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Grant Details

Grant Number: 2U54CA180905-06 Interpret this number
Primary Investigator: Pentz, Mary Ann
Organization: University Of Southern California
Project Title: Tobacco Regulatory Science Investigating the Intersections of Products with Diverse Populations
Fiscal Year: 2018
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Abstract

ABSTRACT: Overall Tobacco products are increasingly diverse. Non-cigarette products now garner a large market share; their use and health impact varies across populations. Youth and young adult non-users of tobacco products are vulner- able to initiation of e-cigarettes?a product posing risks both of nicotine dependence and of combustible tobacco uptake. Yet, middle-aged/older adults may switch from combustible to e-cigarette products with potential health benefits. The FDA is required to consider how regulatory policy has differing impact across subgroups to ensure protection of the ?population as a whole.? Research addressing population diversity is scant. Through its theme, the Intersections of Products with Populations, the University of Southern California Tobacco Center of Regula- tory Science (USC-TCORS) will conduct research on the use and health effects of specific e-cigarette products across populations. We will study e-cigarette product characteristics and marketing approaches hypothesized to increase tobacco product attraction, use, and addiction in youth and young adult non-smokers and have little impact on tobacco product use in older smokers. These e-cigarette products include: (a) non-tobacco flavorings; (b) constituents and devices that produce large vapor clouds; (c) modifiable devices; (d) device designs not resembling cigarettes; (e) cartoons in packaging and advertising; (f) candy flavors or other youth-oriented mar- keting themes. Product standards and marketing requirements limiting non-combustible products with these features to protect young people, while minimizing collateral effects on switching in adult smokers, would satisfy FDA?s mission to protect the overall population. We will provide evidence to forecast whether such requirements would have equitable impact across vulnerable groups defined by ethnicity, socioeconomic status, and sex that are affected by widening tobacco disparities. Four complementary research projects employing differing meth- odologies will test shared hypotheses on variation of the impact of e-cigarette product diversity on tobacco prod- uct use by age, combustible tobacco use, and sociodemographic diversity: (1) characterization of publicly avail- able social media postings of e-cigarette product characteristics and marketing themes that will be linked pro- spectively with tobacco product use behavior in youth and young adults, (2) intercept interviews with customers at vape shops to assess the impact of scenarios of e-cigarette regulation on tobacco product use, (3) cohort studies of associations of e-cigarette product characteristics and marketing exposures with tobacco product use and dependence across 10 years of early life, (4) laboratory tests of the impact of e-cigarette product character- istics and marketing exposure manipulations on product appeal, abuse liability, and other outcomes. Supported by a Center-wide scientific and career development infrastructure, USC-TCORS will provide the FDA with a robust body of evidence to assess how various regulatory approaches to e-cigarettes are likely to affect the health of vulnerable groups and the whole population. Scientific Domains: Addiction, Behavior, and Marketing.

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Publications

Understanding individual differences in vulnerability to cigarette smoking is enhanced by attention to the intersection of common risk factors.
Authors: Gaalema D.E. , Leventhal A.M. , Priest J.S. , Higgins S.T. .
Source: Preventive Medicine, 2018 Dec; 117, p. 38-42.
EPub date: 2018-09-14 00:00:00.0.
PMID: 30222998
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Vaping associated with healthy food words: A content analysis of Twitter.
Authors: Basáńez T. , Majmundar A. , Cruz T.B. , Unger J.B. .
Source: Addictive Behaviors Reports, 2018 Dec; 8, p. 147-153.
EPub date: 2018-09-24 00:00:00.0.
PMID: 30320201
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JUUL: Spreading Online and Offline.
Authors: Chu K.H. , Colditz J.B. , Primack B.A. , Shensa A. , Allem J.P. , Miller E. , Unger J.B. , Cruz T.B. .
Source: The Journal Of Adolescent Health : Official Publication Of The Society For Adolescent Medicine, 2018 Nov; 63(5), p. 582-586.
PMID: 30348280
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Characterizing JUUL-related posts on Twitter.
Authors: Allem J.P. , Dharmapuri L. , Unger J.B. , Cruz T.B. .
Source: Drug And Alcohol Dependence, 2018-09-01 00:00:00.0; 190, p. 1-5.
EPub date: 2018-06-23 00:00:00.0.
PMID: 29958115
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Could Social Bots Pose a Threat to Public Health?
Authors: Allem J.P. , Ferrara E. .
Source: American Journal Of Public Health, 2018 Aug; 108(8), p. 1005-1006.
PMID: 29995482
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A Descriptive Longitudinal Study of Changes in Vape Shop Characteristics and Store Policies in Anticipation of the 2016 FDA Regulations of Tobacco Products, Including E-Cigarettes.
Authors: Yu S. , Escobedo P. , Garcia R. , Cruz T.B. , Unger J.B. , Baezconde-Garbanati L. , Meza L. , Sussman S. .
Source: International Journal Of Environmental Research And Public Health, 2018-02-11 00:00:00.0; 15(2), .
EPub date: 2018-02-11 00:00:00.0.
PMID: 29439464
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E-Cigarette Surveillance With Social Media Data: Social Bots, Emerging Topics, and Trends.
Authors: Allem J.P. , Ferrara E. , Uppu S.P. , Cruz T.B. , Unger J.B. .
Source: Jmir Public Health And Surveillance, 2017-12-20 00:00:00.0; 3(4), p. e98.
EPub date: 2017-12-20 00:00:00.0.
PMID: 29263018
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Just a Spoonful of Sugar Helps the Messages Go Down: Using Stories and Vicarious Self-Affirmation to Reduce e-Cigarette Use.
Authors: Walter N. , Demetriades S.Z. , Murphy S.T. .
Source: Health Communication, 2017-12-13 00:00:00.0; , p. 1-9.
EPub date: 2017-12-13 00:00:00.0.
PMID: 29236554
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Should the FDA Ban Cigarette Filter Ventilation?
Authors: Samet J.M. , Aladadyan L. .
Source: Journal Of The National Cancer Institute, 2017-12-01 00:00:00.0; 109(12), .
PMID: 28525913
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Associations of Electronic Cigarette Nicotine Concentration With Subsequent Cigarette Smoking and Vaping Levels in Adolescents.
Authors: Goldenson N.I. , Leventhal A.M. , Stone M.D. , McConnell R.S. , Barrington-Trimis J.L. .
Source: Jama Pediatrics, 2017-12-01 00:00:00.0; 171(12), p. 1192-1199.
PMID: 29059261
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Establishing consensus on survey measures for electronic nicotine and non-nicotine delivery system use: Current challenges and considerations for researchers.
Authors: Weaver S.R. , Kim H. , Glasser A.M. , Sutfin E.L. , Barrington-Trimis J. , Payne T.J. , Saddleson M. , Loukas A. .
Source: Addictive Behaviors, 2017-11-16 00:00:00.0; , .
EPub date: 2017-11-16 00:00:00.0.
PMID: 29173942
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Exposure to tobacco websites: Associations with cigarette and e-cigarette use and susceptibility among adolescents.
Authors: Unger J.B. , Bartsch L. .
Source: Addictive Behaviors, 2017-11-10 00:00:00.0; 78, p. 120-123.
EPub date: 2017-11-10 00:00:00.0.
PMID: 29154150
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Vape pen product placement in popular music videos.
Authors: Allem J.P. , Escobedo P. , Cruz T.B. , Unger J.B. .
Source: Addictive Behaviors, 2017-11-03 00:00:00.0; , .
EPub date: 2017-11-03 00:00:00.0.
PMID: 29128149
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Perceived stress and poly-tobacco product use across adolescence: Patterns of association and gender differences.
Authors: Leventhal A.M. , Urman R. , Barrington-Trimis J.L. , Goldenson N.I. , Gallegos K. , Chou C.P. , Wang K. , Berhane K. , Cruz T.B. , Pentz M.A. , et al. .
Source: Journal Of Psychiatric Research, 2017 Nov; 94, p. 172-179.
EPub date: 2017-07-14 00:00:00.0.
PMID: 28738287
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Identifying Sentiment of Hookah-Related Posts on Twitter.
Authors: Allem J.P. , Ramanujam J. , Lerman K. , Chu K.H. , Boley Cruz T. , Unger J.B. .
Source: Jmir Public Health And Surveillance, 2017-10-18 00:00:00.0; 3(4), p. e74.
EPub date: 2017-10-18 00:00:00.0.
PMID: 29046267
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Monitoring tobacco brand websites to understand marketing strategies aimed at tobacco product users and potential users.
Authors: Escobedo P. , Cruz T.B. , Tsai K.Y. , Allem J.P. , Soto D.W. , Kirkpatrick M.G. , Pattarroyo M. , Unger J.B. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2017-09-11 00:00:00.0; , .
EPub date: 2017-09-11 00:00:00.0.
PMID: 29059386
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Performance of cigarette susceptibility index among e-cigarette and hookah users.
Authors: Barrington-Trimis J.L. , Leventhal A.M. , Alonzo T.A. , Cruz T.B. , Urman R. , Liu F. , Pentz M.A. , Unger J.B. , McConnell R. .
Source: Drug And Alcohol Dependence, 2017-08-31 00:00:00.0; 183, p. 43-50.
EPub date: 2017-08-31 00:00:00.0.
PMID: 29223916
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Assessing electronic cigarette effects and regulatory impact: Challenges with user self-reported device power.
Authors: Rudy A.K. , Leventhal A.M. , Goldenson N.I. , Eissenberg T. .
Source: Drug And Alcohol Dependence, 2017-08-18 00:00:00.0; 179, p. 337-340.
EPub date: 2017-08-18 00:00:00.0.
PMID: 28843084
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Association Between Initial Use of e-Cigarettes and Subsequent Cigarette Smoking Among Adolescents and Young Adults: A Systematic Review and Meta-analysis.
Authors: Soneji S. , Barrington-Trimis J.L. , Wills T.A. , Leventhal A.M. , Unger J.B. , Gibson L.A. , Yang J. , Primack B.A. , Andrews J.A. , Miech R.A. , et al. .
Source: Jama Pediatrics, 2017-08-01 00:00:00.0; 171(8), p. 788-797.
PMID: 28654986
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Images of Little Cigars and Cigarillos on Instagram Identified by the Hashtag #swisher: Thematic Analysis.
Authors: Allem J.P. , Escobedo P. , Chu K.H. , Boley Cruz T. , Unger J.B. .
Source: Journal Of Medical Internet Research, 2017-07-14 00:00:00.0; 19(7), p. e255.
EPub date: 2017-07-14 00:00:00.0.
PMID: 28710057
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Mentoring for Success in Tobacco Regulatory Science: A Qualitative Study.
Authors: Russo A.R. , Solis A.C. , Villanti A.C. , Wipfli H.L. , Kern T.T. , Lawley R.K. , Collins L.K. , Abudayyeh H.S. , Chansky M.C. , Glantz S.A. , et al. .
Source: Tobacco Regulatory Science, 2017 Jul; 3(3), p. 280-292.
PMID: 28758143
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Associations between anhedonia and marijuana use escalation across mid-adolescence.
Authors: Leventhal A.M. , Cho J. , Stone M.D. , Barrington-Trimis J.L. , Chou C.P. , Sussman S.Y. , Riggs N.R. , Unger J.B. , Audrain-McGovern J. , Strong D.R. .
Source: Addiction (abingdon, England), 2017-06-17 00:00:00.0; , .
EPub date: 2017-06-17 00:00:00.0.
PMID: 28623880
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Longitudinal relationships of sleep and inhibitory control deficits to early adolescent cigarette and alcohol use.
Authors: Warren C.M. , Riggs N.R. , Pentz M.A. .
Source: Journal Of Adolescence, 2017 Jun; 57, p. 31-41.
EPub date: 2017-03-21 00:00:00.0.
PMID: 28334632
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Electronic Cigarette Use and Respiratory Symptoms in Adolescents.
Authors: McConnell R. , Barrington-Trimis J.L. , Wang K. , Urman R. , Hong H. , Unger J. , Samet J. , Leventhal A. , Berhane K. .
Source: American Journal Of Respiratory And Critical Care Medicine, 2017-04-15 00:00:00.0; 195(8), p. 1043-1049.
PMID: 27806211
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Methods For Coding Tobacco-related Twitter Data: A Systematic Review
Authors: Lienemann B.A. , Unger J.B. , Cruz T.B. , Chu K.H. .
Source: Journal Of Medical Internet Research, 2017-03-31 00:00:00.0; 19(3), p. e91.
PMID: 28363883
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Type Of E-cigarette Device Used Among Adolescents And Young Adults: Findings From A Pooled Analysis Of 8 Studies Of 2,166 Vapers
Authors: Barrington-Trimis J.L. , Gibson L.A. , Halpern-Felsher B. , Harrell M.B. , Kong G. , Krishnan-Sarin S. , Leventhal A.M. , Loukas A. , McConnell R. , Weaver S.R. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2017-03-22 00:00:00.0; , .
PMID: 28371890
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Campaigns and counter campaigns: reactions on Twitter to e-cigarette education.
Authors: Allem J.P. , Escobedo P. , Chu K.H. , Soto D.W. , Cruz T.B. , Unger J.B. .
Source: Tobacco Control, 2017 Mar; 26(2), p. 226-229.
PMID: 26956467
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Waterpipe Promotion and Use on Instagram: #Hookah.
Authors: Allem J.P. , Chu K.H. , Cruz T.B. , Unger J.B. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2017-01-11 00:00:00.0; , .
EPub date: 2017-01-11 00:00:00.0.
PMID: 28077449
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Electronic Cigarette Retailers Use Pokémon Go To Market Products
Authors: Kirkpatrick M.G. , Cruz T.B. , Goldenson N.I. , Allem J.P. , Chu K.H. , Pentz M.A. , Unger J.B. .
Source: Tobacco Control, 2017-01-02 00:00:00.0; , .
PMID: 28044010
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Why do people use electronic nicotine delivery systems (electronic cigarettes)? A content analysis of Twitter, 2012-2015.
Authors: Ayers J.W. , Leas E.C. , Allem J.P. , Benton A. , Dredze M. , Althouse B.M. , Cruz T.B. , Unger J.B. .
Source: Plos One, 2017; 12(3), p. e0170702.
EPub date: 2017-03-01 00:00:00.0.
PMID: 28248987
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The Associations between Yelp Online Reviews and Vape Shops Closing or Remaining Open One Year Later.
Authors: Kong G. , Unger J. , Baezconde-Garbanati L. , Sussman S. .
Source: Tobacco Prevention & Cessation, 2017; 2(Suppl), .
EPub date: 2017-02-02 00:00:00.0.
PMID: 29057379
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Challenges to Mediation Analysis From Experimental Designs.
Authors: Allem J.P. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2016-12-07 00:00:00.0; , .
EPub date: 2016-12-07 00:00:00.0.
PMID: 27928051
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Association Of E-cigarette Vaping And Progression To Heavier Patterns Of Cigarette Smoking
Authors: Leventhal A.M. , Stone M.D. , Andrabi N. , Barrington-Trimis J. , Strong D.R. , Sussman S. , Audrain-McGovern J. .
Source: Jama, 2016-11-08 00:00:00.0; 316(18), p. 1918-1920.
PMID: 27825000
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Flavoured tobacco products and the public's health: lessons from the TPSAC menthol report.
Authors: Samet J.M. , Pentz M.A. , Unger J.B. .
Source: Tobacco Control, 2016 Nov; 25(Suppl 2), p. ii103-ii105.
EPub date: 2016-09-15 00:00:00.0.
PMID: 27633765
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E-cigarettes, Conventional Cigarettes, And Dual Use In Korean Adolescents And University Students: Prevalence And Risk Factors
Authors: Jeon C. , Jung K.J. , Kimm H. , Lee S. , Barrington-Trimis J.L. , McConnell R. , Samet J.M. , Jee S.H. .
Source: Drug And Alcohol Dependence, 2016-11-01 00:00:00.0; 168, p. 99-103.
PMID: 27635996
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Effects Of Sweet Flavorings And Nicotine On The Appeal And Sensory Properties Of E-cigarettes Among Young Adult Vapers: Application Of A Novel Methodology
Authors: Goldenson N.I. , Kirkpatrick M.G. , Barrington-Trimis J.L. , Pang R.D. , McBeth J.F. , Pentz M.A. , Samet J.M. , Leventhal A.M. .
Source: Drug And Alcohol Dependence, 2016-11-01 00:00:00.0; 168, p. 176-180.
PMID: 27676583
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Emerging adulthood themes and hookah use among college students in Southern California.
Authors: Allem J.P. , Unger J.B. .
Source: Addictive Behaviors, 2016 Oct; 61, p. 16-9.
PMID: 27208879
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Progression Of Poly-tobacco Product Use Patterns In Adolescents
Authors: Huh J. , Leventhal A.M. .
Source: American Journal Of Preventive Medicine, 2016 Oct; 51(4), p. 513-7.
PMID: 27211895
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Vaping On Instagram: Cloud Chasing, Hand Checks And Product Placement
Authors: Chu K.H. , Allem J.P. , Cruz T.B. , Unger J.B. .
Source: Tobacco Control, 2016-09-22 00:00:00.0; , .
PMID: 27660111
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Commentary: Forces That Drive the Vape Shop Industry and Implications for the Health Professions.
Authors: Sussman S. , Baezconde-Garbanati L. , Garcia R. , Barker D.C. , Samet J.M. , Leventhal A. , Unger J.B. .
Source: Evaluation & The Health Professions, 2016 Sep; 39(3), p. 379-88.
PMID: 25967071
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The Importance Of Debiasing Social Media Data To Better Understand E-cigarette-related Attitudes And Behaviors
Authors: Allem J.P. , Ferrara E. .
Source: Journal Of Medical Internet Research, 2016-08-09 00:00:00.0; 18(8), p. e219.
PMID: 27507563
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E-cigarettes, Cigarettes, and the Prevalence of Adolescent Tobacco Use.
Authors: Barrington-Trimis J.L. , Urman R. , Leventhal A.M. , Gauderman W.J. , Cruz T.B. , Gilreath T.D. , Howland S. , Unger J.B. , Berhane K. , Samet J.M. , et al. .
Source: Pediatrics, 2016 Aug; 138(2), .
EPub date: 2016-07-11 00:00:00.0.
PMID: 27401102
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The Revised Inventory of the Dimensions of Emerging Adulthood (IDEA-R) and Substance Use Among College Students.
Authors: Allem J.P. , Sussman S. , Unger J.B. .
Source: Evaluation & The Health Professions, 2016-07-27 00:00:00.0; , .
EPub date: 2016-07-27 00:00:00.0.
PMID: 27468859
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Defining Tobacco Regulatory Science Competencies
Authors: Wipfli H.L. , Berman M. , Hanson K. , Kelder S. , Solis A. , Villanti A.C. , Ribeiro C.M. , Meissner H.I. , Anderson R. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2016-07-14 00:00:00.0; , .
PMID: 27613917
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When a ban really is not a ban: internet loopholes and Djarum flavoured cigarettes in the USA.
Authors: Allem J.P. , Ayers J.W. , Althouse B.M. , Williams R. .
Source: Tobacco Control, 2016 Jul; 25(4), p. 489-90.
PMID: 26085123
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The E-cigarette Social Environment, E-cigarette Use, and Susceptibility to Cigarette Smoking.
Authors: Barrington-Trimis J.L. , Berhane K. , Unger J.B. , Cruz T.B. , Urman R. , Chou C.P. , Howland S. , Wang K. , Pentz M.A. , Gilreath T.D. , et al. .
Source: The Journal Of Adolescent Health : Official Publication Of The Society For Adolescent Medicine, 2016 Jul; 59(1), p. 75-80.
PMID: 27161417
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E-Cigarettes and Future Cigarette Use.
Authors: Barrington-Trimis J.L. , Urman R. , Berhane K. , Unger J.B. , Cruz T.B. , Pentz M.A. , Samet J.M. , Leventhal A.M. , McConnell R. .
Source: Pediatrics, 2016 Jul; 138(1), .
EPub date: 2016-06-13 00:00:00.0.
PMID: 27296866
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Improving substance use prevention efforts with executive function training.
Authors: Pentz M.A. , Riggs N.R. , Warren C.M. .
Source: Drug And Alcohol Dependence, 2016-06-01 00:00:00.0; 163 Suppl 1, p. S54-9.
PMID: 27306732
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Breast Cancer Symptom Clusters Derived from Social Media and Research Study Data Using Improved K-Medoid Clustering.
Authors: Ping Q. , Yang C.C. , Marshall S.A. , Avis N.E. , Ip E.H. .
Source: Ieee Transactions On Computational Social Systems, 2016 Jun; 3(2), p. 63-74.
EPub date: 2016-11-07 00:00:00.0.
PMID: 29152536
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Perceptions Of Secondhand E-cigarette Aerosol Among Twitter Users
Authors: Unger J.B. , Escobedo P. , Allem J.P. , Soto D.W. , Chu K.H. , Cruz T. .
Source: Tobacco Regulatory Science, 2016 Apr; 2(2), p. 146-152.
PMID: 28090560
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