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Grant Details

Grant Number: 5P01CA180945-05 Interpret this number
Primary Investigator: Fiore, Michael
Organization: University Of Wisconsin-Madison
Project Title: Optimized Chronic Care for Smokers: a Comparative Effectiveness Approach
Fiscal Year: 2018
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Abstract

DESCRIPTION (provided by applicant): Cigarette smoking is the chief preventable cause of morbidity and mortality in the US and is the leading preventable cause of cancer. Healthcare settings provide enormous potential for reaching smokers and delivering effective smoking treatments. Yet, too few smokers receive smoking treatments in these settings and the treatments they receive are not sufficiently effective. This Program Project aims to address these gaps by developing and implementing both an electronic health record (EHR) system that increases smokers' recruitment into treatment and a highly effective chronic care treatment with intervention components for all smokers. First, a new EHR system will be implemented in 18 clinics in 3 healthcare systems and experimentally evaluated on its ability to increase the recruitment of smokers into chronic care treatment (Project 1). Then, using highly efficient research methods, we will experimentally compare multiple intervention components that, when combined, will produce an optimized treatment package that addresses all phases of the smoking treatment process. The package will: increase quitting motivation among smokers initially unwilling to quit and prepare them for cessation (Project 2), enhance quitting success and prevent relapse when smokers are ready to quit (Project 3), and re-engage smokers in treatment and restore their abstinence if they have relapsed (Project 4). Our highly integrated research projects, supported by four cores, will thus implement a powerful new EHR strategy to efficiently recruit primary care patients who smoke into chronic care treatment for smoking. Our team has unique strengths in: smoking cessation treatment research in healthcare settings, established collaborations with EHR vendors and primary care clinics, comparative effectiveness research, and research methods. Project integration is fostered by a shared EHR-based recruitment platform, overlapping samples across projects as participant's transition through phases of the cessation process, and use of common measures across projects. Conducting this work in real-world clinics increases its potential for real-world application. The results of this Program Project will advance both research methods and the successful treatment of smoking in healthcare settings.

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Publications

What a difference a day makes: differences in initial abstinence response during a smoking cessation attempt.
Authors: Piper M.E. , Vasilenko S.A. , Cook J.W. , Lanza S.T. .
Source: Addiction (abingdon, England), 2017 Feb; 112(2), p. 330-339.
PMID: 27633341
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Transitions In Smokers' Social Networks After Quit Attempts: A Latent Transition Analysis
Authors: Bray B.C. , Smith R.A. , Piper M.E. , Roberts L.J. , Baker T.B. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2016 Dec; 18(12), p. 2243-2251.
PMID: 27613925
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Implementing Multifactorial Psychotherapy Research In Online Virtual Environments (improve-2): Study Protocol For A Phase Iii Trial Of The Most Randomized Component Selection Method For Internet Cognitive-behavioural Therapy For Depression
Authors: Watkins E. , Newbold A. , Tester-Jones M. , Javaid M. , Cadman J. , Collins L.M. , Graham J. , Mostazir M. .
Source: Bmc Psychiatry, 2016-10-06 00:00:00.0; 16(1), p. 345.
PMID: 27716200
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Just-in-time Adaptive Interventions (jitais) In Mobile Health: Key Components And Design Principles For Ongoing Health Behavior Support
Authors: Nahum-Shani I. , Smith S.N. , Spring B.J. , Collins L.M. , Witkiewitz K. , Tewari A. , Murphy S.A. .
Source: Annals Of Behavioral Medicine : A Publication Of The Society Of Behavioral Medicine, 2016-09-23 00:00:00.0; , .
PMID: 27663578
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Genetic Risk Can Be Decreased: Quitting Smoking Decreases And Delays Lung Cancer For Smokers With High And Low Chrna5 Risk Genotypes - A Meta-analysis
Authors: Chen L.S. , Baker T. , Hung R.J. , Horton A. , Culverhouse R. , Hartz S. , Saccone N. , Cheng I. , Deng B. , Han Y. , et al. .
Source: Ebiomedicine, 2016 Sep; 11, p. 219-226.
PMID: 27543155
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Exploring Issues Of Comorbid Conditions In People Who Smoke
Authors: Rojewski A.M. , Baldassarri S. , Cooperman N.A. , Gritz E.R. , Leone F.T. , Piper M.E. , Toll B.A. , Warren G.W. , Comorbidities Workgroup of the Society for Research on Nicotine and Tobacco (SRNT) Treatment Network .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2016 Aug; 18(8), p. 1684-96.
PMID: 26783291
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Identification Of Subgroups With Differential Treatment Effects For Longitudinal And Multiresponse Variables
Authors: Loh W.Y. , Fu H. , Man M. , Champion V. , Yu M. .
Source: Statistics In Medicine, 2016-06-27 00:00:00.0; , .
PMID: 27346729
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A Survey Of Baseline Tobacco Cessation Clinical Practices And Receptivity To Academic Detailing
Authors: Adsit R. , Wisinski K. , Mattison R. , Bailey H. , Fiore M. .
Source: Wmj : Official Publication Of The State Medical Society Of Wisconsin, 2016 Jun; 115(3), p. 143-6.
PMID: 27443091
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Don't Wait for COPD to Treat Tobacco Use.
Authors: Fiore M.C. , Jorenby D.E. , Baker T.B. .
Source: Chest, 2016 Mar; 149(3), p. 617-8.
PMID: 26965965
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Effects Of Nicotine Patch Vs Varenicline Vs Combination Nicotine Replacement Therapy On Smoking Cessation At 26 Weeks: A Randomized Clinical Trial
Authors: Baker T.B. , Piper M.E. , Stein J.H. , Smith S.S. , Bolt D.M. , Fraser D.L. , Fiore M.C. .
Source: Jama, 2016-01-26 00:00:00.0; 315(4), p. 371-9.
PMID: 26813210
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Comparative effectiveness of intervention components for producing long-term abstinence from smoking: a factorial screening experiment.
Authors: Schlam T.R. , Fiore M.C. , Smith S.S. , Fraser D. , Bolt D.M. , Collins L.M. , Mermelstein R. , Piper M.E. , Cook J.W. , Jorenby D.E. , et al. .
Source: Addiction (abingdon, England), 2016 Jan; 111(1), p. 142-55.
PMID: 26581819
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Enhancing the effectiveness of smoking treatment research: conceptual bases and progress.
Authors: Baker T.B. , Collins L.M. , Mermelstein R. , Piper M.E. , Schlam T.R. , Cook J.W. , Bolt D.M. , Smith S.S. , Jorenby D.E. , Fraser D. , et al. .
Source: Addiction (abingdon, England), 2016 Jan; 111(1), p. 107-16.
PMID: 26581974
Related Citations

Comparative effectiveness of motivation phase intervention components for use with smokers unwilling to quit: a factorial screening experiment.
Authors: Cook J.W. , Collins L.M. , Fiore M.C. , Smith S.S. , Fraser D. , Bolt D.M. , Baker T.B. , Piper M.E. , Schlam T.R. , Jorenby D. , et al. .
Source: Addiction (abingdon, England), 2016 Jan; 111(1), p. 117-28.
PMID: 26582140
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Identifying effective intervention components for smoking cessation: a factorial screening experiment.
Authors: Piper M.E. , Fiore M.C. , Smith S.S. , Fraser D. , Bolt D.M. , Collins L.M. , Mermelstein R. , Schlam T.R. , Cook J.W. , Jorenby D.E. , et al. .
Source: Addiction (abingdon, England), 2016 Jan; 111(1), p. 129-41.
PMID: 26582269
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Genome-wide Meta-analysis Reveals Common Splice Site Acceptor Variant In Chrna4 Associated With Nicotine Dependence
Authors: Hancock D.B. , Reginsson G.W. , Gaddis N.C. , Chen X. , Saccone N.L. , Lutz S.M. , Qaiser B. , Sherva R. , Steinberg S. , Zink F. , et al. .
Source: Translational Psychiatry, 2015-10-06 00:00:00.0; 5, p. e651.
PMID: 26440539
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Reduced-Nicotine Cigarettes--A Promising Regulatory Pathway.
Authors: Fiore M. , Baker T. .
Source: The New England Journal Of Medicine, 2015 Oct; 373(14), p. 1289-91.
PMID: 26422720
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Utilization of the Electronic Health Record to Improve Provision of Smoking Cessation Resources for Vascular Surgery Inpatients.
Authors: Smith B.K. , Adsit R.T. , Jorenby D.E. , Matsumura J.S. , Fiore M.C. .
Source: International Journal Of Cardiovascular Research, 2015; 4(5), .
PMID: 26566531
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Advancing Models and Theories for Digital Behavior Change Interventions.
Authors: Hekler E.B. , Michie S. , Pavel M. , Rivera D.E. , Collins L.M. , Jimison H.B. , Garnett C. , Parral S. , Spruijt-Metz D. .
Source: American Journal Of Preventive Medicine, 2016 11; 51(5), p. 825-832.
PMID: 27745682
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Identifying Differences in Rates of Invitation to Participate in Tobacco Treatment in Primary Care.
Authors: Berg K.M. , Smith S.S. , Piper M.E. , Fiore M.C. , Jorenby D.E. .
Source: Wmj : Official Publication Of The State Medical Society Of Wisconsin, 2018 Aug; 117(3), p. 111-115.
PMID: 30193019
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Can we increase smokers' adherence to nicotine replacement therapy and does this help them quit?
Authors: Schlam T.R. , Cook J.W. , Baker T.B. , Hayes-Birchler T. , Bolt D.M. , Smith S.S. , Fiore M.C. , Piper M.E. .
Source: Psychopharmacology, 2018-04-25 00:00:00.0; , .
EPub date: 2018-04-25 00:00:00.0.
PMID: 29696311
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Extreme Response Style and the Measurement of Intra-Individual Variability in Affect.
Authors: Deng S. , E McCarthy D. , E Piper M. , B Baker T. , Bolt D.M. .
Source: Multivariate Behavioral Research, 2018 Mar-Apr; 53(2), p. 199-218.
EPub date: 2018-01-11 00:00:00.0.
PMID: 29324049
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Offering smoking treatment to primary care patients in two Wisconsin healthcare systems: Who chooses smoking reduction versus cessation?
Authors: Petersen A. , Mermelstein R. , Berg K.M. , Baker T.B. , Smith S.S. , Jorenby D. , Piper M.E. , Schlam T.R. , Cook J.W. .
Source: Preventive Medicine, 2017 Dec; 105, p. 332-336.
EPub date: 2017-10-06 00:00:00.0.
PMID: 28988997
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Evaluating the effect of smoking cessation treatment on a complex dynamical system.
Authors: Bekiroglu K. , Russell M.A. , Lagoa C.M. , Lanza S.T. , Piper M.E. .
Source: Drug And Alcohol Dependence, 2017-11-01 00:00:00.0; 180, p. 215-222.
EPub date: 2017-08-25 00:00:00.0.
PMID: 28922651
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How Cancer Patients Use and Benefit from an Interactive Cancer Communication System.
Authors: Han J.Y. , Hawkins R. , Baker T. , Shah D.V. , Pingree S. , Gustafson D.H. .
Source: Journal Of Health Communication, 2017 Oct; 22(10), p. 792-799.
EPub date: 2017-09-18 00:00:00.0.
PMID: 28922091
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Implementing Clinical Research Using Factorial Designs: A Primer.
Authors: Baker T.B. , Smith S.S. , Bolt D.M. , Loh W.Y. , Mermelstein R. , Fiore M.C. , Piper M.E. , Collins L.M. .
Source: Behavior Therapy, 2017 Jul; 48(4), p. 567-580.
EPub date: 2017-01-07 00:00:00.0.
PMID: 28577591
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Multilevel Factorial Designs With Experiment-Induced Clustering.
Authors: Nahum-Shani I. , Dziak J.J. , Collins L.M. .
Source: Psychological Methods, 2017-04-06 00:00:00.0; , .
EPub date: 2017-04-06 00:00:00.0.
PMID: 28383950
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Genetic Correlation Between Smoking Behaviors And Schizophrenia
Authors: Hartz S.M. , Horton A.C. , Hancock D.B. , Baker T.B. , Caporaso N.E. , Chen L.S. , Hokanson J.E. , Lutz S.M. , Marazita M.L. , McNeil D.W. , et al. .
Source: Schizophrenia Research, 2017-03-08 00:00:00.0; , .
PMID: 28285025
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The 2016 Ferno Award Address: Three Things
Authors: Baker T.B. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2017-02-11 00:00:00.0; , .
PMID: 28201626
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Longitudinal Impact Of Smoking And Smoking Cessation On Inflammatory Markers Of Cardiovascular Disease Risk
Authors: King C.C. , Piper M.E. , Gepner A.D. , Fiore M.C. , Baker T.B. , Stein J.H. .
Source: Arteriosclerosis, Thrombosis, And Vascular Biology, 2017 Feb; 37(2), p. 374-379.
PMID: 27932354
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Nicotine Levels, Withdrawal Symptoms, And Smoking Reduction Success In Real World Use: A Comparison Of Cigarette Smokers And Dual Users Of Both Cigarettes And E-cigarettes
Authors: Jorenby D.E. , Smith S.S. , Fiore M.C. , Baker T.B. .
Source: Drug And Alcohol Dependence, 2017-01-01 00:00:00.0; 170, p. 93-101.
PMID: 27883949
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Smoking Cessation And Electronic Cigarettes In Community Mental Health Centers: Patient And Provider Perspectives
Authors: Chen L.S. , Baker T. , Brownson R.C. , Carney R.M. , Jorenby D. , Hartz S. , Smock N. , Johnson M. , Ziedonis D. , Bierut L.J. .
Source: Community Mental Health Journal, 2016-11-30 00:00:00.0; , .
PMID: 27900650
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Toward Precision Smoking Cessation Treatment I: Moderator Results From A Factorial Experiment
Authors: Piper M.E. , Schlam T.R. , Cook J.W. , Smith S.S. , Bolt D.M. , Loh W.Y. , Mermelstein R. , Collins L.M. , Fiore M.C. , Baker T.B. .
Source: Drug And Alcohol Dependence, 2016-11-25 00:00:00.0; 171, p. 59-65.
PMID: 28013098
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Toward Precision Smoking Cessation Treatment Ii: Proximal Effects Of Smoking Cessation Intervention Components On Putative Mechanisms Of Action
Authors: Piper M.E. , Cook J.W. , Schlam T.R. , Smith S.S. , Bolt D.M. , Collins L.M. , Mermelstein R. , Fiore M.C. , Baker T.B. .
Source: Drug And Alcohol Dependence, 2016-11-24 00:00:00.0; 171, p. 50-58.
PMID: 28013097
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Optimization Of Multicomponent Behavioral And Biobehavioral Interventions For The Prevention And Treatment Of Hiv/aids
Authors: Collins L.M. , Kugler K.C. , Gwadz M.V. .
Source: Aids And Behavior, 2016 Jan; 20 Suppl 1, p. 197-214.
PMID: 26238037
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Withdrawal: Expanding a Key Addiction Construct.
Authors: Piper M.E. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2015 Dec; 17(12), p. 1405-15.
PMID: 25744958
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Defining and predicting short-term alcohol use changes during a smoking cessation attempt.
Authors: Berg K.M. , Piper M.E. , Smith S.S. , Fiore M.C. , Jorenby D.E. .
Source: Addictive Behaviors, 2015 Sep; 48, p. 52-7.
PMID: 25997014
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Genetic variation (CHRNA5), medication (combination nicotine replacement therapy vs. varenicline), and smoking cessation.
Authors: Chen L.S. , Baker T.B. , Jorenby D. , Piper M. , Saccone N. , Johnson E. , Breslau N. , Hatsukami D. , Carney R.M. , Bierut L.J. .
Source: Drug And Alcohol Dependence, 2015-09-01 00:00:00.0; 154, p. 278-82.
EPub date: 2015-09-01 00:00:00.0.
PMID: 26142345
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Paths To Tobacco Abstinence: A Repeated-measures Latent Class Analysis
Authors: McCarthy D.E. , Ebssa L. , Witkiewitz K. , Shiffman S. .
Source: Journal Of Consulting And Clinical Psychology, 2015 Aug; 83(4), p. 696-708.
PMID: 25867447
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CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysis.
Authors: Chen L.S. , Hung R.J. , Baker T. , Horton A. , Culverhouse R. , Saccone N. , Cheng I. , Deng B. , Han Y. , Hansen H.M. , et al. .
Source: Journal Of The National Cancer Institute, 2015 May; 107(5), .
PMID: 25873736
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Treating More Smokers, More Of The Time, More Successfully
Authors: Baker T.B. , Fiore M.C. .
Source: Addiction (abingdon, England), 2015 Mar; 110(3), p. 388-9.
PMID: 25678285
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Rates and predictors of renewed quitting after relapse during a one-year follow-up among primary care patients.
Authors: Bold K.W. , Rasheed A.S. , McCarthy D.E. , Jackson T.C. , Fiore M.C. , Baker T.B. .
Source: Annals Of Behavioral Medicine : A Publication Of The Society Of Behavioral Medicine, 2015 Feb; 49(1), p. 128-40.
PMID: 24796541
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Anhedonia as a component of the tobacco withdrawal syndrome.
Authors: Cook J.W. , Piper M.E. , Leventhal A.M. , Schlam T.R. , Fiore M.C. , Baker T.B. .
Source: Journal Of Abnormal Psychology, 2015 Feb; 124(1), p. 215-25.
PMID: 25384069
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Anticipation Of Smoking Sufficiently Dampens Stress Reactivity In Nicotine-deprived Smokers
Authors: Bradford D.E. , Curtin J.J. , Piper M.E. .
Source: Journal Of Abnormal Psychology, 2015 Feb; 124(1), p. 128-36.
PMID: 25688439
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Cigarette Smoking, Desire to Quit, and Tobacco-Related Counseling Among Patients at Adult Health Centers.
Authors: Lebrun-Harris L.A. , Fiore M.C. , Tomoyasu N. , Ngo-Metzger Q. .
Source: American Journal Of Public Health, 2015 Jan; 105(1), p. 180-188.
PMID: 24625147
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Helping Smokers Quit--opportunities Created By The Affordable Care Act
Authors: McAfee T. , Babb S. , McNabb S. , Fiore M.C. .
Source: The New England Journal Of Medicine, 2015-01-01 00:00:00.0; 372(1), p. 5-7.
PMID: 25409263
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Smoking cessation in smokers who smoke menthol and non-menthol cigarettes.
Authors: Smith S.S. , Fiore M.C. , Baker T.B. .
Source: Addiction (abingdon, England), 2014 Dec; 109(12), p. 2107-17.
PMID: 24938369
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Organic cation transporter variation and response to smoking cessation therapies.
Authors: Bergen A.W. , Javitz H.S. , Krasnow R. , Michel M. , Nishita D. , Conti D.V. , Edlund C.K. , Kwok P.Y. , McClure J.B. , Kim R.B. , et al. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2014 Dec; 16(12), p. 1638-46.
PMID: 25143296
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Interplay of genetic risk (CHRNA5) and environmental risk (partner smoking) on cigarette smoking reduction.
Authors: Chen L.S. , Baker T.B. , Piper M.E. , Smith S.S. , Gu C. , Grucza R.A. , Smith G.D. , Munafo M. , Bierut L.J. .
Source: Drug And Alcohol Dependence, 2014-10-01 00:00:00.0; 143, p. 36-43.
EPub date: 2014-10-01 00:00:00.0.
PMID: 25073833
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Smokers' physical activity and weight gain one year after a successful versus unsuccessful quit attempt.
Authors: Gennuso K.P. , Thraen-Borowski K.M. , Schlam T.R. , LaRowe T.L. , Fiore M.C. , Baker T.B. , Colbert L.H. .
Source: Preventive Medicine, 2014 Oct; 67, p. 189-92.
PMID: 25091879
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Factorial Experiments: Efficient Tools For Evaluation Of Intervention Components
Authors: Collins L.M. , Dziak J.J. , Kugler K.C. , Trail J.B. .
Source: American Journal Of Preventive Medicine, 2014 Oct; 47(4), p. 498-504.
PMID: 25092122
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