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Grant Details

Grant Number: 5R01CA169141-07 Interpret this number
Primary Investigator: Fuchs, Charles
Organization: Yale University
Project Title: Impact of Celecoxib and Inflammation on Survival in Stage Iii Colon Cancer
Fiscal Year: 2018
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Abstract

DESCRIPTION (provided by applicant): Epidemiologic and scientific research indicates that diet, lifestyle, and other modifiable factors have a significant influence on the risk of developin colorectal cancer (CRC). However, the influence of these interventions on the survival of patients with established CRC remains poorly understood. While randomized clinical trials (RCTs) demonstrate a significant survival advantage for stage III colon cancer patients who receive adjuvant fluorouracil-based chemotherapy, 35-40% of stage III patients receiving current adjuvant chemotherapy still develop cancer recurrence. Patients often seek to understand what, if any diet, lifestyle or supplement will reduce their chances of cancer recurrence. Moreover, how diet and lifestyle influence prognosis may depend, in part, on specific patient characteristics as well as molecular alterations in the tumor. We propose to address these gaps in knowledge within a NCI-sponsored, large, double-blind, placebo- controlled RCT assessing the influence of celecoxib on survival in stage III colon cancer patients who are concurrently receiving standard adjuvant chemotherapy (CALGB 80702). Beyond directly addressing the role of COX inhibition, the trial provides a) two longitudinal prospective assessments of diet, medication usage, and lifestyle habits; b) tumor specimens to examine how exogenous factors interact with specific molecular alterations; c) prospectively collected blood and germline DNA; and d) extensive data on cancer recurrence, mortality, and treated-related toxicity. Since pathologic stage, performance status, post-operative therapy and follow-up are carefully defined in this trial, residual confounding by disease and treatment characteristics should be minimized. In this application, we propose to examine the influence celecoxib and inflammation (Aim 1), and relevant effect modifying pathways (Aim 2) on the risk of cancer recurrence, mortality, and treatment-related toxicity. Each aim extends current knowledge in these areas. Beyond the aforementioned hypotheses, this cohort will allow for the rapid examination of future hypotheses as they emerge. Ultimately, the proposed work seeks to improve our understanding of CRC biology, identify interventions that can improve patient survival, and, with the extensive clinical pathologic, genomic, and biomarker data available for analysis, inform clinicians how to maximally utilize these interventions to improve clinical care.

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Publications

Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status.
Authors: Hamada T. , Zhang X. , Mima K. , Bullman S. , Sukawa Y. , Nowak J.A. , Kosumi K. , Masugi Y. , Twombly T.S. , Cao Y. , et al. .
Source: Cancer Immunology Research, 2018-09-18 00:00:00.0; , .
EPub date: 2018-09-18 00:00:00.0.
PMID: 30228205
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Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour.
Authors: Hamada T. , Liu L. , Nowak J.A. , Mima K. , Cao Y. , Ng K. , Twombly T.S. , Song M. , Jung S. , Dou R. , et al. .
Source: European Journal Of Cancer (oxford, England : 1990), 2018-09-12 00:00:00.0; 103, p. 98-107.
EPub date: 2018-09-12 00:00:00.0.
PMID: 30219720
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Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma.
Authors: Ng K. , Hendifar A. , Starodub A. , Chaves J. , Yang Y. , Koh B. , Barbie D. , Hahn W.C. , Fuchs C.S. .
Source: Investigational New Drugs, 2018-07-30 00:00:00.0; , .
EPub date: 2018-07-30 00:00:00.0.
PMID: 30105668
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Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum.
Authors: Liu L. , Tabung F.K. , Zhang X. , Nowak J.A. , Qian Z.R. , Hamada T. , Nevo D. , Bullman S. , Mima K. , Kosumi K. , et al. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2018-04-24 00:00:00.0; , .
EPub date: 2018-04-24 00:00:00.0.
PMID: 29702299
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Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance).
Authors: Fadelu T. , Zhang S. , Niedzwiecki D. , Ye X. , Saltz L.B. , Mayer R.J. , Mowat R.B. , Whittom R. , Hantel A. , Benson A.B. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2018-04-10 00:00:00.0; 36(11), p. 1112-1120.
EPub date: 2018-02-28 00:00:00.0.
PMID: 29489429
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Marine ?-3 Polyunsaturated Fatty Acid and Fish Intake after Colon Cancer Diagnosis and Survival: CALGB 89803 (Alliance).
Authors: Van Blarigan E.L. , Fuchs C.S. , Niedzwiecki D. , Ye X. , Zhang S. , Song M. , Saltz L.B. , Mayer R.J. , Mowat R.B. , Whittom R. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2018 Apr; 27(4), p. 438-445.
EPub date: 2018-01-22 00:00:00.0.
PMID: 29358223
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Garlic intake and gastric cancer risk: results from two large prospective US cohort studies.
Authors: Kim H. , Keum N. , Giovannucci E.L. , Fuchs C.S. , Bao Y. .
Source: International Journal Of Cancer, 2018-03-23 00:00:00.0; , .
EPub date: 2018-03-23 00:00:00.0.
PMID: 29569711
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Genetic mechanisms of immune evasion in colorectal cancer.
Authors: Grasso C.S. , Giannakis M. , Wells D.K. , Hamada T. , Mu X.J. , Quist M. , Nowak J.A. , Nishihara R. , Qian Z.R. , Inamura K. , et al. .
Source: Cancer Discovery, 2018-03-06 00:00:00.0; , .
EPub date: 2018-03-06 00:00:00.0.
PMID: 29510987
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Association of Dietary Inflammatory Potential With Colorectal Cancer Risk in Men and Women.
Authors: Tabung F.K. , Liu L. , Wang W. , Fung T.T. , Wu K. , Smith-Warner S.A. , Cao Y. , Hu F.B. , Ogino S. , Fuchs C.S. , et al. .
Source: Jama Oncology, 2018-03-01 00:00:00.0; 4(3), p. 366-373.
PMID: 29346484
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Inherited DNA-Repair Defects in Colorectal Cancer.
Authors: AlDubayan S.H. , Giannakis M. , Moore N.D. , Han G.C. , Reardon B. , Hamada T. , Mu X.J. , Nishihara R. , Qian Z. , Liu L. , et al. .
Source: American Journal Of Human Genetics, 2018-03-01 00:00:00.0; 102(3), p. 401-414.
EPub date: 2018-02-22 00:00:00.0.
PMID: 29478780
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Grain Intake and Clinical Outcome in Stage III Colon Cancer: Results From CALGB 89803 (Alliance).
Authors: Brown J.C. , Zhang S. , Niedzwiecki D. , Saltz L.B. , Mayer R.J. , Mowat R.B. , Whittom R. , Hantel A. , Benson A. , Atienza D. , et al. .
Source: Jnci Cancer Spectrum, 2018 Feb; 2(2), p. pky017.
EPub date: 2018-05-30 00:00:00.0.
PMID: 29877501
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(PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas.
Authors: Hamada T. , Soong T.R. , Masugi Y. , Kosumi K. , Nowak J.A. , da Silva A. , Mu X.J. , Twombly T.S. , Koh H. , Yang J. , et al. .
Source: Oncoimmunology, 2018; 7(7), p. e1442999.
EPub date: 2018-03-19 00:00:00.0.
PMID: 29900052
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Tumor expression of calcium sensing receptor and colorectal cancer survival: Results from the nurses' health study and health professionals follow-up study.
Authors: Momen-Heravi F. , Masugi Y. , Qian Z.R. , Nishihara R. , Liu L. , Smith-Warner S.A. , Keum N. , Zhang L. , Tchrakian N. , Nowak J.A. , et al. .
Source: International Journal Of Cancer, 2017-12-15 00:00:00.0; 141(12), p. 2471-2479.
EPub date: 2017-09-20 00:00:00.0.
PMID: 28856682
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Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer.
Authors: Bullman S. , Pedamallu C.S. , Sicinska E. , Clancy T.E. , Zhang X. , Cai D. , Neuberg D. , Huang K. , Guevara F. , Nelson T. , et al. .
Source: Science (new York, N.y.), 2017-12-15 00:00:00.0; 358(6369), p. 1443-1448.
EPub date: 2017-11-23 00:00:00.0.
PMID: 29170280
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Social integration and survival after diagnosis of colorectal cancer.
Authors: Sarma E.A. , Kawachi I. , Poole E.M. , Tworoger S.S. , Giovannucci E.L. , Fuchs C.S. , Bao Y. .
Source: Cancer, 2017-11-21 00:00:00.0; , .
EPub date: 2017-11-21 00:00:00.0.
PMID: 29160897
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Association Between Coffee Intake After Diagnosis of Colorectal Cancer and Reduced mortality.
Authors: Hu Y. , Ding M. , Yuan C. , Wu K. , Smith-Warner S.A. , Hu F.B. , Chan A.T. , Meyerhardt J.A. , Ogino S. , Fuchs C.S. , et al. .
Source: Gastroenterology, 2017-11-17 00:00:00.0; , .
EPub date: 2017-11-17 00:00:00.0.
PMID: 29158191
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Adjuvant Chemoradiotherapy With Epirubicin, Cisplatin, and Fluorouracil Compared With Adjuvant Chemoradiotherapy With Fluorouracil and Leucovorin After Curative Resection of Gastric Cancer: Results From CALGB 80101 (Alliance).
Authors: Fuchs C.S. , Niedzwiecki D. , Mamon H.J. , Tepper J.E. , Ye X. , Swanson R.S. , Enzinger P.C. , Haller D.G. , Dragovich T. , Alberts S.R. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2017-11-10 00:00:00.0; 35(32), p. 3671-3677.
EPub date: 2017-10-04 00:00:00.0.
PMID: 28976791
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Real-world treatment patterns and effectiveness among patients with metastatic colorectal cancer treated with ziv-aflibercept in community oncology practices in the USA.
Authors: Ivanova J.I. , Saverno K.R. , Sung J. , Duh M.S. , Zhao C. , Cai S. , Vekeman F. , Peevyhouse A. , Dhawan R. , Fuchs C.S. .
Source: Medical Oncology (northwood, London, England), 2017-11-04 00:00:00.0; 34(12), p. 193.
EPub date: 2017-11-04 00:00:00.0.
PMID: 29103187
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Fiber Intake and Survival After Colorectal Cancer Diagnosis.
Authors: Song M. , Wu K. , Meyerhardt J.A. , Ogino S. , Wang M. , Fuchs C.S. , Giovannucci E.L. , Chan A.T. .
Source: Jama Oncology, 2017-11-02 00:00:00.0; , .
EPub date: 2017-11-02 00:00:00.0.
PMID: 29098294
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Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells.
Authors: Gu M. , Nishihara R. , Chen Y. , Li W. , Shi Y. , Masugi Y. , Hamada T. , Kosumi K. , Liu L. , da Silva A. , et al. .
Source: Oncotarget, 2017-10-20 00:00:00.0; 8(50), p. 87379-87389.
EPub date: 2017-09-18 00:00:00.0.
PMID: 29152088
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Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer.
Authors: Masugi Y. , Nishihara R. , Hamada T. , Song M. , da Silva A. , Kosumi K. , Gu M. , Shi Y. , Li W. , Liu L. , et al. .
Source: Cancer Immunology Research, 2017-10-16 00:00:00.0; , .
EPub date: 2017-10-16 00:00:00.0.
PMID: 29038297
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Influence of dietary insulin scores on survival in colorectal cancer patients.
Authors: Yuan C. , Bao Y. , Sato K. , Nimptsch K. , Song M. , Brand-Miller J.C. , Morales-Oyarvide V. , Zoltick E.S. , Keum N. , Wolpin B.M. , et al. .
Source: British Journal Of Cancer, 2017-09-26 00:00:00.0; 117(7), p. 1079-1087.
EPub date: 2017-08-17 00:00:00.0.
PMID: 28817837
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Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor.
Authors: Liu L. , Nishihara R. , Qian Z.R. , Tabung F.K. , Nevo D. , Zhang X. , Song M. , Cao Y. , Mima K. , Masugi Y. , et al. .
Source: Gastroenterology, 2017-08-30 00:00:00.0; , .
EPub date: 2017-08-30 00:00:00.0.
PMID: 28865736
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Calcium intake and risk of colorectal cancer according to expression status of calcium-sensing receptor (CASR).
Authors: Yang W. , Liu L. , Masugi Y. , Qian Z.R. , Nishihara R. , Keum N. , Wu K. , Smith-Warner S. , Ma Y. , Nowak J.A. , et al. .
Source: Gut, 2017-07-04 00:00:00.0; , .
EPub date: 2017-07-04 00:00:00.0.
PMID: 28676564
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Development and Validation of the PREMM5 Model for Comprehensive Risk Assessment of Lynch Syndrome.
Authors: Kastrinos F. , Uno H. , Ukaegbu C. , Alvero C. , McFarland A. , Yurgelun M.B. , Kulke M.H. , Schrag D. , Meyerhardt J.A. , Fuchs C.S. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2017-07-01 00:00:00.0; 35(19), p. 2165-2172.
EPub date: 2017-05-10 00:00:00.0.
PMID: 28489507
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Biomarker correlation network in colorectal carcinoma by tumor anatomic location.
Authors: Nishihara R. , Glass K. , Mima K. , Hamada T. , Nowak J.A. , Qian Z.R. , Kraft P. , Giovannucci E.L. , Fuchs C.S. , Chan A.T. , et al. .
Source: Bmc Bioinformatics, 2017-06-17 00:00:00.0; 18(1), p. 304.
EPub date: 2017-06-17 00:00:00.0.
PMID: 28623901
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Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance).
Authors: Fuchs M.A. , Yuan C. , Sato K. , Niedzwiecki D. , Ye X. , Saltz L.B. , Mayer R.J. , Mowat R.B. , Whittom R. , Hantel A. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology, 2017-06-01 00:00:00.0; 28(6), p. 1359-1367.
PMID: 28327908
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Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status.
Authors: Hamada T. , Cao Y. , Qian Z.R. , Masugi Y. , Nowak J.A. , Yang J. , Song M. , Mima K. , Kosumi K. , Liu L. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2017-06-01 00:00:00.0; 35(16), p. 1836-1844.
EPub date: 2017-04-13 00:00:00.0.
PMID: 28406723
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Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status.
Authors: Hanyuda A. , Cao Y. , Hamada T. , Nowak J.A. , Qian Z.R. , Masugi Y. , da Silva A. , Liu L. , Kosumi K. , Soong T.R. , et al. .
Source: European Journal Of Epidemiology, 2017-05-16 00:00:00.0; , .
EPub date: 2017-05-16 00:00:00.0.
PMID: 28510098
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Long-term use of antibiotics and risk of colorectal adenoma.
Authors: Cao Y. , Wu K. , Mehta R. , Drew D.A. , Song M. , Lochhead P. , Nguyen L.H. , Izard J. , Fuchs C.S. , Garrett W.S. , et al. .
Source: Gut, 2017-04-04 00:00:00.0; , .
EPub date: 2017-04-04 00:00:00.0.
PMID: 28377387
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Dietary Glycemic And Insulin Scores And Colorectal Cancer Survival By Tumor Molecular Biomarkers
Authors: Keum N. , Yuan C. , Nishihara R. , Zoltick E. , Hamada T. , Fernandez A.M. , Zhang X. , Hanyuda A. , Liu L. , Kosumi K. , et al. .
Source: International Journal Of Cancer, 2017-03-07 00:00:00.0; , .
PMID: 28268248
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Association Of Dietary Patterns With Risk Of Colorectal Cancer Subtypes Classified By Fusobacterium Nucleatum In Tumor Tissue
Authors: Mehta R.S. , Nishihara R. , Cao Y. , Song M. , Mima K. , Qian Z.R. , Nowak J.A. , Kosumi K. , Hamada T. , Masugi Y. , et al. .
Source: Jama Oncology, 2017-01-26 00:00:00.0; , .
PMID: 28125762
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Rotating Night Shift Work, Sleep, And Colorectal Adenoma In Women
Authors: Devore E.E. , Massa J. , Papantoniou K. , Schernhammer E.S. , Wu K. , Zhang X. , Willett W.C. , Fuchs C.S. , Chan A.T. , Ogino S. , et al. .
Source: International Journal Of Colorectal Disease, 2017-01-17 00:00:00.0; , .
PMID: 28097381
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Tumor SQSTM1 (p62) expression and T cells in colorectal cancer.
Authors: Kosumi K. , Masugi Y. , Yang J. , Qian Z.R. , Kim S.A. , Li W. , Shi Y. , da Silva A. , Hamada T. , Liu L. , et al. .
Source: Oncoimmunology, 2017; 6(3), p. e1284720.
EPub date: 2017-01-31 00:00:00.0.
PMID: 28405513
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Obesity And Energy Balance In Gi Cancer
Authors: Brown J.C. , Meyerhardt J.A. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2016-12-10 00:00:00.0; 34(35), p. 4217-4224.
PMID: 27903148
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Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis.
Authors: Mima K. , Nishihara R. , Qian Z.R. , Cao Y. , Sukawa Y. , Nowak J.A. , Yang J. , Dou R. , Masugi Y. , Song M. , et al. .
Source: Gut, 2016 Dec; 65(12), p. 1973-1980.
PMID: 26311717
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Fusobacterium Nucleatum In Colorectal Carcinoma Tissue According To Tumor Location
Authors: Mima K. , Cao Y. , Chan A.T. , Qian Z.R. , Nowak J.A. , Masugi Y. , Shi Y. , Song M. , da Silva A. , Gu M. , et al. .
Source: Clinical And Translational Gastroenterology, 2016-11-03 00:00:00.0; 7(11), p. e200.
PMID: 27811909
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Regular Aspirin Use Associates With Lower Risk of ColorectalCancers With Low Numbers of Tumor-Infiltrating Lymphocytes.
Authors: Cao Y. , Nishihara R. , Qian Z.R. , Song M. , Mima K. , Inamura K. , Nowak J.A. , Drew D.A. , Lochhead P. , Nosho K. , et al. .
Source: Gastroenterology, 2016 Nov; 151(5), p. 879-892.e4.
PMID: 27475305
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Microrna Let-7, T Cells, And Patient Survival In Colorectal Cancer
Authors: Dou R. , Nishihara R. , Cao Y. , Hamada T. , Mima K. , Masuda A. , Masugi Y. , Shi Y. , Gu M. , Li W. , et al. .
Source: Cancer Immunology Research, 2016 Nov; 4(11), p. 927-935.
PMID: 27737877
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Relationship of prediagnostic body mass index with survival after colorectal cancer: Stage-specific associations.
Authors: Kocarnik J.M. , Chan A.T. , Slattery M.L. , Potter J.D. , Meyerhardt J. , Phipps A. , Nan H. , Harrison T. , Rohan T.E. , Qi L. , et al. .
Source: International Journal Of Cancer, 2016-09-01 00:00:00.0; 139(5), p. 1065-72.
EPub date: 2016-09-01 00:00:00.0.
PMID: 27121247
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Marine -3 Polyunsaturated Fatty Acid Intake and Risk of Colorectal Cancer Characterized by Tumor-Infiltrating T Cells.
Authors: Song M. , Nishihara R. , Cao Y. , Chun E. , Qian Z.R. , Mima K. , Inamura K. , Masugi Y. , Nowak J.A. , Nosho K. , et al. .
Source: Jama Oncology, 2016-09-01 00:00:00.0; 2(9), p. 1197-206.
PMID: 27148825
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Analysis of Body Mass Index and Mortality in Patients With Colorectal Cancer Using Causal Diagrams.
Authors: Kroenke C.H. , Neugebauer R. , Meyerhardt J. , Prado C.M. , Weltzien E. , Kwan M.L. , Xiao J. , Caan B.J. .
Source: Jama Oncology, 2016-09-01 00:00:00.0; 2(9), p. 1137-45.
PMID: 27196302
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Tumor LINE-1 methylation level and colorectal cancer location in relation to patient survival.
Authors: Mima K. , Nowak J.A. , Qian Z.R. , Cao Y. , Song M. , Masugi Y. , Shi Y. , da Silva A. , Gu M. , Li W. , et al. .
Source: Oncotarget, 2016-08-23 00:00:00.0; 7(34), p. 55098-55109.
PMID: 27391152
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Body Mass Index And Risk Of Colorectal Cancer According To Tumor Lymphocytic Infiltrate
Authors: Hanyuda A. , Ogino S. , Qian Z.R. , Nishihara R. , Song M. , Mima K. , Inamura K. , Masugi Y. , Wu K. , Meyerhardt J.A. , et al. .
Source: International Journal Of Cancer, 2016-08-15 00:00:00.0; 139(4), p. 854-68.
PMID: 27037951
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MicroRNA MIR21 (miR-21) and PTGS2 Expression in Colorectal Cancer and Patient Survival.
Authors: Mima K. , Nishihara R. , Yang J. , Dou R. , Masugi Y. , Shi Y. , da Silva A. , Cao Y. , Song M. , Nowak J. , et al. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2016-08-01 00:00:00.0; 22(15), p. 3841-8.
EPub date: 2016-08-01 00:00:00.0.
PMID: 26957558
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Plasma 25-Hydroxyvitamin D, Vitamin D Binding Protein, and Risk of Colorectal Cancer in the Nurses' Health Study.
Authors: Song M. , Konijeti G.G. , Yuan C. , Ananthakrishnan A.N. , Ogino S. , Fuchs C.S. , Giovannucci E.L. , Ng K. , Chan A.T. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2016 Aug; 9(8), p. 664-72.
PMID: 27246684
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Development And Validation Of An Empirical Dietary Inflammatory Index
Authors: Tabung F.K. , Smith-Warner S.A. , Chavarro J.E. , Wu K. , Fuchs C.S. , Hu F.B. , Chan A.T. , Willett W.C. , Giovannucci E.L. .
Source: The Journal Of Nutrition, 2016 Aug; 146(8), p. 1560-70.
PMID: 27358416
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Tumour CD274 (PD-L1) expression and T cells in colorectal cancer.
Authors: Masugi Y. , Nishihara R. , Yang J. , Mima K. , da Silva A. , Shi Y. , Inamura K. , Cao Y. , Song M. , Nowak J.A. , et al. .
Source: Gut, 2016-05-05 00:00:00.0; , .
EPub date: 2016-05-05 00:00:00.0.
PMID: 27196573
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Sedentary behaviors and light-intensity activities in relation to colorectal cancer risk.
Authors: Keum N. , Cao Y. , Oh H. , Smith-Warner S.A. , Orav J. , Wu K. , Fuchs C.S. , Cho E. , Giovannucci E.L. .
Source: International Journal Of Cancer, 2016-05-01 00:00:00.0; 138(9), p. 2109-17.
EPub date: 2016-05-01 00:00:00.0.
PMID: 26649988
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Vitamin D And Physical Activity In Patients With Colorectal Cancer: Epidemiological Evidence And Therapeutic Implications
Authors: Morales-Oyarvide V. , Meyerhardt J.A. , Ng K. .
Source: Cancer Journal (sudbury, Mass.), 2016 May-Jun; 22(3), p. 223-31.
PMID: 27341603
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