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Grant Details

Grant Number: 5P50CA180523-05 Interpret this number
Primary Investigator: Clark, Pamela
Organization: Univ Of Maryland, College Park
Project Title: Rapid Response Characterization of New and Manipulated Tobacco Products
Fiscal Year: 2017
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DESCRIPTION (provided by applicant): Proposed is a Tobacco Center of Regulatory Science (TCORS) for Research Relevant to the Family Smoking Prevention and Tobacco Control Act (FSPTCA). The proposed Center will characterize combustible and non-combustible, conventional, new and manipulated nicotine/tobacco products and the impact of variations in those products on human behavior and exposure. The focus of the Center is the products and resulting human use behaviors and exposures, examined in crossover acute laboratory trials. Objective 1. To characterize the chemical profiles and physical properties of combustible, non-combustible, conventional, new and manipulated tobacco products (Project I and Core B). Objective 2. To differentiate the appeal and consumer acceptance of combustible tobacco products that differ only on a single characteristic of interest (e.g., menthol concentration, smok pH) (Project II). Objective 3. To explore tobacco microbial constituents and the oral microbiome of tobacco users (Project III). Objective 4. To support the data management and statistical needs of the Center, and provide FDA CTP/NIH and select other Centers with early access to the data. Objective 5. To train the next generation of transdisciplinary scientists in science to inform tobacco regulation. Objective 6. To expand the knowledge base through a rapid response system of developmental/pilot projects. The results of the proposed research will provide scientific data to inform the regulation of tobacco products by the FDA Center for Tobacco Products (CTP). The proposed Center will address, at a minimum, two research priorities: 1) "Diversity of Tobacco Products - understanding the constituents, components, ingredients, additives, and design features; use behaviors"; 2)"Adverse Health Consequences - understanding health risks of multiple tobacco types..." RELEVANCE: In most studies, one can only examine a single dimension of tobacco harm. This is a proposal to simultaneously measure harm in three orthoganal contexts: toxicity, consumer accepance and liking, and bacterial exposure, providing a much clearer picture of where a product lies in a continuum of harm, and a scientific basis for regulation of particular product design features.

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Responses to cigarette health warning labels, harm perceptions and knowledge in a national sample of pregnant and non-pregnant women of reproductive age.
Authors: Mead E.L. , Cruz-Cano R. , Groom A. , Hart J.L. , Walker K.L. , Giachello A.L. , Robertson R.M. , Oncken C. .
Source: Addictive Behaviors, 2018-10-13 00:00:00.0; 90, p. 10-13.
EPub date: 2018-10-13 00:00:00.0.
PMID: 30352339
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Authors: Mead E.L. , Johnson S.L. , Siddiqui J. , Butler J. , Kirchner T. , Feldman R.H. .
Source: Addiction Research & Theory, 2018; 26(5), p. 349-360.
EPub date: 2017-09-01 00:00:00.0.
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Little Cigars vs 3R4F Cigarette: Physical Properties and HPHC Yields.
Authors: Hamad S.H. , Johnson N.M. , Tefft M.E. , Brinkman M.C. , Gordon S.M. , Clark P.I. , Buehler S.S. .
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Smokeless tobacco products harbor diverse bacterial microbiota that differ across products and brands.
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Mentholation affects the cigarette microbiota by selecting for bacteria resistant to harsh environmental conditions and selecting against potential bacterial pathogens.
Authors: Chopyk J. , Chattopadhyay S. , Kulkarni P. , Claye E. , Babik K.R. , Reid M.C. , Smyth E.M. , Hittle L.E. , Paulson J.N. , Cruz-Cano R. , et al. .
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E-Cigarettes Use Behavior and Experience of Adults: Qualitative Research Findings to Inform E-Cigarette Use Measure Development.
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Temporal Variations in Cigarette Tobacco Bacterial Community Composition and Tobacco-Specific Nitrosamine Content Are Influenced by Brand and Storage Conditions.
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Determination of nicotine, glycerol, propylene glycol and water in electronic cigarette fluids using quantitative (1) H NMR.
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Role of sweet and other flavours in liking and disliking of electronic cigarettes.
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Source: Tobacco Control, 2016 Nov; 25(Suppl 2), p. ii55-ii61.
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Variability in Puff Topography and Exhaled CO in Waterpipe Tobacco Smoking.
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Source: Tobacco Regulatory Science, 2016 Oct; 2(4), p. 301-308.
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Real-Time Measurement of Electronic Cigarette Aerosol Size Distribution and Metals Content Analysis.
Authors: Mikheev V.B. , Brinkman M.C. , Granville C.A. , Gordon S.M. , Clark P.I. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2016 Sep; 18(9), p. 1895-902.
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Design and Validation of a Research-Grade Waterpipe Equipped With Puff Topography Analyzer.
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Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2016 May; 18(5), p. 785-93.
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Identification of New and Distinctive Exposures from Little Cigars.
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Source: Chemical Research In Toxicology, 2016-02-15 00:00:00.0; 29(2), p. 162-8.
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