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Grant Details

Grant Number: 5U01CA193632-03 Interpret this number
Primary Investigator: Barrett, Lisa
Organization: Northeastern University
Project Title: Fundamental Subcortical Mechanisms of Affective Processing
Fiscal Year: 2018
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Abstract

? DESCRIPTION (provided by applicant): Between 50-66% of deaths caused by cancer could be prevented through behavioral modification. Accumulating evidence points towards a family of basic, affective psychological processes related to emotion, stress, and pain that influence behavioral choices, facilitating healthful choices or promoting unhealthful choices, and that have the capacity to influence key aspects of successful survivorship. While the links between affect and cancer-related decision making are becoming well-known, the research remains largely descriptive. A mechanistic understanding of these links is hampered by a major barrier: the neural circuitry underlying affective processing is still largely underspecified. A further barrierto progress is that subdomains of affective science including stress, emotion, and pain, have largely been studied independently of one another even though they overlap tremendously as psychological constructs. The historical divides that pose a critical barrier to using affective processes to improve cancer-related decision-making are exacerbated by a tendency for researchers to focus either on peripheral and central biomarkers of affect, but not to study them simultaneously. Our goal is to unify subdomains of affective processes into a common neural framework centered on subcortical brainstem regions that are known to be critically involved in affective processes, with a particular emphasis on the periaqueductal gray (PAG) which non-human animal research shows is a critical hub controlling autonomic output, analgesic responses, and other physiological responses during emotion, pain, and stress. Affective research in humans relies primarily on non-invasive neuroimaging techniques, but the spatial resolution of these techniques in prior work has been too small to examine the brainstem and particularly the PAG and its connectivity with any degree of specificity. We have developed an ultra-high field magnetic resonance imaging procedure at 7 Tesla that overcomes this problem. In Specific Aim 1, we will map the structural and functional connectivity of the brainstem, with a focus on the PAG, within subcortical and cortical networks using anatomical, diffusion weighted, and resting state (task-independent) functional connectivity within a 7T imaging environment. In Specific Aim 2, we will examine the functional organization of these brainstem networks across tasks that evoke stress, pain, and emotional experience to assess the construct validity of these three affective processes from a unified neuroscience perspective, and we further examine how these brainstem networks participate in executive function using a working memory task. Finally, in the Exploratory Aim, we will examine the extent to which peripheral physiological measurements (e.g., heart rate variability, skin conductance, respiratory rate) mediate the relation between brainstem network structure / activity and behavioral responses in each affective domain. Our main deliverable at the end of this R01 is a working neural theory of affective processes that can be used by cancer researchers to study the influence of affect on cancer-related decision making.

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Publications

Physiological indices of challenge and threat: A data-driven investigation of autonomic nervous system reactivity during an active coping stressor task.
Authors: Wormwood J.B. , Khan Z. , Siegel E. , Lynn S.K. , Dy J. , Barrett L.F. , Quigley K.S. .
Source: Psychophysiology, 2019-08-13; , p. e13454.
EPub date: 2019-08-13.
PMID: 31407813
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Functional Involvement of Human Periaqueductal Gray and Other Midbrain Nuclei in Cognitive Control.
Authors: Kragel P.A. , Bianciardi M. , Hartley L. , Matthewson G. , Choi J.K. , Quigley K.S. , Wald L.L. , Wager T.D. , Feldman Barrett L. , Satpute A.B. .
Source: The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019-07-31; 39(31), p. 6180-6189.
EPub date: 2019-06-03.
PMID: 31160537
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Emotional Expressions Reconsidered: Challenges to Inferring Emotion From Human Facial Movements.
Authors: Barrett L.F. , Adolphs R. , Marsella S. , Martinez A.M. , Pollak S.D. .
Source: Psychological science in the public interest : a journal of the American Psychological Society, 2019 Jul; 20(1), p. 1-68.
PMID: 31313636
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Deconstructing arousal into wakeful, autonomic and affective varieties.
Authors: Satpute A.B. , Kragel P.A. , Barrett L.F. , Wager T.D. , Bianciardi M. .
Source: Neuroscience letters, 2019-02-06; 693, p. 19-28.
EPub date: 2018-01-31.
PMID: 29378297
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Concepts dissolve artificial boundaries in the study of emotion and cognition, uniting body, brain, and mind.
Authors: Hoemann K. , Feldman Barrett L. .
Source: Cognition & emotion, 2019 Feb; 33(1), p. 67-76.
EPub date: 2018-10-18.
PMID: 30336722
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Primary Interoceptive Cortex Activity during Simulated Experiences of the Body.
Authors: Wilson-Mendenhall C.D. , Henriques A. , Barsalou L.W. , Barrett L.F. .
Source: Journal of cognitive neuroscience, 2019 Feb; 31(2), p. 221-235.
EPub date: 2018-10-02.
PMID: 30277431
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Words are a context for mental inference.
Authors: Betz N. , Hoemann K. , Barrett L.F. .
Source: Emotion (Washington, D.C.), 2019-01-10; , .
EPub date: 2019-01-10.
PMID: 30628815
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Vegetarians' and omnivores' affective and physiological responses to images of food.
Authors: Anderson E.C. , Wormwood J. , Barrett L.F. , Quigley K.S. .
Source: Food quality and preference, 2019 Jan; 71, p. 96-105.
EPub date: 2018-06-26.
PMID: 31217670
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Concepts, Goals and the Control of Survival-Related Behaviors.
Authors: Barrett L.F. , Finlay B.L. .
Source: Current opinion in behavioral sciences, 2018 Dec; 24, p. 172-179.
EPub date: 2018-10-29.
PMID: 31157289
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Context facilitates performance on a classic cross-cultural emotion perception task.
Authors: Hoemann K. , Crittenden A.N. , Msafiri S. , Liu Q. , Li C. , Roberson D. , Ruark G.A. , Gendron M. , Feldman Barrett L. .
Source: Emotion (Washington, D.C.), 2018-11-26; , .
EPub date: 2018-11-26.
PMID: 30475026
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Conscious awareness is necessary for affective faces to influence social judgments.
Authors: Kleckner I.R. , Anderson E.C. , Betz N.J. , Wormwood J.B. , Eskew R.T. , Barrett L.F. .
Source: Journal of experimental social psychology, 2018 Nov; 79, p. 181-187.
EPub date: 2018-08-04.
PMID: 31097841
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Cross-Species Evidence of Interplay Between Neural Connectivity at the Micro- and Macroscale of Connectome Organization in Human, Mouse, and Rat Brain.
Authors: Scholtens L.H. , Feldman Barrett L. , van den Heuvel M.P. .
Source: Brain connectivity, 2018 12; 8(10), p. 595-603.
PMID: 30479137
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Hormonal Cycles, Brain Network Connectivity, and Windows of Vulnerability to Affective Disorder.
Authors: Andreano J.M. , Touroutoglou A. , Dickerson B. , Barrett L.F. .
Source: Trends in neurosciences, 2018 10; 41(10), p. 660-676.
EPub date: 2018-09-25.
PMID: 30274602
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Seeing Fear: It's All in the Eyes?
Authors: Barrett L.F. .
Source: Trends in neurosciences, 2018 09; 41(9), p. 559-563.
PMID: 30143181
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Historical pitfalls and new directions in the neuroscience of emotion.
Authors: Barrett L.F. , Satpute A.B. .
Source: Neuroscience letters, 2019-02-06; 693, p. 9-18.
EPub date: 2017-07-26.
PMID: 28756189
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Representation, Pattern Information, and Brain Signatures: From Neurons to Neuroimaging.
Authors: Kragel P.A. , Koban L. , Barrett L.F. , Wager T.D. .
Source: Neuron, 2018-07-25; 99(2), p. 257-273.
PMID: 30048614
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Emotion fingerprints or emotion populations? A meta-analytic investigation of autonomic features of emotion categories.
Authors: Siegel E.H. , Sands M.K. , Van den Noortgate W. , Condon P. , Chang Y. , Dy J. , Quigley K.S. , Barrett L.F. .
Source: Psychological bulletin, 2018 04; 144(4), p. 343-393.
EPub date: 2018-02-01.
PMID: 29389177
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Nature of Emotion Categories: Comment on Cowen and Keltner.
Authors: Barrett L.F. , Khan Z. , Dy J. , Brooks D. .
Source: Trends in cognitive sciences, 2018 02; 22(2), p. 97-99.
EPub date: 2018-01-16.
PMID: 29373283
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Facial expression predictions as drivers of social perception.
Authors: Chanes L. , Wormwood J.B. , Betz N. , Barrett L.F. .
Source: Journal of personality and social psychology, 2018 Mar; 114(3), p. 380-396.
EPub date: 2018-01-25.
PMID: 29369657
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Learning situated emotions.
Authors: Lebois L.A.M. , Wilson-Mendenhall C.D. , Simmons W.K. , Barrett L.F. , Barsalou L.W. .
Source: Neuropsychologia, 2018-01-09; , .
EPub date: 2018-01-09.
PMID: 29330097
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Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex.
Authors: Kragel P.A. , Kano M. , Van Oudenhove L. , Ly H.G. , Dupont P. , Rubio A. , Delon-Martin C. , Bonaz B.L. , Manuck S.B. , Gianaros P.J. , et al. .
Source: Nature neuroscience, 2018 02; 21(2), p. 283-289.
EPub date: 2018-01-01.
PMID: 29292378
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The theory of constructed emotion: an active inference account of interoception and categorization.
Authors: Barrett L.F. .
Source: Social cognitive and affective neuroscience, 2017-11-01; 12(11), p. 1833.
PMID: 28472391
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Categories and Their Role in the Science of Emotion.
Authors: Barrett L.F. .
Source: Psychological inquiry, 2017; 28(1), p. 20-26.
EPub date: 2017-02-26.
PMID: 29276364
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Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans.
Authors: Kleckner I.R. , Zhang J. , Touroutoglou A. , Chanes L. , Xia C. , Simmons W.K. , Quigley K.S. , Dickerson B.C. , Barrett L.F. .
Source: Nature human behaviour, 2017; 1, .
EPub date: 2017-04-24.
PMID: 28983518
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Functionalism cannot save the classical view of emotion.
Authors: Barrett L.F. .
Source: Social cognitive and affective neuroscience, 2017-01-01; 12(1), p. 34-36.
PMID: 27798259
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The theory of constructed emotion: an active inference account of interoception and categorization.
Authors: Barrett L.F. .
Source: Social cognitive and affective neuroscience, 2017-01-01; 12(1), p. 1-23.
PMID: 27798257
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An active inference theory of allostasis and interoception in depression.
Authors: Barrett L.F. , Quigley K.S. , Hamilton P. .
Source: Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016-11-19; 371(1708), .
EPub date: 2016-10-10.
PMID: 28080969
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Thalamic Bursts and the Epic Pain Model.
Authors: Saab C.Y. , Barrett L.F. .
Source: Frontiers in computational neuroscience, 2016; 10, p. 147.
EPub date: 2017-01-12.
PMID: 28127285
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