Skip to main content
Grant Details

Grant Number: 5U01CA199335-04 Interpret this number
Primary Investigator: Zauber, Ann
Organization: Sloan-Kettering Inst Can Research
Project Title: Comparative Modeling of Colorectal Cancer: Informing Health Policies and Prioritizing Future Research
Fiscal Year: 2018
Back to top


Abstract

 DESCRIPTION (provided by applicant): Colorectal cancer (CRC) is the second leading cause of cancer death in the United States. The long-term goal of our proposed project is to reduce the population burden of CRC by providing the information needed to address key policy questions and prioritize future research. To accomplish this goal we will use our population- based microsimulation models to: 1) Inform emerging issues in health policy across the CRC-control spectrum; 2) Guide CRC research priorities and study design using a value of information (VOI) framework; and 3) Engage stakeholders, train modelers, and promote model transparency to ensure high-quality evaluation of CRC control measures, now and in the future. Our team will fill critical gaps in knowledge, enabling decision makers to act. Important gaps in knowledge include the impact of failures in screening and treatment processes on CRC burden; the potential to safely reduce screening and surveillance intensity among some patients based on currently available tools for risk-stratification; the potential benefit of new targeted screening approaches based on patient-level information (i.e., "precision medicine"); and the importance of clinical management of diminutive polyps. The three participating modeling groups are well-positioned to carry out this work, bringing a wealth of experience, expertise, and insight to issues related to microsimulation modeling of CRC, and have a proven track record of collaborating and disseminating our work to health policy decision makers.

Back to top


Publications

Potential Bias Associated with Modeling the Effectiveness of Healthcare Interventions in Reducing Mortality Using an Overall Hazard Ratio.
Authors: Alarid-Escudero F. , Kuntz K.M. .
Source: PharmacoEconomics, 2019-11-22; , .
EPub date: 2019-11-22.
PMID: 31755032
Related Citations

A Need for Change! A Coding Framework for Improving Transparency in Decision Modeling.
Authors: Alarid-Escudero F. , Krijkamp E.M. , Pechlivanoglou P. , Jalal H. , Kao S.Z. , Yang A. , Enns E.A. .
Source: PharmacoEconomics, 2019 Nov; 37(11), p. 1329-1339.
PMID: 31549359
Related Citations

Cost-Effectiveness of Colonoscopy-Based Colorectal Cancer Screening in Childhood Cancer Survivors.
Authors: Gini A. , Meester R.G.S. , Keshavarz H. , Oeffinger K.C. , Ahmed S. , Hodgson D.C. , Lansdorp-Vogelaar I. .
Source: Journal of the National Cancer Institute, 2019-11-01; 111(11), p. 1161-1169.
PMID: 30980665
Related Citations

Cost-effectiveness of Active Identification and Subsequent Colonoscopy Surveillance of Lynch Syndrome Cases.
Authors: Peterse E.F.P. , Naber S.K. , Daly C. , Pollett A. , Paszat L.F. , Spaander M.C.W. , Aronson M. , Gryfe R. , Rabeneck L. , Lansdorp-Vogelaar I. , et al. .
Source: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2019-10-17; , .
EPub date: 2019-10-17.
PMID: 31629885
Related Citations

Trends in Incidence and Stage at Diagnosis of Colorectal Cancer in Adults Aged 40 Through 49 Years, 1975-2015.
Authors: Meester R.G.S. , Mannalithara A. , Lansdorp-Vogelaar I. , Ladabaum U. .
Source: JAMA, 2019-05-21; 321(19), p. 1933-1934.
PMID: 31112249
Related Citations

"Time Traveling Is Just Too Dangerous" but Some Methods Are Worth Revisiting: The Advantages of Expected Loss Curves Over Cost-Effectiveness Acceptability Curves and Frontier.
Authors: Alarid-Escudero F. , Enns E.A. , Kuntz K.M. , Michaud T.L. , Jalal H. .
Source: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 2019 05; 22(5), p. 611-618.
PMID: 31104743
Related Citations

The Global Paradigm Shift in Screening for Colorectal Cancer.
Authors: Young G.P. , Rabeneck L. , Winawer S.J. .
Source: Gastroenterology, 2019 03; 156(4), p. 843-851.e2.
EPub date: 2019-02-16.
PMID: 30776340
Related Citations

The Curve of Optimal Sample Size (COSS): A Graphical Representation of the Optimal Sample Size from a Value of Information Analysis.
Authors: Jutkowitz E. , Alarid-Escudero F. , Kuntz K.M. , Jalal H. .
Source: PharmacoEconomics, 2019 07; 37(7), p. 871-877.
PMID: 30761461
Related Citations

Evidence-based sizing of non-inferiority trials using decision models.
Authors: Lansdorp-Vogelaar I. , Jagsi R. , Jayasekera J. , Stout N.K. , Mitchell S.A. , Feuer E.J. .
Source: BMC medical research methodology, 2019-01-07; 19(1), p. 3.
EPub date: 2019-01-07.
PMID: 30612554
Related Citations

Modeling in Colorectal Cancer Screening: Assessing External and Predictive Validity of MISCAN-Colon Microsimulation Model Using NORCCAP Trial Results.
Authors: Buskermolen M. , Gini A. , Naber S.K. , Toes-Zoutendijk E. , de Koning H.J. , Lansdorp-Vogelaar I. .
Source: Medical decision making : an international journal of the Society for Medical Decision Making, 2018 11; 38(8), p. 917-929.
EPub date: 2018-10-20.
PMID: 30343626
Related Citations

Nonidentifiability in Model Calibration and Implications for Medical Decision Making.
Authors: Alarid-Escudero F. , MacLehose R.F. , Peralta Y. , Kuntz K.M. , Enns E.A. .
Source: Medical decision making : an international journal of the Society for Medical Decision Making, 2018 10; 38(7), p. 810-821.
PMID: 30248276
Related Citations

Optimizing colorectal cancer screening by race and sex: Microsimulation analysis II to inform the American Cancer Society colorectal cancer screening guideline.
Authors: Meester R.G.S. , Peterse E.F.P. , Knudsen A.B. , de Weerdt A.C. , Chen J.C. , Lietz A.P. , Dwyer A. , Ahnen D.J. , Siegel R.L. , Smith R.A. , et al. .
Source: Cancer, 2018-07-15; 124(14), p. 2974-2985.
EPub date: 2018-05-30.
PMID: 29846942
Related Citations

The impact of the rising colorectal cancer incidence in young adults on the optimal age to start screening: Microsimulation analysis I to inform the American Cancer Society colorectal cancer screening guideline.
Authors: Peterse E.F.P. , Meester R.G.S. , Siegel R.L. , Chen J.C. , Dwyer A. , Ahnen D.J. , Smith R.A. , Zauber A.G. , Lansdorp-Vogelaar I. .
Source: Cancer, 2018-07-15; 124(14), p. 2964-2973.
EPub date: 2018-05-30.
PMID: 29846933
Related Citations

Microsimulation Modeling for Health Decision Sciences Using R: A Tutorial.
Authors: Krijkamp E.M. , Alarid-Escudero F. , Enns E.A. , Jalal H.J. , Hunink M.G.M. , Pechlivanoglou P. .
Source: Medical decision making : an international journal of the Society for Medical Decision Making, 2018 04; 38(3), p. 400-422.
PMID: 29587047
Related Citations

The IARC Perspective on Colorectal Cancer Screening.
Authors: Lauby-Secretan B. , Vilahur N. , Bianchini F. , Guha N. , Straif K. , International Agency for Research on Cancer Handbook Working Group .
Source: The New England journal of medicine, 2018-05-03; 378(18), p. 1734-1740.
EPub date: 2018-03-26.
PMID: 29580179
Related Citations

Value Of Waiving Coinsurance For Colorectal Cancer Screening In Medicare Beneficiaries.
Authors: Peterse E.F.P. , Meester R.G.S. , Gini A. , Doubeni C.A. , Anderson D.S. , Berger F.G. , Zauber A.G. , Lansdorp-Vogelaar I. .
Source: Health affairs (Project Hope), 2017 12; 36(12), p. 2151-2159.
PMID: 29200350
Related Citations

Effect of Time to Diagnostic Testing for Breast, Cervical, and Colorectal Cancer Screening Abnormalities on Screening Efficacy: A Modeling Study.
Authors: Rutter C.M. , Kim J.J. , Meester R.G.S. , Sprague B.L. , Burger E.A. , Zauber A.G. , Ergun M.A. , Campos N.G. , Doubeni C.A. , Trentham-Dietz A. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2018 02; 27(2), p. 158-164.
EPub date: 2017-11-17.
PMID: 29150480
Related Citations

Cost Effectiveness of Screening Individuals With Cystic Fibrosis for Colorectal Cancer.
Authors: Gini A. , Zauber A.G. , Cenin D.R. , Omidvari A.H. , Hempstead S.E. , Fink A.K. , Lowenfels A.B. , Lansdorp-Vogelaar I. .
Source: Gastroenterology, 2018 02; 154(3), p. 556-567.e18.
EPub date: 2017-11-02.
PMID: 29102616
Related Citations

Cost Effectiveness of Age-Specific Screening Intervals for People With Family Histories of Colorectal Cancer.
Authors: Naber S.K. , Kuntz K.M. , Henrikson N.B. , Williams M.S. , Calonge N. , Goddard K.A.B. , Zallen D.T. , Ganiats T.G. , Webber E.M. , Janssens A.C.J.W. , et al. .
Source: Gastroenterology, 2018 01; 154(1), p. 105-116.e20.
EPub date: 2017-09-28.
PMID: 28964749
Related Citations

Harms, benefits and costs of fecal immunochemical testing versus guaiac fecal occult blood testing for colorectal cancer screening.
Authors: Goede S.L. , Rabeneck L. , van Ballegooijen M. , Zauber A.G. , Paszat L.F. , Hoch J.S. , Yong J.H. , Kroep S. , Tinmouth J. , Lansdorp-Vogelaar I. .
Source: PloS one, 2017; 12(3), p. e0172864.
EPub date: 2017-03-15.
PMID: 28296927
Related Citations

Reply.
Authors: Wernli K.J. , Brenner A.T. , Rutter C.M. , Inadomi J.M. .
Source: Gastroenterology, 2016 09; 151(3), p. 564.
EPub date: 2016-08-03.
PMID: 27496674
Related Citations

Colorectal cancer screening: Estimated future colonoscopy need and current volume and capacity.
Authors: Joseph D.A. , Meester R.G. , Zauber A.G. , Manninen D.L. , Winges L. , Dong F.B. , Peaker B. , van Ballegooijen M. .
Source: Cancer, 2016-08-15; 122(16), p. 2479-86.
EPub date: 2016-05-20.
PMID: 27200481
Related Citations

A restricted look at CRC screening: not considering annual stool testing as an option.
Authors: Kuntz K.M. , Zauber A.G. , Knudsen A.B. , Rutter C.M. , Lansdorp-Vogelaar I. , Berger B.M. , Levin B. .
Source: The American journal of managed care, 2016-07-01; 22(7), p. e270-4.
EPub date: 2016-07-01.
PMID: 27442311
Related Citations

Estimation of Benefits, Burden, and Harms of Colorectal Cancer Screening Strategies: Modeling Study for the US Preventive Services Task Force.
Authors: Knudsen A.B. , Zauber A.G. , Rutter C.M. , Naber S.K. , Doria-Rose V.P. , Pabiniak C. , Johanson C. , Fischer S.E. , Lansdorp-Vogelaar I. , Kuntz K.M. .
Source: JAMA, 2016-06-21; 315(23), p. 2595-609.
PMID: 27305518
Related Citations

Consequences of Increasing Time to Colonoscopy Examination After Positive Result From Fecal Colorectal Cancer Screening Test.
Authors: Meester R.G. , Zauber A.G. , Doubeni C.A. , Jensen C.D. , Quinn V.P. , Helfand M. , Dominitz J.A. , Levin T.R. , Corley D.A. , Lansdorp-Vogelaar I. .
Source: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2016 10; 14(10), p. 1445-1451.e8.
EPub date: 2016-05-19.
PMID: 27211498
Related Citations

Validation of Models Used to Inform Colorectal Cancer Screening Guidelines: Accuracy and Implications.
Authors: Rutter C.M. , Knudsen A.B. , Marsh T.L. , Doria-Rose V.P. , Johnson E. , Pabiniak C. , Kuntz K.M. , van Ballegooijen M. , Zauber A.G. , Lansdorp-Vogelaar I. .
Source: Medical decision making : an international journal of the Society for Medical Decision Making, 2016 07; 36(5), p. 604-14.
EPub date: 2016-01-08.
PMID: 26746432
Related Citations




Back to Top