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Grant Details

Grant Number: 5U01CA057030-30 Interpret this number
Primary Investigator: Carroll, Raymond
Organization: Texas A&M University
Project Title: Measurement Error, Nutrition, Physical Activity and Cancer
Fiscal Year: 2018
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Abstract

DESCRIPTION (provided by applicant): This proposal reflects our continuing interest in the development of new statistical methods, and their application to problems related to diet, physical activity and cancer. The projects mentioned here will be undertaken with NCI scientists specializing in nutrition, physical activity and statistics. The P.I. has visited the NCI on many occasions, including 3 sabbaticals, the most recent being in 2013-2014. An important outgrowth of these continuing relationships is that we have access to a large number of unique data sets, the analysis of which will guide our research program. Locally, besides the P.I., we have assembled a team that has experts in a wide variety of statistical methodology relevant to diet, physical activity and cancer outcomes. In specific aim 1 we will develop new models and methods for the analysis of dietary patterns, a field of major importance in nutrition. This will include analyzing many dietary components simultaneously, estimating from short term instruments the number of people who do not consume certain dietary components, e.g., alcoholic beverages, and building new dietary indices that combine adherence to dietary guidelines with power to predict the risk of cancer and other health outcomes. In specific aim 2, we explain that the assessment of dietary intakes and physical activity is being revolutionized by new technologies, including web-based instruments, increasing use of accelerometers, longer-term studies with repeated dietary assessment, and biomarker studies. To take advantage of these new data structures, we will propose a series of projects including physical activity pattern analysis and risk, within and between individual variance function esti- mation, modeling of time-varying usual dietary intake and physical activity with interactions, and misclassification and measurement error, and latent variable models. In specific aim 3, we will develop new methods for the analysis of case-control studies, including the analysis of gene-environment interactions on risk, efficient semi parametric regression in the analysis of secondary outcomes.

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Publications

Semiparametrically efficient estimation in quantile regression of secondary analysis.
Authors: Liang L. , Ma Y. , Wei Y. , Carroll R.J. .
Source: Journal Of The Royal Statistical Society. Series B, Statistical Methodology, 2018 Sep; 80(4), p. 625-648.
EPub date: 2018-04-14 00:00:00.0.
PMID: 30337833
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Measurement of Active and Sedentary Behavior in Context of Large Epidemiologic Studies.
Authors: Matthews C.E. , Kozey Keadle S. , Moore S.C. , Schoeller D.S. , Carroll R.J. , Troiano R.P. , Sampson J.N. .
Source: Medicine And Science In Sports And Exercise, 2018 Feb; 50(2), p. 266-276.
PMID: 28930863
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Additive Function-on-Function Regression.
Authors: Kim J.S. , Staicu A.M. , Maity A. , Carroll R.J. , Ruppert D. .
Source: Journal Of Computational And Graphical Statistics : A Joint Publication Of American Statistical Association, Institute Of Mathematical Statistics, Interface Foundation Of North America, 2018; 27(1), p. 234-244.
EPub date: 2017-07-19 00:00:00.0.
PMID: 29780218
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Bayesian Semiparametric Multivariate Density Deconvolution.
Authors: Sarkar A. , Pati D. , Chakraborty A. , Mallick B.K. , Carroll R.J. .
Source: Journal Of The American Statistical Association, 2018; 113(521), p. 401-416.
EPub date: 2017-11-13 00:00:00.0.
PMID: 30078920
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Dimension reduction and estimation in the secondary analysis of case-control studies.
Authors: Liang L. , Carroll R. , Ma Y. .
Source: Electronic Journal Of Statistics, 2018; 12(1), p. 1782-1821.
EPub date: 2018-06-12 00:00:00.0.
PMID: 30100949
Related Citations

Semiparametric analysis of complex polygenic gene-environment interactions in case-control studies.
Authors: Stalder O. , Asher A. , Liang L. , Carroll R.J. , Ma Y. , Chatterjee N. .
Source: Biometrika, 2017 Dec; 104(4), p. 801-812.
EPub date: 2017-09-15 00:00:00.0.
PMID: 29430038
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A joint modeling and estimation method for multivariate longitudinal data with mixed types of responses to analyze physical activity data generated by accelerometers.
Authors: Li H. , Zhang Y. , Carroll R.J. , Keadle S.K. , Sampson J.N. , Matthews C.E. .
Source: Statistics In Medicine, 2017-11-10 00:00:00.0; 36(25), p. 4028-4040.
EPub date: 2017-08-07 00:00:00.0.
PMID: 28786180
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Testing for gene-environment interaction under exposure misspecification.
Authors: Sun R. , Carroll R.J. , Christiani D.C. , Lin X. .
Source: Biometrics, 2017-11-09 00:00:00.0; , .
EPub date: 2017-11-09 00:00:00.0.
PMID: 29120492
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Three-part joint modeling methods for complex functional data mixed with zero-and-one-inflated proportions and zero-inflated continuous outcomes with skewness.
Authors: Li H. , Staudenmayer J. , Wang T. , Keadle S.K. , Carroll R.J. .
Source: Statistics In Medicine, 2017-10-19 00:00:00.0; , .
EPub date: 2017-10-19 00:00:00.0.
PMID: 29052239
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Frequentist Standard Errors of Bayes Estimators.
Authors: Lee D. , Carroll R.J. , Sinha S. .
Source: Computational Statistics, 2017 Sep; 32(3), p. 867-888.
EPub date: 2017-01-30 00:00:00.0.
PMID: 28943721
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Data integration with high dimensionality.
Authors: Gao X. , Carroll R.J. .
Source: Biometrika, 2017 Jun; 104(2), p. 251-272.
EPub date: 2017-05-09 00:00:00.0.
PMID: 28757650
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Functional multiple indicators, multiple causes measurement error models.
Authors: Tekwe C.D. , Zoh R.S. , Bazer F.W. , Wu G. , Carroll R.J. .
Source: Biometrics, 2017-05-08 00:00:00.0; , .
EPub date: 2017-05-08 00:00:00.0.
PMID: 28482110
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Two Wrongs Make a Right: Addressing Underreporting in Binary Data from Multiple Sources.
Authors: Cook S.J. , Blas B. , Carroll R.J. , Sinha S. .
Source: Political Analysis : An Annual Publication Of The Methodology Section Of The American Political Science Association, 2017 Apr; 25(2), p. 223-240.
EPub date: 2017-04-11 00:00:00.0.
PMID: 29104409
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Inference in a survival cure model with mismeasured covariates using a simulation-extrapolation approach.
Authors: Bertrand A. , Legrand C. , Carroll R.J. , De Meester C. , Van Keilegom I. .
Source: Political Analysis : An Annual Publication Of The Methodology Section Of The American Political Science Association, 2017-03-01 00:00:00.0; 104(1), p. 31-50.
EPub date: 2017-01-03 00:00:00.0.
PMID: 29151774
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Estimating Varying Coefficients For Partial Differential Equation Models
Authors: Zhang X. , Cao J. , Carroll R.J. .
Source: Biometrics, 2017-01-11 00:00:00.0; , .
PMID: 28076654
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An Evaluation Of Accelerometer-derived Metrics To Assess Daily Behavioral Patterns
Authors: Keadle S.K. , Sampson J.N. , Li H. , Lyden K. , Matthews C.E. , Carroll R.J. .
Source: Medicine And Science In Sports And Exercise, 2017 Jan; 49(1), p. 54-63.
PMID: 27992396
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On the impact of model selection on predictor identification and parameter inference.
Authors: Pfeiffer R.M. , Redd A. , Carroll R.J. .
Source: Computational Statistics, 2017; 32(2), p. 667-690.
EPub date: 2016-10-22 00:00:00.0.
PMID: 28690368
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Estimation and inference of error-prone covariate effect in the presence of confounding variables.
Authors: Liu J. , Ma Y. , Zhu L. , Carroll R.J. .
Source: Electronic Journal Of Statistics, 2017; 11(1), p. 480-501.
EPub date: 2017-03-02 00:00:00.0.
PMID: 28983388
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SiAM: A Hybrid of Single Index Models and Additive Models.
Authors: Ma S. , Lian H. , Liang H. , Carroll R.J. .
Source: Electronic Journal Of Statistics, 2017; 11(1), p. 2397-2423.
EPub date: 2017-05-29 00:00:00.0.
PMID: 29104711
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PLEMT: A NOVEL PSEUDOLIKELIHOOD BASED EM TEST FOR HOMOGENEITY IN GENERALIZED EXPONENTIAL TILT MIXTURE MODELS.
Authors: Hong C. , Chen Y. , Ning Y. , Wang S. , Wu H. , Carroll R.J. .
Source: Journal Of The American Statistical Association, 2017; 112(520), p. 1393-1404.
EPub date: 2017-02-27 00:00:00.0.
PMID: 29416190
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Linear Model Selection when Covariates Contain Errors.
Authors: Zhang X. , Wang H. , Ma Y. , Carroll R.J. .
Source: Journal Of The American Statistical Association, 2017; 112(520), p. 1553-1561.
EPub date: 2017-06-29 00:00:00.0.
PMID: 29416191
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A Semiparametric Single-Index Risk Score Across Populations.
Authors: Ma S. , Ma Y. , Wang Y. , Kravitz E.S. , Carroll R.J. .
Source: Journal Of The American Statistical Association, 2017; 112(520), p. 1648-1662.
EPub date: 2017-07-18 00:00:00.0.
PMID: 29520120
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Spatial Regression With Covariate Measurement Error: A Semiparametric Approach
Authors: Huque M.H. , Bondell H.D. , Carroll R.J. , Ryan L.M. .
Source: Biometrics, 2016 Sep; 72(3), p. 678-86.
PMID: 26788930
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The Impact Of Stratification By Implausible Energy Reporting Status On Estimates Of Diet-health Relationships
Authors: Tooze J.A. , Freedman L.S. , Carroll R.J. , Midthune D. , Kipnis V. .
Source: Biometrical Journal. Biometrische Zeitschrift, 2016-08-23 00:00:00.0; , .
PMID: 27550787
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Exact Sampling Of The Unobserved Covariates In Bayesian Spline Models For Measurement Error Problems
Authors: Bhadra A. , Carroll R.J. .
Source: Statistics And Computing, 2016 Jul; 26(4), p. 827-840.
PMID: 27418743
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Statistical Issues Related To Dietary Intake As The Response Variable In Intervention Trials
Authors: Keogh R.H. , Carroll R.J. , Tooze J.A. , Kirkpatrick S.I. , Freedman L.S. .
Source: Statistics In Medicine, 2016-06-20 00:00:00.0; , .
PMID: 27324170
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Exposure Enriched Case-control (eecc) Design For The Assessment Of Gene-environment Interaction
Authors: Huque M.H. , Carroll R.J. , Diao N. , Christiani D.C. , Ryan L.M. .
Source: Genetic Epidemiology, 2016-06-17 00:00:00.0; , .
PMID: 27313007
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Calibration And Seasonal Adjustment For Matched Case-control Studies Of Vitamin D And Cancer
Authors: Gail M.H. , Wu J. , Wang M. , Yaun S.S. , Cook N.R. , Eliassen A.H. , McCullough M.L. , Yu K. , Zeleniuch-Jacquotte A. , Smith-Warner S.A. , et al. .
Source: Statistics In Medicine, 2016-06-15 00:00:00.0; 35(13), p. 2133-48.
PMID: 27133461
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Moment Reconstruction And Moment-adjusted Imputation When Exposure Is Generated By A Complex, Nonlinear Random Effects Modeling Process
Authors: Potgieter C.J. , Wei R. , Kipnis V. , Freedman L.S. , Carroll R.J. .
Source: Biometrics, 2016-04-08 00:00:00.0; , .
PMID: 27061196
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Measurement Error Models With Interactions
Authors: Midthune D. , Carroll R.J. , Freedman L.S. , Kipnis V. .
Source: Biostatistics (oxford, England), 2016 Apr; 17(2), p. 277-90.
PMID: 26530858
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Spatial Measurement Error And Correction By Spatial Simex In Linear Regression Models When Using Predicted Air Pollution Exposures
Authors: Alexeeff S.E. , Carroll R.J. , Coull B. .
Source: Biostatistics (oxford, England), 2016 Apr; 17(2), p. 377-89.
PMID: 26621845
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Pcan: Probabilistic Correlation Analysis Of Two Non-normal Data Sets
Authors: Zoh R.S. , Mallick B. , Ivanov I. , Baladandayuthapani V. , Manyam G. , Chapkin R.S. , Lampe J.W. , Carroll R.J. .
Source: Biometrics, 2016-04-01 00:00:00.0; , .
PMID: 27037601
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A bivariate measurement error model for semicontinuous and continuous variables: Application to nutritional epidemiology.
Authors: Kipnis V. , Freedman L.S. , Carroll R.J. , Midthune D. .
Source: Biometrics, 2016 Mar; 72(1), p. 106-15.
PMID: 26332011
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Factors Associated With Allergic Rhinitis In Colombian Subpopulations Aged 1 To 17 And 18 To 59
Authors: Peñaranda A. , Garcia E. , Barragán A.M. , Rondón M.A. , Pérez A. , Rojas M.X. , Caraballo L. , Dennis R.J. .
Source: Rhinology, 2016 Mar; 54(1), p. 56-67.
PMID: 26567471
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Constrained Maximum Likelihood Estimation For Model Calibration Using Summary-level Information From External Big Data Sources
Authors: Chatterjee N. , Chen Y.H. , Maas P. , Carroll R.J. .
Source: Journal Of The American Statistical Association, 2016 Mar; 111(513), p. 107-117.
PMID: 27570323
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Estimation Of Radiation Risk In Presence Of Classical Additive And Berkson Multiplicative Errors In Exposure Doses
Authors: Masiuk S.V. , Shklyar S.V. , Kukush A.G. , Carroll R.J. , Kovgan L.N. , Likhtarov I.A. .
Source: Biostatistics (oxford, England), 2016-01-20 00:00:00.0; , .
PMID: 26795191
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Semiparametric Estimation In The Secondary Analysis Of Case-control Studies
Authors: Ma Y. , Carroll R.J. .
Source: Journal Of The Royal Statistical Society. Series B, Statistical Methodology, 2016 Jan; 78(1), p. 127-151.
PMID: 26834506
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Bayesian Regression Analysis Of Data With Random Effects Covariates From Nonlinear Longitudinal Measurements
Authors: De la Cruz R. , Meza C. , Arribas-Gil A. , Carroll R.J. .
Source: Journal Of Multivariate Analysis, 2016 Jan; 143, p. 94-106.
PMID: 27274601
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Methods To Assess Measurement Error In Questionnaires Of Sedentary Behavior
Authors: Sampson J.N. , Matthews C.E. , Freedman L. , Carroll R.J. , Kipnis V. .
Source: Journal Of Applied Statistics, 2016; 43(9), p. 1706-1721.
PMID: 27340315
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Longitudinal Functional Additive Model With Continuous Proportional Outcomes For Physical Activity Data
Authors: Li H. , Kozey-Keadle S. , Kipnis V. , Carroll R.J. .
Source: Stat (international Statistical Institute), 2016; 5(1), p. 242-250.
PMID: 27904749
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A Statistical Model For Measurement Error That Incorporates Variation Over Time In The Target Measure, With Application To Nutritional Epidemiology
Authors: Freedman L.S. , Midthune D. , Dodd K.W. , Carroll R.J. , Kipnis V. .
Source: Statistics In Medicine, 2015-11-30 00:00:00.0; 34(27), p. 3590-605.
PMID: 26173857
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In vivo regulation of colonic cell proliferation, differentiation, apoptosis, and P27Kip1 by dietary fish oil and butyrate in rats.
Authors: Hong M.Y. , Turner N.D. , Murphy M.E. , Carroll R.J. , Chapkin R.S. , Lupton J.R. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2015 Nov; 8(11), p. 1076-83.
PMID: 26323483
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Application of a New Statistical Model for Measurement Error to the Evaluation of Dietary Self-report Instruments.
Authors: Freedman L.S. , Midthune D. , Carroll R.J. , Commins J.M. , Arab L. , Baer D.J. , Moler J.E. , Moshfegh A.J. , Neuhouser M.L. , Prentice R.L. , et al. .
Source: Epidemiology (cambridge, Mass.), 2015 Nov; 26(6), p. 925-33.
PMID: 26360372
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Estimation And Inference In Generalized Additive Coefficient Models For Nonlinear Interactions With High-dimensional Covariates
Authors: Shujie M.A. , Carroll R.J. , Liang H. , Xu S. .
Source: Annals Of Statistics, 2015 Oct; 43(5), p. 2102-2131.
PMID: 26412908
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The Direct Integral Method For Confidence Intervals For The Ratio Of Two Location Parameters
Authors: Wang Y. , Wang S. , Carroll R.J. .
Source: Biometrics, 2015 Sep; 71(3), p. 704-13.
PMID: 25939421
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Functional And Structural Methods With Mixed Measurement Error And Misclassification In Covariates
Authors: Yi G.Y. , Ma Y. , Spiegelman D. , Carroll R.J. .
Source: Journal Of The American Statistical Association, 2015-06-01 00:00:00.0; 110(510), p. 681-696.
PMID: 26190876
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Sparse Regression By Projection And Sparse Discriminant Analysis
Authors: Qi X. , Luo R. , Carroll R.J. , Zhao H. .
Source: Journal Of Computational And Graphical Statistics : A Joint Publication Of American Statistical Association, Institute Of Mathematical Statistics, Interface Foundation Of North America, 2015-04-01 00:00:00.0; 24(2), p. 416-438.
PMID: 26345204
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On The Selection Of Ordinary Differential Equation Models With Application To Predator-prey Dynamical Models
Authors: Zhang X. , Cao J. , Carroll R.J. .
Source: Biometrics, 2015 Mar; 71(1), p. 131-8.
PMID: 25287611
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Rapid Publication-ready Ms-word Tables For Two-way Anova
Authors: Assaad H.I. , Hou Y. , Zhou L. , Carroll R.J. , Wu G. .
Source: Springerplus, 2015; 4, p. 33.
PMID: 25635246
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Variance Function Partially Linear Single-index Models(1.)
Authors: Lian H. , Liang H. , Carroll R.J. .
Source: Journal Of The Royal Statistical Society. Series B, Statistical Methodology, 2015-01-01 00:00:00.0; 77(1), p. 171-194.
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