||5R01CA207158-03 Interpret this number
||Wake Forest University Health Sciences
||Implementation of Smoking Cessation Services Within NCI Ncorp Community Sites with Organized Lung Cancer Screening Programs
Implementing effective tobacco cessation programs within LDCT lung cancer screening is needed as quitting
smoking increases life expectancy, decreases risk of competing causes of death, improves length of survival
among lung cancer patients, and maximizes the cost-effectiveness of lung cancer screening. Our research
team, including experts in smoking cessation, lung cancer screening, and implementation science, will: (1)
evaluate a multi-faceted training program to improve short-term smoking cessation rates and sustained
abstinence among 1,114 patients who present for LDCT lung cancer screening in 22 community-based
practices using a cluster, randomized control trial design; (2) characterize the adoption and adaptation of
evidence-based tobacco cessation strategies within community-based LDCT lung cancer screening programs
using extensive qualitative data, including analysis of strategic planning documents, a team blog and
performance coaching notes, key informant interviews, and observational data; and (3) develop and evaluate
an implementation toolkit that explains how to integrate evidence-based tobacco cessation strategies in
community-based LDCT lung cancer screening programs in absence of the research team. The majority of
lung cancer screening will occur in non-academic, community-based settings with diverse patient populations
who are at high risk for lung cancer and other smoking-related illnesses. This effectiveness-implementation
hybrid design is intended to promote the rapid translation of the evidence-based tobacco cessation strategies
into community-based practices offering LDCT lung cancer screening to reduce smoking-related morbidity and
The OaSiS trial: A hybrid type II, national cluster randomized trial to implement smoking cessation during CT screening for lung cancer.
, Miller D.P.
, Weaver K.
, Sutfin E.L.
, Petty W.J.
, Bellinger C.
, Spangler J.
, Stone R.J.
, Lawler D.
, Davis W.
, et al.
Contemporary clinical trials, 2020 Apr; 91, p. 105963.
Lung Cancer Screening and Smoking Cessation Clinical Trials. SCALE (Smoking Cessation within the Context of Lung Cancer Screening) Collaboration.
, Rothman A.J.
, Almirall D.
, Begnaud A.
, Chiles C.
, Cinciripini P.M.
, Fu S.S.
, Graham A.L.
, Lindgren B.R.
, Melzer A.C.
, et al.
American journal of respiratory and critical care medicine, 2018-01-15; 197(2), p. 172-182.