Skip to main content
Grant Details

Grant Number: 5R35CA197735-04 Interpret this number
Primary Investigator: Ogino, Shuji
Organization: Dana-Farber Cancer Inst
Project Title: Accelerating Transdisciplinary Epidemiology of Colorectal Cancer
Fiscal Year: 2018
Back to top


Abstract

? DESCRIPTION (provided by applicant): Accelerating Transdisciplinary Epidemiology of Colorectal Cancer Summary Tumor evolution is a heterogeneous process influenced by somatic molecular alterations, host immunity, diet, lifestyle, microbiota, and environment. Thus, I plan to take a transdisciplinary approach integrating molecular- level research, population-level study design, and assessment of environment, diet and lifestyle, utilizing my unique interdisciplinary expertise. I have been developing the transdisciplinary field of Molecular Pathological Epidemiology (MPE) with integrated strengths of both pathology and epidemiology. I will pursue two interconnecting synergistic Themes: (1) MPE of colorectal cancer (CRC) and (2) accelerating transdisciplinary epidemiology. In Theme 1, I will integrate tumor molecular and immunity analyses in 2,500 CRCs in the Nurses' Health Study (NHS), the NHS2 and the Health Professionals Follow-up Study (HPFS). I have successfully built an unprecedented high-dimensional CRC database on long-term exposures, tumor pathology, microbial, molecular and immunity data, and clinical outcome, to test the following broad-term hypotheses: (1.1) Dietary, lifestyle, environmental and genetic factors influence CRC incidence differentially by molecular, microbial and immunity subtypes. (1.2) CRC molecular features influence immune response to CRC. (1.3) CRC molecular and immunity status influences patient survival and response to drugs or modifiable dietary, lifestyle or environmental factors. (1.4) The degree of CRC intratumor heterogeneity is associated with worse prognosis and specific epidemiologic, clinical, and pathological features. We will extend our integrative research to various other settings to replicate findings and assess potential effect modifications by ethnic, socioeconomic and other factors. This project may identify potential strategies to target molecular alterations, immunity and microbiota for CRC prevention and therapy. My Theme 2 plans are; (2.1) to develop research frameworks, analysis designs and statistical methods, to address molecular and etiologic heterogeneity of cancer; (2.2) to grow the ongoing International MPE Meeting Series, to facilitate seamless transdisciplinary integration with a goal of making "the STROBE-MPE guidelines"; and (2.3) to synergize with experts and build new integrative transdisciplinary models, "causal inference-MPE" and "MPE-health communication research". Thus, I aim to promote transdisciplinary integration of molecular pathology and population cancer science, and to address a critical unmet need to integrate analyses of cancer immunity, tumor molecular profiles (including microbiota and intratumor heterogeneity), modifiable exposures, genetics, and CRC incidence and death. I also try to address challenges in transdisciplinary epidemiology, including paucity of interdisciplinary experts and training programs, as well as lack of research guidelines in MPE. My unique qualifications and transdisciplinary research program can not only provide new insights on CRC etiologies in a population-based scale, but also develop novel methods / frameworks, and frontiers of population cancer science. As such, my proposed research will likely have major impacts on future research, clinical practice and public health.

Back to top


Publications

Association Between Intake of Red and Processed Meat and Survival in Patients With Colorectal Cancer in a Pooled Analysis.
Authors: Carr P.R. , Banbury B. , Berndt S.I. , Campbell P.T. , Chang-Claude J. , Hayes R.B. , Howard B.V. , Jansen L. , Jacobs E. , Lane D.S. , et al. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2018-11-23 00:00:00.0; , .
EPub date: 2018-11-23 00:00:00.0.
PMID: 30476588
Related Citations

Association of Obesity With Risk of Early-Onset Colorectal Cancer Among Women.
Authors: Liu P.H. , Wu K. , Ng K. , Zauber A.G. , Nguyen L.H. , Song M. , He X. , Fuchs C.S. , Ogino S. , Willett W.C. , et al. .
Source: Jama Oncology, 2018-10-11 00:00:00.0; , .
EPub date: 2018-10-11 00:00:00.0.
PMID: 30326010
Related Citations

Characterization of the Neuroendocrine Tumor Immune Microenvironment.
Authors: da Silva A. , Bowden M. , Zhang S. , Masugi Y. , Thorner A.R. , Herbert Z.T. , Zhou C.W. , Brais L. , Chan J.A. , Hodi F.S. , et al. .
Source: Pancreas, 2018 Oct; 47(9), p. 1123-1129.
PMID: 30153220
Related Citations

Gene Regulatory Network Analysis Identifies Sex-Linked Differences in Colon Cancer Drug Metabolism.
Authors: Lopes-Ramos C.M. , Kuijjer M.L. , Ogino S. , Fuchs C.S. , DeMeo D.L. , Glass K. , Quackenbush J. .
Source: Cancer Research, 2018-10-01 00:00:00.0; 78(19), p. 5538-5547.
PMID: 30275053
Related Citations

Continuity of transcriptomes among colorectal cancer subtypes based on meta-analysis.
Authors: Ma S. , Ogino S. , Parsana P. , Nishihara R. , Qian Z. , Shen J. , Mima K. , Masugi Y. , Cao Y. , Nowak J.A. , et al. .
Source: Genome Biology, 2018-09-25 00:00:00.0; 19(1), p. 142.
EPub date: 2018-09-25 00:00:00.0.
PMID: 30253799
Related Citations

Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status.
Authors: Hamada T. , Zhang X. , Mima K. , Bullman S. , Sukawa Y. , Nowak J.A. , Kosumi K. , Masugi Y. , Twombly T.S. , Cao Y. , et al. .
Source: Cancer Immunology Research, 2018-09-18 00:00:00.0; , .
EPub date: 2018-09-18 00:00:00.0.
PMID: 30228205
Related Citations

Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour.
Authors: Hamada T. , Liu L. , Nowak J.A. , Mima K. , Cao Y. , Ng K. , Twombly T.S. , Song M. , Jung S. , Dou R. , et al. .
Source: European Journal Of Cancer (oxford, England : 1990), 2018-09-12 00:00:00.0; 103, p. 98-107.
EPub date: 2018-09-12 00:00:00.0.
PMID: 30219720
Related Citations

Dysbiosis of the gut microbiota and colorectal cancer: the key target of molecular pathological epidemiology.
Authors: Kosumi K. , Mima K. , Baba H. , Ogino S. .
Source: Journal Of Laboratory And Precision Medicine, 2018 Sep; 3, .
EPub date: 2018-09-25 00:00:00.0.
PMID: 30345420
Related Citations

Insights into Pathogenic Interactions Among Environment, Host, and Tumor at the Crossroads of Molecular Pathology and Epidemiology.
Authors: Ogino S. , Nowak J.A. , Hamada T. , Milner D.A. , Nishihara R. .
Source: Annual Review Of Pathology, 2018-08-20 00:00:00.0; , .
EPub date: 2018-08-20 00:00:00.0.
PMID: 30125150
Related Citations

Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival: CALGB 89803 (Alliance).
Authors: Van Blarigan E.L. , Ou F.S. , Niedzwiecki D. , Zhang S. , Fuchs C.S. , Saltz L. , Mayer R.J. , Venook A. , Ogino S. , Song M. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2018-07-23 00:00:00.0; , .
EPub date: 2018-07-23 00:00:00.0.
PMID: 30038051
Related Citations

Influence of smoking, body mass index and other factors on the preventive effect of nonsteroidal anti-inflammatory drugs on colorectal cancer risk.
Authors: Wang X. , Chan A.T. , Slattery M.L. , Chang-Claude J. , Potter J.D. , Gallinger S. , Caan B. , Lampe J.W. , Newcomb P.A. , Zubair N. , et al. .
Source: Cancer Research, 2018-06-19 00:00:00.0; , .
EPub date: 2018-06-19 00:00:00.0.
PMID: 29921691
Related Citations

Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer.
Authors: Neumeyer S. , Banbury B.L. , Arndt V. , Berndt S.I. , Bezieau S. , Bien S.A. , Buchanan D.D. , Butterbach K. , Caan B.J. , Campbell P.T. , et al. .
Source: British Journal Of Cancer, 2018 Jun; 118(12), p. 1639-1647.
EPub date: 2018-05-24 00:00:00.0.
PMID: 29795306
Related Citations

Immunoscore for (colorectal) cancer precision medicine.
Authors: Ogino S. , Giannakis M. .
Source: Lancet (london, England), 2018-05-10 00:00:00.0; , .
EPub date: 2018-05-10 00:00:00.0.
PMID: 29754776
Related Citations

Association between Risk Factors for Colorectal Cancer and Risk of Serrated Polyps and Conventional Adenomas.
Authors: He X. , Wu K. , Ogino S. , Giovannucci E.L. , Chan A.T. , Song M. .
Source: Gastroenterology, 2018-04-24 00:00:00.0; , .
EPub date: 2018-04-24 00:00:00.0.
PMID: 29702117
Related Citations

Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum.
Authors: Liu L. , Tabung F.K. , Zhang X. , Nowak J.A. , Qian Z.R. , Hamada T. , Nevo D. , Bullman S. , Mima K. , Kosumi K. , et al. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2018-04-24 00:00:00.0; , .
EPub date: 2018-04-24 00:00:00.0.
PMID: 29702299
Related Citations

Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance).
Authors: Fadelu T. , Zhang S. , Niedzwiecki D. , Ye X. , Saltz L.B. , Mayer R.J. , Mowat R.B. , Whittom R. , Hantel A. , Benson A.B. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2018-04-10 00:00:00.0; 36(11), p. 1112-1120.
EPub date: 2018-02-28 00:00:00.0.
PMID: 29489429
Related Citations

Regular Use of Aspirin or Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs Is Not Associated With Risk of Incident Pancreatic Cancer in Two Large Cohort Studies.
Authors: Khalaf N. , Yuan C. , Hamada T. , Cao Y. , Babic A. , Morales-Oyarvide V. , Kraft P. , Ng K. , Giovannucci E. , Ogino S. , et al. .
Source: Gastroenterology, 2018 Apr; 154(5), p. 1380-1390.e5.
EPub date: 2017-12-08 00:00:00.0.
PMID: 29229401
Related Citations

Marine ?-3 Polyunsaturated Fatty Acid and Fish Intake after Colon Cancer Diagnosis and Survival: CALGB 89803 (Alliance).
Authors: Van Blarigan E.L. , Fuchs C.S. , Niedzwiecki D. , Ye X. , Zhang S. , Song M. , Saltz L.B. , Mayer R.J. , Mowat R.B. , Whittom R. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2018 Apr; 27(4), p. 438-445.
EPub date: 2018-01-22 00:00:00.0.
PMID: 29358223
Related Citations

Genetic mechanisms of immune evasion in colorectal cancer.
Authors: Grasso C.S. , Giannakis M. , Wells D.K. , Hamada T. , Mu X.J. , Quist M. , Nowak J.A. , Nishihara R. , Qian Z.R. , Inamura K. , et al. .
Source: Cancer Discovery, 2018-03-06 00:00:00.0; , .
EPub date: 2018-03-06 00:00:00.0.
PMID: 29510987
Related Citations

Association of Dietary Inflammatory Potential With Colorectal Cancer Risk in Men and Women.
Authors: Tabung F.K. , Liu L. , Wang W. , Fung T.T. , Wu K. , Smith-Warner S.A. , Cao Y. , Hu F.B. , Ogino S. , Fuchs C.S. , et al. .
Source: Jama Oncology, 2018-03-01 00:00:00.0; 4(3), p. 366-373.
PMID: 29346484
Related Citations

Inherited DNA-Repair Defects in Colorectal Cancer.
Authors: AlDubayan S.H. , Giannakis M. , Moore N.D. , Han G.C. , Reardon B. , Hamada T. , Mu X.J. , Nishihara R. , Qian Z. , Liu L. , et al. .
Source: American Journal Of Human Genetics, 2018-03-01 00:00:00.0; 102(3), p. 401-414.
EPub date: 2018-02-22 00:00:00.0.
PMID: 29478780
Related Citations

Pre-diagnosis Use of Statins Associates With Increased Survival Times of Patients With Pancreatic Cancer.
Authors: Hamada T. , Khalaf N. , Yuan C. , Morales-Oyarvide V. , Babic A. , Nowak J.A. , Qian Z.R. , Ng K. , Rubinson D.A. , Kraft P. , et al. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2018-02-20 00:00:00.0; , .
EPub date: 2018-02-20 00:00:00.0.
PMID: 29474971
Related Citations

Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic Factors.
Authors: Jeon J. , Du M. , Schoen R.E. , Hoffmeister M. , Newcomb P.A. , Berndt S.I. , Caan B. , Campbell P.T. , Chan A.T. , Chang-Claude J. , et al. .
Source: Gastroenterology, 2018-02-16 00:00:00.0; , .
EPub date: 2018-02-16 00:00:00.0.
PMID: 29458155
Related Citations

Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine.
Authors: Ogino S. , Nowak J.A. , Hamada T. , Phipps A.I. , Peters U. , Milner D.A. , Giovannucci E.L. , Nishihara R. , Giannakis M. , Garrett W.S. , et al. .
Source: Gut, 2018-02-06 00:00:00.0; , .
EPub date: 2018-02-06 00:00:00.0.
PMID: 29437869
Related Citations

Statin use and pancreatic cancer risk in two prospective cohort studies.
Authors: Hamada T. , Khalaf N. , Yuan C. , Babic A. , Morales-Oyarvide V. , Qian Z.R. , Nowak J.A. , Ng K. , Kraft P. , Rubinson D.A. , et al. .
Source: Journal Of Gastroenterology, 2018-01-23 00:00:00.0; , .
EPub date: 2018-01-23 00:00:00.0.
PMID: 29362938
Related Citations

Utility of inverse probability weighting in molecular pathological epidemiology.
Authors: Liu L. , Nevo D. , Nishihara R. , Cao Y. , Song M. , Twombly T.S. , Chan A.T. , Giovannucci E.L. , VanderWeele T.J. , Wang M. , et al. .
Source: European Journal Of Epidemiology, 2017-12-20 00:00:00.0; , .
EPub date: 2017-12-20 00:00:00.0.
PMID: 29264788
Related Citations

Tumor expression of calcium sensing receptor and colorectal cancer survival: Results from the nurses' health study and health professionals follow-up study.
Authors: Momen-Heravi F. , Masugi Y. , Qian Z.R. , Nishihara R. , Liu L. , Smith-Warner S.A. , Keum N. , Zhang L. , Tchrakian N. , Nowak J.A. , et al. .
Source: International Journal Of Cancer, 2017-12-15 00:00:00.0; 141(12), p. 2471-2479.
EPub date: 2017-09-20 00:00:00.0.
PMID: 28856682
Related Citations

Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer.
Authors: Bullman S. , Pedamallu C.S. , Sicinska E. , Clancy T.E. , Zhang X. , Cai D. , Neuberg D. , Huang K. , Guevara F. , Nelson T. , et al. .
Source: Science (new York, N.y.), 2017-12-15 00:00:00.0; 358(6369), p. 1443-1448.
EPub date: 2017-11-23 00:00:00.0.
PMID: 29170280
Related Citations

Lymph node metastases in resected pancreatic ductal adenocarcinoma: predictors of disease recurrence and survival.
Authors: Morales-Oyarvide V. , Rubinson D.A. , Dunne R.F. , Kozak M.M. , Bui J.L. , Yuan C. , Qian Z.R. , Babic A. , Da Silva A. , Nowak J.A. , et al. .
Source: British Journal Of Cancer, 2017-12-05 00:00:00.0; 117(12), p. 1874-1882.
EPub date: 2017-10-05 00:00:00.0.
PMID: 28982112
Related Citations

The role of intestinal bacteria in the development and progression of gastrointestinal tract neoplasms.
Authors: Mima K. , Ogino S. , Nakagawa S. , Sawayama H. , Kinoshita K. , Krashima R. , Ishimoto T. , Imai K. , Iwatsuki M. , Hashimoto D. , et al. .
Source: Surgical Oncology, 2017 Dec; 26(4), p. 368-376.
EPub date: 2017-07-21 00:00:00.0.
PMID: 29113654
Related Citations

Association Between Coffee Intake After Diagnosis of Colorectal Cancer and Reduced mortality.
Authors: Hu Y. , Ding M. , Yuan C. , Wu K. , Smith-Warner S.A. , Hu F.B. , Chan A.T. , Meyerhardt J.A. , Ogino S. , Fuchs C.S. , et al. .
Source: Gastroenterology, 2017-11-17 00:00:00.0; , .
EPub date: 2017-11-17 00:00:00.0.
PMID: 29158191
Related Citations

Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma.
Authors: Qian Z.R. , Rubinson D.A. , Nowak J.A. , Morales-Oyarvide V. , Dunne R.F. , Kozak M.M. , Welch M.W. , Brais L.K. , Da Silva A. , Li T. , et al. .
Source: Jama Oncology, 2017-11-02 00:00:00.0; , .
EPub date: 2017-11-02 00:00:00.0.
PMID: 29098284
Related Citations

Fiber Intake and Survival After Colorectal Cancer Diagnosis.
Authors: Song M. , Wu K. , Meyerhardt J.A. , Ogino S. , Wang M. , Fuchs C.S. , Giovannucci E.L. , Chan A.T. .
Source: Jama Oncology, 2017-11-02 00:00:00.0; , .
EPub date: 2017-11-02 00:00:00.0.
PMID: 29098294
Related Citations

Cell Cycle Protein Expression in Neuroendocrine Tumors: Association of CDK4/CDK6, CCND1, and Phosphorylated Retinoblastoma Protein With Proliferative Index.
Authors: Shi Y. , Qian Z.R. , Zhang S. , Li W. , Masugi Y. , Li T. , Chan J.A. , Yang J. , Da Silva A. , Gu M. , et al. .
Source: Pancreas, 2017 Nov/Dec; 46(10), p. 1347-1353.
PMID: 28991877
Related Citations

Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells.
Authors: Gu M. , Nishihara R. , Chen Y. , Li W. , Shi Y. , Masugi Y. , Hamada T. , Kosumi K. , Liu L. , da Silva A. , et al. .
Source: Oncotarget, 2017-10-20 00:00:00.0; 8(50), p. 87379-87389.
EPub date: 2017-09-18 00:00:00.0.
PMID: 29152088
Related Citations

Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer.
Authors: Masugi Y. , Nishihara R. , Hamada T. , Song M. , da Silva A. , Kosumi K. , Gu M. , Shi Y. , Li W. , Liu L. , et al. .
Source: Cancer Immunology Research, 2017-10-16 00:00:00.0; , .
EPub date: 2017-10-16 00:00:00.0.
PMID: 29038297
Related Citations

Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor.
Authors: Liu L. , Nishihara R. , Qian Z.R. , Tabung F.K. , Nevo D. , Zhang X. , Song M. , Cao Y. , Mima K. , Masugi Y. , et al. .
Source: Gastroenterology, 2017-08-30 00:00:00.0; , .
EPub date: 2017-08-30 00:00:00.0.
PMID: 28865736
Related Citations

The competing risks Cox model with auxiliary case covariates under weaker missing-at-random cause of failure.
Authors: Nevo D. , Nishihara R. , Ogino S. , Wang M. .
Source: Lifetime Data Analysis, 2017-08-04 00:00:00.0; , .
EPub date: 2017-08-04 00:00:00.0.
PMID: 28779227
Related Citations

Calcium intake and risk of colorectal cancer according to expression status of calcium-sensing receptor (CASR).
Authors: Yang W. , Liu L. , Masugi Y. , Qian Z.R. , Nishihara R. , Keum N. , Wu K. , Smith-Warner S. , Ma Y. , Nowak J.A. , et al. .
Source: Gut, 2017-07-04 00:00:00.0; , .
EPub date: 2017-07-04 00:00:00.0.
PMID: 28676564
Related Citations

Energy sensing pathways: Bridging type 2 diabetes and colorectal cancer?
Authors: Yang J. , Nishihara R. , Zhang X. , Ogino S. , Qian Z.R. .
Source: Journal Of Diabetes And Its Complications, 2017 Jul; 31(7), p. 1228-1236.
EPub date: 2017-04-13 00:00:00.0.
PMID: 28465145
Related Citations

Quantifying the genetic correlation between multiple cancer types.
Authors: Lindström S. , Finucane H. , Bulik-Sullivan B. , Schumacher F.R. , Amos C.I. , Hung R.J. , Rand K. , Gruber S.B. , Conti D. , Permuth J.B. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017-06-21 00:00:00.0; , .
EPub date: 2017-06-21 00:00:00.0.
PMID: 28637796
Related Citations

Biomarker correlation network in colorectal carcinoma by tumor anatomic location.
Authors: Nishihara R. , Glass K. , Mima K. , Hamada T. , Nowak J.A. , Qian Z.R. , Kraft P. , Giovannucci E.L. , Fuchs C.S. , Chan A.T. , et al. .
Source: Bmc Bioinformatics, 2017-06-17 00:00:00.0; 18(1), p. 304.
EPub date: 2017-06-17 00:00:00.0.
PMID: 28623901
Related Citations

Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance).
Authors: Fuchs M.A. , Yuan C. , Sato K. , Niedzwiecki D. , Ye X. , Saltz L.B. , Mayer R.J. , Mowat R.B. , Whittom R. , Hantel A. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology, 2017-06-01 00:00:00.0; 28(6), p. 1359-1367.
PMID: 28327908
Related Citations

Cigarette Smoking and Pancreatic Cancer Survival.
Authors: Yuan C. , Morales-Oyarvide V. , Babic A. , Clish C.B. , Kraft P. , Bao Y. , Qian Z.R. , Rubinson D.A. , Ng K. , Giovannucci E.L. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2017-06-01 00:00:00.0; 35(16), p. 1822-1828.
EPub date: 2017-03-30 00:00:00.0.
PMID: 28358654
Related Citations

Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status.
Authors: Hamada T. , Cao Y. , Qian Z.R. , Masugi Y. , Nowak J.A. , Yang J. , Song M. , Mima K. , Kosumi K. , Liu L. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2017-06-01 00:00:00.0; 35(16), p. 1836-1844.
EPub date: 2017-04-13 00:00:00.0.
PMID: 28406723
Related Citations

Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status.
Authors: Hanyuda A. , Cao Y. , Hamada T. , Nowak J.A. , Qian Z.R. , Masugi Y. , da Silva A. , Liu L. , Kosumi K. , Soong T.R. , et al. .
Source: European Journal Of Epidemiology, 2017-05-16 00:00:00.0; , .
EPub date: 2017-05-16 00:00:00.0.
PMID: 28510098
Related Citations

Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies.
Authors: Nimptsch K. , Song M. , Aleksandrova K. , Katsoulis M. , Freisling H. , Jenab M. , Gunter M.J. , Tsilidis K.K. , Weiderpass E. , Bueno-De-Mesquita H.B. , et al. .
Source: European Journal Of Epidemiology, 2017 May; 32(5), p. 419-430.
EPub date: 2017-05-26 00:00:00.0.
PMID: 28550647
Related Citations

Pik3ca Mutations Contribute To Acquired Cetuximab Resistance In Metastatic Colorectal Cancer Patients
Authors: Xu J.M. , Wang Y. , Wang Y.L. , Wang Y. , Liu T. , Ni M. , Li M.S. , Lin L. , Ge F.J. , Gong C. , et al. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2017-04-19 00:00:00.0; , .
PMID: 28424201
Related Citations

Long-term use of antibiotics and risk of colorectal adenoma.
Authors: Cao Y. , Wu K. , Mehta R. , Drew D.A. , Song M. , Lochhead P. , Nguyen L.H. , Izard J. , Fuchs C.S. , Garrett W.S. , et al. .
Source: Gut, 2017-04-04 00:00:00.0; , .
EPub date: 2017-04-04 00:00:00.0.
PMID: 28377387
Related Citations

Dietary Glycemic And Insulin Scores And Colorectal Cancer Survival By Tumor Molecular Biomarkers
Authors: Keum N. , Yuan C. , Nishihara R. , Zoltick E. , Hamada T. , Fernandez A.M. , Zhang X. , Hanyuda A. , Liu L. , Kosumi K. , et al. .
Source: International Journal Of Cancer, 2017-03-07 00:00:00.0; , .
PMID: 28268248
Related Citations




Back to Top