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Grant Details

Grant Number: 1R01CA222147-01 Interpret this number
Primary Investigator: Vanderweele, Tyler
Organization: Harvard School Of Public Health
Project Title: Theory and Methods for Mediation and Interaction
Fiscal Year: 2018
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Abstract

Project Summary The proposed research will develop novel methods to assess mediation and interaction between genetic and environmental exposures and different disease subtypes so as to better tailor treatments and prevention efforts to individuals' characteristics and so as to better understand the mechanisms governing disease. Methods will be developed for settings in which there are multiple disease subtypes and these disease subtypes may have different prognosis for survival and may be more amenable to different types of treatment and preventive efforts. Methodology for assessing the role of interaction in understanding mechanisms will also be developed. This will include elucidating the role of gene-environment interaction in the heritability of disease, understanding mediating pathways from exposure to disease in the presence of interaction, and identifying sufficient cause interaction for diseases or disease subtypes such that an outcome would occur if two (or more) exposures are present, but not if only one or the other were present. The methodology will be applied to understand prognosis, treatment decisions, preventive interventions, and mechanisms for colorectal cancer, and also for the development of skin lesions; the methodology will also be applied to understand the role of gene-environment interaction in the heritability of numerous traits.

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Publications

The Interaction Continuum.
Authors: VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2019 Sep; 30(5), p. 648-658.
PMID: 31205287
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A general approach to detect gene (G)-environment (E) additive interaction leveraging G-E independence in case-control studies.
Authors: Tchetgen Tchetgen E.J. , Shi X. , Wong B.H.W. , Sofer T. .
Source: Statistics in medicine, 2019-08-23; , .
EPub date: 2019-08-23.
PMID: 31441522
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Mediational E-values: Approximate sensitivity analysis for unmeasured mediator-outcome confounding.
Authors: Smith L.H. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2019-07-23; , .
EPub date: 2019-07-23.
PMID: 31348008
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Universal Testing, Expanded Treatment, and Incidence of HIV Infection in Botswana.
Authors: Makhema J. , Wirth K.E. , Pretorius Holme M. , Gaolathe T. , Mmalane M. , Kadima E. , Chakalisa U. , Bennett K. , Leidner J. , Manyake K. , et al. .
Source: The New England journal of medicine, 2019-07-18; 381(3), p. 230-242.
PMID: 31314967
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Positive parenting improves multiple aspects of health and well-being in young adulthood.
Authors: Chen Y. , Haines J. , Charlton B.M. , VanderWeele T.J. .
Source: Nature human behaviour, 2019 Jul; 3(7), p. 684-691.
EPub date: 2019-05-06.
PMID: 31061491
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Bounding Bias Due to Selection.
Authors: Smith L.H. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2019 Jul; 30(4), p. 509-516.
PMID: 31033690
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Principles of confounder selection.
Authors: VanderWeele T.J. .
Source: European journal of epidemiology, 2019 Mar; 34(3), p. 211-219.
EPub date: 2019-03-06.
PMID: 30840181
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Religiously or Spiritually-Motivated Forgiveness and Subsequent Health and Well-Being among Young Adults: An Outcome-Wide Analysis.
Authors: Chen Y. , Harris S.K. , Worthington E.L. , VanderWeele T.J. .
Source: The journal of positive psychology, 2019; 14(5), p. 649-658.
EPub date: 2018-09-13.
PMID: 31360213
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Selecting Optimal Subgroups for Treatment Using Many Covariates.
Authors: VanderWeele T.J. , Luedtke A.R. , van der Laan M.J. , Kessler R.C. .
Source: Epidemiology (Cambridge, Mass.), 2019 05; 30(3), p. 334-341.
PMID: 30789432
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Multiplicative Interactions Under Differential Outcome Measurement Error with Perfect Specificity.
Authors: VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2019 05; 30(3), p. e15-e16.
PMID: 30789429
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New metrics for meta-analyses of heterogeneous effects.
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Statistics in medicine, 2019-04-15; 38(8), p. 1336-1342.
EPub date: 2018-12-04.
PMID: 30513552
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Sense of Mission and Subsequent Health and Well-Being Among Young Adults: An Outcome-Wide Analysis.
Authors: Chen Y. , Kim E.S. , Koh H.K. , Frazier A.L. , VanderWeele T.J. .
Source: American journal of epidemiology, 2019-04-01; 188(4), p. 664-673.
PMID: 30649174
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SOME DESIRABLE PROPERTIES OF THE BONFERRONI CORRECTION: IS THE BONFERRONI CORRECTION REALLY SO BAD?
Authors: VanderWeele T.J. , Mathur M.B. .
Source: American journal of epidemiology, 2019-03-01; 188(3), p. 617-618.
PMID: 30452538
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Association of Short Interpregnancy Interval With Pregnancy Outcomes According to Maternal Age.
Authors: Schummers L. , Hutcheon J.A. , Hernandez-Diaz S. , Williams P.L. , Hacker M.R. , VanderWeele T.J. , Norman W.V. .
Source: JAMA internal medicine, 2018-12-01; 178(12), p. 1661-1670.
PMID: 30383085
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Decomposition Analysis to Identify Intervention Targets for Reducing Disparities.
Authors: Jackson J.W. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2018 11; 29(6), p. 825-835.
PMID: 30063540
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Web Site and R Package for Computing E-values.
Authors: Mathur M.B. , Ding P. , Riddell C.A. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2018 09; 29(5), p. e45-e47.
PMID: 29912013
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On Well-defined Hypothetical Interventions in the Potential Outcomes Framework.
Authors: VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2018 07; 29(4), p. e24-e25.
PMID: 29561280
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R Function for Additive Interaction Measures.
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Epidemiology (Cambridge, Mass.), 2018 01; 29(1), p. e5-e6.
PMID: 28901974
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