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Grant Details

Grant Number: 5R03CA219450-02 Interpret this number
Primary Investigator: Zhu, Liang
Organization: University Of Texas Hlth Sci Ctr Houston
Project Title: Statistical Analysis for Mixed Outcome Measures in Recurrent Event Studies
Fiscal Year: 2018


Abstract

Project Summary/Abstract: This application addresses the development and application of new analytic strategies for mixed panel-binary/panel- ordinal/panel-count/recurrent-event data in event history studies. While these 4 data types are all generated from recurrent- event processes, they have different endpoints. Recurrent-event data record the occurring time points of each event, panel- count data record the number of events since the last observation, panel-ordinal data record the number of events categorically, and panel-binary data record if any event has happened since the last observation. At times we must deal with mixed data as different endpoints may be collected for the same variable in multiple observations. Among the 4 data types, recurrent-event data offer the greatest amount of relevant information, followed by panel-count, ordinal, and binary data. The statistical literature on mixed panel-binary/panel-ordinal/panel-count/recurrent-event data is sparse though examples of these data types exist abundantly in cancer and non-cancer studies. The renowned longitudinal Childhood Cancer Survivor Study (CCSS) is an example. Standard multivariate or longitudinal methods cannot reflect the special structure of the event process underlying the panel-binary or ordinal data. There is an urgent need to develop intuitive, efficient, and computationally feasible methods for analyzing complex data in event history studies. In this proposal, we plan to: 1) develop a likelihood-based semiparametric estimation method for regression analysis of mixed panel-binary and panel-count data; 2) develop a likelihood-based semiparametric estimation method for regression analysis of mixed panel-binary data, panel-count data, and recurrent-event data and apply that method to the CCSS data; 3) develop likelihood-based semiparametric estimation methods for regression analysis of mixed panel-binary/pane-ordinal/panel-count/recurrent-event data. These approaches will address a gap in statistical analysis in the context of recurrent events and potentially have strong statistical and clinical relevance for the study of complex event history data.



Publications

Regression analysis of mixed panel-count data with application to cancer studies.
Authors: Li Y. , Zhu L. , Liu L. , Robison L.L. .
Source: Statistics In Biosciences, 2021 Apr; 13(1), p. 178-195.
EPub date: 2020-08-17 00:00:00.0.
PMID: 33747242
Related Citations

Regression analysis of mixed panel count data with informative indicator processes.
Authors: Ge L. , Zhu L. , Sun J. .
Source: Statistics In Medicine, 2021-02-28 00:00:00.0; 40(5), p. 1262-1271.
EPub date: 2020-12-03 00:00:00.0.
PMID: 33274467
Related Citations

Statistical analysis of clustered mixed recurrent-event data with application to a cancer survivor study.
Authors: Zhu L. , Choi S. , Li Y. , Huang X. , Sun J. , Robison L.L. .
Source: Lifetime Data Analysis, 2020-07-12 00:00:00.0; , .
EPub date: 2020-07-12 00:00:00.0.
PMID: 32656612
Related Citations

Females Are Less Likely Invited Speakers to the International Stroke Conference: Time's Up to Address Sex Disparity.
Authors: Fournier L.E. , Hopping G.C. , Zhu L. , Perez-Pinzon M.A. , Ovbiagele B. , McCullough L.D. , Sharrief A.Z. .
Source: Stroke, 2020 Feb; 51(2), p. 674-678.
EPub date: 2020-01-06 00:00:00.0.
PMID: 31902331
Related Citations

An Additive-Multiplicative Mean Model for Panel Count Data with Dependent Observation and Dropout Processes.
Authors: Yu G. , Li Y. , Zhu L. , Zhao H. , Sun J. , Robison L.L. .
Source: Scandinavian Journal Of Statistics, Theory And Applications, 2019 Jun; 46(2), p. 414-431.
EPub date: 2018-11-20 00:00:00.0.
PMID: 31223184
Related Citations

Variable selection for recurrent event data with broken adaptive ridge regression.
Authors: Zhao H. , Sun D. , Li G. , Sun J. .
Source: The Canadian Journal Of Statistics = Revue Canadienne De Statistique, 2018 Sep; 46(3), p. 416-428.
EPub date: 2018-08-10 00:00:00.0.
PMID: 32999527
Related Citations

A semiparametric likelihood-based method for regression analysis of mixed panel-count data.
Authors: Zhu L. , Zhang Y. , Li Y. , Sun J. , Robison L.L. .
Source: Biometrics, 2017-09-15 00:00:00.0; , .
EPub date: 2017-09-15 00:00:00.0.
PMID: 28914961
Related Citations




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