Cancer Research, 2016-12-15 00:00:00.0; 76(24), p. 7160-7167.
EPub date: 2016-10-25 00:00:00.0.
PMID: 27780823
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Body Mass Index, Waist Circumference, Diabetes, And Risk Of Liver Cancer For U.s. Adults
Authors: Campbell P.T. , Newton C.C. , Freedman N.D. , Koshiol J. , Alavanja M.C. , Beane Freeman L.E. , Buring J.E. , Chan A.T. , Chong D.Q. , Datta M. , et al. .
Source: Cancer Research, 2016-10-15 00:00:00.0; 76(20), p. 6076-6083.
PMID: 27742674
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Three New Pancreatic Cancer Susceptibility Signals Identified On Chromosomes 1q32.1, 5p15.33 And 8q24.21
Authors: Zhang M. , Wang Z. , Obazee O. , Jia J. , Childs E.J. , Hoskins J. , Figlioli G. , Mocci E. , Collins I. , Chung C.C. , et al. .
Source: Oncotarget, 2016-10-11 00:00:00.0; 7(41), p. 66328-66343.
PMID: 27579533
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Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.
Authors: Liu C. , Kraja A.T. , Smith J.A. , Brody J.A. , Franceschini N. , Bis J.C. , Rice K. , Morrison A.C. , Lu Y. , Weiss S. , et al. .
Source: Nature Genetics, 2016 Oct; 48(10), p. 1162-70.
EPub date: 2016-09-12 00:00:00.0.
PMID: 27618448
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The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
Authors: Ehret G.B. , Ferreira T. , Chasman D.I. , Jackson A.U. , Schmidt E.M. , Johnson T. , Thorleifsson G. , Luan J. , Donnelly L.A. , Kanoni S. , et al. .
Source: Nature Genetics, 2016 Oct; 48(10), p. 1171-84.
EPub date: 2016-09-12 00:00:00.0.
PMID: 27618452
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Prospective Comorbidity-matched Study Of Parkinson's Disease And Risk Of Mortality Among Women
Authors: Winter A.C. , Rist P.M. , Buring J.E. , Kurth T. .
Source: Bmj Open, 2016-09-26 00:00:00.0; 6(9), p. e011888.
PMID: 27670518
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Association Between Markers of Inflammation and Total Stroke by Hypertensive Status Among Women.
Authors: Jiménez M.C. , Rexrode K.M. , Kotler G. , Everett B.M. , Glynn R.J. , Lee I.M. , Buring J.E. , Ridker P.M. , Sesso H.D. .
Source: American Journal Of Hypertension, 2016 Sep; 29(9), p. 1117-24.
EPub date: 2016-05-28 00:00:00.0.
PMID: 27235695
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Ovarian Cancer Risk Factors By Histologic Subtype: An Analysis From The Ovarian Cancer Cohort Consortium
Authors: Wentzensen N. , Poole E.M. , Trabert B. , White E. , Arslan A.A. , Patel A.V. , Setiawan V.W. , Visvanathan K. , Weiderpass E. , Adami H.O. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2016-08-20 00:00:00.0; 34(24), p. 2888-98.
PMID: 27325851
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Prediagnostic Plasma 25-hydroxyvitamin D And Pancreatic Cancer Survival
Authors: Yuan C. , Qian Z.R. , Babic A. , Morales-Oyarvide V. , Rubinson D.A. , Kraft P. , Ng K. , Bao Y. , Giovannucci E.L. , Ogino S. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2016-08-20 00:00:00.0; 34(24), p. 2899-905.
PMID: 27325858
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Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies.
Authors: Joshi A.D. , Andersson C. , Buch S. , Stender S. , Noordam R. , Weng L.C. , Weeke P.E. , Auer P.L. , Boehm B. , Chen C. , et al. .
Source: Gastroenterology, 2016 Aug; 151(2), p. 351-363.e28.
EPub date: 2016-04-16 00:00:00.0.
PMID: 27094239
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Meta-analysis Of 375,000 Individuals Identifies 38 Susceptibility Loci For Migraine
Authors: Gormley P. , Anttila V. , Winsvold B.S. , Palta P. , Esko T. , Pers T.H. , Farh K.H. , Cuenca-Leon E. , Muona M. , Furlotte N.A. , et al. .
Source: Nature Genetics, 2016 Aug; 48(8), p. 856-66.
PMID: 27322543
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Multivitamin use and the risk of hypertension in a prospective cohort study of women.
Authors: Rautiainen S. , Wang L. , Lee I.M. , Manson J.E. , Gaziano J.M. , Buring J.E. , Sesso H.D. .
Source: Journal Of Hypertension, 2016 Aug; 34(8), p. 1513-9.
PMID: 27327440
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Catechol-O-methyltransferase association with hemoglobin A1c.
Authors: Hall K.T. , Jablonski K.A. , Chen L. , Harden M. , Tolkin B.R. , Kaptchuk T.J. , Bray G.A. , Ridker P.M. , Florez J.C. , Diabetes Prevention Program Research Group , et al. .
Source: Metabolism: Clinical And Experimental, 2016 Jul; 65(7), p. 961-7.
EPub date: 2016-04-14 00:00:00.0.
PMID: 27282867
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Endophenotype Network Models: Common Core of Complex Diseases.
Authors: Ghiassian S.D. , Menche J. , Chasman D.I. , Giulianini F. , Wang R. , Ricchiuto P. , Aikawa M. , Iwata H. , Müller C. , Zeller T. , et al. .
Source: Scientific Reports, 2016-06-09 00:00:00.0; 6, p. 27414.
EPub date: 2016-06-09 00:00:00.0.
PMID: 27278246
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Physical and neurobehavioral determinants of reproductive onset and success.
Authors: Day F.R. , Helgason H. , Chasman D.I. , Rose L.M. , Loh P.R. , Scott R.A. , Helgason A. , Kong A. , Masson G. , Magnusson O.T. , et al. .
Source: Nature Genetics, 2016 Jun; 48(6), p. 617-23.
EPub date: 2016-04-18 00:00:00.0.
PMID: 27089180
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Lipid biomarkers and long-term risk of cancer in the Women's Health Study.
Authors: Chandler P.D. , Song Y. , Lin J. , Zhang S. , Sesso H.D. , Mora S. , Giovannucci E.L. , Rexrode K.E. , Moorthy M.V. , Li C. , et al. .
Source: The American Journal Of Clinical Nutrition, 2016 Jun; 103(6), p. 1397-407.
EPub date: 2016-04-20 00:00:00.0.
PMID: 27099252
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Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas.
Authors: Eising E. , Huisman S.M. , Mahfouz A. , Vijfhuizen L.S. , Anttila V. , Winsvold B.S. , Kurth T. , Ikram M.A. , Freilinger T. , Kaprio J. , et al. .
Source: Human Genetics, 2016 Apr; 135(4), p. 425-39.
EPub date: 2016-02-22 00:00:00.0.
PMID: 26899160
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Dairy consumption in association with weight change and risk of becoming overweight or obese in middle-aged and older women: a prospective cohort study.
Authors: Rautiainen S. , Wang L. , Lee I.M. , Manson J.E. , Buring J.E. , Sesso H.D. .
Source: The American Journal Of Clinical Nutrition, 2016 Apr; 103(4), p. 979-88.
EPub date: 2016-02-24 00:00:00.0.
PMID: 26912496
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Circulating N-linked Glycoprotein Acetyls And Longitudinal Mortality Risk
Authors: Lawler P.R. , Akinkuolie A.O. , Chandler P.D. , Moorthy M.V. , Vandenburgh M.J. , Schaumberg D.A. , Lee I.M. , Glynn R.J. , Ridker P.M. , Buring J.E. , et al. .
Source: Circulation Research, 2016-04-01 00:00:00.0; 118(7), p. 1106-15.
PMID: 26951635
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Healthy Lifestyle And Functional Outcomes From Stroke In Women
Authors: Rist P.M. , Buring J.E. , Kase C.S. , Kurth T. .
Source: The American Journal Of Medicine, 2016-02-17 00:00:00.0; , .
PMID: 26899753
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Anthropometric Factors and Thyroid Cancer Risk by Histological Subtype: Pooled Analysis of 22 Prospective Studies.
Authors: Kitahara C.M. , McCullough M.L. , Franceschi S. , Rinaldi S. , Wolk A. , Neta G. , Olov Adami H. , Anderson K. , Andreotti G. , Beane Freeman L.E. , et al. .
Source: Thyroid : Official Journal Of The American Thyroid Association, 2016 Feb; 26(2), p. 306-18.
PMID: 26756356
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Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.
Authors: Ma Y. , Follis J.L. , Smith C.E. , Tanaka T. , Manichaikul A.W. , Chu A.Y. , Samieri C. , Zhou X. , Guan W. , Wang L. , et al. .
Source: The American Journal Of Clinical Nutrition, 2016 Feb; 103(2), p. 567-78.
EPub date: 2016-01-20 00:00:00.0.
PMID: 26791180
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Comparison of physical activity assessed using hip- and wrist-worn accelerometers.
Authors: Kamada M. , Shiroma E.J. , Harris T.B. , Lee I.M. .
Source: Gait & Posture, 2016 Feb; 44, p. 23-8.
PMID: 27004628
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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
Authors: Pattaro C. , Teumer A. , Gorski M. , Chu A.Y. , Li M. , Mijatovic V. , Garnaas M. , Tin A. , Sorice R. , Li Y. , et al. .
Source: Nature Communications, 2016-01-21 00:00:00.0; 7, p. 10023.
EPub date: 2016-01-21 00:00:00.0.
PMID: 26831199
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Genome-wide Meta-analysis Uncovers Novel Loci Influencing Circulating Leptin Levels
Authors: Kilpeläinen T.O. , Carli J.F. , Skowronski A.A. , Sun Q. , Kriebel J. , Feitosa M.F. , Hedman Å.K. , Drong A.W. , Hayes J.E. , Zhao J. , et al. .
Source: Nature Communications, 2016; 7, p. 10494.
PMID: 26833098
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Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium.
Authors: Norby F.L. , Eryd S.A. , Niemeijer M.N. , Rose L.M. , Smith A.V. , Yin X. , Agarwal S.K. , Arking D.E. , Chasman D.L. , Chen L.Y. , et al. .
Source: Plos One, 2016; 11(3), p. e0151932.
EPub date: 2016-03-21 00:00:00.0.
PMID: 26999784
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An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group.
Authors: Sung Y.J. , Winkler T.W. , Manning A.K. , Aschard H. , Gudnason V. , Harris T.B. , Smith A.V. , Boerwinkle E. , Brown M.R. , Morrison A.C. , et al. .
Source: Genetic Epidemiology, 2016 07; 40(5), p. 404-15.
PMID: 27230302
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Fish Intake, Genetic Predisposition to Alzheimer Disease, and Decline in Global Cognition and Memory in 5 Cohorts of Older Persons.
Authors: Samieri C. , Morris M.C. , Bennett D.A. , Berr C. , Amouyel P. , Dartigues J.F. , Tzourio C. , Chasman D.I. , Grodstein F. .
Source: American Journal Of Epidemiology, 2018-05-01 00:00:00.0; 187(5), p. 933-940.
PMID: 29053784
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Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease.
Authors: Emdin C.A. , Khera A.V. , Chaffin M. , Klarin D. , Natarajan P. , Aragam K. , Haas M. , Bick A. , Zekavat S.M. , Nomura A. , et al. .
Source: Nature Communications, 2018-04-24 00:00:00.0; 9(1), p. 1613.
EPub date: 2018-04-24 00:00:00.0.
PMID: 29691411
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Markers of Inflammation and Incident Breast Cancer Risk in the Women's Health Study.
Authors: Tobias D.K. , Akinkuolie A.O. , Chandler P.D. , Lawler P.R. , Manson J.E. , Buring J.E. , Ridker P.M. , Wang L. , Lee I.M. , Mora S. .
Source: American Journal Of Epidemiology, 2018-04-01 00:00:00.0; 187(4), p. 705-716.
PMID: 28641369
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Circulating Branched-Chain Amino Acids and Incident Cardiovascular Disease in a Prospective Cohort of US Women.
Authors: Tobias D.K. , Lawler P.R. , Harada P.H. , Demler O.V. , Ridker P.M. , Manson J.E. , Cheng S. , Mora S. .
Source: Circulation. Genomic And Precision Medicine, 2018 Apr; 11(4), p. e002157.
PMID: 29572205
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Migraine and invasive epithelial ovarian cancer risk in the Nurses' Health Study II and the Women's Health Study.
Authors: Rice M.S. , Rist P.M. , Winter A.C. , Kurth T. , Tworoger S.S. .
Source: International Journal Of Cancer, 2018-02-01 00:00:00.0; 142(3), p. 534-539.
EPub date: 2017-10-30 00:00:00.0.
PMID: 28929486
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Association between Vitamin D Genetic Risk Score and Cancer Risk in a Large Cohort of U.S. Women.
Authors: Chandler P.D. , Tobias D.K. , Wang L. , Smith-Warner S.A. , Chasman D.I. , Rose L. , Giovannucci E.L. , Buring J.E. , Ridker P.M. , Cook N.R. , et al. .
Source: Nutrients, 2018-01-09 00:00:00.0; 10(1), .
EPub date: 2018-01-09 00:00:00.0.
PMID: 29315215
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Adiposity and Genetic Factors in Relation to Triglycerides and Triglyceride-Rich Lipoproteins in the Women's Genome Health Study.
Authors: Ahmad S. , Mora S. , Franks P.W. , Orho-Melander M. , Ridker P.M. , Hu F.B. , Chasman D.I. .
Source: Clinical Chemistry, 2018 Jan; 64(1), p. 231-241.
EPub date: 2017-11-02 00:00:00.0.
PMID: 29097515
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Migraine and the risk of incident hypertension among women.
Authors: Rist P.M. , Winter A.C. , Buring J.E. , Sesso H.D. , Kurth T. .
Source: Cephalalgia : An International Journal Of Headache, 2018-01-01 00:00:00.0; , p. 333102418756865.
EPub date: 2018-01-01 00:00:00.0.
PMID: 29388437
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Accelerometer-Measured Physical Activity and Sedentary Behavior in Relation to All-Cause Mortality: The Women's Health Study.
Authors: Lee I.M. , Shiroma E.J. , Evenson K.R. , Kamada M. , LaCroix A.Z. , Buring J.E. .
Source: Circulation, 2017-11-06 00:00:00.0; , .
EPub date: 2017-11-06 00:00:00.0.
PMID: 29109088
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Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry.
Authors: Sapkota Y. , Vivo I. , Steinthorsdottir V. , Fassbender A. , Bowdler L. , Buring J.E. , Edwards T.L. , Jones S. , O D. , Peterse D. , et al. .
Source: Scientific Reports, 2017-09-12 00:00:00.0; 7(1), p. 11380.
EPub date: 2017-09-12 00:00:00.0.
PMID: 28900119
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Lipoprotein insulin resistance score and risk of incident diabetes during extended follow-up of 20 years: The Women's Health Study.
Authors: Harada P.H.N. , Demler O.V. , Dugani S.B. , Akinkuolie A.O. , Moorthy M.V. , Ridker P.M. , Cook N.R. , Pradhan A.D. , Mora S. .
Source: Journal Of Clinical Lipidology, 2017 Sep - Oct; 11(5), p. 1257-1267.e2.
EPub date: 2017-06-21 00:00:00.0.
PMID: 28733174
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Association of High-Density Lipoprotein-Cholesterol Versus Apolipoprotein A-I With Risk of Coronary Heart Disease: The European Prospective Investigation Into Cancer-Norfolk Prospective Population Study, the Atherosclerosis Risk in Communities Study, and the Women's Health Study.
Authors: van Capelleveen J.C. , Bochem A.E. , Boekholdt S.M. , Mora S. , Hoogeveen R.C. , Ballantyne C.M. , Ridker P.M. , Sun W. , Barter P.J. , Tall A.R. , et al. .
Source: Journal Of The American Heart Association, 2017-08-03 00:00:00.0; 6(8), .
EPub date: 2017-08-03 00:00:00.0.
PMID: 28775061
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Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.
Authors: Wain L.V. , Vaez A. , Jansen R. , Joehanes R. , van der Most P.J. , Erzurumluoglu A.M. , O'Reilly P.F. , Cabrera C.P. , Warren H.R. , Rose L.M. , et al. .
Source: Hypertension (dallas, Tex. : 1979), 2017-07-24 00:00:00.0; , .
EPub date: 2017-07-24 00:00:00.0.
PMID: 28739976
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Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study.
Authors: Lindström S. , Germain M. , Crous-Bou M. , Smith E.N. , Morange P.E. , van Hylckama Vlieg A. , de Haan H.G. , Chasman D. , Ridker P. , Brody J. , et al. .
Source: Human Genetics, 2017 Jul; 136(7), p. 897-902.
EPub date: 2017-05-20 00:00:00.0.
PMID: 28528403
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Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.
Authors: Day F.R. , Thompson D.J. , Helgason H. , Chasman D.I. , Finucane H. , Sulem P. , Ruth K.S. , Whalen S. , Sarkar A.K. , Albrecht E. , et al. .
Source: Nature Genetics, 2017 Jun; 49(6), p. 834-841.
EPub date: 2017-04-24 00:00:00.0.
PMID: 28436984
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Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
Authors: Justice A.E. , Winkler T.W. , Feitosa M.F. , Graff M. , Fisher V.A. , Young K. , Barata L. , Deng X. , Czajkowski J. , Hadley D. , et al. .
Source: Nature Communications, 2017-04-26 00:00:00.0; 8, p. 14977.
EPub date: 2017-04-26 00:00:00.0.
PMID: 28443625
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Androgens Are Differentially Associated With Ovarian Cancer Subtypes In The Ovarian Cancer Cohort Consortium
Authors: Ose J. , Poole E.M. , Schock H. , Lehtinen M. , Arslan A.A. , Zeleniuch-Jacquotte A. , Visvanathan K. , Helzlsouer K.J. , Buring J.E. , Lee I.M. , et al. .
Source: Cancer Research, 2017-04-05 00:00:00.0; , .
PMID: 28381542
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Body Size Indicators And Risk Of Gallbladder Cancer: Pooled Analysis Of Individual-level Data From 19 Prospective Cohort Studies
Authors: Campbell P.T. , Newton C.C. , Kitahara C.M. , Patel A.V. , Hartge P. , Koshiol J. , McGlynn K.A. , Adami H.O. , Berrington de González A. , Beane Freeman L.E. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017-03-17 00:00:00.0; , .
PMID: 28314823
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Genetic Obesity And The Risk Of Atrial Fibrillation: Causal Estimates From Mendelian Randomization
Authors: Chatterjee N.A. , Giulianini F. , Geelhoed B. , Lunetta K.L. , Misialek J.R. , Niemeijer M.N. , Rienstra M. , Rose L.M. , Smith A.V. , Arking D.E. , et al. .
Source: Circulation, 2017-02-21 00:00:00.0; 135(8), p. 741-754.
PMID: 27974350
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