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Grant Details

Grant Number: 7R01CA158313-05 Interpret this number
Primary Investigator: Michels, Karin
Organization: University Of California Los Angeles
Project Title: Predictors of Mammary Gland Development & Breast Fibroglandular Volume at Puberty
Fiscal Year: 2015


DESCRIPTION (provided by applicant): The global burden of breast cancer is on the rise making it the malignancy with the highest incidence among women worldwide. Yet, much of the international variation of breast cancer incidence cannot be explained with known or suspected risk factors. Attention has shifted to earlier time periods of a women's life recognizing the specil susceptibility of the prepubertal mammary gland tissue to environmental influences. The considerable time lag between events prior to or at puberty and diagnosis of breast cancer spanning several decades have made prospective studies difficult to accomplish. Early onset of mammary gland development and high breast density have been associated with an increased risk of breast cancer and can serve as early putative markers of breast cancer risk. A high proportion of radiographically dense area of the breast is one of the strongest known risk factor for breast cancer and may be established at the time of breast development at puberty. We propose to use an existing cohort of about 515 prepubertal Chilean girls born in 2002 to address the relation between putative early markers of breast cancer risk, specifically onset of mammary gland development (Tanner stage 2) and volume of dense breast tissue measured by DXA at Tanner stage 4 and a number of antecedents: endocrine-disrupting chemicals, specifically bisphenol A and phthalates; frequent consumption of high fat dairy products and red meat; blood levels of inflammatory markers, specifically interleukin-6, tumor necrosis factor, and C-reactive protein; global DNA methylation, promoter methylation pattern, and methylation of the ER gene.


Association between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche.
Authors: Michels K.B. , Keller K. , Pereira A. , Kim C.E. , Santos J.L. , Shepherd J. , Corvalan C. , Binder A.M. .
Source: Breast cancer research : BCR, 2020-10-01; 22(1), p. 104.
EPub date: 2020-10-01.
PMID: 33004039
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Effect of excessive gestational weight on daughters' breast density at the end of puberty onset.
Authors: López A. , Garmendia M.L. , Shepherd J. , Michels K. , Corvalán C. , Pereira A. .
Source: Scientific reports, 2020-04-20; 10(1), p. 6636.
EPub date: 2020-04-20.
PMID: 32313106
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Prepubertal and Pubertal Endocrine-Disrupting Chemical Exposure and Breast Density among Chilean Adolescents.
Authors: Binder A.M. , Corvalan C. , Pereira A. , Calafat A.M. , Ye X. , Shepherd J. , Michels K.B. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2018 12; 27(12), p. 1491-1499.
EPub date: 2018-08-29.
PMID: 30158279
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Inverse association between estrogen receptor-α DNA methylation and breast composition in adolescent Chilean girls.
Authors: Binder A.M. , Stiemsma L.T. , Keller K. , van Otterdijk S.D. , Mericq V. , Pereira A. , Santos J.L. , Shepherd J. , Michels K.B. .
Source: Clinical epigenetics, 2018-10-04; 10(1), p. 122.
EPub date: 2018-10-04.
PMID: 30286806
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Childhood and adolescent phenol and phthalate exposure and the age of menarche in Latina girls.
Authors: Binder A.M. , Corvalan C. , Calafat A.M. , Ye X. , Mericq V. , Pereira A. , Michels K.B. .
Source: Environmental health : a global access science source, 2018-04-03; 17(1), p. 32.
EPub date: 2018-04-03.
PMID: 29615064
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Faster ticking rate of the epigenetic clock is associated with faster pubertal development in girls.
Authors: Binder A.M. , Corvalan C. , Mericq V. , Pereira A. , Santos J.L. , Horvath S. , Shepherd J. , Michels K.B. .
Source: Epigenetics, 2018; 13(1), p. 85-94.
EPub date: 2018-02-15.
PMID: 29235933
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Multiplexed Reduced Representation Bisulfite Sequencing with Magnetic Bead Fragment Size Selection.
Authors: Accomando W.P. , Michels K.B. .
Source: Methods in molecular biology (Clifton, N.J.), 2018; 1708, p. 137-159.
PMID: 29224143
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Reply to AT Wijayabahu.
Authors: Gaskins A.J. , Corvalán C. , Michels K.B. , (on behalf of the authors) .
Source: The American journal of clinical nutrition, 2017 08; 106(2), p. 707.
PMID: 28765394
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Dairy intake in relation to breast and pubertal development in Chilean girls.
Authors: Gaskins A.J. , Pereira A. , Quintiliano D. , Shepherd J.A. , Uauy R. , Corvalán C. , Michels K.B. .
Source: The American journal of clinical nutrition, 2017 05; 105(5), p. 1166-1175.
EPub date: 2017-04-05.
PMID: 28381475
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Determinants of volumetric breast density in Chilean premenopausal women.
Authors: Pereira A. , Garmendia M.L. , Uauy R. , Neira P. , Lopez-Arana S. , Malkov S. , Shepherd J. .
Source: Breast cancer research and treatment, 2017 04; 162(2), p. 343-352.
EPub date: 2017-01-28.
PMID: 28132392
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Milk Consumption after Age 9 Years Does Not Predict Age at Menarche.
Authors: Carwile J.L. , Willett W.C. , Wang M. , Rich-Edwards J. , Frazier A.L. , Michels K.B. .
Source: The Journal of nutrition, 2015 Aug; 145(8), p. 1900-8.
EPub date: 2015-07-01.
PMID: 26136590
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Sugar-sweetened beverage consumption and age at menarche in a prospective study of US girls.
Authors: Carwile J.L. , Willett W.C. , Spiegelman D. , Hertzmark E. , Rich-Edwards J. , Frazier A.L. , Michels K.B. .
Source: Human reproduction (Oxford, England), 2015 Mar; 30(3), p. 675-83.
EPub date: 2015-01-27.
PMID: 25628346
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Pyrosequencing Evaluation of Widely Available Bisulfite Conversion Methods: Considerations for Application.
Authors: Izzi B. , Binder A.M. , Michels K.B. .
Source: Medical epigenetics, 2014-01-01; 2(1), p. 28-36.
PMID: 24944560
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Antidepressant use and risk for preeclampsia.
Authors: Palmsten K. , Huybrechts K.F. , Michels K.B. , Williams P.L. , Mogun H. , Setoguchi S. , Hernández-Díaz S. .
Source: Epidemiology (Cambridge, Mass.), 2013 Sep; 24(5), p. 682-91.
PMID: 23873072
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