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Grant Details

Grant Number: 5UM1CA186107-05 Interpret this number
Primary Investigator: Stampfer, Meir
Organization: Brigham And Women'S Hospital
Project Title: Long Term Multidisciplinary Study of Cancer in Women: the Nurses Health Study
Fiscal Year: 2018
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Abstract

DESCRIPTION (provided by applicant): This is a UIVII application to support the infrastructure of the original Nurses' Health Study (NHS). The NHS began in 1976 with 121,700 women, and has accumulated data from 19 questionnaires over 37 years; follow-up remains about 90 percent. The wealth of behavioral data combined with multiple bio-specimen collections, including blood, toenails, urine, buccal cells and tumor tissues beginning in 1.983 from a substantial proportion of women, provide an unparalleled resource in studying cancer prevention, etiology, and survival. Sustained follow-up of the NHS through repeated questionnaire mailings and continued identification of cancer incidence and mortality will permit critical new research. With the cohort's maturation (women are now 66+ years, at peak ages for cancer incidence), we propose to add emphasis to two overarching themes. First, we propose to expand the infrastructure for cancer survival research, including both the duration and quality of life in cancer patients. The many years of characterization of cancer patients before and after diagnosis, will allow us to distinguish between causes and consequences of cancer and its treatment. Second, we propose to improve our infrastructure to support a systems biology approach to our research, integrating questionnaire data with biomarkers in DNA, blood, tumor tissue, and other bio specimens; such research simultaneously integrating multiple "systems", including behavior, genomics, transcriptomics, metabolomics, etc., may illuminate new mechanisms underlying cancer. Our large and growing number of incident cancer cases, and the unique combination of questionnaires and bio specimens, are a necessity for such integrative research. Specifically, our Aims include new collection of quality of life data, new (collection of tumor tissue (resulting in tissue collections, across 17 cancer sites), improved dat management/statistical support for "big data" analyses, and enhanced infrastructure for data sharing (the NHS resource is already extensively utilized - we have provided access to >75 external investigators in the past 5-6 years and 27 NCI cancer consortia). The NHS structure combines the long experience of senior leaders with support of several developing leaders; this combination is purposeful, to maintain leadership to sustain the cohort's future. In conclusion, NHS is well-positioned to continue cutting-edge research to reduce cancer morbidity and mortality. With the previous investment from NIH and investigators, the incremental costs of continuing this cohort are modest in relation to the uniquely valuable findings that will emerge in the coming 5 years. RELEVANCE: This UMI application is to extend follow-up of the original Nurses' Health Study, with extensive data on health, and lifestyle, integrated with biologic data (e.g., genomics, plasma biomarkers, tumor tissue, etc.), enabling novel research on cancer etiology, prevention and survival. No other cohort of comparable size includes such long follow-up with repeated behavioral measures, and bio specimens from 82,000 women. This enables studies of the time frame for causal and preventive factors for cancer etiology and survival.

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Publications

Ophthalmic and Glaucoma Treatment Characteristics Associated With Changes in Health-related Quality of Life Before and After Newly Diagnosed Primary Open-angle Glaucoma in Nurses' Health Study Participants.
Authors: Bailey L.A. , Okereke O.I. , Kawachi I. , Cioffi G.A. , Pasquale L.R. , Kang J.H. .
Source: Journal Of Glaucoma, 2016 Mar; 25(3), p. e220-8.
PMID: 26125994
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Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status.
Authors: Song M. , Nishihara R. , Wang M. , Chan A.T. , Qian Z.R. , Inamura K. , Zhang X. , Ng K. , Kim S.A. , Mima K. , et al. .
Source: Gut, 2016 Feb; 65(2), p. 296-304.
PMID: 25591978
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Prospective Study of Ambient Particulate Matter Exposure and Risk of Pulmonary Embolism in the Nurses' Health Study Cohort.
Authors: Pun V.C. , Hart J.E. , Kabrhel C. , Camargo C.A. , Baccarelli A.A. , Laden F. .
Source: Environmental Health Perspectives, 2015 Dec; 123(12), p. 1265-70.
PMID: 25956005
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Assessing individual risk for high-risk colorectal adenoma at first-time screening colonoscopy.
Authors: Cao Y. , Rosner B.A. , Ma J. , Tamimi R.M. , Chan A.T. , Fuchs C.S. , Wu K. , Giovannucci E.L. .
Source: International Journal Of Cancer, 2015-10-01 00:00:00.0; 137(7), p. 1719-28.
EPub date: 2015-10-01 00:00:00.0.
PMID: 25820865
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Interactions between amino acid-defined major histocompatibility complex class II variants and smoking in seropositive rheumatoid arthritis.
Authors: Kim K. , Jiang X. , Cui J. , Lu B. , Costenbader K.H. , Sparks J.A. , Bang S.Y. , Lee H.S. , Okada Y. , Raychaudhuri S. , et al. .
Source: Arthritis & Rheumatology (hoboken, N.j.), 2015 Oct; 67(10), p. 2611-23.
PMID: 26098791
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Association Between Plasma Levels of Macrophage Inhibitory Cytokine-1 Before Diagnosis of Colorectal Cancer and Mortality.
Authors: Mehta R.S. , Chong D.Q. , Song M. , Meyerhardt J.A. , Ng K. , Nishihara R. , Qian Z. , Morikawa T. , Wu K. , Giovannucci E.L. , et al. .
Source: Gastroenterology, 2015 Sep; 149(3), p. 614-22.
PMID: 26026393
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Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer.
Authors: Khalili H. , Gong J. , Brenner H. , Austin T.R. , Hutter C.M. , Baba Y. , Baron J.A. , Berndt S.I. , Bézieau S. , Caan B. , et al. .
Source: Carcinogenesis, 2015 Sep; 36(9), p. 999-1007.
PMID: 26071399
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Proportion of colon cancer attributable to lifestyle in a cohort of US women.
Authors: Erdrich J. , Zhang X. , Giovannucci E. , Willett W. .
Source: Cancer Causes & Control : Ccc, 2015 Sep; 26(9), p. 1271-9.
PMID: 26092381
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Citrus Consumption and Risk of Cutaneous Malignant Melanoma.
Authors: Wu S. , Han J. , Feskanich D. , Cho E. , Stampfer M.J. , Willett W.C. , Qureshi A.A. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2015-08-10 00:00:00.0; 33(23), p. 2500-8.
EPub date: 2015-08-10 00:00:00.0.
PMID: 26124488
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The interaction between early-life body size and physical activity on risk of breast cancer.
Authors: Oh H. , Boeke C.E. , Tamimi R.M. , Smith-Warner S.A. , Wang M. , Willett W.C. , Eliassen A.H. .
Source: International Journal Of Cancer, 2015-08-01 00:00:00.0; 137(3), p. 571-81.
EPub date: 2015-08-01 00:00:00.0.
PMID: 25335465
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Prospective study of body size throughout the life-course and the incidence of endometrial cancer among premenopausal and postmenopausal women.
Authors: Dougan M.M. , Hankinson S.E. , Vivo I.D. , Tworoger S.S. , Glynn R.J. , Michels K.B. .
Source: International Journal Of Cancer, 2015-08-01 00:00:00.0; 137(3), p. 625-37.
EPub date: 2015-08-01 00:00:00.0.
PMID: 25641700
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Plasma C-reactive protein and risk of breast cancer in two prospective studies and a meta-analysis.
Authors: Wang J. , Lee I.M. , Tworoger S.S. , Buring J.E. , Ridker P.M. , Rosner B. , Hankinson S.E. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2015 Aug; 24(8), p. 1199-206.
PMID: 25994740
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Oral contraceptive use and colorectal cancer in the Nurses' Health Study I and II.
Authors: Charlton B.M. , Wu K. , Zhang X. , Giovannucci E.L. , Fuchs C.S. , Missmer S.A. , Rosner B. , Hankinson S.E. , Willett W.C. , Michels K.B. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2015 Aug; 24(8), p. 1214-21.
PMID: 26063479
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Genome-wide significant risk associations for mucinous ovarian carcinoma.
Authors: Kelemen L.E. , Lawrenson K. , Tyrer J. , Li Q. , Lee J.M. , Seo J.H. , Phelan C.M. , Beesley J. , Chen X. , Spindler T.J. , et al. .
Source: Nature Genetics, 2015 Aug; 47(8), p. 888-97.
PMID: 26075790
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A Meta-Regression Method for Studying Etiological Heterogeneity Across Disease Subtypes Classified by Multiple Biomarkers.
Authors: Wang M. , Kuchiba A. , Ogino S. .
Source: American Journal Of Epidemiology, 2015-08-01 00:00:00.0; 182(3), p. 263-70.
EPub date: 2015-08-01 00:00:00.0.
PMID: 26116215
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Circulating Very-Long-Chain Saturated Fatty Acids and Incident Coronary Heart Disease in US Men and Women.
Authors: Malik V.S. , Chiuve S.E. , Campos H. , Rimm E.B. , Mozaffarian D. , Hu F.B. , Sun Q. .
Source: Circulation, 2015-07-28 00:00:00.0; 132(4), p. 260-8.
EPub date: 2015-07-28 00:00:00.0.
PMID: 26048094
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Genetic variants of adiponectin and risk of colorectal cancer.
Authors: Song M. , Gong J. , Giovannucci E.L. , Berndt S.I. , Brenner H. , Chang-Claude J. , Curtis K.R. , Harrison T.A. , Hoffmeister M. , Hsu L. , et al. .
Source: International Journal Of Cancer, 2015-07-01 00:00:00.0; 137(1), p. 154-64.
EPub date: 2015-07-01 00:00:00.0.
PMID: 25431318
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Genetic Predisposition to Central Obesity and Risk of Type 2 Diabetes: Two Independent Cohort Studies.
Authors: Huang T. , Qi Q. , Zheng Y. , Ley S.H. , Manson J.E. , Hu F.B. , Qi L. .
Source: Diabetes Care, 2015 Jul; 38(7), p. 1306-11.
PMID: 25852209
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Adulthood Weight Change and Risk of Colorectal Cancer in the Nurses' Health Study and Health Professionals Follow-up Study.
Authors: Song M. , Hu F.B. , Spiegelman D. , Chan A.T. , Wu K. , Ogino S. , Fuchs C.S. , Willett W.C. , Giovannucci E.L. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2015 Jul; 8(7), p. 620-7.
PMID: 25930050
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Plasma matrix metalloproteinase 2 levels and breast cancer risk.
Authors: Aroner S.A. , Rosner B.A. , Tamimi R.M. , Tworoger S.S. , Baur N. , Joos T.O. , Hankinson S.E. .
Source: Cancer Epidemiology, 2015 Jun; 39(3), p. 321-7.
PMID: 25799912
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Periodontal bone loss and risk of epithelial ovarian cancer.
Authors: Babic A. , Poole E.M. , Terry K.L. , Cramer D.W. , Teles R.P. , Tworoger S.S. .
Source: Cancer Causes & Control : Ccc, 2015 Jun; 26(6), p. 941-7.
PMID: 25837263
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Adult body size and physical activity in relation to risk of breast cancer according to tumor androgen receptor status.
Authors: Zhang X. , Eliassen A.H. , Tamimi R.M. , Hazra A. , Beck A.H. , Brown M. , Collins L.C. , Rosner B. , Hankinson S.E. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2015 Jun; 24(6), p. 962-8.
PMID: 25855627
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Plasma carotenoids and risk of breast cancer over 20 y of follow-up.
Authors: Eliassen A.H. , Liao X. , Rosner B. , Tamimi R.M. , Tworoger S.S. , Hankinson S.E. .
Source: The American Journal Of Clinical Nutrition, 2015 Jun; 101(6), p. 1197-205.
PMID: 25877493
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Hypertension, Antihypertensive Medications, and Risk of Incident Primary Hyperparathyroidism.
Authors: Vaidya A. , Curhan G.C. , Paik J.M. , Kronenberg H. , Taylor E.N. .
Source: The Journal Of Clinical Endocrinology And Metabolism, 2015 Jun; 100(6), p. 2396-404.
PMID: 25885946
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Premenopausal plasma carotenoids, fluorescent oxidation products, and subsequent breast cancer risk in the nurses' health studies.
Authors: Sisti J.S. , Lindström S. , Kraft P. , Tamimi R.M. , Rosner B.A. , Wu T. , Willett W.C. , Eliassen A.H. .
Source: Breast Cancer Research And Treatment, 2015 Jun; 151(2), p. 415-25.
PMID: 25917867
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Association between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses.
Authors: Adebamowo S.N. , Spiegelman D. , Willett W.C. , Rexrode K.M. .
Source: The American Journal Of Clinical Nutrition, 2015 Jun; 101(6), p. 1269-77.
PMID: 25948665
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Dense and nondense mammographic area and risk of breast cancer by age and tumor characteristics.
Authors: Bertrand K.A. , Scott C.G. , Tamimi R.M. , Jensen M.R. , Pankratz V.S. , Norman A.D. , Visscher D.W. , Couch F.J. , Shepherd J. , Chen Y.Y. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2015 May; 24(5), p. 798-809.
PMID: 25716949
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The association of long-term exposure to PM2.5 on all-cause mortality in the Nurses' Health Study and the impact of measurement-error correction.
Authors: Hart J.E. , Liao X. , Hong B. , Puett R.C. , Yanosky J.D. , Suh H. , Kioumourtzoglou M.A. , Spiegelman D. , Laden F. .
Source: Environmental Health : A Global Access Science Source, 2015-05-01 00:00:00.0; 14, p. 38.
EPub date: 2015-05-01 00:00:00.0.
PMID: 25926123
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Early life body fatness and risk of colorectal cancer in u.s. Women and men-results from two large cohort studies.
Authors: Zhang X. , Wu K. , Giovannucci E.L. , Ma J. , Colditz G.A. , Fuchs C.S. , Willett W.C. , Stampfer M.J. , Nimptsch K. , Ogino S. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2015 Apr; 24(4), p. 690-7.
PMID: 25777804
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Association between dietary whole grain intake and risk of mortality: two large prospective studies in US men and women.
Authors: Wu H. , Flint A.J. , Qi Q. , van Dam R.M. , Sampson L.A. , Rimm E.B. , Holmes M.D. , Willett W.C. , Hu F.B. , Sun Q. .
Source: Jama Internal Medicine, 2015 Mar; 175(3), p. 373-84.
PMID: 25559238
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Total and cause-specific mortality of U.S. nurses working rotating night shifts.
Authors: Gu F. , Han J. , Laden F. , Pan A. , Caporaso N.E. , Stampfer M.J. , Kawachi I. , Rexrode K.M. , Willett W.C. , Hankinson S.E. , et al. .
Source: American Journal Of Preventive Medicine, 2015 Mar; 48(3), p. 241-52.
PMID: 25576495
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Mammographic breast density and breast cancer risk: interactions of percent density, absolute dense, and non-dense areas with breast cancer risk factors.
Authors: Yaghjyan L. , Colditz G.A. , Rosner B. , Tamimi R.M. .
Source: Breast Cancer Research And Treatment, 2015 Feb; 150(1), p. 181-9.
PMID: 25677739
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Antihypertensive medication use and incident breast cancer in women.
Authors: Devore E.E. , Kim S. , Ramin C.A. , Wegrzyn L.R. , Massa J. , Holmes M.D. , Michels K.B. , Tamimi R.M. , Forman J.P. , Schernhammer E.S. .
Source: Breast Cancer Research And Treatment, 2015 Feb; 150(1), p. 219-29.
PMID: 25701121
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Bioactive prolactin levels and risk of breast cancer: a nested case-control study.
Authors: Tworoger S.S. , Rice M.S. , Rosner B.A. , Feeney Y.B. , Clevenger C.V. , Hankinson S.E. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2015 Jan; 24(1), p. 73-80.
PMID: 25315962
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Intakes of fat and micronutrients between ages 13 and 18 years and the incidence of proliferative benign breast disease.
Authors: Su X. , Boeke C.E. , Collins L.C. , Baer H.J. , Willett W.C. , Schnitt S.J. , Connolly J.L. , Rosner B. , Colditz G.A. , Tamimi R.M. .
Source: Cancer Causes & Control : Ccc, 2015 Jan; 26(1), p. 79-90.
PMID: 25376828
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Survival among patients with pancreatic cancer and long-standing or recent-onset diabetes mellitus.
Authors: Yuan C. , Rubinson D.A. , Qian Z.R. , Wu C. , Kraft P. , Bao Y. , Ogino S. , Ng K. , Clancy T.E. , Swanson R.S. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2015-01-01 00:00:00.0; 33(1), p. 29-35.
EPub date: 2015-01-01 00:00:00.0.
PMID: 25403204
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Immunoassay and Nb2 lymphoma bioassay prolactin levels and mammographic density in premenopausal and postmenopausal women the Nurses' Health Studies.
Authors: Rice M.S. , Tworoger S.S. , Bertrand K.A. , Hankinson S.E. , Rosner B.A. , Feeney Y.B. , Clevenger C.V. , Tamimi R.M. .
Source: Breast Cancer Research And Treatment, 2015 Jan; 149(1), p. 245-53.
PMID: 25503962
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Premenopausal plasma 25-hydroxyvitamin D, mammographic density, and risk of breast cancer.
Authors: Bertrand K.A. , Rosner B. , Eliassen A.H. , Hankinson S.E. , Rexrode K.M. , Willett W. , Tamimi R.M. .
Source: Breast Cancer Research And Treatment, 2015 Jan; 149(2), p. 479-87.
PMID: 25543181
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Intakes of caffeine, coffee and tea and risk of amyotrophic lateral sclerosis: Results from five cohort studies.
Authors: Fondell E. , O'Reilly É.I. , Fitzgerald K.C. , Falcone G.J. , Kolonel L.N. , Park Y. , Gapstur S.M. , Ascherio A. .
Source: Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2015; 16(5-6), p. 366-71.
PMID: 25822002
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No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk.
Authors: Du M. , Zhang X. , Hoffmeister M. , Schoen R.E. , Baron J.A. , Berndt S.I. , Brenner H. , Carlson C.S. , Casey G. , Chan A.T. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2014 Dec; 23(12), p. 2971-6.
PMID: 25192705
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Plasma matrix metalloproteinase 1, 3, and 7 levels and breast cancer risk in the Nurses' Health study.
Authors: Aroner S.A. , Rosner B.A. , Tamimi R.M. , Tworoger S.S. , Baur N. , Joos T.O. , Hankinson S.E. .
Source: Cancer Causes & Control : Ccc, 2014 Dec; 25(12), p. 1717-23.
PMID: 25225035
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Diet, Lifestyle, And Genetic Risk Factors For Type 2 Diabetes: A Review From The Nurses' Health Study, Nurses' Health Study 2, And Health Professionals' Follow-up Study
Authors: Ardisson Korat A.V. , Willett W.C. , Hu F.B. .
Source: Current Nutrition Reports, 2014-12-01 00:00:00.0; 3(4), p. 345-354.
PMID: 25599007
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Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
Authors: Cerhan J.R. , Berndt S.I. , Vijai J. , Ghesquières H. , McKay J. , Wang S.S. , Wang Z. , Yeager M. , Conde L. , de Bakker P.I. , et al. .
Source: Nature Genetics, 2014 Nov; 46(11), p. 1233-8.
PMID: 25261932
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Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
Authors: Lindström S. , Thompson D.J. , Paterson A.D. , Li J. , Gierach G.L. , Scott C. , Stone J. , Douglas J.A. , dos-Santos-Silva I. , Fernandez-Navarro P. , et al. .
Source: Nature Communications, 2014-10-24 00:00:00.0; 5, p. 5303.
EPub date: 2014-10-24 00:00:00.0.
PMID: 25342443
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The association of reproductive and lifestyle factors with a score of multiple endogenous hormones.
Authors: Shafrir A.L. , Zhang X. , Poole E.M. , Hankinson S.E. , Tworoger S.S. .
Source: Hormones & Cancer, 2014 Oct; 5(5), p. 324-35.
PMID: 25048255
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Plasma magnesium and risk of ischemic stroke among women.
Authors: Akarolo-Anthony S.N. , Jiménez M.C. , Chiuve S.E. , Spiegelman D. , Willett W.C. , Rexrode K.M. .
Source: Stroke; A Journal Of Cerebral Circulation, 2014 Oct; 45(10), p. 2881-6.
PMID: 25116874
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Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.
Authors: Mayers J.R. , Wu C. , Clish C.B. , Kraft P. , Torrence M.E. , Fiske B.P. , Yuan C. , Bao Y. , Townsend M.K. , Tworoger S.S. , et al. .
Source: Nature Medicine, 2014 Oct; 20(10), p. 1193-8.
PMID: 25261994
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Body size and multiple myeloma mortality: a pooled analysis of 20 prospective studies.
Authors: Teras L.R. , Kitahara C.M. , Birmann B.M. , Hartge P.A. , Wang S.S. , Robien K. , Patel A.V. , Adami H.O. , Weiderpass E. , Giles G.G. , et al. .
Source: British Journal Of Haematology, 2014 Sep; 166(5), p. 667-76.
PMID: 24861847
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Gene-environment interaction involving recently identified colorectal cancer susceptibility Loci.
Authors: Kantor E.D. , Hutter C.M. , Minnier J. , Berndt S.I. , Brenner H. , Caan B.J. , Campbell P.T. , Carlson C.S. , Casey G. , Chan A.T. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2014 Sep; 23(9), p. 1824-33.
PMID: 24994789
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Predicted 25(OH)D score and colorectal cancer risk according to vitamin D receptor expression.
Authors: Jung S. , Qian Z.R. , Yamauchi M. , Bertrand K.A. , Fitzgerald K.C. , Inamura K. , Kim S.A. , Mima K. , Sukawa Y. , Zhang X. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2014 Aug; 23(8), p. 1628-37.
PMID: 24920642
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