Skip to main content
Grant Details

Grant Number: 5R00CA201542-03 Interpret this number
Primary Investigator: James, Peter
Organization: Harvard Pilgrim Health Care, Inc.
Project Title: High Resolution Measures of Behavioral Cancer Risk Factors From Mobile Technology
Fiscal Year: 2018
Back to top


Abstract

? DESCRIPTION (provided by applicant): Obesity is an established driver of cancer risk, and substantial evidence has linked obesity to inadequate physical activity and sleep. Geographic contextual measures, including neighborhood walkability and access to green space, have been demonstrated to affect physical activity, sleep patterns, and obesity. These factors are typically measured with questionnaires, which have substantial error. Novel mobile technologies, such as global positioning systems (GPS) enabled smartphones and consumer wearable accelerometry devices, can provide efficient, rigorous, and objective measures of geographic context, physical activity, and sleep with high spatio-temporal resolution. However, managing, processing, and analyzing streaming high-dimensional data presents significant logistical and analytical challenges, especially when linking these data to existing data from large prospective cohorts. My long term career goals are to assess the effect of dynamic measures of geographic context on objective measures of physical activity and sleep, as well as subsequent obesity and cancer risk within the full Nurses' Health Study 3 (NHS3). NHS3 is a web-based, nationwide, prospective open cohort with a current enrollment of ~40,000 male and female nurses aged 19-46 years old. In Aims 1 and 2 of this proposal, I will measure the interdependent relationships between geographic context, physical activity, sleep, and obesity by deploying smartphone applications and wearable devices within a subsample (n=500) of the NHS3. I will use mobile technologies to collect streaming, high spatio-temporal resolution measures of geographic context (walkability and green space), physical activity, and sleep over a seven day monitoring period, four times over one year. I will then apply state-of-the-science statistical methods to examine the interrelationships between these high-dimensional, big data measures of context and behavior. For Aim 3, I will apply statistical approaches for measurement error correction to examine the relationship between error-corrected measures of context/behavior and obesity in the full NHS3 cohort. I am well suited to perform this research based on 1) my past research experience in contextual measures and health, 2) the exceptional mentoring team I have assembled to ensure that this research is of the highest quality, and 3) the unique resources of NHS3. This study will enable me to rigorously quantify contextual exposures, physical activity and sleep, and to identify the influence of geographic contextual factors on these interdependent behavioral risk factors for cancer and obesity. I will be guided by a world-class team of mentors to expand my expertise in the objective measurement of geographic context, physical activity, and sleep through mobile technology; big data methods; and measurement error correction. The proposed research and training will provide me the skills to establish an independent career as a leader in the epidemiology of behavioral risk factors for cancer.

Back to top


Publications

Evaluation of quality of care in relation to health-related quality of life of patients diagnosed with brain tumor: a novel clinic for proton beam therapy.
Authors: Langegård U. , Ahlberg K. , Fransson P. , Johansson B. , Sjövall K. , Bjork-Eriksson T. , Ohlsson-Nevo E. , Proton Care Study Group .
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2018-11-27 00:00:00.0; , .
EPub date: 2018-11-27 00:00:00.0.
PMID: 30484013
Related Citations

Modeling a bivariate residential-workplace neighborhood effect when estimating the effect of proximity to fast-food establishments on body mass index.
Authors: O'Malley A.J. , James P. , MacKenzie T.A. , Byun J. , Subramanian S.V. , Block J.P. .
Source: Statistics In Medicine, 2018-11-20 00:00:00.0; , .
EPub date: 2018-11-20 00:00:00.0.
PMID: 30460712
Related Citations

Neighborhood walkability and physical activity among older women: Tests of mediation by environmental perceptions and moderation by depressive symptoms.
Authors: Orstad S.L. , McDonough M.H. , James P. , Klenosky D.B. , Laden F. , Mattson M. , Troped P.J. .
Source: Preventive Medicine, 2018 Nov; 116, p. 60-67.
EPub date: 2018-08-06 00:00:00.0.
PMID: 30092314
Related Citations

Zeitgebers and their association with rest-activity patterns.
Authors: Quante M. , Mariani S. , Weng J. , Marinac C.R. , Kaplan E.R. , Rueschman M. , Mitchell J.A. , James P. , Hipp J.A. , Cespedes Feliciano E.M. , et al. .
Source: Chronobiology International, 2018-10-26 00:00:00.0; , p. 1-11.
EPub date: 2018-10-26 00:00:00.0.
PMID: 30365354
Related Citations

Residential Greenness and Birthweight in the State of Massachusetts, USA.
Authors: Fong K.C. , Kloog I. , Coull B.A. , Koutrakis P. , Laden F. , Schwartz J.D. , James P. .
Source: International Journal Of Environmental Research And Public Health, 2018-06-12 00:00:00.0; 15(6), .
EPub date: 2018-06-12 00:00:00.0.
PMID: 29895795
Related Citations

Exposure to hazardous air pollutants and risk of incident breast cancer in the nurses' health study II.
Authors: Hart J.E. , Bertrand K.A. , DuPre N. , James P. , Vieira V.M. , VoPham T. , Mittleman M.R. , Tamimi R.M. , Laden F. .
Source: Environmental Health : A Global Access Science Source, 2018-03-27 00:00:00.0; 17(1), p. 28.
EPub date: 2018-03-27 00:00:00.0.
PMID: 29587753
Related Citations

The relationship between surrounding greenness in childhood and adolescence and depressive symptoms in adolescence and early adulthood.
Authors: Bezold C.P. , Banay R.F. , Coull B.A. , Hart J.E. , James P. , Kubzansky L.D. , Missmer S.A. , Laden F. .
Source: Annals Of Epidemiology, 2018-02-02 00:00:00.0; , .
EPub date: 2018-02-02 00:00:00.0.
PMID: 29426730
Related Citations

Environmental Supports for Physical Activity, National Health Interview Survey-2015.
Authors: Whitfield G.P. , Carlson S.A. , Ussery E.N. , Watson K.B. , Adams M.A. , James P. , Brownson R.C. , Berrigan D. , Fulton J.E. .
Source: American Journal Of Preventive Medicine, 2018 Feb; 54(2), p. 294-298.
EPub date: 2017-12-13 00:00:00.0.
PMID: 29246673
Related Citations

A Review of Epidemiologic Studies on Greenness and Health: Updated Literature Through 2017.
Authors: Fong K.C. , Hart J.E. , James P. .
Source: Current Environmental Health Reports, 2018-02-01 00:00:00.0; , .
EPub date: 2018-02-01 00:00:00.0.
PMID: 29392643
Related Citations

The Association Between Natural Environments and Depressive Symptoms in Adolescents Living in the United States.
Authors: Bezold C.P. , Banay R.F. , Coull B.A. , Hart J.E. , James P. , Kubzansky L.D. , Missmer S.A. , Laden F. .
Source: The Journal Of Adolescent Health : Official Publication Of The Society For Adolescent Medicine, 2017-12-19 00:00:00.0; , .
EPub date: 2017-12-19 00:00:00.0.
PMID: 29273301
Related Citations

Race, Ethnicity, Income Concentration and 10-Year Change in Urban Greenness in the United States.
Authors: Casey J.A. , James P. , Cushing L. , Jesdale B.M. , Morello-Frosch R. .
Source: International Journal Of Environmental Research And Public Health, 2017-12-10 00:00:00.0; 14(12), .
EPub date: 2017-12-10 00:00:00.0.
PMID: 29232867
Related Citations

Actigraphy-Derived Daily Rest-Activity Patterns and Body Mass Index in Community-Dwelling Adults.
Authors: Cespedes Feliciano E.M. , Quante M. , Weng J. , Mitchell J.A. , James P. , Marinac C.R. , Mariani S. , Redline S. , Kerr J. , Godbole S. , et al. .
Source: Sleep, 2017-12-01 00:00:00.0; 40(12), .
PMID: 29029250
Related Citations

Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
Authors: GBD 2016 DALYs and HALE Collaborators .
Source: Lancet (london, England), 2017-09-16 00:00:00.0; 390(10100), p. 1260-1344.
PMID: 28919118
Related Citations

Environmental radon exposure and breast cancer risk in the Nurses' Health Study II.
Authors: VoPham T. , DuPré N. , Tamimi R.M. , James P. , Bertrand K.A. , Vieira V. , Laden F. , Hart J.E. .
Source: Environmental Health : A Global Access Science Source, 2017-09-07 00:00:00.0; 16(1), p. 97.
EPub date: 2017-09-07 00:00:00.0.
PMID: 28882148
Related Citations

Outdoor Light at Night and Breast Cancer Incidence in the Nurses' Health Study II.
Authors: James P. , Bertrand K.A. , Hart J.E. , Schernhammer E.S. , Tamimi R.M. , Laden F. .
Source: Environmental Health Perspectives, 2017-08-17 00:00:00.0; 125(8), p. 087010.
EPub date: 2017-08-17 00:00:00.0.
PMID: 28886600
Related Citations

Interrelationships between Walkability, Air Pollution, Greenness, and Body Mass Index.
Authors: James P. , Kioumourtzoglou M.A. , Hart J.E. , Banay R.F. , Kloog I. , Laden F. .
Source: Epidemiology (cambridge, Mass.), 2017-07-31 00:00:00.0; , .
EPub date: 2017-07-31 00:00:00.0.
PMID: 28767514
Related Citations

Race/Ethnicity, Socioeconomic Status, Residential Segregation, and Spatial Variation in Noise Exposure in the Contiguous United States.
Authors: Casey J.A. , Morello-Frosch R. , Mennitt D.J. , Fristrup K. , Ogburn E.L. , James P. .
Source: Environmental Health Perspectives, 2017-07-25 00:00:00.0; 125(7), p. 077017.
EPub date: 2017-07-25 00:00:00.0.
PMID: 28749369
Related Citations

Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015.
Authors: GBD 2015 Healthcare Access and Quality Collaborators. Electronic address: cjlm@uw.edu , GBD 2015 Healthcare Access and Quality Collaborators .
Source: Lancet (london, England), 2017-07-15 00:00:00.0; 390(10091), p. 231-266.
EPub date: 2017-05-18 00:00:00.0.
PMID: 28528753
Related Citations

Changes in the food environment over time: examining 40 years of data in the Framingham Heart Study.
Authors: James P. , Seward M.W. , James O'Malley A. , Subramanian S.V. , Block J.P. .
Source: The International Journal Of Behavioral Nutrition And Physical Activity, 2017-06-24 00:00:00.0; 14(1), p. 84.
EPub date: 2017-06-24 00:00:00.0.
PMID: 28646894
Related Citations

GPS-Based Exposure to Greenness and Walkability and Accelerometry-Based Physical Activity.
Authors: James P. , Hart J.E. , Hipp J.A. , Mitchell J.A. , Kerr J. , Hurvitz P.M. , Glanz K. , Laden F. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017 Apr; 26(4), p. 525-532.
EPub date: 2017-02-14 00:00:00.0.
PMID: 28196848
Related Citations

Comparison Of Accelerometry Methods For Estimating Physical Activity
Authors: Kerr J. , Marinac C.R. , Ellis K. , Godbole S. , Hipp A. , Glanz K. , Mitchell J. , Laden F. , James P. , Berrigan D. .
Source: Medicine And Science In Sports And Exercise, 2017 Mar; 49(3), p. 617-624.
PMID: 27755355
Related Citations

Built Environment And Depression In Low-income African Americans And Whites
Authors: James P. , Hart J.E. , Banay R.F. , Laden F. , Signorello L.B. .
Source: American Journal Of Preventive Medicine, 2017 Jan; 52(1), p. 74-84.
PMID: 27720338
Related Citations

Residential greenness: current perspectives on its impact on maternal health and pregnancy outcomes.
Authors: Banay R.F. , Bezold C.P. , James P. , Hart J.E. , Laden F. .
Source: International Journal Of Women's Health, 2017; 9, p. 133-144.
EPub date: 2017-02-28 00:00:00.0.
PMID: 28280395
Related Citations

Variation in actigraphy-estimated rest-activity patterns by demographic factors.
Authors: Mitchell J.A. , Quante M. , Godbole S. , James P. , Hipp J.A. , Marinac C.R. , Mariani S. , Cespedes Feliciano E.M. , Glanz K. , Laden F. , et al. .
Source: Chronobiology International, 2017; 34(8), p. 1042-1056.
EPub date: 2017-06-26 00:00:00.0.
PMID: 28650674
Related Citations

The relations between sleep, time of physical activity, and time outdoors among adult women.
Authors: Murray K. , Godbole S. , Natarajan L. , Full K. , Hipp J.A. , Glanz K. , Mitchell J. , Laden F. , James P. , Quante M. , et al. .
Source: Plos One, 2017; 12(9), p. e0182013.
EPub date: 2017-09-06 00:00:00.0.
PMID: 28877192
Related Citations

"Spatial Energetics": Integrating Data From GPS, Accelerometry, and GIS to Address Obesity and Inactivity.
Authors: James P. , Jankowska M. , Marx C. , Hart J.E. , Berrigan D. , Kerr J. , Hurvitz P.M. , Hipp J.A. , Laden F. .
Source: American Journal Of Preventive Medicine, 2016 Nov; 51(5), p. 792-800.
PMID: 27528538
Related Citations

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.
Authors: GBD 2015 Mortality and Causes of Death Collaborators .
Source: Lancet (london, England), 2016-10-08 00:00:00.0; 388(10053), p. 1459-1544.
PMID: 27733281
Related Citations

No Evidence of Reciprocal Associations between Daily Sleep and Physical Activity.
Authors: Mitchell J.A. , Godbole S. , Moran K. , Murray K. , James P. , Laden F. , Hipp J.A. , Kerr J. , Glanz K. .
Source: Medicine And Science In Sports And Exercise, 2016 Oct; 48(10), p. 1950-6.
PMID: 27285490
Related Citations

Long-term Particulate Matter Exposures During Adulthood And Risk Of Breast Cancer Incidence In The Nurses' Health Study Ii Prospective Cohort
Authors: Hart J.E. , Bertrand K.A. , DuPre N. , James P. , Vieira V.M. , Tamimi R.M. , Laden F. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2016-06-02 00:00:00.0; , .
PMID: 27257091
Related Citations




Back to Top