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Grant Details

Grant Number: 5R01CA185623-04 Interpret this number
Primary Investigator: Bandera, Elisa
Organization: Rbhs -Cancer Institute Of New Jersey
Project Title: Obesity, Related Comorbidities, and Breast Cancer Outcomes in African Americans
Fiscal Year: 2017
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Abstract

DESCRIPTION (provided by applicant): Poorer breast cancer (BrCa) prognosis among African Americans (AAs) compared to other racial and ethnic groups in the United States is likely multifactorial, including tumor characteristics, socio-economic factors and poor access to care. While there is strong evidence that obesity and obesity-related comorbidities increase BrCa and competing cause mortality among women of European ancestry (EAs), its prognostic role among AAs is uncertain, and potential mediating mechanisms have not been elucidated. We propose to evaluate (1) the impact of body fatness (body mass index, body fat distribution, and body composition) on BrCa treatment received (including chemotherapy dose reduction and delay) and outcomes (BrCa-specific mortality, competing-cause mortality, all-cause mortality, quality-of-life); (2) the impact of obesity-related comorbidities which are more common among AAs, including hypertension and diabetes, in relation to BrCa treatment and outcomes, and whether optimal management of these conditions impact outcomes; and (3) potential mechanistic pathways, including immune factors, vitamin D, adipokines, and indicators of insulin resistance that potentially mediate the effects obesity and obesity-related comorbidities. Estimates of genomic ancestry, obtained using genotypes from Ancestry Informative Markers (AIMs) will be included in all analyses. We propose a cost-effective study that builds upon an ongoing population-based case-control study of BrCa in AA women (P01 CA151135). Rapid case ascertainment by the NJ State Cancer Registry (NJSCR) is used to identify newly diagnosed BrCa cases in ten counties in NJ. Here we propose to extend recruitment of AA cases up to March 2018, increasing the total number to ~1,700, with ~1,100 cases with blood samples collected 18 to 24 months after diagnosis and ~860 blood samples collected 30 to 36 months after diagnosis. We propose to establish a cohort of AA BrCa survivors to assess disparities in care, quality-of-life (QoL), and survival, particularly in relation to obesity. A baeline home interview conducted shortly after diagnosis collects information on risk factors, including lifetime weight history. Anthropometric and body composition measurements are taken and a saliva sample is collected. Medical records from multiple providers are obtained and reviewed. We propose to collect blood samples ~12 months and ~24 months after completion of treatment to evaluate obesity-related biomarkers, and to conduct annual active and passive follow-up and obtain detailed medical records. Active follow-up will involve interviews to collect annual updates on anthropometric measurements, diet and physical activity, medical history, including information on comorbidities and their management, as well as survivorship factors (e.g., QoL, lymphedema, perceived stress, and fatigue). Passive follow-up will include record linkage with the NJSCR to obtain vital status and time and causes of death for those who are deceased. Findings from this study have great potential to improve clinical management of obese AA BrCa patients to improve the survival and QoL of BrCa survivors.

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Publications

Genetic ancestry and population differences in levels of inflammatory cytokines in women: Role for evolutionary selection and environmental factors.
Authors: Yao S. , Hong C.C. , Ruiz-NarvŠez E.A. , Evans S.S. , Zhu Q. , Schaefer B.A. , Yan L. , Coignet M.V. , Lunetta K.L. , Sucheston-Campbell L.E. , et al. .
Source: PLoS genetics, 2018 06; 14(6), p. e1007368.
EPub date: 2018-06-07.
PMID: 29879116
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A survey of microRNA single nucleotide polymorphisms identifies novel breast cancer susceptibility loci in a case-control, population-based study of African-American women.
Authors: Bensen J.T. , Graff M. , Young K.L. , Sethupathy P. , Parker J. , Pecot C.V. , Currin K. , Haddad S.A. , Ruiz-NarvŠez E.A. , Haiman C.A. , et al. .
Source: Breast cancer research : BCR, 2018-06-05; 20(1), p. 45.
EPub date: 2018-06-05.
PMID: 29871690
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Validity of self-reported weight, height, and body mass index among African American breast cancer survivors.
Authors: Qin B. , Llanos A.A.M. , Lin Y. , Szamreta E.A. , Plascak J.J. , Oh H. , Pawlish K. , Ambrosone C.B. , Demissie K. , Hong C.C. , et al. .
Source: Journal of cancer survivorship : research and practice, 2018 08; 12(4), p. 460-468.
EPub date: 2018-03-13.
PMID: 29536415
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Frequency of breast cancer subtypes among African American women in the AMBER consortium.
Authors: Allott E.H. , Geradts J. , Cohen S.M. , Khoury T. , Zirpoli G.R. , Bshara W. , Davis W. , Omilian A. , Nair P. , Ondracek R.P. , et al. .
Source: Breast cancer research : BCR, 2018-02-06; 20(1), p. 12.
EPub date: 2018-02-06.
PMID: 29409530
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Genetic Variants in Immune-Related Pathways and Breast Cancer Risk in African American Women in the AMBER Consortium.
Authors: Hong C.C. , Sucheston-Campbell L.E. , Liu S. , Hu Q. , Yao S. , Lunetta K.L. , Haddad S.A. , Ruiz-NarvŠez E.A. , Bensen J.T. , Cheng T.D. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2018 03; 27(3), p. 321-330.
EPub date: 2018-01-16.
PMID: 29339359
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Biology and Etiology of Young-Onset Breast Cancers among Premenopausal African American Women: Results from the AMBER Consortium.
Authors: Chollet-Hinton L. , Olshan A.F. , Nichols H.B. , Anders C.K. , Lund J.L. , Allott E.H. , Bethea T.N. , Hong C.C. , Cohen S.M. , Khoury T. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017 12; 26(12), p. 1722-1729.
EPub date: 2017-09-13.
PMID: 28903991
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Hair product use and breast cancer risk among African American and White women.
Authors: Llanos A.A.M. , Rabkin A. , Bandera E.V. , Zirpoli G. , Gonzalez B.D. , Xing C.Y. , Qin B. , Lin Y. , Hong C.C. , Demissie K. , et al. .
Source: Carcinogenesis, 2017-09-01; 38(9), p. 883-892.
PMID: 28605409
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Alcohol Intake and Breast Cancer Risk in African American Women from the AMBER Consortium.
Authors: Williams L.A. , Olshan A.F. , Hong C.C. , Bandera E.V. , Rosenberg L. , Cheng T.D. , Lunetta K.L. , McCann S.E. , Poole C. , Kolonel L.N. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017 05; 26(5), p. 787-794.
EPub date: 2017-04-18.
PMID: 28420652
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Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry.
Authors: Feng Y. , Rhie S.K. , Huo D. , Ruiz-Narvaez E.A. , Haddad S.A. , Ambrosone C.B. , John E.M. , Bernstein L. , Zheng W. , Hu J.J. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017 07; 26(7), p. 1016-1026.
EPub date: 2017-04-04.
PMID: 28377418
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Trans-ethnic follow-up of breast cancer GWAS hits using the preferential linkage disequilibrium approach.
Authors: Zhu Q. , Shepherd L. , Lunetta K.L. , Yao S. , Liu Q. , Hu Q. , Haddad S.A. , Sucheston-Campbell L. , Bensen J.T. , Bandera E.V. , et al. .
Source: Oncotarget, 2016-12-13; 7(50), p. 83160-83176.
PMID: 27825120
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The Quest for Mindful Sleep: A Critical Synthesis of the Impact of Mindfulness-Based Interventions for Insomnia.
Authors: Garland S.N. , Zhou E.S. , Gonzalez B.D. , Rodriguez N. .
Source: Current sleep medicine reports, 2016 Sep; 2(3), p. 142-151.
EPub date: 2016-07-05.
PMID: 28191449
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Vigorous physical activity and risk of breast cancer in the African American breast cancer epidemiology and risk consortium.
Authors: Gong Z. , Hong C.C. , Bandera E.V. , Adams-Campbell L.L. , Troester M.A. , Park S.Y. , McInerney K.A. , Zirpoli G. , Olshan A.F. , Palmer J.R. , et al. .
Source: Breast cancer research and treatment, 2016 Sep; 159(2), p. 347-56.
EPub date: 2016-08-11.
PMID: 27514396
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Genetic variation in the insulin, insulin-like growth factor, growth hormone, and leptin pathways in relation to breast cancer in African-American women: the AMBER consortium.
Authors: Ruiz-NarvŠez E.A. , Lunetta K.L. , Hong C.C. , Haddad S. , Yao S. , Cheng T.D. , Bensen J.T. , Bandera E.V. , Haiman C.A. , Troester M.A. , et al. .
Source: NPJ breast cancer, 2016; 2, .
EPub date: 2016-10-26.
PMID: 27942580
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Quality of life trajectories after diagnosis of gynecologic cancer: a theoretically based approach.
Authors: Gonzalez B.D. , Manne S.L. , Stapleton J. , Myers-Virtue S. , Ozga M. , Kissane D. , Heckman C. , Morgan M. .
Source: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2017 02; 25(2), p. 589-598.
EPub date: 2016-10-19.
PMID: 27757706
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Admixture Mapping of African-American Women in the AMBER Consortium Identifies New Loci for Breast Cancer and Estrogen-Receptor Subtypes.
Authors: Ruiz-NarvŠez E.A. , Sucheston-Campbell L. , Bensen J.T. , Yao S. , Haddad S. , Haiman C.A. , Bandera E.V. , John E.M. , Bernstein L. , Hu J.J. , et al. .
Source: Frontiers in genetics, 2016; 7, p. 170.
EPub date: 2016-09-21.
PMID: 27708667
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Single nucleotide variants in metastasis-related genes are associated with breast cancer risk, by lymph node involvement and estrogen receptor status, in women with European and African ancestry.
Authors: Roberts M.R. , Sucheston-Campbell L.E. , Zirpoli G.R. , Higgins M. , Freudenheim J.L. , Bandera E.V. , Ambrosone C.B. , Yao S. .
Source: Molecular carcinogenesis, 2017 03; 56(3), p. 1000-1009.
EPub date: 2016-09-21.
PMID: 27597141
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Genetic variants in the mTOR pathway and interaction with body size and weight gain on breast cancer risk in African-American and European American women.
Authors: Cheng T.Y. , Shankar J. , Zirpoli G. , Roberts M.R. , Hong C.C. , Bandera E.V. , Ambrosone C.B. , Yao S. .
Source: Cancer causes & control : CCC, 2016 08; 27(8), p. 965-76.
EPub date: 2016-06-17.
PMID: 27314662
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Breast cancer risk factor associations differ for pure versus invasive carcinoma with an in situ component in case-control and case-case analyses.
Authors: Ruszczyk M. , Zirpoli G. , Kumar S. , Bandera E.V. , Bovbjerg D.H. , Jandorf L. , Khoury T. , Hwang H. , Ciupak G. , Pawlish K. , et al. .
Source: Cancer causes & control : CCC, 2016 Feb; 27(2), p. 183-98.
EPub date: 2015-11-30.
PMID: 26621543
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Genetic variants in the mTOR pathway and breast cancer risk in African American women.
Authors: Cheng T.D. , Ambrosone C.B. , Hong C.C. , Lunetta K.L. , Liu S. , Hu Q. , Yao S. , Sucheston-Campbell L. , Bandera E.V. , Ruiz-NarvŠez E.A. , et al. .
Source: Carcinogenesis, 2016 Jan; 37(1), p. 49-55.
EPub date: 2015-11-16.
PMID: 26577839
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Racial and ethnic disparities in the impact of obesity on breast cancer risk and survival: a global perspective.
Authors: Bandera E.V. , Maskarinec G. , Romieu I. , John E.M. .
Source: Advances in nutrition (Bethesda, Md.), 2015 Nov; 6(6), p. 803-19.
EPub date: 2015-11-13.
PMID: 26567202
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Important Role of Menarche in Development of Estrogen Receptor-Negative Breast Cancer in African American Women.
Authors: Ambrosone C.B. , Zirpoli G. , Hong C.C. , Yao S. , Troester M.A. , Bandera E.V. , Schedin P. , Bethea T.N. , Borges V. , Park S.Y. , et al. .
Source: Journal of the National Cancer Institute, 2015 Sep; 107(9), .
EPub date: 2015-06-17.
PMID: 26085483
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Obesity, body fat distribution, and risk of breast cancer subtypes in African American women participating in the AMBER Consortium.
Authors: Bandera E.V. , Chandran U. , Hong C.C. , Troester M.A. , Bethea T.N. , Adams-Campbell L.L. , Haiman C.A. , Park S.Y. , Olshan A.F. , Ambrosone C.B. , et al. .
Source: Breast cancer research and treatment, 2015 Apr; 150(3), p. 655-66.
EPub date: 2015-03-26.
PMID: 25809092
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Effect of travel distance and time to radiotherapy on likelihood of receiving mastectomy.
Authors: Goyal S. , Chandwani S. , Haffty B.G. , Demissie K. .
Source: Annals of surgical oncology, 2015 Apr; 22(4), p. 1095-101.
EPub date: 2014-09-23.
PMID: 25245129
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