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Grant Details

Grant Number: 5UM1CA182934-04 Interpret this number
Primary Investigator: Zeleniuch-Jaquotte, Anne
Organization: New York University School Of Medicine
Project Title: The Nyu Women's Health Study
Fiscal Year: 2018
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Abstract

? DESCRIPTION (provided by applicant): The NYU Women's Health Study (NYUWHS) is a prospective cohort study of 14,274 healthy women who were enrolled in 1985-1991 at a breast cancer screening clinic in New York City. In addition to data on reproductive factors, medical history and lifestyle, the study collected serum samples from all participants at enrollment. Serum samples were also collected at subsequent breast cancer screening visits from over half the women. DNA is available for all study participants. To date, the NYUWHS has led to over 170 publications, 57 since 2010. The NYUWHS has initiated or participated in studies of cancer of the breast, endometrium, colorectum, ovary, lung, pancreas, kidney, liver and non-Hodgkin lymphoma (NHL). Exposures studied include diet, reproductive factors, and circulating levels of hormones, dietary markers, cytokines, and other biomarkers. The NYUWHS also participates in genome-wide association studies of pancreatic cancer, NHL, and glioma. Finally, the NYUWHS has been funded to conduct studies on cardiovascular disease and the NYUWHS data have motivated the development of new statistical methods. The objectives of this application are to maintain and enhance the infrastructure of the study. The specific aims are to: 1) continue cancer case ascertainment through both active and passive follow-up; 2) update exposure data, including diet and outdoor walking, through follow- up questionnaires; 3) collect tumor blocks for major cancer sites (breast, colorectal, endometrial, and lung) in order to assess risk factors according to molecular subtypes; 4) collect and validate data on neighborhood walkability. The continued follow-up is expected to identify an additional 1,389 cancer cases and the collection of tumor blocks will enhance the value of the study, as will the collection of data on neighborhood walkability. The NYUWHS has several specific strengths. First, serum collected at enrollment and DNA are available for all participants, making the biorepository a valuable resource to study associations between genetic variation, biomarkers, and disease risk. Second, repeat serum samples are available for over half of the participants and are very valuable to assess and improve temporal reliability of circulating markers. Third, while several large cancer cohorts started enrollment at age 50, 6,659 NYUWHS participants were <50 years of age at enrollment/blood donation, providing opportunities for the study of cancer risk factors among younger women. Finally, New York City is a particularly well-suited location for studies of walkability because there is a wide range in walkability across different neighborhoods.

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Publications

Serological response to Helicobacter pylori proteins associate with risk of colorectal cancer among diverse populations in the United States.
Authors: Butt J. , Varga M.G. , Blot W.J. , Teras L. , Visvanathan K. , Le Marchand L. , Haiman C. , Chen Y. , Bao Y. , Sesso H.D. , et al. .
Source: Gastroenterology, 2018-10-05 00:00:00.0; , .
EPub date: 2018-10-05 00:00:00.0.
PMID: 30296434
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Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
Authors: Ostrom Q.T. , Kinnersley B. , Armstrong G. , Rice T. , Chen Y. , Wiencke J.K. , McCoy L.S. , Hansen H.M. , Amos C.I. , Bernstein J.L. , et al. .
Source: International Journal Of Cancer, 2018-08-27 00:00:00.0; , .
EPub date: 2018-08-27 00:00:00.0.
PMID: 30152087
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Temporal reliability of serum soluble and endogenous secretory receptors for advanced glycation end-products (sRAGE and esRAGE) in healthy women.
Authors: Wu F. , Afanasyeva Y. , Zeleniuch-Jacquotte A. , Zhang J. , Schmidt A.M. , Chen Y. .
Source: Cancer Causes & Control : Ccc, 2018-08-11 00:00:00.0; , .
EPub date: 2018-08-11 00:00:00.0.
PMID: 30099629
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Reply to: Anti-Mullerian hormone and breast cancer risk- is the correlation possibly associated with the PCOS?
Authors: Clendenen T.V. , Dorgan J. , Zeleniuch-Jacquotte A. .
Source: International Journal Of Cancer, 2018-07-11 00:00:00.0; , .
EPub date: 2018-07-11 00:00:00.0.
PMID: 29992648
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Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women.
Authors: Premenopausal Breast Cancer Collaborative Group , Schoemaker M.J. , Nichols H.B. , Wright L.B. , Brook M.N. , Jones M.E. , O'Brien K.M. , Adami H.O. , Baglietto L. , Bernstein L. , et al. .
Source: Jama Oncology, 2018-06-21 00:00:00.0; , p. e181771.
EPub date: 2018-06-21 00:00:00.0.
PMID: 29931120
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Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3).
Authors: Larose T.L. , Guida F. , Fanidi A. , Langhammer A. , Kveem K. , Stevens V.L. , Jacobs E.J. , Smith-Warner S.A. , Giovannucci E. , Albanes D. , et al. .
Source: International Journal Of Epidemiology, 2018-06-12 00:00:00.0; , .
EPub date: 2018-06-12 00:00:00.0.
PMID: 29901778
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Tobacco, alcohol use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The Liver Cancer Pooling Project.
Authors: Petrick J.L. , Campbell P.T. , Koshiol J. , Thistle J.E. , Andreotti G. , Beane-Freeman L.E. , Buring J.E. , Chan A.T. , Chong D.Q. , Doody M.M. , et al. .
Source: British Journal Of Cancer, 2018 Apr; 118(7), p. 1005-1012.
EPub date: 2018-03-09 00:00:00.0.
PMID: 29520041
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Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
Authors: Klein A.P. , Wolpin B.M. , Risch H.A. , Stolzenberg-Solomon R.Z. , Mocci E. , Zhang M. , Canzian F. , Childs E.J. , Hoskins J.W. , Jermusyk A. , et al. .
Source: Nature Communications, 2018-02-08 00:00:00.0; 9(1), p. 556.
EPub date: 2018-02-08 00:00:00.0.
PMID: 29422604
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Circulating Anti-Müllerian Hormone and Breast Cancer Risk: A Study in Ten Prospective Cohorts.
Authors: Ge W. , Clendenen T.V. , Afanasyeva Y. , Koenig K.L. , Agnoli C. , Brinton L.A. , Dorgan J.F. , Eliassen A.H. , Falk R.T. , Hallmans G. , et al. .
Source: International Journal Of Cancer, 2018-01-08 00:00:00.0; , .
EPub date: 2018-01-08 00:00:00.0.
PMID: 29315564
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Impaired functional vitamin B6 status is associated with increased risk of lung cancer.
Authors: Theofylaktopoulou D. , Midttun Ř. , Ueland P.M. , Meyer K. , Fanidi A. , Zheng W. , Shu X.O. , Xiang Y.B. , Prentice R. , Pettinger M. , et al. .
Source: International Journal Of Cancer, 2017-12-14 00:00:00.0; , .
EPub date: 2017-12-14 00:00:00.0.
PMID: 29238985
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Anti-Mullerian hormone and endometrial cancer: a multi-cohort study.
Authors: Fortner R.T. , Schock H. , Jung S. , Allen N.E. , Arslan A.A. , Brinton L.A. , Egleston B.L. , Falk R.T. , Gunter M.J. , Helzlsouer K.J. , et al. .
Source: British Journal Of Cancer, 2017-10-24 00:00:00.0; 117(9), p. 1412-1418.
EPub date: 2017-09-05 00:00:00.0.
PMID: 28873086
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Anti-Müllerian hormone and risk of ovarian cancer in nine cohorts.
Authors: Jung S. , Allen N. , Arslan A.A. , Baglietto L. , Barricarte A. , Brinton L.A. , Egleston B.L. , Falk R.T. , Fortner R.T. , Helzlsouer K.J. , et al. .
Source: International Journal Of Cancer, 2017-09-18 00:00:00.0; , .
EPub date: 2017-09-18 00:00:00.0.
PMID: 28921520
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The Premenopausal Breast Cancer Collaboration: A pooling project of studies participating in the National Cancer Institute Cohort Consortium.
Authors: Nichols H.B. , Schoemaker M.J. , Wright L.B. , McGowan C. , Brook M.N. , McClain K.M. , Jones M.E. , Adami H.O. , Agnoli C. , Baglietto L. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017-06-09 00:00:00.0; , .
EPub date: 2017-06-09 00:00:00.0.
PMID: 28600297
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Circulating concentrations of biomarkers and metabolites related to vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations.
Authors: Midttun Ř. , Theofylaktopoulou D. , McCann A. , Fanidi A. , Muller D.C. , Meyer K. , Ulvik A. , Zheng W. , Shu X.O. , Xiang Y.B. , et al. .
Source: The American Journal Of Clinical Nutrition, 2017 Jun; 105(6), p. 1314-1326.
EPub date: 2017-04-19 00:00:00.0.
PMID: 28424186
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Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148.
Authors: Fang J. , Jia J. , Makowski M. , Xu M. , Wang Z. , Zhang T. , Hoskins J.W. , Choi J. , Han Y. , Zhang M. , et al. .
Source: Nature Communications, 2017-05-02 00:00:00.0; 8, p. 15034.
EPub date: 2017-05-02 00:00:00.0.
PMID: 28447668
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Demographic, Lifestyle, And Other Factors In Relation To Antimüllerian Hormone Levels In Mostly Late Premenopausal Women
Authors: Jung S. , Allen N. , Arslan A.A. , Baglietto L. , Brinton L.A. , Egleston B.L. , Falk R. , Fortner R.T. , Helzlsouer K.J. , Idahl A. , et al. .
Source: Fertility And Sterility, 2017 Apr; 107(4), p. 1012-1022.e2.
PMID: 28366409
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Body Size Indicators And Risk Of Gallbladder Cancer: Pooled Analysis Of Individual-level Data From 19 Prospective Cohort Studies
Authors: Campbell P.T. , Newton C.C. , Kitahara C.M. , Patel A.V. , Hartge P. , Koshiol J. , McGlynn K.A. , Adami H.O. , Berrington de González A. , Beane Freeman L.E. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017-03-17 00:00:00.0; , .
PMID: 28314823
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Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma.
Authors: Bernatsky S. , Velásquez García H.A. , Spinelli J.J. , Gaffney P. , Smedby K.E. , Ramsey-Goldman R. , Wang S.S. , Adami H.O. , Albanes D. , Angelucci E. , et al. .
Source: Lupus Science & Medicine, 2017; 4(1), p. e000187.
EPub date: 2017-11-12 00:00:00.0.
PMID: 29214033
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Calibration And Seasonal Adjustment For Matched Case-control Studies Of Vitamin D And Cancer
Authors: Gail M.H. , Wu J. , Wang M. , Yaun S.S. , Cook N.R. , Eliassen A.H. , McCullough M.L. , Yu K. , Zeleniuch-Jacquotte A. , Smith-Warner S.A. , et al. .
Source: Statistics In Medicine, 2016-06-15 00:00:00.0; 35(13), p. 2133-48.
PMID: 27133461
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Can Walkable Urban Design Play A Role In Reducing The Incidence Of Obesity-related Conditions?
Authors: Rundle A.G. , Heymsfield S.B. .
Source: Jama, 2016 May 24-31; 315(20), p. 2175-7.
PMID: 27218628
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Premenopausal Circulating Androgens And Risk Of Endometrial Cancer: Results Of A Prospective Study
Authors: Clendenen T.V. , Hertzmark K. , Koenig K.L. , Lundin E. , Rinaldi S. , Johnson T. , Krogh V. , Hallmans G. , Idahl A. , Lukanova A. , et al. .
Source: Hormones & Cancer, 2016-02-29 00:00:00.0; , .
PMID: 26925952
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NSAID Use and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: The Liver Cancer Pooling Project.
Authors: Petrick J.L. , Sahasrabuddhe V.V. , Chan A.T. , Alavanja M.C. , Beane-Freeman L.E. , Buring J.E. , Chen J. , Chong D.Q. , Freedman N.D. , Fuchs C.S. , et al. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2015 Dec; 8(12), p. 1156-62.
PMID: 26391917
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Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types.
Authors: Sampson J.N. , Wheeler W.A. , Yeager M. , Panagiotou O. , Wang Z. , Berndt S.I. , Lan Q. , Abnet C.C. , Amundadottir L.T. , Figueroa J.D. , et al. .
Source: Journal Of The National Cancer Institute, 2015 Dec; 107(12), p. djv279.
PMID: 26464424
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Central adiposity, obesity during early adulthood, and pancreatic cancer mortality in a pooled analysis of cohort studies.
Authors: Genkinger J.M. , Kitahara C.M. , Bernstein L. , Berrington de Gonzalez A. , Brotzman M. , Elena J.W. , Giles G.G. , Hartge P. , Singh P.N. , Stolzenberg-Solomon R.Z. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology, 2015 Nov; 26(11), p. 2257-66.
PMID: 26347100
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Coffee Consumption and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma by Sex: The Liver Cancer Pooling Project.
Authors: Petrick J.L. , Freedman N.D. , Graubard B.I. , Sahasrabuddhe V.V. , Lai G.Y. , Alavanja M.C. , Beane-Freeman L.E. , Boggs D.A. , Buring J.E. , Chan A.T. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2015 Sep; 24(9), p. 1398-406.
PMID: 26126626
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Intake Of Vitamins A, C, And E And Folate And The Risk Of Ovarian Cancer In A Pooled Analysis Of 10 Cohort Studies
Authors: Koushik A. , Wang M. , Anderson K.E. , van den Brandt P. , Clendenen T.V. , Eliassen A.H. , Freudenheim J.L. , Genkinger J.M. , Hĺkansson N. , Marshall J.R. , et al. .
Source: Cancer Causes & Control : Ccc, 2015 Sep; 26(9), p. 1315-27.
PMID: 26169298
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Alcohol Consumption And Breast Cancer Risk By Estrogen Receptor Status: In A Pooled Analysis Of 20 Studies
Authors: Jung S. , Wang M. , Anderson K. , Baglietto L. , Bergkvist L. , Bernstein L. , van den Brandt P.A. , Brinton L. , Buring J.E. , Heather Eliassen A. , et al. .
Source: International Journal Of Epidemiology, 2015-08-28 00:00:00.0; , .
PMID: 26320033
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Steroid Hormone Measurements From Different Types Of Assays In Relation To Body Mass Index And Breast Cancer Risk In Postmenopausal Women: Reanalysis Of Eighteen Prospective Studies
Authors: Key T.J. , Appleby P.N. , Reeves G.K. , Travis R.C. , Brinton L.A. , Helzlsouer K.J. , Dorgan J.F. , Gapstur S.M. , Gaudet M.M. , Kaaks R. , et al. .
Source: Steroids, 2015 Jul; 99(Pt A), p. 49-55.
PMID: 25304359
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Further Confirmation Of Germline Glioma Risk Variant Rs78378222 In Tp53 And Its Implication In Tumor Tissues Via Integrative Analysis Of Tcga Data
Authors: Wang Z. , Rajaraman P. , Melin B.S. , Chung C.C. , Zhang W. , McKean-Cowdin R. , Michaud D. , Yeager M. , Ahlbom A. , Albanes D. , et al. .
Source: Human Mutation, 2015 Jul; 36(7), p. 684-8.
PMID: 25907361
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Reproductive factors, exogenous hormone use and risk of hepatocellular carcinoma among US women: results from the Liver Cancer Pooling Project.
Authors: McGlynn K.A. , Sahasrabuddhe V.V. , Campbell P.T. , Graubard B.I. , Chen J. , Schwartz L.M. , Petrick J.L. , Alavanja M.C. , Andreotti G. , Boggs D.A. , et al. .
Source: British Journal Of Cancer, 2015-03-31 00:00:00.0; 112(7), p. 1266-72.
EPub date: 2015-03-31 00:00:00.0.
PMID: 25742475
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Characterization Of Large Structural Genetic Mosaicism In Human Autosomes
Authors: Machiela M.J. , Zhou W. , Sampson J.N. , Dean M.C. , Jacobs K.B. , Black A. , Brinton L.A. , Chang I.S. , Chen C. , Chen C. , et al. .
Source: American Journal Of Human Genetics, 2015-03-05 00:00:00.0; 96(3), p. 487-97.
PMID: 25748358
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Infertility And Incident Endometrial Cancer Risk: A Pooled Analysis From The Epidemiology Of Endometrial Cancer Consortium (e2c2)
Authors: Yang H.P. , Cook L.S. , Weiderpass E. , Adami H.O. , Anderson K.E. , Cai H. , Cerhan J.R. , Clendenen T.V. , Felix A.S. , Friedenreich C.M. , et al. .
Source: British Journal Of Cancer, 2015-03-03 00:00:00.0; 112(5), p. 925-33.
PMID: 25688738
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Intrauterine devices and endometrial cancer risk: a pooled analysis of the Epidemiology of Endometrial Cancer Consortium.
Authors: Felix A.S. , Gaudet M.M. , La Vecchia C. , Nagle C.M. , Shu X.O. , Weiderpass E. , Adami H.O. , Beresford S. , Bernstein L. , Chen C. , et al. .
Source: International Journal Of Cancer, 2015-03-01 00:00:00.0; 136(5), p. E410-22.
EPub date: 2015-03-01 00:00:00.0.
PMID: 25242594
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Risk factors for endometrial cancer in black and white women: a pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2).
Authors: Cote M.L. , Alhajj T. , Ruterbusch J.J. , Bernstein L. , Brinton L.A. , Blot W.J. , Chen C. , Gass M. , Gaussoin S. , Henderson B. , et al. .
Source: Cancer Causes & Control : Ccc, 2015 Feb; 26(2), p. 287-96.
PMID: 25534916
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A genome-wide association study of marginal zone lymphoma shows association to the HLA region.
Authors: Vijai J. , Wang Z. , Berndt S.I. , Skibola C.F. , Slager S.L. , de Sanjose S. , Melbye M. , Glimelius B. , Bracci P.M. , Conde L. , et al. .
Source: Nature Communications, 2015-01-08 00:00:00.0; 6, p. 5751.
EPub date: 2015-01-08 00:00:00.0.
PMID: 25569183
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Vitamin D metabolic pathway genes and pancreatic cancer risk.
Authors: Arem H. , Yu K. , Xiong X. , Moy K. , Freedman N.D. , Mayne S.T. , Albanes D. , Arslan A.A. , Austin M. , Bamlet W.R. , et al. .
Source: Plos One, 2015; 10(3), p. e0117574.
PMID: 25799011
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Genotyping Of Single Nucleotide Polymorphisms In Dna Isolated From Serum Using Sequenom Massarray Technology
Authors: Clendenen T.V. , Rendleman J. , Ge W. , Koenig K.L. , Wirgin I. , Currie D. , Shore R.E. , Kirchhoff T. , Zeleniuch-Jacquotte A. .
Source: Plos One, 2015; 10(8), p. e0135943.
PMID: 26274499
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Genetic Polymorphisms In Vitamin D Metabolism And Signaling Genes And Risk Of Breast Cancer: A Nested Case-control Study
Authors: Clendenen T.V. , Ge W. , Koenig K.L. , Axelsson T. , Liu M. , Afanasyeva Y. , Andersson A. , Arslan A.A. , Chen Y. , Hallmans G. , et al. .
Source: Plos One, 2015; 10(10), p. e0140478.
PMID: 26488576
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