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Grant Details

Grant Number: 5U01CA199335-04 Interpret this number
Primary Investigator: Zauber, Ann
Organization: Sloan-Kettering Inst Can Research
Project Title: Comparative Modeling of Colorectal Cancer: Informing Health Policies and Prioritizing Future Research
Fiscal Year: 2018
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? DESCRIPTION (provided by applicant): Colorectal cancer (CRC) is the second leading cause of cancer death in the United States. The long-term goal of our proposed project is to reduce the population burden of CRC by providing the information needed to address key policy questions and prioritize future research. To accomplish this goal we will use our population- based microsimulation models to: 1) Inform emerging issues in health policy across the CRC-control spectrum; 2) Guide CRC research priorities and study design using a value of information (VOI) framework; and 3) Engage stakeholders, train modelers, and promote model transparency to ensure high-quality evaluation of CRC control measures, now and in the future. Our team will fill critical gaps in knowledge, enabling decision makers to act. Important gaps in knowledge include the impact of failures in screening and treatment processes on CRC burden; the potential to safely reduce screening and surveillance intensity among some patients based on currently available tools for risk-stratification; the potential benefit of new targeted screening approaches based on patient-level information (i.e., "precision medicine"); and the importance of clinical management of diminutive polyps. The three participating modeling groups are well-positioned to carry out this work, bringing a wealth of experience, expertise, and insight to issues related to microsimulation modeling of CRC, and have a proven track record of collaborating and disseminating our work to health policy decision makers.

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Nonidentifiability in Model Calibration and Implications for Medical Decision Making.
Authors: Alarid-Escudero F. , MacLehose R.F. , Peralta Y. , Kuntz K.M. , Enns E.A. .
Source: Medical Decision Making : An International Journal Of The Society For Medical Decision Making, 2018 Oct; 38(7), p. 810-821.
PMID: 30248276
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The impact of the rising colorectal cancer incidence in young adults on the optimal age to start screening: Microsimulation analysis I to inform the American Cancer Society colorectal cancer screening guideline.
Authors: Peterse E.F.P. , Meester R.G.S. , Siegel R.L. , Chen J.C. , Dwyer A. , Ahnen D.J. , Smith R.A. , Zauber A.G. , Lansdorp-Vogelaar I. .
Source: Cancer, 2018-05-30 00:00:00.0; , .
EPub date: 2018-05-30 00:00:00.0.
PMID: 29846933
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Optimizing colorectal cancer screening by race and sex: Microsimulation analysis II to inform the American Cancer Society colorectal cancer screening guideline.
Authors: Meester R.G.S. , Peterse E.F.P. , Knudsen A.B. , de Weerdt A.C. , Chen J.C. , Lietz A.P. , Dwyer A. , Ahnen D.J. , Siegel R.L. , Smith R.A. , et al. .
Source: Cancer, 2018-05-30 00:00:00.0; , .
EPub date: 2018-05-30 00:00:00.0.
PMID: 29846942
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Cost Effectiveness of Screening Individuals With Cystic Fibrosisfor Colorectal Cancer.
Authors: Gini A. , Zauber A.G. , Cenin D.R. , Omidvari A.H. , Hempstead S.E. , Fink A.K. , Lowenfels A.B. , Lansdorp-Vogelaar I. .
Source: Gastroenterology, 2018 Feb; 154(3), p. 556-567.e18.
EPub date: 2017-11-02 00:00:00.0.
PMID: 29102616
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Value Of Waiving Coinsurance For Colorectal Cancer Screening In Medicare Beneficiaries.
Authors: Peterse E.F.P. , Meester R.G.S. , Gini A. , Doubeni C.A. , Anderson D.S. , Berger F.G. , Zauber A.G. , Lansdorp-Vogelaar I. .
Source: Health Affairs (project Hope), 2017 Dec; 36(12), p. 2151-2159.
PMID: 29200350
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Effect of Time to Diagnostic Testing for Breast, Cervical, and Colorectal Cancer Screening Abnormalities on Screening Efficacy: A Modeling Study.
Authors: Rutter C.M. , Kim J.J. , Meester R.G.S. , Sprague B.L. , Burger E.A. , Zauber A.G. , Ergun M.A. , Campos N.G. , Doubeni C.A. , Trentham-Dietz A. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017-11-17 00:00:00.0; , .
EPub date: 2017-11-17 00:00:00.0.
PMID: 29150480
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Cost-effectiveness of High-performance Biomarker Tests vs Fecal Immunochemical Test for Non-Invasive Colorectal Cancer Screening.
Authors: Lansdorp-Vogelaar I. , Goede S.L. , Bosch L.J.W. , Melotte V. , Carvalho B. , van Engeland M. , Meijer G.A. , de Koning H.J. , van Ballegooijen M. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2017-07-18 00:00:00.0; , .
EPub date: 2017-07-18 00:00:00.0.
PMID: 28733262
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Harms, benefits and costs of fecal immunochemical testing versus guaiac fecal occult blood testing for colorectal cancer screening.
Authors: Goede S.L. , Rabeneck L. , van Ballegooijen M. , Zauber A.G. , Paszat L.F. , Hoch J.S. , Yong J.H. , Kroep S. , Tinmouth J. , Lansdorp-Vogelaar I. .
Source: Plos One, 2017; 12(3), p. e0172864.
EPub date: 2017-03-15 00:00:00.0.
PMID: 28296927
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Consequences of Increasing Time to Colonoscopy ExaminationAfter Positive Result From Fecal Colorectal CancerScreening Test.
Authors: Meester R.G. , Zauber A.G. , Doubeni C.A. , Jensen C.D. , Quinn V.P. , Helfand M. , Dominitz J.A. , Levin T.R. , Corley D.A. , Lansdorp-Vogelaar I. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2016 Oct; 14(10), p. 1445-1451.e8.
PMID: 27211498
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Colorectal cancer screening: Estimated future colonoscopy need and current volume and capacity.
Authors: Joseph D.A. , Meester R.G. , Zauber A.G. , Manninen D.L. , Winges L. , Dong F.B. , Peaker B. , van Ballegooijen M. .
Source: Cancer, 2016-08-15 00:00:00.0; 122(16), p. 2479-86.
EPub date: 2016-05-20 00:00:00.0.
PMID: 27200481
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A restricted look at CRC screening: not considering annual stool testing as an option.
Authors: Kuntz K.M. , Zauber A.G. , Knudsen A.B. , Rutter C.M. , Lansdorp-Vogelaar I. , Berger B.M. , Levin B. .
Source: The American Journal Of Managed Care, 2016-07-01 00:00:00.0; 22(7), p. e270-4.
EPub date: 2016-07-01 00:00:00.0.
PMID: 27442311
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Estimation Of Benefits, Burden, And Harms Of Colorectal Cancer Screening Strategies: Modeling Study For The Us Preventive Services Task Force
Authors: Knudsen A.B. , Zauber A.G. , Rutter C.M. , Naber S.K. , Doria-Rose V.P. , Pabiniak C. , Johanson C. , Fischer S.E. , Lansdorp-Vogelaar I. , Kuntz K.M. .
Source: Jama, 2016-06-21 00:00:00.0; 315(23), p. 2595-609.
PMID: 27305518
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Validation Of Models Used To Inform Colorectal Cancer Screening Guidelines: Accuracy And Implications
Authors: Rutter C.M. , Knudsen A.B. , Marsh T.L. , Doria-Rose V.P. , Johnson E. , Pabiniak C. , Kuntz K.M. , van Ballegooijen M. , Zauber A.G. , Lansdorp-Vogelaar I. .
Source: Medical Decision Making : An International Journal Of The Society For Medical Decision Making, 2016-01-08 00:00:00.0; , .
PMID: 26746432
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Authors: Wernli K.J. , Brenner A.T. , Rutter C.M. , Inadomi J.M. .
Source: Gastroenterology, 2016 09; 151(3), p. 564.
EPub date: 2016-08-03 00:00:00.0.
PMID: 27496674
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Cost Effectiveness of Age-Specific Screening Intervals for People With Family Histories of Colorectal Cancer.
Authors: Naber S.K. , Kuntz K.M. , Henrikson N.B. , Williams M.S. , Calonge N. , Goddard K.A.B. , Zallen D.T. , Ganiats T.G. , Webber E.M. , Janssens A.C.J.W. , et al. .
Source: Gastroenterology, 2018 01; 154(1), p. 105-116.e20.
EPub date: 2017-09-28 00:00:00.0.
PMID: 28964749
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